KR20160055248A - 유전자증폭기에 열 균일성을 제공하기 위한 장치, 시스템 및 방법 - Google Patents

유전자증폭기에 열 균일성을 제공하기 위한 장치, 시스템 및 방법 Download PDF

Info

Publication number
KR20160055248A
KR20160055248A KR1020167009569A KR20167009569A KR20160055248A KR 20160055248 A KR20160055248 A KR 20160055248A KR 1020167009569 A KR1020167009569 A KR 1020167009569A KR 20167009569 A KR20167009569 A KR 20167009569A KR 20160055248 A KR20160055248 A KR 20160055248A
Authority
KR
South Korea
Prior art keywords
thermal
sample block
block assembly
thermoelectric
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020167009569A
Other languages
English (en)
Korean (ko)
Inventor
혼 시우 신
친 용 쿠
웨이 쑤앙 리
치 키옹 림
치 위 칭
니로샨 라마찬드란
Original Assignee
라이프 테크놀로지스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 라이프 테크놀로지스 코포레이션 filed Critical 라이프 테크놀로지스 코포레이션
Publication of KR20160055248A publication Critical patent/KR20160055248A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
KR1020167009569A 2013-09-16 2014-09-15 유전자증폭기에 열 균일성을 제공하기 위한 장치, 시스템 및 방법 Withdrawn KR20160055248A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361878464P 2013-09-16 2013-09-16
US61/878,464 2013-09-16
PCT/US2014/055615 WO2015039014A1 (en) 2013-09-16 2014-09-15 Apparatuses, systems and methods for providing thermocycler thermal uniformity

Publications (1)

Publication Number Publication Date
KR20160055248A true KR20160055248A (ko) 2016-05-17

Family

ID=51656080

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167009569A Withdrawn KR20160055248A (ko) 2013-09-16 2014-09-15 유전자증폭기에 열 균일성을 제공하기 위한 장치, 시스템 및 방법

Country Status (9)

Country Link
US (2) US20160214110A1 (enExample)
EP (1) EP3046671B1 (enExample)
JP (1) JP6655539B2 (enExample)
KR (1) KR20160055248A (enExample)
CN (2) CN105813754B (enExample)
CA (1) CA2922854A1 (enExample)
MX (1) MX2016003395A (enExample)
SG (1) SG11201601275UA (enExample)
WO (1) WO2015039014A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180117454A (ko) * 2017-04-19 2018-10-29 주식회사 넥서스비 휴대용 실시간 pcr 측정기기

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160214110A1 (en) 2013-09-16 2016-07-28 Life Technologies Corporation Apparatuses, Systems and Methods for Providing Thermocycler Thermal Uniformity
SG11201606590UA (en) 2014-02-18 2016-09-29 Life Technologies Corp Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices
GB2531260B (en) * 2014-10-13 2019-08-14 Bae Systems Plc Peltier effect heat transfer system
EA036930B1 (ru) * 2015-07-23 2021-01-15 Сифиид Устройство термоуправления и способы применения
WO2017048987A1 (en) * 2015-09-15 2017-03-23 Life Technologies Corporation Systems and methods for biological analysis
US11583862B2 (en) 2015-09-15 2023-02-21 Life Technologies Corporation Systems and methods for biological analysis
KR102022198B1 (ko) * 2018-09-17 2019-09-18 서강대학교산학협력단 플라즈몬 가열 및 온도 산출 시스템 및 그 방법
US20220184612A1 (en) * 2019-03-18 2022-06-16 Seegene, Inc. Thermal cycler comprising sample holder assembly
CN113804902B (zh) * 2020-06-16 2025-09-09 深圳迈瑞生物医疗电子股份有限公司 样本分析仪故障自诊断的方法及样本分析仪
CN111575470B (zh) * 2020-06-28 2021-01-15 西北工业大学 一种棒状材料连续温度梯度热处理装置和方法
GB2599645B (en) * 2020-10-05 2022-10-26 James Wyllie Nicholas Improvements relating to thermoelectric coolers, thermoelectric generators & thermoelectric assemblies
GB2599463A (en) * 2020-10-05 2022-04-06 James Wyllie Nicholas Improvements relating to thermoelectric coolers, thermoelectric generators & thermoelectric assemblies
GB2621263B (en) * 2020-10-05 2024-09-04 James Wyllie Nicholas Improvements relating to thermoelectric coolers, thermoelectric generators & thermoelectric assemblies
CN114400211A (zh) * 2022-01-17 2022-04-26 长鑫存储技术有限公司 一种半导体结构及其形成方法
US12478969B2 (en) * 2022-09-29 2025-11-25 Seegene, Inc. Device for heating sample

