KR20170079804A - Natural complex extract composition for preventing skin aging and anti-inflammatory, natural cosmetic composition comprising that - Google Patents
Natural complex extract composition for preventing skin aging and anti-inflammatory, natural cosmetic composition comprising that Download PDFInfo
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- KR20170079804A KR20170079804A KR1020150190773A KR20150190773A KR20170079804A KR 20170079804 A KR20170079804 A KR 20170079804A KR 1020150190773 A KR1020150190773 A KR 1020150190773A KR 20150190773 A KR20150190773 A KR 20150190773A KR 20170079804 A KR20170079804 A KR 20170079804A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
Abstract
The present invention relates to a natural complex composition for preventing skin aging and antiinflammation and a natural cosmetic composition containing the same. More particularly, the present invention relates to a natural complex composition for skin aging prevention and antiinflammation, ≪ / RTI > Since the natural complex composition according to the present invention has excellent antioxidant activity, excellent nitrogen monoxide inhibition activity, and does not affect cell viability at all concentrations, it has no side effects and is excellent in antioxidation, anti-inflammation and skin safety. . ≪ / RTI >
Description
The present invention relates to a natural complex composition for preventing skin aging and antiinflammation, and a natural cosmetic composition comprising the same, and more particularly, to a natural cosmetic composition comprising a natural cosmetic composition comprising horse riding, blueberry, licorice root, oolong tea, will be.
Recently, there has been an increasing interest in active oxygen involved in various adult diseases and aging due to changes in living environment and eating habits. In the human body, stable oxygen is detected by a biochemical mechanism, such as superoxide anion radical, hydrogen peroxide radical, singlet oxygen, reactive oxygen species ) (Kwon, GJ, DS Choi, and MH Wang, 2007. Biological activities of hot water extracts from euonymus alatus leaf, Korean J. Food Sci. Technol., 39, 569-574.).
(O2-), hydrogen peroxide (H2O2), hydroxyl radicals (hydroxyl radicals) generated by normal intracellular activity in vivo or generated by environmental pollution, chemical exposure, etc. OH) are called reactive oxygen species (ROS). It is known that active oxygen is oxygen with free radicals and is unstable. It is known to induce oxidative stress of cells due to strong reactivity with surrounding substances (Kim, YC, Hong, HD, Rho, JH, Cho, CW, Rhee, YK and Yim, JH 2007. Changes of phenolic acid contents and radical scavenging activities of ginseng according to steaming times. J Ginseng Res 31, 230-236.). Oxygen radicals Oxygen radicals, hydrogen peroxide radicals, and active oxygen such as singlet oxygen accelerate oxidation in vivo and cause peroxidation of unsaturated fatty acids in phospholipids, which enhances the permeability of cell membranes and leads to cytotoxicity, (Meneghini, R., Martins, EAL and Calderaro, M. 1993. DNA damage by reactive oxygen species: The role of metal. Pp. 102-112, In: Free Radicals: From Basic Science to Medicine: Molecular and cell biology updates. In Poli, G., Albano, E. and Dianzani, MU (eds.), Birkhauser Verlag, Basel, Switzerland). Currently, various studies are being conducted on natural materials that protect cells from the oxidative acceleration of active oxygen, and materials that can protect the living body by regulating protein expression involved in inflammation.
The extracts of horse riding were found to have antioxidant activity in vitro and anti - inflammatory effects in cell model experiments through experiments on pharmacological activity in cosmetics, but their activity was not remarkably noted. Therefore, many studies have been conducted to mix other extracts with horse riding extracts. For example, Korean Patent Laid-Open Publication No. 10-2014-0145278 provides a cosmetic composition containing horse-radish extract, marine oil extract and in-plant extract having skin convergence and elasticity effect. In Korean Patent No. 10-1047644, , Horse riding, sunscreen, or extract of Ganoderma lucidum.
