KR20170074506A - Cosmetics compositions for prevention and improvement of wrinkle - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing and improving wrinkles.
The cosmetic composition for prevention and improvement of wrinkles according to the present invention contains a component for preventing and improving wrinkles having specific functional groups capable of covalent bonding with protein residues on the surface of the skin to form a covalent bond without damaging the skin, And an improvement effect.

Description

[0001] Cosmetic compositions for prevention and improvement of wrinkles [

The present invention relates to a composition for preventing and improving wrinkles and a cosmetic composition for preventing and improving wrinkles, the functional group being bonded to a protein.

Recently, there have been many studies on the prevention and improvement of facial wrinkles ranging from the medical field to the cosmetics industry. Especially in the cosmetics industry, wrinkle improvement is so important that it is included in the three functional categories along with whitening and ultraviolet screening, and the wrinkles of modern people living in the age of 100 will be said to be heavier than before.

Factors involved in wrinkle formation include ultraviolet rays, elastin in the skin tissue, collagen, substrate, and active oxygen. To improve this, various methods such as promotion of collagen synthesis, cell regeneration, antioxidation, and inhibition of skin muscle movement are used. However, unlike medical procedures in which drugs are injected below the epidermal layer using direct syringes, cosmetics that require repeated application of formulations to the skin over a long period of time are not able to follow the level of medical treatment in terms of efficacy and persistence.

In order to solve the weak penetration and persistence of functional substances in cosmetics, lipids, ceramides, surfactants and minerals having affinity to the skin surface or affinity to the skin surface are used, or techniques for increasing skin permeability are applied, Is small. If bioconjugation techniques that chemically modify the surface of the skin and chemically bond it with the desired functional material are applied, the functional material will remain on the skin for a long time and its effectiveness and durability will be improved.

In recent years, a method has been proposed in which the artificial tanning effect of dihydroxyacetone (DHA) can be rapidly obtained by modifying the skin with alkoxysilane introduced with an amine group in Loreal (Patent Document 1), but a substance such as alkoxysilane, It is difficult to apply the method of the present invention. Also, Dupont (Patent Document 2) and Rose et. al. (Patent Document 3) suggests a similar skin modification method, but there are few cases where bioconjugation technology is directly applied to cosmetics, so the need for technology development is urgent.

U.S. Patent Application Publication No. 2010-0516546 U.S. Patent Application Publication No. 2011-0274639 United States Patent Application Publication 2006-0233729

It is an object of the present invention to provide a cosmetic composition for prevention and improvement of wrinkles which can continuously impart the effect of preventing and improving wrinkles without damaging the skin.

As means for solving the above problems, the present invention relates to a phosphonium compound; And a cosmetic composition for prevention and improvement of wrinkles comprising a wrinkle preventing and improving component.

As another means for solving the above problems, the present invention provides a cosmetic composition for prevention and improvement of wrinkles further comprising a peptide binding-promoting additive in the composition.

The cosmetic composition for prevention and improvement of wrinkles according to the present invention contains a reactive wrinkle preventing and improving component and / or a phosphonium compound that incorporates a specific functional group capable of covalent bonding with protein residues of the skin, Thereby providing a semi-permanent anti-wrinkle effect. It also provides an effective wrinkle prevention and improvement effect, including a peptide bond formation promoting additive.

The present invention relates to a cosmetic composition for preventing and improving wrinkles containing a phosphonium compound and a wrinkle preventing and improving component.

The cosmetic composition for prevention and improvement of wrinkles according to the present invention can be produced by, for example, reacting a phosphonium compound with a wrinkle preventing and improving component, By forming a bond, the effect of preventing and improving wrinkles can be maximized.

The phosphonium compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the entire cosmetic composition. When the content is less than 0.001 part by weight, there is a problem that continuous wrinkle prevention and improvement effect is hardly exhibited. When the content exceeds 10 parts by weight, a phosphonium compound which is excessively present in the skin at a reaction position is not reacted with skin , There is a problem that it can act as a component to be lost, which does not help to improve persistence.

In the present invention, the term 'wrinkle prevention and improvement effect' means to prevent wrinkles from forming on the skin, in particular, the face skin, or to improve the wrinkles that have already been formed to help the skin.