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3036893A (en) 1960-03-14 1962-05-29 Scientific Industries Automatic chemical analyzer
US3260413A (en) 1964-08-31 1966-07-12 Scientific Industries Automatic chemical analyzer
US3216804A (en) 1962-01-31 1965-11-09 Scientific Industries Automatic chemical analyzer and sample dispenser
US3128239A (en) 1962-06-29 1964-04-07 Robert Z Page Biological detection equipment
US3261668A (en) 1962-08-14 1966-07-19 Scientific Industries Chemical analyzer tape
US3271112A (en) 1962-12-12 1966-09-06 Donald L Williams Apparatus for laboratory testing
US3368872A (en) 1964-08-31 1968-02-13 Scientific Industries Automatic chemical analyzer
EP0089383B1 (de) 1982-03-18 1985-08-28 Turgut Koruk Quantisierte (digitale) Heizplatte
US5038852A (en) 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
CA1339653C (en) 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
EP0342155A3 (de) 1988-05-13 1990-06-27 Agrogen-Stiftung Laboratoriumsgerät zum wahlweisen Heizen und Kühlen
GB8814962D0 (en) 1988-06-23 1988-07-27 Lep Scient Ltd Biochemical reaction machine
US4865986A (en) 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
DE8814398U1 (de) 1988-11-17 1989-02-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV, 3400 Göttingen Thermostatiergerät
US4950608A (en) 1989-04-25 1990-08-21 Scinics Co., Ltd. Temperature regulating container
US5504007A (en) 1989-05-19 1996-04-02 Becton, Dickinson And Company Rapid thermal cycle apparatus
DE4029004C1 (enExample) 1990-09-13 1992-04-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
DE4234086A1 (de) 1992-02-05 1993-08-12 Diagen Inst Molekularbio Verfahren zur bestimmung von in vitro amplifizierten nukleinsaeuresequenzen
US5601141A (en) * 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5441576A (en) 1993-02-01 1995-08-15 Bierschenk; James L. Thermoelectric cooler
CA2130517C (en) 1993-09-10 1999-10-05 Walter Fassbind Array of reaction containers for an apparatus for automatic performance of temperature cycles
US5525300A (en) 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
DE4435107C1 (de) 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturisierter Fluß-Thermocycler
US20020068357A1 (en) 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US6825047B1 (en) 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
WO1998005060A1 (en) 1996-07-31 1998-02-05 The Board Of Trustees Of The Leland Stanford Junior University Multizone bake/chill thermal cycling module
DE29623597U1 (de) 1996-11-08 1999-01-07 Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg Temperierblock mit Temperiereinrichtungen
DE19646115C2 (de) 1996-11-08 2000-05-25 Eppendorf Geraetebau Netheler Verwendung von Temperiereinrichtungen zur Temperierung eines Temperierblockes
JP2001521379A (ja) 1997-03-28 2001-11-06 ザ パーキン−エルマー コーポレーション Ｐｃｒのための熱サイクラの改良
US5874667A (en) * 1997-06-27 1999-02-23 Kasman; David H. Block-type heater assembly for isothermally heating samples with observation access
US6106784A (en) 1997-09-26 2000-08-22 Applied Chemical & Engineering Systems, Inc. Thawing station
US6558947B1 (en) 1997-09-26 2003-05-06 Applied Chemical & Engineering Systems, Inc. Thermal cycler
AU9786798A (en) 1997-10-10 1999-05-03 Biosepra Inc. Aligned multiwell multiplate stack and method for processing biological/chemicalsamples using the same
US7188001B2 (en) 1998-03-23 2007-03-06 Cepheid System and method for temperature control
US6093370A (en) 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
JP2000102376A (ja) * 1998-09-30 2000-04-11 Sanyo Electric Co Ltd インキュベータの温度制御装置
US6337435B1 (en) * 1999-07-30 2002-01-08 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6633785B1 (en) 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
DE29917313U1 (de) 1999-10-01 2001-02-15 MWG-BIOTECH AG, 85560 Ebersberg Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen
JP4457331B2 (ja) * 2000-03-31 2010-04-28 エイブル株式会社 振とう培養機及び培養液の計測または制御方法
US6720187B2 (en) * 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
GB2366628B (en) 2000-09-11 2002-09-18 Bookham Technology Plc Method and apparatus for temperature control
