KR20170033439A - 대사 장애에 대한 마이크로rna의 표적화 - Google Patents

대사 장애에 대한 마이크로rna의 표적화 Download PDF

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KR20170033439A
KR20170033439A KR1020177005873A KR20177005873A KR20170033439A KR 20170033439 A KR20170033439 A KR 20170033439A KR 1020177005873 A KR1020177005873 A KR 1020177005873A KR 20177005873 A KR20177005873 A KR 20177005873A KR 20170033439 A KR20170033439 A KR 20170033439A
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certain embodiments
compound
nucleoside
mir
modified
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발크리쉔 바트
네일 더블유. 깁슨
데이드레 맥켄나
브랜디 와그너
데이비드 바텔
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레굴루스 테라퓨틱스 인크
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KR1020177005873A 2014-08-07 2015-08-06 대사 장애에 대한 마이크로rna의 표적화 Withdrawn KR20170033439A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462034739P 2014-08-07 2014-08-07
US62/034,739 2014-08-07
US201462062749P 2014-10-10 2014-10-10
US62/062,749 2014-10-10
US201562143434P 2015-04-06 2015-04-06
US62/143,434 2015-04-06
PCT/US2015/043926 WO2016022753A1 (en) 2014-08-07 2015-08-06 Targeting micrornas for metabolic disorders

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KR20170033439A true KR20170033439A (ko) 2017-03-24

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KR1020177005873A Withdrawn KR20170033439A (ko) 2014-08-07 2015-08-06 대사 장애에 대한 마이크로rna의 표적화

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US (4) US9487783B2 (enExample)
EP (1) EP3177721A1 (enExample)
JP (1) JP2017523790A (enExample)
KR (1) KR20170033439A (enExample)
CN (1) CN106559995A (enExample)
AU (1) AU2015301057A1 (enExample)
BR (1) BR112017001931A2 (enExample)
CA (1) CA2953883A1 (enExample)
CL (1) CL2017000312A1 (enExample)
CO (1) CO2017000950A2 (enExample)
IL (1) IL249819A0 (enExample)
MA (1) MA40463A (enExample)
MX (1) MX2017001493A (enExample)
RU (1) RU2017105342A (enExample)
SG (1) SG11201610877PA (enExample)
TW (1) TW201613949A (enExample)
WO (1) WO2016022753A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017105342A (ru) 2014-08-07 2018-09-13 Регулус Терапьютикс Инк. НАЦЕЛИВАНИЕ НА микроРНК ПРИ РАССТРОЙСТВАХ ОБМЕНА ВЕЩЕСТВ
KR102608220B1 (ko) * 2016-05-06 2023-11-29 아이오니스 파마수티컬즈, 인코포레이티드 Glp-1 수용체 리간드 모이어티 컨쥬게이트된 올리고뉴클레오티드 및 이의 용도
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
KR101869308B1 (ko) * 2017-02-28 2018-06-20 대구가톨릭대학교산학협력단 Srebp-1 디코이 올리고디옥시뉴클레오티드 및 이를 유효성분으로 함유하는 지방간 질환의 예방 또는 치료용 약학 조성물
AU2019209491B2 (en) * 2018-01-17 2022-05-19 Joslin Diabetes Center, Inc. Methods for treating diabetes, hepatitis, and/or inflammatory liver disease
WO2020010059A1 (en) * 2018-07-02 2020-01-09 Aptamir Therapeutics, Inc. Targeted delivery of therapeutic agents to human adipocytes
EP3824087A1 (en) * 2018-07-20 2021-05-26 Regulus Therapeutics Inc. Methods for oral delivery of oligonucleotides
US10844383B1 (en) 2019-09-18 2020-11-24 Dasman Diabetes Institute Microrna dyslipidemia inhibitor

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0862439A4 (en) 1995-11-22 2001-01-10 O Paul O P Ts LIGANDS FOR INCREASING THE CELLULAR UPtake OF BIOMOLECULES
US7491805B2 (en) 2001-05-18 2009-02-17 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
CA2504694C (en) 2002-11-05 2013-10-01 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
EP1648914A4 (en) 2003-07-31 2009-12-16 Regulus Therapeutics Inc OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA
JP4731324B2 (ja) 2003-08-28 2011-07-20 武 今西 N−o結合性架橋構造型新規人工核酸
WO2006078278A2 (en) 2004-04-27 2006-07-27 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
EP2290071B1 (en) 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
EP2990410A1 (en) 2004-08-10 2016-03-02 Alnylam Pharmaceuticals Inc. Chemically modified oligonucleotides
EP2314688B1 (en) 2004-11-12 2014-07-16 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20060185027A1 (en) 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
AU2006279906B2 (en) 2005-08-10 2012-05-10 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
WO2007027894A2 (en) 2005-08-29 2007-03-08 Isis Pharmaceuticals, Inc. Antisense compounds having enhanced anti-microrna activity
EP2388327A1 (en) 2006-01-27 2011-11-23 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for the use in modulation of micrornas
ES2516815T3 (es) 2006-01-27 2014-10-31 Isis Pharmaceuticals, Inc. Análogos de ácidos nucleicos bicíclicos modificados en la posición 6
KR101407707B1 (ko) 2006-04-03 2014-06-19 산타리스 팔마 에이/에스 Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물
CA2927045A1 (en) 2006-10-03 2008-04-10 Muthiah Manoharan Lipid containing formulations
CN101121934B (zh) 2007-04-11 2011-12-07 哈尔滨医科大学 多靶点miRNA反义核苷酸的制备方法
WO2008150729A2 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
EP2173760B2 (en) 2007-06-08 2015-11-04 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
AU2008272918B2 (en) 2007-07-05 2012-09-13 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
US8288356B2 (en) 2007-10-04 2012-10-16 Santaris Pharma A/S MicroRNAs
EP3705125B1 (en) 2007-12-04 2023-07-05 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
EP2268811A1 (en) 2008-03-07 2011-01-05 Santaris Pharma A/S Pharmaceutical compositions for treatment of microrna related diseases
AU2010250838B2 (en) * 2009-05-20 2016-01-21 Eth Zurich Targeting microRNAs for metabolic disorders
SG176716A1 (en) 2009-06-08 2012-01-30 Miragen Therapeutics CHEMICAL MODIFICATION MOTIFS FOR miRNA INHIBITORS AND MIMETICS
ES2562817T3 (es) 2010-02-24 2016-03-08 Arrowhead Research Corporation Composiciones para el suministro dirigido de ARNip
WO2011117353A1 (en) * 2010-03-24 2011-09-29 Mirrx Therapeutics A/S Bivalent antisense oligonucleotides
KR20130132475A (ko) 2010-12-17 2013-12-04 애로우헤드 리서치 코오포레이션 siRNA의 갈락토오스 클러스터-약동학적 조절제 표적 물질
US8877722B2 (en) 2011-03-25 2014-11-04 Idera Pharmaceuticals, Inc. Compositions for inhibiting gene expression and uses thereof
EP2751270B1 (en) 2011-08-29 2018-08-22 Ionis Pharmaceuticals, Inc. Oligomer-conjugate complexes and their use
EP3533873A1 (en) * 2011-09-14 2019-09-04 Translate Bio MA, Inc. Multimeric oligonucleotide compounds
JP5536963B2 (ja) 2012-03-04 2014-07-02 株式会社ボナック microRNA阻害剤
JP6208228B2 (ja) 2012-06-21 2017-10-04 ミラゲン セラピューティクス, インコーポレイテッド ロックド核酸モチーフを含むオリゴヌクレオチドベースの阻害剤
US9163235B2 (en) 2012-06-21 2015-10-20 MiRagen Therapeutics, Inc. Inhibitors of the miR-15 family of micro-RNAs
WO2014043544A1 (en) 2012-09-14 2014-03-20 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
US9725721B2 (en) 2012-09-26 2017-08-08 Mirrx Therapeutics Oligomers with improved off-target profile
SG11201503821YA (en) * 2012-11-15 2015-06-29 Roche Innovation Ct Copenhagen As Oligonucleotide conjugates
RU2649367C2 (ru) 2013-01-30 2018-04-02 Ф. Хоффманн-Ля Рош Аг Конъюгаты углевода и lna-олигонуклеотида
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
CA2909868C (en) 2013-05-01 2021-10-19 Regulus Therapeutics Inc. Compounds and methods for enhanced cellular uptake
KR102482890B1 (ko) 2013-05-01 2022-12-30 아이오니스 파마수티컬즈, 인코포레이티드 아포지질단백질 (a) 발현을 조절하는 조성물 및 방법
CA2935426C (en) 2014-01-30 2023-07-25 F. Hoffmann-La Roche Ag Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target
RU2017105342A (ru) 2014-08-07 2018-09-13 Регулус Терапьютикс Инк. НАЦЕЛИВАНИЕ НА микроРНК ПРИ РАССТРОЙСТВАХ ОБМЕНА ВЕЩЕСТВ

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