The wrinkle preventing and improving component used in the present invention may include, but is not limited to, extracts derived from natural products such as copper, plants and minerals, amino acids, hormones, vitamins and the like. For example, there may be mentioned vitamin A (retinoid), vitamin E (tocopherol), flavonoid, polyphenol, superoxide dismutase (SOD), coenzyme Q10, alpha-lipoic acid, acetylhexapeptide, retinol, retinyl palmitate, retinyl acetate, A group consisting of adenosine, vitamin C, collagen, hexapeptide 3, skin cell growth factor (EGF), kinetin, snail mucilage, aquanomide, ceramide, glycerin, hyaluronic acid, betaine, chitosan, urea and derivatives thereof But the present invention is not limited thereto.

It is preferable that 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight of the anti-wrinkle agent is used with respect to 100 parts by weight of the entire cosmetic composition. When the content is less than 0.001, the effect is insufficient and there is a limit. When the content is more than 50 parts by weight, there is a problem in formulation and stabilization.

In particular, in the present invention, the wrinkle preventing and improving component can increase the reaction efficiency with a phosphonium compound by including a carboxyl group or an amine group in the molecule.

In the present invention, the wrinkle preventing and improving component may have a functional group capable of covalently bonding to protein residues on the skin surface.

The functional groups covalently bonded to the protein include carbodiimide, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy amines, But are not limited to, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, Selected from the group consisting of imidazole, oxycarbonyl imidazole, imine, thiol, maleimide, vinyl sulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide, ketone, carboxylic acid and phosphate It may be more than one, but it is not limited anymore.

In addition, the protein may comprise reactive residues of thiol, hydroxyl, carboxyl or amine.

The phosphonium-based compound may be a compound represented by the following Formula 1:

[Chemical Formula 1]

In Formula 1,

R1 represents a water-soluble nonionic polymer, a polymer resin in bead or resin form, or a silica bead,

R ₂ is selected from the group consisting of benzotriazole-yloxy, azabenzotriazole-yloxy, nitrobenzotriazole-yloxy, pentafluoropenyl- -O-), pyridylthio, hydrooxobenzotriazin, cyanoethoxycarbonylmethylidene and halogen, and the substituent may be selected from the group consisting of hydrogen,

R ₃ to R ₅ are the same or different from each other and are a dialkylamino compound or a heterocycloamine compound.

The dialkylamino compound may be a compound having 1 to 10 carbon atoms and preferably has 3 or less carbon atoms. The heterocyclic amine compound may be a compound having 2 to 10 carbon atoms and preferably 3 to 6 carbon atoms.

The water-soluble nonionic polymer preferably has a weight average molecular weight of 1,000 Da or more and less than 300,000 Da. When the molecular weight is 300,000 Da or more, the proportion of the dihydroxyquinoline-based compound that induces covalent bonding is too small to exhibit its efficacy.

The water-soluble nonionic polymer may specifically be selected from the group consisting of polyethylene glycol, polyvinyl alcohol, polyethylene oxide, polyacrylonitrile, polyvinylpyrrolidone, polyisopropylacrylamide, cellulose derivatives, starch derivatives, dextran and guar gum And at least one polymer selected from the group consisting of

The bead or resin type polymer preferably has a weight average molecular weight of 1,000 Da or more and less than 300,000 Da. When the molecular weight is 300,000 Da or more, the proportion of the phosphonium compound that induces covalent bond is too small to exhibit the efficacy.

The bead-shaped or resin-type polymer resin may specifically include a resin such as styrene, ethylene, butadiene, acrylonitrile, methylstyrene, terephthalate, ethylene chloride, ether ketone, etherimide, ether sulfone, phthalamide, phenylene ether, , Phenylene sulfide, sulfone, urethane, vinylidene fluoride, and tetrafluoroethylene.

The polymer beads preferably have an average particle diameter of 100 nm to 1 mm, preferably 100 nm to 100 μm, more preferably 1 μm to 100 μm, most preferably 1 μm to 70 μm . If the diameter of the polymer bead is less than 100 nm, safety problems may occur on the surface of the skin. If the diameter of the polymer bead is larger than 1 mm, there is a problem in formulation and stabilization.

The silica beads preferably have an average particle diameter of 100 nm to 1 mm, preferably 100 nm to 100 μm, more preferably 1 μm to 100 μm, most preferably 1 μm to 70 μm . When the diameter of the silica beads is less than 100 nm, safety problems may occur on the surface of the skin. If the diameter of the silica beads is larger than 1 mm, there is a problem in formulation and stabilization.

In a preferred embodiment of the cosmetic composition for prevention and improvement of wrinkles according to the present invention, the wrinkle preventing and improving component having a carboxyl group is directly made into a form of preventing and improving wrinkle of reactive ester having a bioreactivity or skin keratin (15.5 to 23.5 (Ex, aspartic acid, and glutamic acid) existing in excess in the amount of 1% to 5% by weight can be reactively esterified to increase the reaction efficiency by enhancing the wrinkle preventing and improving component including the amine group. In a more preferred embodiment, the first step of firstly reacting the polymer-type phosphonium compound of formula (1) on the surface of the wrinkle preventing and improving component molecule or skin protein having a carboxyl group to form a reactive ester and reacting the amine with the reactive ester functional group The wrinkle preventing and improving component of the present invention can be reacted with an amine on the surface of the skin.

In the following Reaction Scheme 1, a reaction scheme is shown in which a wrinkle preventing and improving component having a carboxyl group is firstly reacted with a phosphonium compound to form a reactive ester, followed by reaction with an amino acid having an amine residue to form a covalent bond.

 [Reaction Scheme 1]

As shown in Reaction Scheme 2, asparaginic acid and glutamic acid, which have carboxyl groups on the surface of protein of skin, first react with phosphonium compounds to form a reactive ester, and then react with a wrinkle preventing and improving component having an amine residue to form a covalent bond The reaction scheme is shown in Fig.

In the following Reaction Scheme 2, asparaginic acid and glutamic acid, which are carboxylamino group-bearing biosynthetic amino acids on the surface of skin proteins, react with a phosphonium-based compound in a primary reaction to form a reactive ester, and then react with a wrinkle preventing and improving component having an amine residue to form a covalent bond .

 [Reaction Scheme 2]

Using the phosphonium compound, the wrinkle preventing and improving components adhered to the skin by protein and peptide bond can be removed from the skin by a cleaning method such as soap and cleanser, and can be kept permanently attached to the skin.

The use of phosphonium compounds to prevent skin wrinkles and improve the reaction efficiency of the wrinkle improves the effectiveness of the wrinkle preventing and improving components attached to the skin. Can be maintained.

The present invention also relates to a composition for preventing and improving wrinkles comprising at least one compound selected from the group consisting of carbodiimide, imidoesters, aryl azides, diazirines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, But are not limited to, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, Which is composed of imidyl ester, imidazole, oxycarbonyl imidazole, imine, thiol, maleimide, vinyl sulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide, ketone, carboxylic acid and phosphate Reactivity with a functional group covalently bonded to at least one protein selected from the group Name may include the prevention and improvement of components.

For example, as shown in Reaction Scheme 1, it may include a wrinkle preventing and improving component to which a phosphonium compound formed by a first reaction of a phosphonium compound is bound. In addition, the present invention may include a cosmetic composition for prevention and improvement of wrinkles containing the reactive wrinkle preventing and improving component.

In the cosmetic composition for prevention and improvement of wrinkles according to the present invention, it is preferred that the cosmetic composition for preventing and improving wrinkles contains at least one compound selected from the group consisting of hydroxysuccinimide, hydroxycarboximide, hydroxytriazole, hydroxybenzotriazole, hydroxypyridinone, hydroxyphenylbenzimidazole, One or more peptide bond formation reaction promoting additives selected from the group consisting of dicarboxylic acid, dicarboxylic acid, decanone, hydroxybenzotriazine and oximar. The peptide bond formation reaction promoting additive may be used in an amount of 0.0001 to 10 parts by weight based on 100 parts by weight of the total composition. Preferably 0.001 to 1 part by weight, more preferably 0.001 to 0.1 part by weight. Even if 10 parts by weight or more is used, the rate of the chemical reaction is saturated, so that the product is not economical and does not contribute to the stability of the product. When used below 0.0001, little or no help is given to reactivity.

