KR20170018084A - Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 - Google Patents

Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Download PDF

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Publication number
KR20170018084A
KR20170018084A KR1020177002960A KR20177002960A KR20170018084A KR 20170018084 A KR20170018084 A KR 20170018084A KR 1020177002960 A KR1020177002960 A KR 1020177002960A KR 20177002960 A KR20177002960 A KR 20177002960A KR 20170018084 A KR20170018084 A KR 20170018084A
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mmol
aryl
halogen
alkyl
alkoxy
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Korean (ko)
Inventor
댄 테오도레스쿠
마이클 벰페
데이비드 로스
챠오 얀
필립 레이건
Original Assignee
더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트
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Publication of KR20170018084A publication Critical patent/KR20170018084A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020177002960A 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Ceased KR20170018084A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022946P 2014-07-10 2014-07-10
US62/022,946 2014-07-10
PCT/US2015/040021 WO2016007905A1 (en) 2014-07-10 2015-07-10 Anti-cancer compounds target ral gtpases and methods of using the same

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KR1020197005669A Division KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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KR20170018084A true KR20170018084A (ko) 2017-02-15

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KR1020177002960A Ceased KR20170018084A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020197005669A Expired - Fee Related KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020207008228A Ceased KR20200034824A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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KR1020197005669A Expired - Fee Related KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020207008228A Ceased KR20200034824A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

Country Status (9)

Country Link
US (4) US10202397B2 (https=)
EP (2) EP3166609B1 (https=)
JP (2) JP6672255B2 (https=)
KR (3) KR20170018084A (https=)
CN (1) CN106604731B (https=)
AU (2) AU2015287567A1 (https=)
CA (1) CA2954560C (https=)
IL (1) IL249959A0 (https=)
WO (1) WO2016007905A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10202397B2 (en) 2014-07-10 2019-02-12 The Regents Of The University Of Colorado, A Body Corporate Anti-cancer compounds targeting Ral GTPases and methods of using the same
WO2016145252A1 (en) * 2015-03-10 2016-09-15 The Trustees Of Princeton University Shmt inhibitors
US10077273B2 (en) 2016-09-14 2018-09-18 The Trustees Of Princeton University SHMT inhibitors
CN109305972B (zh) * 2018-09-27 2021-07-09 广州医科大学 一种二氢吡喃并吡唑类化合物及其制备方法和应用
EP3766544A1 (en) * 2019-07-18 2021-01-20 Centre Hospitalier Regional Universitaire de Lille Novel pyrazolone derivatives as pd-1/pd-l1 interaction inhibitors
BR112023009420A2 (pt) * 2020-11-18 2023-10-03 Univ Texas Tech System Terapias para o câncer usando moléculas pequenas que se ligam e inibem proteínas de interação ral
CN114765064A (zh) * 2021-01-14 2022-07-19 南京天顶星医药科技有限公司 一种靶向RalA-GDP蛋白的药物的虚拟筛选方法
BR112023023545A2 (pt) 2021-05-10 2024-02-06 Novalum S A Barra coletora de corrente catódica de uma célula de produção de alumínio
CN114632147B (zh) * 2021-11-09 2024-04-30 南京大学 人类受试者心肌病的治疗

