JP2017512769A - アルツハイマー病の治療のための６−置換エストラジオール誘導体 - Google Patents
アルツハイマー病の治療のための６−置換エストラジオール誘導体 Download PDFInfo
- Publication number
- JP2017512769A JP2017512769A JP2016556841A JP2016556841A JP2017512769A JP 2017512769 A JP2017512769 A JP 2017512769A JP 2016556841 A JP2016556841 A JP 2016556841A JP 2016556841 A JP2016556841 A JP 2016556841A JP 2017512769 A JP2017512769 A JP 2017512769A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- cyclopenta
- phenanthrene
- decahydro
- diol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461955578P | 2014-03-19 | 2014-03-19 | |
| US61/955,578 | 2014-03-19 | ||
| PCT/US2015/021538 WO2015143201A2 (en) | 2014-03-19 | 2015-03-19 | 6-substituted estradiol derivatives for the treatment of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017512769A true JP2017512769A (ja) | 2017-05-25 |
| JP2017512769A5 JP2017512769A5 (cg-RX-API-DMAC7.html) | 2018-04-26 |
Family
ID=54141046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556841A Pending JP2017512769A (ja) | 2014-03-19 | 2015-03-19 | アルツハイマー病の治療のための６−置換エストラジオール誘導体 |
Country Status (11)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102719543B1 (ko) * | 2019-06-03 | 2024-10-17 | 아이홀 코포레이션 | 히알루로난 접합체 및 이의 용도 |
| US20210024568A1 (en) * | 2019-07-23 | 2021-01-28 | Endece Llc | Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008100560A2 (en) * | 2007-02-14 | 2008-08-21 | University Of Southern California | Estrogen receptor modulators, associated pharmaceutical compositions and methods of use |
| WO2012129324A2 (en) * | 2011-03-21 | 2012-09-27 | Endece Llc | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
| JP2013512260A (ja) * | 2009-11-30 | 2013-04-11 | エンディース インコーポレイテッド | ６−置換エストラジオール誘導体およびその使用方法 |
-
2015
- 2015-03-19 JP JP2016556841A patent/JP2017512769A/ja active Pending
- 2015-03-19 AU AU2015231172A patent/AU2015231172A1/en not_active Abandoned
- 2015-03-19 EP EP15765290.0A patent/EP3119402A4/en not_active Withdrawn
- 2015-03-19 SG SG11201607693WA patent/SG11201607693WA/en unknown
- 2015-03-19 CN CN201580014623.7A patent/CN106255501A/zh active Pending
- 2015-03-19 US US14/663,043 patent/US20150265630A1/en not_active Abandoned
- 2015-03-19 KR KR1020167028986A patent/KR20160136363A/ko not_active Withdrawn
- 2015-03-19 MX MX2016012045A patent/MX2016012045A/es unknown
- 2015-03-19 BR BR112016021408A patent/BR112016021408A2/pt not_active IP Right Cessation
- 2015-03-19 CA CA2940536A patent/CA2940536A1/en not_active Abandoned
- 2015-03-19 WO PCT/US2015/021538 patent/WO2015143201A2/en not_active Ceased
-
2018
- 2018-02-12 AU AU2018201003A patent/AU2018201003A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008100560A2 (en) * | 2007-02-14 | 2008-08-21 | University Of Southern California | Estrogen receptor modulators, associated pharmaceutical compositions and methods of use |
| JP2013512260A (ja) * | 2009-11-30 | 2013-04-11 | エンディース インコーポレイテッド | ６−置換エストラジオール誘導体およびその使用方法 |
| WO2012129324A2 (en) * | 2011-03-21 | 2012-09-27 | Endece Llc | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
Non-Patent Citations (3)
| Title |
|---|
| ENDOCRINOLOGY, vol. 149, no. 2, JPN6019001020, 2008, pages 711 - 716, ISSN: 0004092317 * |
| THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 3, JPN6019001021, 1985, pages 1676 - 1681, ISSN: 0004092318 * |
| THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 14, JPN6019001019, 2002, pages 12128 - 12136, ISSN: 0004092316 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016021408A2 (pt) | 2017-12-19 |
| AU2015231172A1 (en) | 2016-09-08 |
| EP3119402A4 (en) | 2017-11-01 |
| KR20160136363A (ko) | 2016-11-29 |
| AU2018201003A1 (en) | 2018-03-01 |
| CA2940536A1 (en) | 2015-09-24 |
| SG11201607693WA (en) | 2016-10-28 |
| CN106255501A (zh) | 2016-12-21 |
| US20150265630A1 (en) | 2015-09-24 |
| EP3119402A2 (en) | 2017-01-25 |
| MX2016012045A (es) | 2017-01-19 |
| WO2015143201A2 (en) | 2015-09-24 |
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