In order to further enhance the effect of the cosmetic composition for prevention and improvement of wrinkles according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, long chain alkyl chains of straight chain and branched chain The cationic surfactants such as cationic surfactants, cationic surfactants, cationic surfactants, cationic surfactants, cationic surfactants, cationic surfactants such as cationic surfactants, cationic surfactants, cationic surfactants and cationic polyvinylpyrrolidone. In order to formulate the composition into a cosmetic preparation, it is also possible to formulate cosmetics such as a solvent, a surfactant, a thickener, a stabilizer, a preservative, a colorant, a pH adjuster, a metal ion sequestrant, a pearlizing agent, an appearance improver, an emollient, Components may be incidentally included. 40 to 99 parts by weight, 60 parts by weight or 98 parts by weight, or 80 parts by weight or 95 parts by weight, based on 100 parts by weight of the total composition, of the components for the formulation can be used.

The cosmetic composition for prevention and improvement of wrinkles according to the present invention can be used for the preparation of a cosmetic composition for prevention and improvement of wrinkles including components having a wrinkle preventing and improving function having a functional group. Examples of application of the hair product include a shampoo composition, a shampoo, a rinse, a treatment, a wax, a gel, a spray, a mousse, a hair lotion, a hair pack, a hair essence, a hair cream, a research hair dye, Non-woven fabric, sheet, and the like. Application examples of the skin product generally include basic cosmetics (lotion, serum, essence, lotion, cream, etc.) for arranging and protecting skin, color cosmetics (makeup base, foundation, powder, Cleansing lotion, cleansing cream, cleansing gel, pack, cosmetics, etc.), makeup for hand and toenails (manicure, nutrient, Mask, soap, cleansing tissue, etc.), sun care cosmetics, body cosmetics (body lotion, shower gel, body cream, body oil, etc.).

More preferably, the cosmetic composition for prevention and improvement of wrinkles according to the present invention contains a phosphonium compound and at the same time contains a component for preventing and improving wrinkles having a reactive functional group. When the activity of the above preparation is lowered in the aqueous system It is easier to maintain its activity in non-aqueous formulations, and the reaction can be effected by mixing with a buffer for pH control just before use, or by contacting with water in a washing process. Examples of non-aqueous formulations include liquid, sheet, powder, tablet, oil, wax, ampoule, gel and the like which are used as ordinary non-aqueous cosmetic preparations. In addition, the phosphonium compound and the component for preventing and improving wrinkles can be formulated into a single agent or two separate forms of encapsulated form. Also, a method of blocking a derivative having a reactive functional group and a component having a wrinkle preventing and improving function from moisture by encapsulation may also be used.

In order to enhance the effect of preventing and improving wrinkles having functional groups in the cosmetic composition for prevention and improvement of wrinkles according to the present invention, a combination of 2-basic acid esters such as dioctylsuccinate, dioctyl adipate and diethyl sebacate, polyol, Glycol, propylene glycol, hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof. The above-mentioned solvents increase the permeability of the skin and are used as a solvent of a poorly soluble substance. More preferably, the solvent used for preventing wrinkles having a functional group and enhancing the activity maintaining effect of the improving component includes diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like .

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Example  1 and Comparative Example  1: cream ( 100 g ) Formulation Manufacturing

The composition and contents of the following Table 1 were used to prepare a cosmetic composition for cream prevention and prevention of wrinkles.

The raw materials 3 to 13 were heated to 70 ° C and then homomixed using a homomixer The mixture was uniformly mixed at 3000 rpm for 5 minutes. The oil phase components 15 to 24 dissolved in advance by heating at 70 占 폚 were added to the mixed water phase and mixed homogeneously at 4000 rpm for 5 minutes using a homomixer. After the temperature was lowered to 50 ° C, a neutralizing agent, 1-hydroxybenzotriazole (HOBt), a phosphonium-based compound, Benzotriazol- 2 and Fragrance 14 were homogeneously mixed with a homomixer for 5 minutes, followed by defoaming, filtration and cooling.

