ES2823748T3 - Análogos de urea con puente y sustituidos como moduladores de sirtuina - Google Patents

Info

Publication number

ES2823748T3

ES2823748T3 ES15801271T ES15801271T ES2823748T3 ES 2823748 T3 ES2823748 T3 ES 2823748T3 ES 15801271 T ES15801271 T ES 15801271T ES 15801271 T ES15801271 T ES 15801271T ES 2823748 T3 ES2823748 T3 ES 2823748T3

Authority

ES

Spain

Prior art keywords

linear

branched

sirtuin

mmol

compound

Prior art date

2014-11-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 108050002485 Sirtuin Proteins 0.000 title description 225
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• 150000001875 compounds Chemical class 0.000 claims abstract description 271
• -1 -N- heterocyclyl Chemical group 0.000 claims abstract description 156
• 150000003839 salts Chemical class 0.000 claims abstract description 56
• 125000003118 aryl group Chemical group 0.000 claims abstract description 51
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 44
• 239000001257 hydrogen Substances 0.000 claims abstract description 43
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 36
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 33
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 26
• 125000001424 substituent group Chemical group 0.000 claims abstract description 26
• 150000002431 hydrogen Chemical group 0.000 claims abstract description 25
• 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 22
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• 150000002367 halogens Chemical group 0.000 claims abstract description 22
• 125000001188 haloalkyl group Chemical group 0.000 claims abstract description 16
• 125000003545 alkoxy group Chemical group 0.000 claims abstract description 13
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 10
• 125000004438 haloalkoxy group Chemical group 0.000 claims abstract 2
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