EP2027251A4 - Thermal cycling system - Google Patents

Thermal cycling system

Info

Publication number
EP2027251A4
EP2027251A4 EP07783905A EP07783905A EP2027251A4 EP 2027251 A4 EP2027251 A4 EP 2027251A4 EP 07783905 A EP07783905 A EP 07783905A EP 07783905 A EP07783905 A EP 07783905A EP 2027251 A4 EP2027251 A4 EP 2027251A4
Authority
EP
European Patent Office
Prior art keywords
thermal cycling
cycling system
thermal
cycling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP07783905A
Other languages
German (de)
French (fr)
Other versions
EP2027251A2 (en
Inventor
George Maltezos
Matthew Johnston
David Goodwin
Axel Scherer
Christopher I Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Priority to EP12178744.4A priority Critical patent/EP2535427A3/en
Publication of EP2027251A2 publication Critical patent/EP2027251A2/en
Publication of EP2027251A4 publication Critical patent/EP2027251A4/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/02—Water baths; Sand baths; Air baths
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
EP07783905A 2006-05-17 2007-05-17 Thermal cycling system Ceased EP2027251A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12178744.4A EP2535427A3 (en) 2006-05-17 2007-05-17 Thermal cycling system

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80117806P 2006-05-17 2006-05-17
US83249206P 2006-07-21 2006-07-21
US87317206P 2006-12-06 2006-12-06
US87308406P 2006-12-06 2006-12-06
PCT/US2007/069197 WO2008070198A2 (en) 2006-05-17 2007-05-17 Thermal cycling system

Publications (2)

Publication Number Publication Date
EP2027251A2 EP2027251A2 (en) 2009-02-25
EP2027251A4 true EP2027251A4 (en) 2010-05-05

Family

ID=39492885

Family Applications (2)

Application Number Title Priority Date Filing Date
EP07783905A Ceased EP2027251A4 (en) 2006-05-17 2007-05-17 Thermal cycling system
EP12178744.4A Withdrawn EP2535427A3 (en) 2006-05-17 2007-05-17 Thermal cycling system

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP12178744.4A Withdrawn EP2535427A3 (en) 2006-05-17 2007-05-17 Thermal cycling system

Country Status (3)

