KR20170083134A - 시르투인 조정제로서의 치환된 가교된 우레아 유사체 - Google Patents
시르투인 조정제로서의 치환된 가교된 우레아 유사체 Download PDFInfo
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- KR20170083134A KR20170083134A KR1020177016278A KR20177016278A KR20170083134A KR 20170083134 A KR20170083134 A KR 20170083134A KR 1020177016278 A KR1020177016278 A KR 1020177016278A KR 20177016278 A KR20177016278 A KR 20177016278A KR 20170083134 A KR20170083134 A KR 20170083134A
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- South Korea
- Prior art keywords
- branched
- straight
- chain
- sirtuin
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US201462081916P | 2014-11-19 | 2014-11-19 | |
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| PCT/IB2015/058977 WO2016079709A1 (en) | 2014-11-19 | 2015-11-19 | Substituted bridged urea analogs as sirtuin modulators |
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| KR20170083134A true KR20170083134A (ko) | 2017-07-17 |
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| KR1020177016277A Withdrawn KR20170083133A (ko) | 2014-11-19 | 2015-11-19 | 시르투인 조정제로서의 치환된 가교된 우레아 유사체 |
| KR1020177016280A Withdrawn KR20170083135A (ko) | 2014-11-19 | 2015-11-19 | 시르투인 조정제로서의 치환된 가교된 우레아 유사체 |
| KR1020177016279A Withdrawn KR20170087907A (ko) | 2014-11-19 | 2015-11-19 | 시르투인 조정제로서의 치환된 가교된 우레아 유사체 |
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| KR1020177016280A Withdrawn KR20170083135A (ko) | 2014-11-19 | 2015-11-19 | 시르투인 조정제로서의 치환된 가교된 우레아 유사체 |
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| US10653782B2 (en) * | 2014-11-25 | 2020-05-19 | Nortwestern University | Retroviral particles expressing Sirt1 embedded within PPCN |
| CN108329388A (zh) * | 2018-01-18 | 2018-07-27 | 天津市湖滨盘古基因科学发展有限公司 | 一种人的沉默配型信息调节蛋白突变蛋白及其应用 |
| CN108395436B (zh) * | 2018-05-14 | 2021-01-12 | 鹤壁市人民医院 | 一种咪唑并吡嗪医药中间体的制备方法 |
| CN108707150B (zh) * | 2018-05-14 | 2021-04-16 | 江苏惠利生物科技有限公司 | 一种咪唑并吡嗪医药中间体的制备方法 |
| CN110478339A (zh) * | 2019-08-12 | 2019-11-22 | 昆明理工大学 | 紫铆因在制备靶向恢复突变p53构象药物中的应用 |
| WO2021043703A1 (de) * | 2019-09-02 | 2021-03-11 | Merck Patent Gmbh | Materialien für organische elektrolumineszenzvorrichtungen |
| CN114929680B (zh) * | 2019-11-19 | 2024-06-14 | 印度鲁宾有限公司 | 制备苯并二氢吡喃化合物的方法 |
| BR112022013865A2 (pt) * | 2020-01-17 | 2022-09-13 | Lupin Ltd | Métodos e composto |
| CN114890955A (zh) * | 2022-06-23 | 2022-08-12 | 江西瑞威尔生物科技有限公司 | 一种n取代吗啉类有机化合物的制备工艺 |
| WO2025194094A1 (en) * | 2024-03-15 | 2025-09-18 | The Regents Of The University Of Michigan | Small molecule modulators of sirt5 and uses thereof |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
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| UA108596C2 (xx) | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| US9556201B2 (en) * | 2009-10-29 | 2017-01-31 | Glaxosmithkline Llc | Bicyclic pyridines and analogs as sirtuin modulators |
| EP2790701A1 (en) * | 2011-12-12 | 2014-10-22 | SMB Innovation | Novel heterocyclic compounds useful in sirtuin binding and modulation |
| ES2718550T3 (es) * | 2013-05-13 | 2019-07-02 | Glaxosmithkline Llc | Análogos de urea con puente sustituidos como moduladores de sirtuinas |
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2017
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