US7727479B2 (en) 2000-09-29 2010-06-01 Applied Biosystems, Llc Device for the carrying out of chemical or biological reactions
JP2002355038A (ja) 2001-03-29 2002-12-10 Japan Science & Technology Corp 遺伝子解析方法およびその解析装置
DE10221763A1 (de) 2002-05-15 2003-12-04 Eppendorf Ag Thermocycler mit in Cyclen angesteuertem Temperierblock
JP3980966B2 (ja) 2002-08-21 2007-09-26 シャープ株式会社 プレゼンテーション用表示装置
US6730883B2 (en) 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
DE20218574U1 (de) 2002-11-30 2003-12-11 Element-System Rudolf Bohnacker Gmbh Trägersystem für Regalelemente
US8676383B2 (en) 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
AU2004243070B2 (en) * 2003-05-23 2010-04-15 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media
US20040241048A1 (en) 2003-05-30 2004-12-02 Applera Corporation Thermal cycling apparatus and method for providing thermal uniformity
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
US20050194367A1 (en) 2004-03-02 2005-09-08 Fredrick William G.Jr. System and method for remote controlled actuation of laser processing head
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
US7670834B2 (en) 2004-06-23 2010-03-02 Applied Biosystems, Llc Gas thermal cycler
US7585663B2 (en) 2004-08-26 2009-09-08 Applied Biosystems, Llc Thermal device, system, and method, for fluid processing device
US7303450B2 (en) 2005-09-06 2007-12-04 Lear Corporation Electrical terminal assembly
EP2027251A4 (en) 2006-05-17 2010-05-05 California Inst Of Techn Thermal cycling system
US20080026483A1 (en) * 2006-06-14 2008-01-31 Oldenburg Kevin R Thermal-cycling devices and methods of using the same
US20080087316A1 (en) 2006-10-12 2008-04-17 Masa Inaba Thermoelectric device with internal sensor
DE102007003754A1 (de) * 2007-01-19 2008-07-24 Eppendorf Ag Temperiervorrichtung mit Kalibrierungseinrichtung
US20080176292A1 (en) 2007-01-23 2008-07-24 Texas A&M University System Portable buoyancy driven pcr thermocycler
US8871470B2 (en) 2007-03-21 2014-10-28 Applied Biosystems, Llc Adaptive thermal block temperature control method and system
US9170060B2 (en) 2008-01-22 2015-10-27 Lawrence Livermore National Security, Llc Rapid microfluidic thermal cycler for nucleic acid amplification
US8586794B2 (en) 2008-07-25 2013-11-19 Basf Se 5-isopropyl-3-aminomethyl-2-methyl-1-amino-cyclohexane (carvone diamine), and method for the production thereof
EP2153901A1 (de) 2008-08-01 2010-02-17 Eppendorf Ag Temperierungsvorrichtung mit Testmöglichkeit und Verfahren zum Testen einer Temperierungsvorrichtung
US20100081191A1 (en) 2008-09-26 2010-04-01 Marlow Industries, Inc. Anisotropic heat spreader for use with a thermoelectric device
US20100124766A1 (en) 2008-11-14 2010-05-20 Life Technologies Corporation Apparatus and Method for Segmented Thermal Cycler
US8672532B2 (en) * 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
SG178411A1 (en) * 2009-09-01 2012-04-27 Life Technologies Corp Thermal block assemblies and instruments providing low thermal non-uniformity for rapid thermal cycling
GB201005704D0 (en) 2010-04-06 2010-05-19 It Is Internat Ltd Improvements in systems for chemical and/or biochemical reactions
SG184539A1 (en) 2010-04-09 2012-11-29 Life Technologies Corp Improved thermal uniformity for thermal cycler instrumentation using dynamic control
JP5867668B2 (ja) 2010-12-01 2016-02-24 セイコーエプソン株式会社 熱サイクル装置及び熱サイクル方法
US9168530B2 (en) * 2010-12-17 2015-10-27 Bjs Ip Ltd. Methods and systems for fast PCR heating
JP5687514B2 (ja) * 2011-02-17 2015-03-18 株式会社日立ハイテクノロジーズ 核酸配列解析装置
US20130157376A1 (en) * 2011-12-20 2013-06-20 Idaho Technology, Inc. Thermal Cycler Calibration Device and Related Methods
EP2825865B1 (en) 2012-03-09 2020-07-22 Ubiquitome Limited Portable device for detecting molecule(s)
US20160214110A1 (en) 2013-09-16 2016-07-28 Life Technologies Corporation Apparatuses, Systems and Methods for Providing Thermocycler Thermal Uniformity
SG11201606590UA (en) 2014-02-18 2016-09-29 Life Technologies Corp Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180117454A (ko) * 2017-04-19 2018-10-29 주식회사 넥서스비 휴대용 실시간 pcr 측정기기

