KR20170025542A - Cosmetic Composition Comprising Extracts of Bidens bipinnata for Enhancing Skin Tightening and Improving Skin Wrinkle - Google Patents
Cosmetic Composition Comprising Extracts of Bidens bipinnata for Enhancing Skin Tightening and Improving Skin Wrinkle Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
Description
Bidens The present invention relates to a cosmetic composition for enhancing skin elasticity and improving skin wrinkles containing an extract of bipinnata as an active ingredient.
In human skin, various physical and chemical changes occur during the aging process. The causes are largely classified into intrinsic aging and photo-aging, and research on this has been actively conducted. Aging can be caused by activation of free radicals due to ultraviolet rays, stress, disease states, environmental factors, wounds, and aging. When such conditions become worse, the antioxidant defense network existing in the living body is destroyed, Thereby promoting adult diseases and aging. Specifically, lipids, proteins, polysaccharides and nucleic acids, which are major components of the skin, are oxidized to destroy skin cells and tissues, resulting in skin aging.
Protein oxidation is a process in which collagen, hyaluronic acid, elastin, proteoglycan, and fibronectin, which are the connective tissues of the skin, are severed, When it gets worse, mutation of DNA leads to mutation, cancer, and immune function. Therefore, it is necessary to protect the cell membrane by destroying the free radicals mediated by free radicals, ultraviolet rays, and inflammation that occur during the metabolism of the body, and to regenerate already damaged cells by vigorous metabolism The skin can quickly recover and maintain healthy skin.
Collagen and elastin, which account for most of the skin's dermis, and matrix metalloproteinase (MMP), an enzyme that breaks down the collagen and elastin, cause wrinkles and sagging skin. The main reason for the increased amount of MMP is UV. However, in daily life, it is exposed to UV for a lot of time, and the wrinkles are continuously increased and the elasticity of the skin gradually decreases.
In order to solve such problems, researches and developments of cosmetics capable of improving the wrinkles of the skin and improving the elasticity have been continuously performed, and the present invention has been made to solve these problems.
The inventors have a result of searching various bioactive skin for the natural plant material to improve skin wrinkle and skin elasticity, imp needles (Bidens bipinnata extract of the present invention has an effect of inhibiting elastase, promoting collagen synthesis and inhibiting MMP-1 production, thereby effectively improving the wrinkles and elasticity of the skin.
Object of the needle is imp (Bidens bipinnata ). < / RTI >
Preferably, the cosmetic composition has an effect of improving skin wrinkles or enhancing skin elasticity.
Preferably, the bogey needles (Bidens bipinnata ) is contained in an amount of 0.0001 to 35.0% (w / w) based on the total weight of the cosmetic composition.
Also, preferably, the extract of the giblet vaccine contains water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms, propylene glycol, 1,3-butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane , Chloroform, and hexane.
The cosmetic composition according to the present invention is a cosmetic composition comprising an active ingredient Bidens bipinnata extract inhibits elastase inhibitory activity, collagen biosynthesis, and MMP-1 production inhibitory effect, thereby improving the effect of improving skin wrinkles and improving skin elasticity.
Bidens The present invention relates to a cosmetic composition for improving skin wrinkles and elasticity, which comprises an extract of bipinnata as an active ingredient.
The Bidens < RTI ID = 0.0 > bipinnata ) is a perennial herbaceous perennial plant of the dicotyledonous plant, and widely distributed in the mountains of Korea, China, Taiwan, Japan and India. The height of the grass varies from 25 to 85cm, with a few hairs, and the stem is square. Leaves are opposite, with hairs on both sides and split into two flags. The split pieces are egg-shaped or long oval-shaped, with sharp tips and serrations. The flowers bloom in August ~ October, and form a conical flower with a diameter of 6 ~ 10mm. The young leaves are used for food, and the juice is applied to the worm when it is bitten by the caterpillar, and the stem and leaves including flowers are used as medicines. The tinnitus of the goby needles is also called an ejaculation needle, an ear mackerel, a paparazzi, a foxtail, a needle needle, a hairy marsh, an ear sword, an acupuncture needle, a golden needle, and a needle needle.
