KR20160136363A - 알츠하이머 질환의 치료를 위한 6-치환된 에스트라디올 유도체 - Google Patents
알츠하이머 질환의 치료를 위한 6-치환된 에스트라디올 유도체 Download PDFInfo
- Publication number
- KR20160136363A KR20160136363A KR1020167028986A KR20167028986A KR20160136363A KR 20160136363 A KR20160136363 A KR 20160136363A KR 1020167028986 A KR1020167028986 A KR 1020167028986A KR 20167028986 A KR20167028986 A KR 20167028986A KR 20160136363 A KR20160136363 A KR 20160136363A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- cyclopenta
- phenanthrene
- decahydro
- diol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(CC1)(C(CC2*)C(C(*)C3)C1c(c(*)c1)c3c(*)c1O)C2O Chemical compound CC(CC1)(C(CC2*)C(C(*)C3)C1c(c(*)c1)c3c(*)c1O)C2O 0.000 description 3
- KCRPDUASAAGWFW-KNLIIKEYSA-N C[C@@](CC1)([C@@H](CO)CC2)[C@@H]2[C@H](C[C@@H](CCCCCCOC)c2c3)[C@H]1c2ccc3O Chemical compound C[C@@](CC1)([C@@H](CO)CC2)[C@@H]2[C@H](C[C@@H](CCCCCCOC)c2c3)[C@H]1c2ccc3O KCRPDUASAAGWFW-KNLIIKEYSA-N 0.000 description 1
- JMIMHNJJOPSQMK-MHFHEPCYSA-N C[C@](CC1)(C(CC2)[C@H](C[C@@H](CNC(OC)=O)c3c4)[C@H]1c3ccc4O)[C@H]2O Chemical compound C[C@](CC1)(C(CC2)[C@H](C[C@@H](CNC(OC)=O)c3c4)[C@H]1c3ccc4O)[C@H]2O JMIMHNJJOPSQMK-MHFHEPCYSA-N 0.000 description 1
- JMIMHNJJOPSQMK-UXKUPATMSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC(CNC(OC)=O)c3c4)[C@H]1c3ccc4O)[C@H]2O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC(CNC(OC)=O)c3c4)[C@H]1c3ccc4O)[C@H]2O JMIMHNJJOPSQMK-UXKUPATMSA-N 0.000 description 1
- UGSFBVXJOYBPOV-ZZQKQPHMSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3COC)[C@H]1[C@@](C)(C=C1)C3=CC1=O)C2=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3COC)[C@H]1[C@@](C)(C=C1)C3=CC1=O)C2=O UGSFBVXJOYBPOV-ZZQKQPHMSA-N 0.000 description 1
- HRBXPMQRXHNCQA-IQLVKUJPSA-N C[C@](CC1)([C@@H](CC2)[C@H](C[C@@H](CCOC)c3c4)[C@H]1c3ccc4O)[C@H]2O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](C[C@@H](CCOC)c3c4)[C@H]1c3ccc4O)[C@H]2O HRBXPMQRXHNCQA-IQLVKUJPSA-N 0.000 description 1
- SVUFRWUSIYEGBK-WCYPQXNZSA-N C[C@](CC1)([C@@H](CC2)[C@H](C[C@@H](COC)C3C4)[C@H]1[C@@]3(C)C=CC4O)[C@H]2O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](C[C@@H](COC)C3C4)[C@H]1[C@@]3(C)C=CC4O)[C@H]2O SVUFRWUSIYEGBK-WCYPQXNZSA-N 0.000 description 1
- HNJSTMBGGRGKSL-BBIBWTOHSA-N C[C@](CC1)([C@@H](CC2)[C@H](C[C@H]3CCCCOC)[C@H]1c(cc1)c3cc1O)[C@H]2O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](C[C@H]3CCCCOC)[C@H]1c(cc1)c3cc1O)[C@H]2O HNJSTMBGGRGKSL-BBIBWTOHSA-N 0.000 description 1
- UGSFBVXJOYBPOV-QAXSQSOOSA-N C[C@](CC1)([C@@H](CC2)[C@H](C[C@H]3COC)[C@H]1[C@@](C)(C=C1)C3=CC1=O)C2=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](C[C@H]3COC)[C@H]1[C@@](C)(C=C1)C3=CC1=O)C2=O UGSFBVXJOYBPOV-QAXSQSOOSA-N 0.000 description 1
- ZXHOGDYDNZUTSO-NHUKNTKWSA-N C[C@](CC1)([C@@H](CC2)[C@H](C[C@H]3OC)[C@H]1c(cc1)c3cc1O)[C@H]2O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](C[C@H]3OC)[C@H]1c(cc1)c3cc1O)[C@H]2O ZXHOGDYDNZUTSO-NHUKNTKWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461955578P | 2014-03-19 | 2014-03-19 | |