Country Link
EP (2) EP2027251A4 (en)
JP (1) JP2009537152A (en)
WO (1) WO2008070198A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102202792A (en) * 2008-09-09 2011-09-28 道格拉斯机械公司 Apparatus and methods for performing real time pcr in array tape
JP5715068B2 (en) * 2009-01-30 2015-05-07 マイクロニクス， インコーポレイテッド Portable high gain fluorescence detection system
JP5138093B2 (en) * 2009-03-31 2013-02-06 財団法人神奈川科学技術アカデミー Liquid reflux type high-speed gene amplification device
DE212010000039U1 (en) * 2009-04-03 2012-02-02 Helixis, Inc. DEVICES FOR HEATING BIOLOGICAL SAMPLES
GB2511692A (en) * 2009-08-08 2014-09-10 Bibby Scient Ltd An apparatus for treating a test sample
GB2512764B (en) * 2009-08-08 2014-12-24 Bibby Scient Ltd An apparatus for treating a test sample
WO2011021640A1 (en) * 2009-08-20 2011-02-24 タカラバイオ株式会社 Temperature cycling device
EP2301666B1 (en) * 2009-09-09 2021-06-30 Cole-Parmer Ltd. Optical system for multiple reactions
JP5343801B2 (en) * 2009-09-30 2013-11-13 凸版印刷株式会社 Heat transfer device for gene processing device and gene processing device
ES2363697B1 (en) 2009-10-26 2012-04-20 Ingenia Biosystems, S.L. APPARATUS FOR LOCKING NUCLEIC ACIDS BY PHOTOACTIVATION OF INTERCALANT AGENTS.
CN102791847B (en) * 2010-01-12 2015-01-21 阿赫姆生物系统公司 Three-stage thermal convection apparatus and uses thereof
CA2786569C (en) 2010-01-29 2019-04-09 Micronics, Inc. Sample-to-answer microfluidic cartridge
SG184539A1 (en) 2010-04-09 2012-11-29 Life Technologies Corp Improved thermal uniformity for thermal cycler instrumentation using dynamic control
US8720209B1 (en) 2010-10-06 2014-05-13 Lawrence Livermore National Security, Llc Solid state rapid thermocycling
WO2012075360A1 (en) * 2010-12-03 2012-06-07 Idaho Technology, Inc. Thermal cycler apparatus and related methods
JP5687514B2 (en) * 2011-02-17 2015-03-18 株式会社日立ハイテクノロジーズ Nucleic acid sequence analyzer
JP2012187054A (en) * 2011-03-11 2012-10-04 Hitachi High-Technologies Corp Nucleic acid amplification reaction apparatus
ES2769028T3 (en) * 2011-04-15 2020-06-24 Becton Dickinson Co Real-time scanning microfluidic thermocycler
JP5663541B2 (en) * 2012-09-19 2015-02-04 株式会社日立ハイテクノロジーズ Reaction vessel, parallel processing device, and sequencer
US20140112829A1 (en) * 2012-10-22 2014-04-24 Qiagen Gaithersburg, Inc. Tube strip handling and heating apparatus
CN107824233B (en) 2012-12-21 2020-06-30 珀金埃尔默健康科学有限公司 Low elasticity membranes for microfluidic applications
KR102102123B1 (en) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. Fluidic circuits and related manufacturing methods
WO2014100725A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CN105189784B (en) 2013-05-07 2020-06-30 珀金埃尔默健康科学有限公司 Device for preparing and analyzing nucleic acids
CA2911303C (en) 2013-05-07 2021-02-16 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
US9352502B2 (en) 2013-06-25 2016-05-31 Lawrence Livermore National Security, Llc Porous media heat transfer for injection molding
KR20160055248A (en) 2013-09-16 2016-05-17 라이프 테크놀로지스 코포레이션 Apparatuses, systems and methods for providing thermocycler thermal uniformity
KR20160123356A (en) 2014-02-18 2016-10-25 라이프 테크놀로지스 코포레이션 Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices
US11298698B2 (en) * 2018-03-15 2022-04-12 Kryptos Biotechnologies, Inc. Method and system for performing heat assisted biochemical reactions
CN109030133B (en) * 2018-06-14 2021-04-30 华东交通大学 Method for manufacturing test piece by using T-shaped sample
US11440015B2 (en) 2018-08-08 2022-09-13 Lawrence Livermore National Security, Llc Integrated solid-state rapid thermo-cycling system
CN109168298A (en) * 2018-10-18 2019-01-08 中国科学院合肥物质科学研究院 A kind of radiator for PCR detector temperature control system
CN113423367A (en) 2018-11-09 2021-09-21 迪格尼塔纳公司 Scalp cooling device, method and system
SG10201908290RA (en) * 2019-09-09 2021-04-29 Star Array Pte Ltd Apparatus for polymerase chain reaction of nucleic acid
DE102022109312A1 (en) 2021-05-05 2022-11-10 Frieder Weidhase Device for accelerated, miniaturized cooling and heating in medical technology
CN114854570B (en) * 2022-07-05 2022-09-02 鲲鹏基因（北京）科技有限责任公司 Temperature control device, liquid cooling temperature control system and PCR instrument