The efficacy of goby needles herbal medicine has antibacterial, anticancer, antipyretic, diuretic, detoxification, exorcism and solves the bloody blood. Applicable diseases include cold, schizophrenia, fever, hepatitis, jaundice, nephritis, stomach pain, diarrhea, enteritis, appendicitis, diabetes, sore throat, bronchitis and urine. It is also known to be used as a remedy for bruises, snake or insect bites.
According to a preferred embodiment of the present invention, ghost needles (Bidens bipinnata extract may be prepared using conventional solvents known in the art, that is, under the conditions of ordinary temperature and pressure, preferably (a) water, 1 to 4 carbon atoms Propanol and butanol), propylene glycol, 1,3-butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane (B) supercritical extraction with carbon dioxide and supercritical extraction with high temperature, or (c) ultrasonic extraction. In the present invention, a solvent extraction method using an extraction solvent is preferably used.
More preferably, the Bidens < RTI ID = 0.0 > bipinnata extract can be obtained from various extraction solvents, for example, water, anhydrous or lower alcohols having 1 to 4 carbon atoms (e.g., methanol, ethanol, propanol and butanol), propylene glycol, 1,3-butylene glycol, glycerin , At least one extraction solvent selected from the group consisting of acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane and mixtures thereof, preferably 70% (v / v) ethanol or water, and most preferably 70% (v / v) ethanol.
On the other hand, ghost needle of the invention (Bidens it is obvious to those skilled in the art that bipinnata extract can be obtained not only in the above-mentioned extraction solvent but also in another extract solvent, which exhibits substantially the same effect. In addition, the Bidens bipinnata extract of the present invention includes an extract obtained by the conventional extraction and fermentation as well as the extract by the above-mentioned extraction solvent. For example, decompression by carbon dioxide, extraction by supercritical extraction with high temperature, extraction by extraction using ultrasound, separation by ultrafiltration membrane with constant molecular weight cutoff value, various chromatography (size, charge, hydrophobic or affinity And the active fraction obtained through various purification and extraction methods, such as an extract obtained by fermentation products using natural or various microorganisms, are also included in the extract of the present invention.
According to the present invention, the giblet acupuncture needles are contained in an amount of 0.0001 to 35.0% by weight, preferably 0.001 to 20% by weight, more preferably 0.1 to 10% by weight based on the total weight of the cosmetic composition do. When the content of the extract is less than 0.0001% by weight, the skin moisturizing effect is not exhibited. When the content of the extract is more than 35.0% by weight, the skin wrinkle improving effect and elasticity improving effect are insignificant, And it is not economical.
The ingredients contained in the cosmetic composition of the present invention may contain, as an active ingredient, the ingredients commonly used in cosmetic compositions in addition to the above-mentioned effective ingredients, and may contain conventional ingredients such as antioxidants, stabilizers, solubilizers, vitamins, Supplements, and carriers. The cosmetic composition of the present invention can be prepared into any of the formulations conventionally produced in the art and can be used in the form of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, , Oil, powdered foundation, emulsion foundation, wax foundation, pack, massage cream and spray, but is not limited thereto. More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.
When the formulation of the present invention is a paste, a cream or a gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide .
When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.
In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.
When the formulation of the present invention is a surfactant-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether Alkylamido betaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester.
When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation or a surfactant-free cleansing formulation, it may be applied to the skin and then wiped off, washed or rinsed with water. As a specific example, the soap is liquid soap, powdered soap, solid soap and oil soap, and the surfactant-containing cleansing formulation is a cleansing foam, a cleansing water, a cleansing towel and a cleansing pack, , Cleansing lotion, cleansing water and cleansing gel, but is not limited thereto.
On the other hand, the cosmetic process of the present invention refers to all cosmetic processes using the cosmetic composition of the present invention. That is, all methods known in the art using a cosmetic composition belong to the cosmetic method of the present invention. The cosmetic composition of the present invention may be used alone or in combination, or may be used in combination with other cosmetic compositions other than the present invention. The cosmetic composition according to the present invention may be used according to a conventional method of use, and may be used in a number of times depending on the skin condition or taste of the user.