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555396A (en) 1982-12-22 1985-11-26 Eastman Kodak Company Use of pyrylium and thiapyrylium compounds as biological stains
US5750550A (en) 1995-09-15 1998-05-12 Sanofi 2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof
JPH10279480A (ja) 1997-04-07 1998-10-20 Mitsubishi Chem Corp 皮膚組織障害の予防・治療剤
US6143471A (en) 1998-03-10 2000-11-07 Mitsubishi Paper Mills Limited Positive type photosensitive composition
AU1853600A (en) 1999-01-06 2000-07-24 Choong-Chin Liew Method for the detection of gene transcripts in blood and uses thereof
US20070105105A1 (en) * 2003-05-23 2007-05-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
CA2533803A1 (en) * 2003-07-29 2005-02-10 Bristol-Myers Squibb Company Biomarkers of cyclin-dependent kinase modulation
KR20080015123A (ko) 2005-05-25 2008-02-18 다나베 미츠비시 세이야꾸 가부시키가이샤 피라졸론 유도체를 포함하는 의약
WO2007016539A2 (en) 2005-07-29 2007-02-08 Children's Hospital Medical Center Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
AU2006286441A1 (en) 2005-09-02 2007-03-08 Janssen R&D Ireland Benzodiazepines as HCV inhibitors
US20090221568A1 (en) 2005-11-04 2009-09-03 Jared Shaw Synthesis of Inhibitors of FtsZ
WO2007081966A2 (en) 2006-01-09 2007-07-19 University Of Southern California Small molecules for treating cancer and abnormal cell proliferation disorders
WO2008143894A2 (en) 2007-05-14 2008-11-27 Dana-Farber Cancer Institute, Inc. Phosphorylated rala
CA2709784A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2011010715A1 (ja) * 2009-07-24 2011-01-27 国立大学法人 東京大学 Ｐr－Ｓｅｔ７阻害剤
WO2011035143A2 (en) * 2009-09-17 2011-03-24 The Regents Of The University Of Michigan Methods and compositions for inhibiting rho-mediated diseases and conditions
US8673913B2 (en) * 2009-11-13 2014-03-18 Case Western Reserve University SHP-2 phosphatase inhibitor
WO2012078902A2 (en) * 2010-12-08 2012-06-14 Proteostasis Therapeutics, Inc. Proteostasis regulators
US9200046B2 (en) * 2011-06-29 2015-12-01 Cornell University Reporter system for high throughput screening of compounds and uses thereof
CA2859985C (en) 2011-12-21 2020-11-03 The Regents Of The University Of Colorado Anti-cancer compounds targeting ral gtpases and methods of using the same
US20150011411A1 (en) 2011-12-21 2015-01-08 THE REGENTS OF THE UNIVERSITY OF COLORADO a body corporation Biomarkers of cancer
WO2013152313A1 (en) 2012-04-05 2013-10-10 The Regents Of The University Of California Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition
EP2858981A1 (en) 2012-06-06 2015-04-15 Basf Se Pyrazolopyrans having herbicidal and pharmaceutical properties
CN103910737B (zh) 2014-03-25 2016-08-17 浙江师范大学 手性的1,4-二氢吡喃(2,3-c)吡唑衍生物及其合成方法和应用
US10202397B2 (en) * 2014-07-10 2019-02-12 The Regents Of The University Of Colorado, A Body Corporate Anti-cancer compounds targeting Ral GTPases and methods of using the same
US20180170942A1 (en) * 2015-06-16 2018-06-21 Nantbio, Inc. Polycyclic derivatives targeting ral gtpases and their therapeutical applications

Also Published As

Publication number Publication date
EP3166609A1 (en) 2017-05-17
US20190135824A1 (en) 2019-05-09
KR20200034824A (ko) 2020-03-31
CA2954560A1 (en) 2016-01-14
US11472812B2 (en) 2022-10-18
KR20190022929A (ko) 2019-03-06
JP2017520588A (ja) 2017-07-27
AU2020277293A1 (en) 2021-01-07
JP6672255B2 (ja) 2020-03-25
US10202397B2 (en) 2019-02-12
AU2020277293B2 (en) 2021-10-21
WO2016007905A1 (en) 2016-01-14
US20170204112A1 (en) 2017-07-20
CN106604731A (zh) 2017-04-26
JP7102012B2 (ja) 2022-07-19
EP3166609A4 (en) 2017-12-27
IL249959A0 (en) 2017-03-30
USRE48557E1 (en) 2021-05-18
CA2954560C (en) 2021-12-28
CN106604731B (zh) 2021-05-18
US20200255442A1 (en) 2020-08-13
AU2015287567A1 (en) 2017-02-16
JP2020105195A (ja) 2020-07-09
EP3686202A1 (en) 2020-07-29
US10676480B2 (en) 2020-06-09
KR102093848B1 (ko) 2020-03-30
EP3166609B1 (en) 2020-03-11

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