| US61/955,578 | 2014-03-19 | ||
| PCT/US2015/021538 WO2015143201A2 (en) | 2014-03-19 | 2015-03-19 | 6-substituted estradiol derivatives for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20160136363A true KR20160136363A (ko) | 2016-11-29 |
Family
ID=54141046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167028986A Withdrawn KR20160136363A (ko) | 2014-03-19 | 2015-03-19 | 알츠하이머 질환의 치료를 위한 6-치환된 에스트라디올 유도체 |
Country Status (11)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210151062A (ko) * | 2019-06-03 | 2021-12-13 | 아이홀 코포레이션 | 히알루로난 접합체 및 이의 용도 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210024568A1 (en) * | 2019-07-23 | 2021-01-28 | Endece Llc | Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| WO2008100560A2 (en) * | 2007-02-14 | 2008-08-21 | University Of Southern California | Estrogen receptor modulators, associated pharmaceutical compositions and methods of use |
| WO2012129324A2 (en) * | 2011-03-21 | 2012-09-27 | Endece Llc | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
-
2015
- 2015-03-19 JP JP2016556841A patent/JP2017512769A/ja active Pending
- 2015-03-19 AU AU2015231172A patent/AU2015231172A1/en not_active Abandoned
- 2015-03-19 EP EP15765290.0A patent/EP3119402A4/en not_active Withdrawn
- 2015-03-19 SG SG11201607693WA patent/SG11201607693WA/en unknown
- 2015-03-19 CN CN201580014623.7A patent/CN106255501A/zh active Pending
- 2015-03-19 US US14/663,043 patent/US20150265630A1/en not_active Abandoned
- 2015-03-19 KR KR1020167028986A patent/KR20160136363A/ko not_active Withdrawn
- 2015-03-19 MX MX2016012045A patent/MX2016012045A/es unknown
- 2015-03-19 BR BR112016021408A patent/BR112016021408A2/pt not_active IP Right Cessation
- 2015-03-19 CA CA2940536A patent/CA2940536A1/en not_active Abandoned
- 2015-03-19 WO PCT/US2015/021538 patent/WO2015143201A2/en not_active Ceased
-
2018
- 2018-02-12 AU AU2018201003A patent/AU2018201003A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210151062A (ko) * | 2019-06-03 | 2021-12-13 | 아이홀 코포레이션 | 히알루로난 접합체 및 이의 용도 |
| US12128108B2 (en) | 2019-06-03 | 2024-10-29 | Aihol Corporation | Hyaluronan conjugates and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016021408A2 (pt) | 2017-12-19 |
| AU2015231172A1 (en) | 2016-09-08 |
| EP3119402A4 (en) | 2017-11-01 |
| AU2018201003A1 (en) | 2018-03-01 |
| CA2940536A1 (en) | 2015-09-24 |
| JP2017512769A (ja) | 2017-05-25 |
| SG11201607693WA (en) | 2016-10-28 |
| CN106255501A (zh) | 2016-12-21 |
| US20150265630A1 (en) | 2015-09-24 |
| EP3119402A2 (en) | 2017-01-25 |
| MX2016012045A (es) | 2017-01-19 |
| WO2015143201A2 (en) | 2015-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20161018 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination |