KR20160079784A

KR20160079784A - 면역글로불린 분자 시료를 분석하는 방법

면역글로불린 분자 시료를 분석하는 방법 Download PDF

Info

Publication number: KR20160079784A
Authority: KR; South Korea
Prior art keywords: polypeptide; gly; ser; lys; val
Prior art date: 2013-09-20
Legal status : Withdrawn

Application number

KR1020167010252A

Other languages

English (en)

Korean (ko)

Inventor

프레드릭 올슨

마리아 노르드그렌

말린 메자레

사라 프레드릭슨

Original Assignee

게노비스 에이비

Priority date

2013-09-20

Filing date

2014-09-18

Publication date

2016-07-06

2014-09-18 Application filed by 게노비스 에이비 filed Critical 게노비스 에이비

2016-07-06 Publication of KR20160079784A publication Critical patent/KR20160079784A/ko

Status Withdrawn legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 45
108060003951 Immunoglobulin Proteins 0.000 title claims abstract description 31
102000018358 immunoglobulin Human genes 0.000 title claims abstract description 31
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 143
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 120
229920001184 polypeptide Polymers 0.000 claims description 109
235000001014 amino acid Nutrition 0.000 claims description 29
239000000203 mixture Substances 0.000 claims description 27
241000282414 Homo sapiens Species 0.000 claims description 25
150000001413 amino acids Chemical class 0.000 claims description 24
239000003814 drug Substances 0.000 claims description 22
229940124597 therapeutic agent Drugs 0.000 claims description 22
239000012634 fragment Substances 0.000 claims description 21
125000003275 alpha amino acid group Chemical group 0.000 claims description 20
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 14
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 14
102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims description 14
108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims description 14
108010005843 Cysteine Proteases Proteins 0.000 claims description 9
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230000004481 post-translational protein modification Effects 0.000 claims description 9
NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 7
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
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