The inventors of the present invention proposed that a natural composite composition based on six antioxidant and antiinflammatory activities, which is a combination of six kinds of natural materials, such as horse riding, blueberry, licorice root, oolong tea, , Licorice root extract, Woron tea extract, and corn oil extract as active ingredients, thereby confirming the stability and safety of the natural cosmetic composition.
Accordingly, an object of the present invention is to provide a natural cosmetic composition comprising, as an active ingredient, an extract of horse riding, blueberry, licorice, wisdom, oolong tea,
In order to accomplish the above object, the present invention provides a natural composition comprising horse riding, blueberry, licorice, wormwood, oolong tea and corn.
According to an embodiment of the present invention, the natural complex composition may contain 10-30% by weight of horse riding, 10-30% by weight of blueberries, 10-30% by weight of licorice, 10-20% 10 to 20% by weight of tea and 10 to 20% by weight of corn.
The present invention also provides a cosmetic composition comprising the natural complex composition.
According to an embodiment of the present invention, the cosmetic composition may contain the natural complex composition in an amount of 0.1 to 20% by weight based on the total weight of the composition.
According to one embodiment of the present invention, the cosmetic composition is skin, lotion, cream, essence. Mist, sunscreen, shampoo, cleanser, powder, hair tonic, and mask pack.
According to one embodiment of the present invention, the cosmetic composition may be used for preventing skin aging or anti-inflammation.
In addition, the present invention relates to a process for producing a mixture (S1) of a mixture of horse riding, blueberries, licorice, witches, oolong tea and corn; Extracting the mixture with a solvent (S2); And (S3) filtering and concentrating the natural complex composition.
According to one embodiment of the present invention, in step S1, the mixture comprises 10 to 30 wt% of horse riding, 10 to 30 wt% of blueberries, 10 to 30 wt% of licorice, 10 to 20 wt% By weight and 10 to 20% by weight can be mixed.
According to an embodiment of the present invention, in the step S2, the solvent may be water, an alcohol having 1 to 4 carbon atoms, or a mixture thereof.
The extracts of horse riding, blueberry, licorice, wormwood, oolong tea and eelgrass according to the present invention have excellent antioxidative activity, excellent nitric oxide inhibitory activity, and do not affect the survival rate of cells at all concentrations, , Antioxidation, anti-inflammation, and skin safety, so that it can be usefully used as a natural cosmetic composition.
FIG. 1 shows the results of measurement of the electron donating ability of the natural composition for skin anti-aging and anti-inflammation of the present invention.
FIG. 2 shows the measurement results of the hydrogen peroxide scavenging ability of the natural composite composition for anti-aging and anti-inflammation of the present invention.
FIG. 3 shows the results of measurement of cytotoxicity of the natural composition composition for skin anti-aging and anti-inflammation of the present invention.
FIG. 4 shows the results of measurement of the inhibitory effect on the production of nitrogen monoxide in macrophage RAW 264.7 cells of a natural compound composition for anti-aging and anti-inflammation of the present invention.
FIG. 5 shows the results of measurement of iNOS and COX-2 expression levels by western blot analysis in macrophage RAW 264.7 cells of a natural compound composition for preventing skin aging and anti-inflammation of the present invention.
The present invention provides a natural combination composition comprising horse riding, blueberries, licorice, witches, oolong tea and curry, and a cosmetic composition comprising the natural composition.
The natural complex composition according to the present invention comprises 10 to 30% by weight of horse riding, 10 to 30% by weight of blueberries, 10 to 30% by weight of licorice, 10 to 20% by weight of wort, 10 to 20% And 10 to 20% by weight of cormorant.
Hereinafter, the present invention will be described in detail.
The horse is a perennial herb about 1 m high and its main ingredient is phenolcarboxylic acids such as ferulic acid, isoferulic acid, cimitin, cimicifugine, salicylic acid, caffeic acid acid), and it has the effect of winning, announcing, tinnitus, and detoxification. In the present invention, it is preferable to mix 10 to 30% by weight with respect to the total dry weight of the composition to be mixed. When the content is less than 10% by weight, the effect is hardly exhibited. When the content exceeds 30% by weight, A physical property problem such as a decrease in viscosity occurs.