The PS-BOP is a polymer resin having a weight average molecular weight of 200,000 Da, represented by the formula (1), wherein R ₁ is represented by the following formula 2 (m + n + x + y: z = 99: 1) ; R ₂ is benzotriazole-yloxy; R ₃ to R ₅ are dimethylamino. Z is a crosslinker that is not attached to a specific site but connects randomly between polymers, and Eur . J. Org . Chem . 2004, 1936_1939.

(2)

ingredient Comparative Example 1 Example 1 Example 2 Example 3 One PS-BOP
(Polystyrene supported BOP [(Benzotriazol-1-yloxy) -tris (dimethylamino) phosphonium] - 0.1 0.1 0.1 2 HOBt
- - 0.01 0.01 3 Hyaluronic acid 2.0 2.0 2.0 4.0 4 glycerin 6.0 6.0 6.0 6.0 5 DPG 3.0 3.0 3.0 3.0 6 1,3-butylene glycol 2.0 2.0 2.0 2.0 7 Urea / HEPES 0.8 0.8 0.8 0.8 8 antiseptic 1.0 1.0 1.0 1.0 9 Anti-inflammatory agent 2.0 2.0 2.0 2.0 10 Carbomer 0.2 0.2 0.2 0.2 11 Xanthan gum 0.05 0.05 0.05 0.05 12 corrector 0.28 0.28 0.28 0.28 13 Purified water To 100 To 100 To 100 To 100 14 Beauty 0.1 0.1 0.1 0.1 15 Cetearyl alcohol 2.5 2.5 2.5 2.5 16 Glyceryl stearate 1.2 1.2 1.2 1.2 17 PEG-100 stearate 0.3 0.3 0.3 0.3 18 PEG-40 stearate 0.5 0.5 0.5 0.5 19 Stearic acid 0.3 0.3 0.3 0.3 20 Cyclohexasiloxane 6.0 6.0 6.0 6.0 21 Petaerythrityl tetraethylhexanoate 3.0 3.0 3.0 3.0 22 Dimethicone 5.0 5.0 5.0 5.0 23 Macadamia oil 2.0 2.0 2.0 2.0 24 Hydrogenated polydecene 4.0 4.0 4.0 4.0

Experimental Example  One

Four compositions prepared according to the compositions of Comparative Example 1 and Experiments 1, 2 and 3 were applied to the entire surface of the facial skin for a total of 20 subjects, each consisting of five subjects, and allowed to stand at room temperature for 30 minutes to induce the reaction. (5 excellent, 4 slightly excellent, 3 no difference, 2 no effect, 1 very no effect), and the wrinkle prevention and improvement effect Are shown in Table 2 below. Table 2 also shows the reduction rate of the wrinkle density measured by image analysis of the skin model before and after the experiment using Bayer's Xantopren.

Period of use Comparative Example 1 (5 persons) Example 1 (5 persons) Example 2 (5 persons) Example 3 (5 persons) Sensory evaluation
(Out of 5 points) 1 week 0.2 1.5 2.0 3.0 2 weeks 0.5 1.9 2.8 3.7 3 weeks 0.8 2.0 3.1 3.8 4 weeks 0.8 2.4 3.1 4.0 Image analysis
(Wrinkle density reduction ratio (%)) 1 week 0.2% 0.5% 0.8% 1.5% 2 weeks 0.4% 0.9% 1.4% 2.1% 3 weeks 0.5% 0.9% 1.6% 2.4% 4 weeks 0.5% 1.2% 1.8% 2.5%

As can be seen from the above experimental results, the wrinkle-improving effect was exhibited in Example 1 in which PS-BOP and hyaluronic acid were added together, as compared with Comparative Example 1 in which 2.0 parts by weight of hyaluronic acid alone was added without PS-BOP and HOBt , Example 2 in which HOBt was added as a peptide bond forming reaction promoting additive to the composition of Example 1 exhibited a better wrinkle-reducing effect. In Example 3, in which hyaluronic acid was added twice as much as in Example 2, Respectively.