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363143A2 (en) * 1988-10-06 1990-04-11 Coy Corporation Temperature control apparatus
JPH07185363A (en) * 1993-12-27 1995-07-25 Shuji Ueda Heating and cooling device
US20020086417A1 (en) * 2000-12-29 2002-07-04 Shuqi Chen Sample processing device and method
US20030157721A1 (en) * 1998-08-13 2003-08-21 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US20040178357A1 (en) * 2003-02-28 2004-09-16 Applera Corporation Excitation and emission filter
WO2004105947A2 (en) * 2003-05-23 2004-12-09 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
KR100236506B1 (en) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 Apparatus for polymerase chain reaction
US5440388A (en) 1993-08-02 1995-08-08 Erickson; Jon W. Chemical analysis and imaging by discrete fourier transform spectroscopy
US5792610A (en) 1996-05-01 1998-08-11 Biorad Laboratories, Inc. Method for conducting multiparametric fluorescence in situ hybridization
ATE318327T1 (en) * 1996-06-04 2006-03-15 Univ Utah Res Found FLUORESCENCE-DONOR-ACCEPTOR PAIR
JPH10117765A (en) * 1996-10-18 1998-05-12 Ngk Insulators Ltd Specimen holder and its production
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6600563B1 (en) 1997-12-12 2003-07-29 Applera Corporation Optical resonance analysis system
US6369893B1 (en) 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6037130A (en) 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US6306658B1 (en) * 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
JP2000214506A (en) 1998-11-03 2000-08-04 Toshiba Research Europe Ltd Radiation light source and image pickup system
WO2000069561A1 (en) * 1999-05-14 2000-11-23 Hitachi Chemical Research Center, Inc. Liquid metal-heating apparatus for biological/chemical sample
DE29917313U1 (en) * 1999-10-01 2001-02-15 Mwg Biotech Ag Device for carrying out chemical or biological reactions
US6852986B1 (en) * 1999-11-12 2005-02-08 E. I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
US6403037B1 (en) 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
US6783934B1 (en) 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
JP2003024063A (en) * 2001-07-12 2003-01-28 Toshio Kawai Method for continuously amplifying dna and device for the same
CN1537229A (en) * 2001-07-31 2004-10-13 ���ְ�˹��ʽ���� Gene inspection apparatus and target nucleic acid extraction method using the same
JP2005504275A (en) 2001-09-18 2005-02-10 ユー．エス． ジェノミクス， インコーポレイテッド Differential tagging of polymers for high-resolution linear analysis
US6928860B1 (en) * 2002-02-08 2005-08-16 King Refrigeration, Inc. Heat-transfer-inhibiting motor and rotor
JP2004028775A (en) * 2002-06-25 2004-01-29 Olympus Corp Genetic testing apparatus and method for detecting using the same
US6998598B2 (en) 2002-08-02 2006-02-14 Sandia National Labroatories Modular optical detector system
US7113624B2 (en) 2002-10-15 2006-09-26 Palo Alto Research Center Incorporated Imaging apparatus and method employing a large linear aperture
KR100480637B1 (en) 2002-11-27 2005-03-31 삼성전자주식회사 Programmable fixed priority and round robin arbiter for providing the high-speed arbitration and bus control method thereof
US20050136448A1 (en) 2003-10-02 2005-06-23 Dakota Technologies, Inc. Apparatus and methods for fluorescent detection of nucleic acids
WO2005040759A2 (en) 2003-10-28 2005-05-06 Dakota Technologies, Inc. Apparatus and methods for detecting target analyte
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
US7489401B2 (en) 2004-03-01 2009-02-10 National Institute Of Advanced Industrial Science And Technology Device for detecting emission light of micro-object

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363143A2 (en) * 1988-10-06 1990-04-11 Coy Corporation Temperature control apparatus
JPH07185363A (en) * 1993-12-27 1995-07-25 Shuji Ueda Heating and cooling device
US20030157721A1 (en) * 1998-08-13 2003-08-21 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US20020086417A1 (en) * 2000-12-29 2002-07-04 Shuqi Chen Sample processing device and method
US20040178357A1 (en) * 2003-02-28 2004-09-16 Applera Corporation Excitation and emission filter
WO2004105947A2 (en) * 2003-05-23 2004-12-09 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media

Also Published As

Publication number Publication date
EP2535427A3 (en) 2013-04-24
JP2009537152A (en) 2009-10-29
WO2008070198A3 (en) 2009-04-16
WO2008070198A8 (en) 2008-12-24
WO2008070198A2 (en) 2008-06-12
EP2535427A2 (en) 2012-12-19
EP2027251A2 (en) 2009-02-25

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