The blueberries are extracted from fruits of blueberries and contain components such as anthocyanins, phenols and other flavonoids to prevent oxidative damage of the skin. In the present invention, the blueberry is preferably mixed at 10 to 30% by weight with respect to the total dry weight of the composition to be mixed, and when mixed at less than 10% by weight, the effect is hardly exhibited, And problems of physical properties such as viscosity decrease occur.
The licorice is rich in vitamin C, including vitamin A and vitamin B, and is effective against acne and eczema. It also has a whitening effect and a skin soothing effect. In the present invention, licorice is preferably mixed in an amount of 10 to 30% by weight based on the total dry weight of the composition to be mixed. When the content is less than 10% by weight, the effect is hardly exhibited. And problems of physical properties such as discoloration and viscosity decrease occur.
It is also called gonorrhea mushroom, has excellent anticancer effect and is effective in preventing adult diseases. In the present invention, wormwood is preferably mixed in an amount of 10 to 20% by weight based on the total dry weight of the composition to be mixed. When the amount is less than 10% by weight, the effect is hardly exhibited. And problems of physical properties such as discoloration and viscosity decrease occur.
The oolong tea is effective for suppressing obesity through promotion of fat metabolism, inhibiting blood cholesterol and triglyceride, and alleviating atopic dermatitis. In the present invention, the oolong tea is preferably mixed at 10 to 20 wt% with respect to the total dry weight of the composition to be mixed. When the oolong tea is mixed at less than 10 wt%, the effect is hardly exhibited. And problems of physical properties such as discoloration and viscosity decrease occur.
The herb is a perennial herbaceous plant belonging to the ginger family. Its main ingredient is curcumin, which is effective in inhibiting antioxidative action, skin pigmentation and skin blackening. In the present invention, it is preferred to mix 10 to 20% by weight of the total dry weight of the composition to be mixed. When the content is less than 10% by weight, little effect is exhibited. And problems of physical properties such as discoloration and viscosity decrease occur.
The natural composite composition, which is an effective ingredient in the cosmetic composition of the present invention,
(S1) mixing a mixture of horse riding, blueberries, licorice, witches, oolong tea and cormorant to prepare a mixture; Extracting the mixture with a solvent (S2); And filtering and concentrating (S3).
In step S1, the mixture comprises 10 to 30 wt% of horse riding, 10 to 30 wt% of blueberries, 10 to 30 wt% of licorice, 10 to 20 wt% of wormwood, 10 to 20 wt% of oolong tea, %.
In step S1, it is preferable that the horse rinse, the blueberry, the licorice, the wormwood, the oolong tea and the wolfberry are washed with water, dried, and then finely mixed.
In the step S2, it is preferable to add a mixed solvent of water and alcohol in an amount of 8 to 10 times the volume of the mixture, followed by solvent extraction at 20 to 25 ° C for 20 to 24 hours. The alcohol having 1 to 4 carbon atoms is preferably methanol or ethanol, and in the present invention, ethanol is most preferable. At this time, it is preferable that the alcohol having 1 to 4 carbon atoms and water have a volume ratio of 7: 3. It is preferable that ethanol solvent extraction is repeated three times.
In step S3, the filtration is preferably performed by passing the extract through a filter paper to remove the residue, and the filtration is performed by concentrating the filtered extract at 40 to 45 DEG C for 6 to 8 hours using a rotary vacuum concentrator .
The extract of the six species according to the present invention is excellent in electron donating ability and hydrogen peroxide inhibiting ability, and has excellent antioxidative and antiinflammatory activity because it does not adversely affect the survival rate of cells at all concentrations, May be useful as a composition.
The skin anti-aging and anti-inflammatory cosmetic composition according to the present invention can be prepared by containing from 0.1 to 20% by weight of the six kinds of extracts based on the total weight of the cosmetic composition, preferably from 1 to 10% by weight of the six kinds of extracts , ≪ / RTI >
The composition of the present invention can be used as cosmetics made in the form of general emulsified formulations and solubilized formulations. Emulsifier-type cosmetics include nutritional lotion, cream, and essence, and cosmetics of the solubilized formulation have softening longevity. Suitable cosmetic formulations include, for example, solutions, gels, solid or kneaded anhydrous products, emulsions obtained by dispersing the oil phase in water, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) In the form of a dispersing agent, in the form of a cream, a skin, a lotion, a powder, an ointment, a spray or a conical stick. It can also be prepared in the form of a foam or an aerosol composition further containing a compressed propellant.
In addition, the composition of the present invention can be used variously as a cosmetic having anti-inflammation and antioxidant activity. For example, skin, lotion, cream, essence. Mist, sunscreen, shampoo, cleanser, powder, hair tonic, and mask pack.
Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples. However, the following examples and experimental examples are intended to illustrate the present invention in detail, and the content of the present invention is not limited by the examples and the experimental examples.
[ Example 1] Production of natural composite composition
100g of horse riding, 100g of blueberries, 100g of licorice, 50g of wormwood, 100g of oolong tea, and 50g of wolfberry were respectively washed with water and dried to a moisture content of 10% or less. The dried natural ingredients were each divided into 3 to 5 cm pieces and mixed. A 10 volume volume of an aqueous ethanol solution (ethanol: water = 7: 3 by volume) was added to the mixture, followed by ethanol extraction at 25 占 폚 for 24 hours. Extraction was repeated three times. The extract was passed through a filter paper (Adventec No.e) and the residue was removed. The extract was concentrated using a rotary vacuum concentrator (HS-10P, Hanshin) at 45 ° C for 8 hours to prepare a natural composite composition.
[ Experimental Example 1] Measurement of antioxidant effect
In order to examine the antioxidant effect of the natural composition of Example 1, the electron donating ability and the hydrogen peroxide scavenging ability were measured.
One. Electron donating ability Measure
The electron donating ability of the natural composite composition prepared in Example 1 was measured. As a control, butylated hydroxyanisole (BHA), a synthetic antioxidant, was used. (EDA, electon donating abilities) of the natural composite composition may be modified by a method of Blois, MS (Antioxidant determination by the use of a stable free radical, Nature, 181, 1190-1200, 1958) Respectively. 50 μl of 0.2 mM DPPH (1,1-diphenyl-2-picryl-hydrazyl) was added to 100 μl of a certain concentration of the sample solution, stirred and reacted at room temperature for 30 minutes, and its absorbance was measured at a wavelength of 517 nm. The results are shown in Fig.
As shown in Fig. 1, the natural composite composition of the present invention showed similar antioxidative activity to that of the control group BHA. Therefore, it is judged that the natural complex composition of the present invention has an excellent antioxidative activity.
2. Hydrogen peroxide Scatters Measure
The hydrogen peroxide scavenging activity of the natural composite composition prepared in Example 1 was measured. The control group was vitamin C (vitamin C). The hydrogen peroxide-inhibiting activity of the natural compound extract was determined by the method of Jayaprakasha et al. (Jayaprakasha, GK, Jaganmohan Rao, L., Sakariak, KK (2004). Bioanorganic & Medicinal Chemistry 12, 5141 -5146) as follows. 500 占 퐇 of PBS and 500 占 퐇 of 40 mM hydrogen peroxide were added to 500 占 퐇 of a certain concentration of the sample solution, reacted at 37 占 폚 for 10 minutes, and then measured at 230 nm. The results are shown in Fig.
As shown in FIG. 2, the natural complex composition of the present invention showed similar antioxidative activities to vitamin C as a control group and exhibited excellent hydrogen peroxide scavenging ability. Therefore, it is judged that the natural complex composition of the present invention has an excellent antioxidative activity.
[ Experimental Example 2] Cytotoxicity Assessment
To evaluate the stability of the natural complex composition of the present invention, a cytotoxicity evaluation test was conducted.
The effect of the sample on the Raw 264.7 cells was evaluated by the method of Carmichael et al. (Carmichael, J., De Graff, WG, Gazdar, AF, Minna, JD and Mitchell, JB: Evaluation of a tetrazolium-based seminomatous colorimetric assay: assessment of chemosensitivity testing. Cancer Res., 47, 936-942, 1987). The cells were dispensed into a 96-well plate at 5 × 10 4 cells / well, and when the confluency reached 80%, the original medium was removed, and serum-free EMEM ). After incubation for 12 hours, the samples were added in concentrations and cultured in an incubator containing 37.5% carbon dioxide. For the control, the same amount of distilled water was added instead of the added sample, followed by incubation under the same conditions. To this was added 0.02 ml of MTT solution prepared at a concentration of 5 mg / ml. After 4 hours, the supernatant was removed. DMSO and ethanol were added at a ratio of 1: 1 (v / v by volume) per well to the reaction mixture for 30 minutes at room temperature. Absorbance was measured at 550 nm with an ELISA reader. The results are shown in Fig.
As shown in Fig. 3, the natural composite composition of the present invention did not affect the survival rate of macrophages and showed the same results at all concentrations. Therefore, the natural composite composition of the present invention does not affect cells, and thus, it is judged that the composition is not cytotoxic.
[ Experimental Example 3] Anti-inflammatory effect measurement
In order to examine the anti-inflammatory effect of the natural composite composition of Example 1, the nitrogen monoxide inhibitory activity was measured. Lipopolysaccharide (LPS) was used as a stimulant causing inflammation (control group).
The amount of nitrogen monoxide produced from macrophages Raw 264.7 cells was determined by the method of Byun et al. (Byun, SH, Yang, CH and Kim, SC: Inhibitory effect of scrophulariae radix extract on TNF-a, IL-1, (20, 7-16, 2005), the following measurements were made. The nitrite ion (NO2-) present in the cell culture was measured using a Griess reagent. 100 μl of the cell culture supernatant and 100 μl of the griess reagent were mixed and reacted for 10 minutes, and the absorbance was measured at 540 nm. The amount of nitrite ions (NO2-) was quantified using a standard curve of sodium nitrite (NaNO2). The results are shown in Fig.
As shown in FIG. 4, the natural complex composition of the present invention exhibited excellent nitric oxide inhibitory activity, and exhibited more excellent nitric oxide inhibitory activity as the content of the natural complex composition was increased. Therefore, it is considered that the natural complex composition of the present invention has an excellent anti-inflammatory effect.
[ Experimental Example 4] by Western blot analysis iNOS , COX-2 expression level
Measurement of the amount of iNOS and COX-2 expression by Western blot analysis was carried out by using W western blotting of Towbin (Stirpe, F. and Corte, ED 1969. The regulation of rat liver xanthine oxidase. J. Biol. Chem. 244, 3855-3863 ) Were used as follows. Cells were lysed by treatment with lipopolysaccharide (LPS) at various concentrations in mouse macrophages RAW 264.7 cells and centrifuged at 15,000 × g for 15 minutes to obtain proteins. Bradford method (Bradford, MM 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding, Anal. Biochem., 72, 248-254. The obtained protein was electrophoresed using SDS-polyacrylamide gel, and then transferred to the NC membrane. iNOS and COX-2 polyclonal antibodies were used to treat the membranes. Secondary antibodies were added and ECN detection was used to confirm the expression of iNOS and COX-2.
[ Formulation example ] Lotion preparation containing the natural composition of the present invention
A lotion containing the natural composition of Example 2 as an active ingredient was prepared, and its preparation criteria are shown in Table 1 below.
[ Comparative formulation example ] Production of Lotion Containing the Natural Composite Composition of the Present Invention
Lotions not containing the natural composite composition of the present invention were prepared, and the production standards thereof are shown in Table 1 below.
[ Experimental Example 5] Evaluation of skin irritation of lotion
In order to examine the skin irritation degree of the lotion of the above-mentioned formulation example, the lotion was applied to a finn chamber and attached vertically to the inside of the arm, and skin reaction was visually observed 24 hours later. The subjects were 20 men and 20 women in their 20s and 40s. The results of the test were evaluated by applying the criteria of the International Contact Dermatitis Research Group and the mean value was calculated. The results are shown in Table 2 below.
As shown in Table 2, all 20 adult men and women who applied the lotion containing the natural complex composition of the present invention did not have any skin troubles such as rash, erythema and itching, and thus the lotion containing the natural complex composition of the present invention Of the skin was verified.
Accordingly, the cosmetic composition containing the natural complex composition of the present invention as an active ingredient has no skin side effects, is excellent in antioxidative, anti-inflammatory and skin soothing effects, and can be used as a natural cosmetic composition.
Claims (9)
Wherein the natural complex composition comprises 10 to 30% by weight of horse riding, 10 to 30% by weight of blueberries, 10 to 30% by weight of licorice, 10 to 20% by weight of wormwood, 10 to 20% by weight of oolong tea, To 20% by weight of the total weight of the composition.
Extracting the mixture with a solvent (S2); And
Filtering and concentrating the mixture (S3).
In step S1, the mixture comprises 10 to 30 wt% of horse riding, 10 to 30 wt% of blueberries, 10 to 30 wt% of licorice, 10 to 20 wt% of wormwood, 10 to 20 wt% of oolong tea, % Of the total weight of the composition.
In the step S2, the solvent is water, an alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR102012732B1 (en) | 2018-06-05 | 2019-08-21 | 주식회사 위노바 | The skin cosmetic composition for anti-inflammation and reducing the skin pore comprising natural complex extracts |
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| KR102184985B1 (en) * | 2020-07-14 | 2020-12-01 | (주)피앤스토리 | Functional cosmetic composition comprising hydrogen and phytoncide as active ingredients |
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| US20060134095A1 (en) * | 2003-01-27 | 2006-06-22 | Shinobu Ito | Antioxidative composition and composition for external use |
| KR20080094459A (en) * | 2007-04-20 | 2008-10-23 | 주식회사 엘지생활건강 | Cosmetic composition having antioxidation activity |
| KR101047644B1 (en) | 2008-08-06 | 2011-07-07 | (주)아모레퍼시픽 | External skin composition containing pogongyoung, horse riding, powder or extract extract |
| KR20140145278A (en) | 2013-06-12 | 2014-12-23 | (주)하이메디코스 | Cosmetic composition containing Cimicifuga heracleifolia extract, Cornus officinalis extract and Geranium nepalense extract for skin convergence and elasticity effect |
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| US20060134095A1 (en) * | 2003-01-27 | 2006-06-22 | Shinobu Ito | Antioxidative composition and composition for external use |
| KR20080094459A (en) * | 2007-04-20 | 2008-10-23 | 주식회사 엘지생활건강 | Cosmetic composition having antioxidation activity |
| KR101047644B1 (en) | 2008-08-06 | 2011-07-07 | (주)아모레퍼시픽 | External skin composition containing pogongyoung, horse riding, powder or extract extract |
| KR20140145278A (en) | 2013-06-12 | 2014-12-23 | (주)하이메디코스 | Cosmetic composition containing Cimicifuga heracleifolia extract, Cornus officinalis extract and Geranium nepalense extract for skin convergence and elasticity effect |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102012732B1 (en) | 2018-06-05 | 2019-08-21 | 주식회사 위노바 | The skin cosmetic composition for anti-inflammation and reducing the skin pore comprising natural complex extracts |
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