Hereinafter, the present invention will be described in more detail with reference to Examples. The present invention will be described in more detail with reference to the following examples and experimental examples. However, the scope of the present invention is not limited thereto.
Production Example 1 - Bidens bipinnata ) extract
A shameless needle ( Bidens) bipinnata ) was refluxed for 3 hours with 70% (v / v) ethanol aqueous solution for 5 hours, cooled down, and filtered through Whatman # 4 filter paper. The filtered extract was concentrated under reduced pressure and freeze-dried at 50 ° C or lower to obtain 20 g of Needle Extract.
Experimental Example 1 - Measurement of Elastase Inhibitory Activity
Elastase is an enzyme that degrades elastin, an important substrate for maintaining skin elasticity in the dermis. Elastase is also a nonspecific hydrolytic enzyme capable of degrading collagen, another important substrate protein. Therefore, the elastase inhibitor shows an action to improve the wrinkles of the skin, and ursolic acid and the like are used as an elastase inhibitor. Elastase is known to be the main cause of wrinkles by decomposing elastin, which is an insoluble elastic fiber protein of animal connective tissue, and breaking the network structure of dermal tissue of skin. In the dermis of the skin, elastin related to the elasticity of collagen and skin forms a network structure. As the network structure is broken, that is, when elastin is decomposed by elastase, the skin is sagged and wrinkles are generated. Occurs. Therefore, skin aging can be suppressed by lowering the activity of elastase, which is one of the main causes of skin aging.
The amount of p-nitroanilide produced from the substrate at 37 ° C for 20 minutes was measured at 445 nm using N-succinyl- (L-Ala) 3-p-nitroanilide, S4760, Sigma as a substrate. (500 μL) of porcine pancreas elastase (E1250, Sigma) (2.5 U / mL) dissolved in 2 mM Tris-HCl buffer (pH 8.6) was added to the test tube, N-succinyl- (L-Ala) 3-p-nitroanilide (500 μg / mL) dissolved in 50 mM Tris-HCl buffer (pH 8.6) was added and the reaction was carried out for 20 minutes. Elastase inhibitory activity was calculated by the following equation (1) as the absorbance reduction ratio of the sample solution and the non-added sample.
Production Example 1
In Table 1, and it showed the IC 50 elastase inhibitory activity at 1000ppm. The results are shown in Table 1. As shown in Table 1, it can be seen that the extract of Pseudomonas aeruginosa has an excellent inhibitory activity against elastase, and thus it is possible to use the Pseudomonas aeruginosa extract as a wrinkle and elasticity improving material.
Experimental Example 2 - Skin cell proliferation effect
To examine the effect of the giblet needle extract prepared in Preparation Example 1 on skin cell proliferation, human normal fibroblasts (Korean Cell Line Bank) were inoculated into each well of a 96-well microplate at 1 x 10 4 Cells, and cultured in DMEM medium (Sigma) for 24 hours at 37 ° C. Then, the control group which was replaced with serum-free DMEM medium containing 500 ~ 1500 ppm of the gibbsite extract and the serum-free DMEM medium without the gibberellin extract was further cultured for 24 hours. Next, 10 μl of each of MTT solution (3- (4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide: 5 mg / ml) was added and the mixture was incubated for 4 hours , The medium was removed and 100 μl of DMSO solution was added to each well and shaken for 20 minutes and the absorbance of the supernatant was measured at 570 nm using a microplate reader (Molecular Devices, Mich.). The cell proliferation (%) of the test sample was calculated with the cell proliferation of the control group as 100%. The cell proliferation rate (%) was substituted into the following equation (2) to calculate the cell proliferation effect, and the results are shown in Table 2 below.
Production Example 1
Experimental Example 3 - Measurement of collagen biosynthesis using an ELISA kit
Human fibroblasts (Human Skin Fibroblast) for 37 ℃, 5% in a CO 2 incubator of 10% in the cell culture medium to maintain a constant humidity FBS, Penicillin (50U / ml) , Streptomycin DMEM (Dulbecco's containing (50 / ml) Modified Eagle's Medium, Gibco, USA), and the cells were seeded at a density of 1 × 10 5 cells / ml in a 24-well plate at a density of 500 μl / well and cultured for 24 hours. Quantification of collagen type I in fibroblasts was performed using an immunosorbent assay (ELISA) using Procollagen Type I c-peptide EIA kit (TaKaRa, Japan) One of the above cell culture supernatants was carefully collected.
First, 100 μl of the culture supernatant, which was incubated for 48 hours on a strip coated with an antibody coated with Procollagen Type I c-peptide, was added and reacted at 37 ° C for 2 hours. After the reaction, unreacted material was removed by washing three times using a washing buffer, and then 100 μl of blocking buffer was added thereto, followed by reaction at 37 ° C for 2 hours. After the reaction, the reaction mixture was washed three times with a washing buffer to remove unreacted substances. Then, another antibody conjugated with 'Procollagen Type I c-peptide' was conjugated with POD (Antiobody- POD conjugate solution) was added and reacted at 37 ° C for 2 hours. After the reaction, the unreacted material was removed by washing three times using a washing buffer, the same amount of substrate solution was added, and the reaction was performed for 30 minutes. Then, stop solution (1N H 2 SO 4 ) And the experiment was completed.
The absorbance at 450 nm was measured at 450 nm, and the amount of newly synthesized collagen was measured by the amount of PICP. The amount of collagen was calculated by multiplying the amount of PICP by ng / 2 × 10 4 cells. Respectively.
(ng / 2 x 10 4 )
Experimental Example 4 - Inhibitory effect on MMP-1 production
TGF-beta (10 ng / ml, Roche, USA), a substance known to have an effect of inhibiting the production of MMP-1, was assayed in order to determine whether the effect of inhibiting the production of MMP- As a comparative group, the effect of inhibiting the production of MMP-1 was measured. Human normal skin cells were inoculated into a 48-well microplate (Nunc, Denmark) at a density of 1 × 10 6 cells per well and cultured in DMEM medium (Sigma, USA) and 37 ° C. After culturing for 24 hours, serum-free DMEM medium supplemented with the final concentration of gibbsite needle extract of Preparation Example 1 and the control group were added to the culture medium for 48 hours in serum-free DMEM medium containing no extract Respectively. After culturing, the supernatant of each well was collected and the amount (ng / ml) of the newly synthesized MMP-1 was measured using an MMP-1 assay kit (Amersham, USA) The inhibition rate (%) was calculated and the results are shown in Table 4.
From the above Experimental Example, it was confirmed that the gibbsite extract of the present invention is excellent in the effect of inhibiting elastase, enhancing collagen synthesis and inhibiting MMP-1 production. Thus, a cosmetic composition containing the extract of the present invention as an active ingredient is prepared and prescribed, but the cosmetic composition of the present invention is not limited to this formulation.
Formulation Example 1 - Lotion
Table 5 shows formulation examples of cosmetic lotion containing cosmetic ingredients containing gum extract.
glycerin
1,3-butylene glycol
PIZZY 1500
Allantoin
DL-Panthenol
EDTA-2Na
Benzophenone-9
Sodium hyaruronate
ethanol
Octidodeces-16
Polysorbate 20
Preservative, fragrance, pigment
Distilled water
5.0
3.0
1.0
0.1
0.3
0.02
0.04
5.0
10.0
0.2
0.2
a very small amount
Balance
5.0
3.0
1.0
0.1
0.3
0.02
0.04
5.0
10.0
0.2
0.2
a very small amount
Balance
Formulation Example 2 - Cream
Formulation examples of creams in cosmetics containing extracts of Pseudomonas aeruginosa are shown in Table 6 below.
Pro-type glycerin monostearate
Cetearyl alcohol
Stearic acid
Wax
Polysorbate 60
Sorbitan stearate
Hardened vegetable oil
Squalane
Mineral oil
Trioctanoin
Dimethicone
Sodium magnesium silicate
glycerin
Betaine
Triethanolamine
Sodium hyaruronate
Preservative, fragrance, pigment
Distilled water
2.0
2.2
1.5
1.0
1.5
0.6
1.0
3.0
5.0
5.0
1.0
0.1
5.0
3.0
1.0
4.0
a very small amount
Balance
2.0
2.2
1.5
1.0
1.5
0.6
1.0
3.0
5.0
5.0
1.0
0.1
5.0
3.0
1.0
4.0
a very small amount
Balance
Formulation Example 3 - Essence
The formulation examples of the essence in cosmetics containing the gibbsite needle extract are shown in Table 7 below.
glycerin
Betaine
PIZZY 1500
Allantoin
DL-Panthenol
Lee D. T.-2Na
Benzophenone-9
Hydroxyethyl cellulose
Sodium hyaruronate
Carboxyvinyl polymer
Triethanolamine
Octyldodecanol
Octyldodec-16
ethanol
Preservative, fragrance, pigment
Distilled water
10.0
5.0
2.0
0.1
0.3
0.02
0.04
0.1
8.0
0.2
0.18
0.3
0.4
6.0
a very small amount
Balance
10.0
5.0
2.0
0.1
0.3
0.02
0.04
0.1
8.0
0.2
0.18
0.3
0.4
6.0
a very small amount
Balance
EXPERIMENTAL EXAMPLE 5 Evaluation of Wrinkle-improving Effect of Cosmetic Containing Needle Extract
The wrinkle-improving effect of the cosmetic composition containing the extract of the present invention of the present invention was evaluated through practical use tests. The cream of Formulation Example 2 containing 2% (v / v) of the giblet needle extract and the cream of Comparative Formulation Example 2 in which the extract was replaced with purified water in the cream of Formulation Example 2 were evaluated. 60 women (30-40 years old) were randomly divided into two groups, and the creams of Formulation Example 2 and Comparative Formulation 2 were washed twice a day, morning and evening, and then the cream was applied continuously for 2 months around the eyes. The wrinkle improvement effect of each subject was evaluated by visual observation. The experimental results are shown in Table 8 below.
As a result, the cosmetic composition containing the extract of the present invention showed a high wrinkle-reducing effect as compared with the comparative formulation not containing the extract of the gibbsite needle. In addition, the cosmetic composition of the present invention No skin irritation could be observed
EXPERIMENTAL EXAMPLE 6 Evaluation of Skin Elasticity Improvement Effect of Cosmetics Containing Needle Extract
The skin elasticity improvement effect of the cosmetic of the present invention was evaluated through practical use tests. The creams of Formulation Example 2 containing 2% (v / v) of the extracts of Gibsonia rhamnosus and the cream of Comparative Formulation Example 2 replacing the gibbsite extract with the purified water in Formulation Example 2 were evaluated. Sixty women between 30 and 40 years old were randomly divided into two groups. After cleansing the cream of prescription example 2 and the comparative example every morning and evening, the appropriate amount of cream was applied continuously for two months, centering on the cheeks. The skin elasticity improvement effect of each subject was evaluated using a cutometer (C + K, Germany). The experimental results are shown in Table 9 below.
Excellent improvement effect
A little bit of improvement
No improvement
As a result, the cream of Formulation Example 2 containing the extract of the present invention showed a higher skin elasticity than the cream of the comparative formulation not containing the extract of the goby needles. In addition, skin irritation could not be observed in the subjects of the skin cosmetic composition of the present invention.
Claims (4)
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| KR102422118B1 (en) * | 2021-05-18 | 2022-07-20 | 주식회사 리즈코스 | Cosmetic composition comprising fermented plant component and hair shampoo using the same |
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| KR102422118B1 (en) * | 2021-05-18 | 2022-07-20 | 주식회사 리즈코스 | Cosmetic composition comprising fermented plant component and hair shampoo using the same |
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