KR20160132885A - 당뇨병, 비만, 이상지질혈증 및 관련된 장애들의 치료를 위한 gpr119 조절제로서의 치환된 융합 헤테로사이클 - Google Patents

당뇨병, 비만, 이상지질혈증 및 관련된 장애들의 치료를 위한 gpr119 조절제로서의 치환된 융합 헤테로사이클 Download PDF

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KR20160132885A
KR20160132885A KR1020167026911A KR20167026911A KR20160132885A KR 20160132885 A KR20160132885 A KR 20160132885A KR 1020167026911 A KR1020167026911 A KR 1020167026911A KR 20167026911 A KR20167026911 A KR 20167026911A KR 20160132885 A KR20160132885 A KR 20160132885A
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formula
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oxo
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로타르 슈빈크
히리스티안 부닝
하이너 글롬비크
마티아스 고쎌
디이터 카데라이트
니스 할란트
마티아스 로만
히리스토프 푀베르라인
쿠르트 리터
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/04Anorexiants; Antiobesity agents
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020167026911A 2014-04-04 2015-04-02 당뇨병, 비만, 이상지질혈증 및 관련된 장애들의 치료를 위한 gpr119 조절제로서의 치환된 융합 헤테로사이클 Withdrawn KR20160132885A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14305494.8 2014-04-04
EP14305494 2014-04-04
PCT/EP2015/057414 WO2015150564A1 (en) 2014-04-04 2015-04-02 Substituted fused heterocycles as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders

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KR20160132885A true KR20160132885A (ko) 2016-11-21

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US (1) US9758520B2 (cg-RX-API-DMAC7.html)
EP (1) EP3126336B1 (cg-RX-API-DMAC7.html)
JP (1) JP2017509679A (cg-RX-API-DMAC7.html)
KR (1) KR20160132885A (cg-RX-API-DMAC7.html)
CN (1) CN106164073A (cg-RX-API-DMAC7.html)
AR (1) AR099936A1 (cg-RX-API-DMAC7.html)
AU (1) AU2015239021A1 (cg-RX-API-DMAC7.html)
CA (1) CA2942753A1 (cg-RX-API-DMAC7.html)
CL (1) CL2016002497A1 (cg-RX-API-DMAC7.html)
CR (1) CR20160460A (cg-RX-API-DMAC7.html)
DO (1) DOP2016000212A (cg-RX-API-DMAC7.html)
EA (1) EA030410B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP16078779A (cg-RX-API-DMAC7.html)
IL (1) IL248129A0 (cg-RX-API-DMAC7.html)
MA (1) MA39346B1 (cg-RX-API-DMAC7.html)
MX (1) MX2016013033A (cg-RX-API-DMAC7.html)
PE (1) PE20161378A1 (cg-RX-API-DMAC7.html)
PH (1) PH12016501619A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201606758SA (cg-RX-API-DMAC7.html)
TW (1) TW201625605A (cg-RX-API-DMAC7.html)
WO (1) WO2015150564A1 (cg-RX-API-DMAC7.html)

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KR20200028796A (ko) * 2018-09-07 2020-03-17 오토텔릭바이오 주식회사 안정성이 향상된 의약 조성물

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AR099936A1 (es) 2014-04-04 2016-08-31 Sanofi Sa Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados
DK3126354T3 (da) 2014-04-04 2020-03-09 H Lundbeck As Halogenerede quinazolin-thf-aminer som pde1-inhibitorer
AR109514A1 (es) 2016-09-09 2018-12-19 Zealand Pharma As Análogos de amilina
EP3585775B1 (en) 2017-02-21 2022-04-06 Sanofi Azetidine compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders
WO2019043635A1 (en) 2017-09-01 2019-03-07 Richter Gedeon Nyrt. COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE
EP3811939A4 (en) * 2018-05-31 2022-05-25 Hua Medicine (Shanghai) Ltd. PHARMACEUTICAL COMBINATION, COMPOSITION AND FORMULATION CONTAINING A GLUCOSIDASE ACTIVATOR AND A &X3B1;-GLUCOSIDASE INHIBITOR, METHODS OF PREPARING THEM AND USES THEREOF
EP3976053A4 (en) * 2019-05-31 2022-11-23 Avolynt COMPOSITIONS AND METHODS OF TREATING A METABOLIC DISEASE
JP7502811B2 (ja) * 2019-11-05 2024-06-19 レスバーロジックス コーポレイション Betブロモドメイン阻害物質およびナトリウム依存性グルコース輸送体2阻害物質の組み合わせで主要な心血管有害事象(mace)を処置および/または予防する方法
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
UY39222A (es) 2020-05-19 2021-11-30 Kallyope Inc Activadores de la ampk
EP4172162A4 (en) 2020-06-26 2024-08-07 Kallyope, Inc. AMPK ACTIVATORS

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AR099936A1 (es) 2014-04-04 2016-08-31 Sanofi Sa Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200028796A (ko) * 2018-09-07 2020-03-17 오토텔릭바이오 주식회사 안정성이 향상된 의약 조성물

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MA39346B1 (fr) 2019-03-29
AU2015239021A1 (en) 2016-10-13
ECSP16078779A (es) 2017-02-24
SG11201606758SA (en) 2016-09-29
EA201692008A1 (ru) 2017-02-28
EP3126336A1 (en) 2017-02-08
TW201625605A (zh) 2016-07-16
PH12016501619A1 (en) 2017-02-06
IL248129A0 (en) 2016-11-30
CN106164073A (zh) 2016-11-23
CA2942753A1 (en) 2015-10-08
DOP2016000212A (es) 2016-11-15
US9758520B2 (en) 2017-09-12
AR099936A1 (es) 2016-08-31
JP2017509679A (ja) 2017-04-06
CL2016002497A1 (es) 2017-03-31
EP3126336B1 (en) 2018-12-05
PE20161378A1 (es) 2016-12-26
US20170022198A1 (en) 2017-01-26
WO2015150564A1 (en) 2015-10-08
MX2016013033A (es) 2017-01-09
MA39346A1 (fr) 2017-09-29
EA030410B1 (ru) 2018-07-31
CR20160460A (es) 2017-02-21

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Patent event date: 20160928

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