Claims (17)

A cosmetic composition for preventing and improving wrinkles comprising a phosphonium compound and a wrinkle preventing and improving component.
The method according to claim 1,
Wherein the phosphonium-based compound is a phosphonium-based compound represented by the following formula (1):
[Chemical Formula 1]

In Formula 1,
R ₁ represents a water-soluble nonionic polymer, a polymer resin in bead or resin form, or a silica bead,
R ₂ is selected from the group consisting of benzotriazole-yloxy, azabenzotriazole-yloxy, nitrobenzotriazole-yloxy, pentafluoropenyl- -O-), pyridylthio, hydrooxobenzotriazin, cyanoethoxycarbonylmethylidene and halogen, and the substituent may be selected from the group consisting of hydrogen,
R ₃ to R ₅ are the same or different and each is a dialkylamino compound having 1 to 10 carbon atoms or a heterocycloamine compound having 2 to 10 carbon atoms.
3. The method of claim 2,
Wherein the water-soluble nonionic polymer has a weight average molecular weight of 1,000 Da or more and less than 300,000 Da.
3. The method of claim 2,
The water-soluble nonionic polymer may be at least one selected from the group consisting of polyethylene glycol, polyvinyl alcohol, polyethylene oxide, polyacrylonitrile, polyvinylpyrrolidone, polyisopropylacrylamide, cellulose derivatives, starch derivatives, dextran, Wherein the cosmetic composition is at least one selected from the group consisting of polyvinylpyrrolidone,
3. The method of claim 2,
Wherein the bead or resin type polymer resin has a weight average molecular weight of 1,000 Da or more and less than 300,000 Da.
3. The method of claim 2,
The bead or resin type polymer resin may be selected from the group consisting of styrene, ethylene, butadiene, acrylonitrile, methylstyrene, terephthalate, ethylene chloride, ether ketone, etherimide, ether sulfone, phthalamide, phenylene ether, Wherein the polymer is a polymer polymerized with monomers selected from the group consisting of rhenium sulfide, sulphone, urethane, vinylidene fluoride and tetrafluoroethylene.
3. The method of claim 2,
Wherein the silica bead has an average particle diameter of 100 nm to 1 mm.
The method according to claim 1,
Wherein the phosphonium compound is 0.001 to 10 parts by weight based on 100 parts by weight of the total composition.
The method according to claim 1,
Wherein the wrinkle preventing and improving component comprises a carboxyl group or an amine group in the molecule.
The method according to claim 1,
The wrinkle preventing and improving ingredient may be at least one selected from the group consisting of vitamin A (retinoid), vitamin E (tocopherol), flavonoid, polyphenol, superoxide dismutase (SOD), coenzyme Q10, alpha-lipoic acid, acetylhexapeptide, retinol, retinyl palmitate, (EGF), kinetin, snail mucilage, aquanomide, ceramide, glycerin, hyaluronic acid, betaine, chitosan, urea and derivatives thereof, and the like. Wherein the cosmetic composition is at least one selected from the group consisting of:
The method according to claim 1,
Wherein the wrinkle preventing and improving component has a functional group capable of being covalently bonded to protein residues on the skin surface.
12. The method of claim 11,
The functional groups covalently bonded to the protein include carbodiimide, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy amines, But are not limited to, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, Selected from the group consisting of imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide, ketone, carboxylic acid and phosphate At least one cosmetic composition for preventing and improving wrinkles.
In the first aspect,
Wherein the wrinkle preventing and improving component is 0.001 to 50 parts by weight based on 100 parts by weight of the total composition.
In the first aspect,
Wherein the composition further comprises a peptide bond formation reaction promoting additive.
15. The method of claim 14,
The peptide bond formation reaction promoting additive may be at least one selected from the group consisting of hydroxysuccinimide, hydroxycarboximide, hydroxytriazole, hydroxybenzotriazole, hydroxypyridinone, hydroxyphenylbenzimidazole, hydroxyindolinone, hydroxy Benzotriazine, and oximar. ≪ RTI ID = 0.0 > 11. < / RTI >
15. The method of claim 14,
Wherein the peptide bond formation reaction promoting additive is 0.0001 to 10 parts by weight based on 100 parts by weight of the total composition.
The method according to claim 1,
A phosphonium compound and a wrinkle preventing and improving ingredient are formulated into a single preparation in an encapsulated form; The present invention relates to a cosmetic composition for preventing and improving wrinkles, which is formulated into a two-component form in which a phosphonium compound and a wrinkle preventing and improving component are separately separated.