KR20160085345A - 조작된 고-친화도의 인간 t 세포 수용체 - Google Patents

조작된 고-친화도의 인간 t 세포 수용체 Download PDF

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KR20160085345A
KR20160085345A KR1020167016132A KR20167016132A KR20160085345A KR 20160085345 A KR20160085345 A KR 20160085345A KR 1020167016132 A KR1020167016132 A KR 1020167016132A KR 20167016132 A KR20167016132 A KR 20167016132A KR 20160085345 A KR20160085345 A KR 20160085345A
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Prior art keywords
tcr
cell
cell receptor
modified
antigen
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Korean (ko)
Inventor
시나 엔. 스미스
다니엘 티. 해리스
데이비드 엠. 크란츠
토마스 엠. 슈미트
필립 디. 그린버그
Original Assignee
더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
프레드 헛친슨 켄서 리서치 센터
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Publication of KR20160085345A publication Critical patent/KR20160085345A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020167016132A 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체 Ceased KR20160085345A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22
US61/907,887 2013-11-22
PCT/US2014/066903 WO2015077615A1 (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

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KR20160085345A true KR20160085345A (ko) 2016-07-15

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KR1020167016132A Ceased KR20160085345A (ko) 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체
KR1020167016131A Active KR102415259B1 (ko) 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체

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EP (2) EP3071594A4 (cg-RX-API-DMAC7.html)
JP (4) JP6476182B2 (cg-RX-API-DMAC7.html)
KR (2) KR20160085345A (cg-RX-API-DMAC7.html)
CN (2) CN105899530B (cg-RX-API-DMAC7.html)
AU (4) AU2014352834B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016011567A2 (cg-RX-API-DMAC7.html)
CA (2) CA2930852C (cg-RX-API-DMAC7.html)
DK (1) DK3071593T3 (cg-RX-API-DMAC7.html)
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CN105873945B (zh) 2020-07-17
JP2017501129A (ja) 2017-01-12
MX371202B (es) 2020-01-22
MX383471B (es) 2025-03-14
DK3071593T3 (da) 2019-06-11
MX2021006932A (es) 2021-07-07
IL245468B (en) 2020-10-29
EP3071594A1 (en) 2016-09-28
JP2022023196A (ja) 2022-02-07
CN105899530A (zh) 2016-08-24
US20160280755A1 (en) 2016-09-29
EP3071594A4 (en) 2017-05-03
AU2014352826A1 (en) 2016-05-26
MX2016006625A (es) 2016-12-02
US10023625B2 (en) 2018-07-17
CN105873945A (zh) 2016-08-17
IL245467A0 (en) 2016-06-30
US20190055298A1 (en) 2019-02-21
SG10201804330YA (en) 2018-07-30
PT3071593T (pt) 2019-06-27
PL3071593T3 (pl) 2019-11-29
TR201908404T4 (tr) 2019-07-22
JP6476182B2 (ja) 2019-02-27
AU2021202274A1 (en) 2021-05-06
WO2015077615A1 (en) 2015-05-28
CA2930852A1 (en) 2015-05-28
AU2019272003A1 (en) 2019-12-19
CN105899530B (zh) 2020-05-08
KR20160087866A (ko) 2016-07-22
RU2016124179A (ru) 2017-12-27
EP3071593A4 (en) 2017-05-03
JP2020007374A (ja) 2020-01-16
US20160280756A1 (en) 2016-09-29
AU2014352826B2 (en) 2019-08-01
IL245468A0 (en) 2016-06-30
AU2019272003B2 (en) 2021-05-06
KR102415259B1 (ko) 2022-06-30
ES2729406T3 (es) 2019-11-04
RU2740648C2 (ru) 2021-01-19
EP3071593A1 (en) 2016-09-28
CA2930847A1 (en) 2015-05-28
ZA201603169B (en) 2020-05-27
MX2016006620A (es) 2017-05-11
SG10201804335QA (en) 2018-06-28
BR112016011583A2 (pt) 2017-09-26
IL245467B (en) 2020-04-30
EP3071593B1 (en) 2019-03-13
US20220396606A1 (en) 2022-12-15
JP6697386B2 (ja) 2020-05-20
US10344075B2 (en) 2019-07-09
ZA201603116B (en) 2018-12-19
CA2930852C (en) 2024-01-23
NZ719707A (en) 2020-09-25
NZ719720A (en) 2020-09-25
JP2017501130A (ja) 2017-01-12
AU2014352834A1 (en) 2016-05-26
BR112016011567A2 (pt) 2017-10-24
RU2729383C2 (ru) 2020-08-06
AU2014352834B2 (en) 2019-08-29
SA516371174B1 (ar) 2019-04-14
RU2016124163A (ru) 2017-12-27
JP6970724B2 (ja) 2021-11-24
WO2015077607A1 (en) 2015-05-28

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