Also Published As

Publication number Publication date
US20180056296A1 (en) 2018-03-01
US10835901B2 (en) 2020-11-17
CN105813754A (zh) 2016-07-27
CN105813754B (zh) 2018-12-14
WO2015039014A1 (en) 2015-03-19
SG11201601275UA (en) 2016-04-28
EP3046671A1 (en) 2016-07-27
MX2016003395A (es) 2016-06-24
JP6655539B2 (ja) 2020-02-26
US20160214110A1 (en) 2016-07-28
CA2922854A1 (en) 2015-03-19
CN204625602U (zh) 2015-09-09
EP3046671B1 (en) 2023-04-12
JP2016539657A (ja) 2016-12-22

Similar Documents

Publication Publication Date Title
KR20160055248A (ko) 유전자증폭기에 열 균일성을 제공하기 위한 장치, 시스템 및 방법
US12196460B2 (en) Thermal control device and methods of use
US10471431B2 (en) Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices
CN103476498B (zh) 用于快速pcr加热的方法及系统
JP2013523165A (ja) 動的制御を用いた熱サイクラ器具に対する熱均一性改良
KR20120107716A (ko) 시료 보관용 온도 제어 장치
US8722394B2 (en) Laboratory apparatus with an arrangement for the tempering of samples and method of tempering samples
US7841247B2 (en) Temperature controller for small fluid samples with different heat capacities
US10391499B2 (en) Thermal cycling
CN113287208A (zh) 热泵设备和组件
CN103374510A (zh) 一种基于低熔点金属液滴的pcr反应装置及其实施方法
WO2002074898A2 (en) Gradient block temperature control device

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20160412

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid