JPH07185363A - Heating and cooling device - Google Patents
Heating and cooling deviceInfo
- Publication number
- JPH07185363A JPH07185363A JP35484093A JP35484093A JPH07185363A JP H07185363 A JPH07185363 A JP H07185363A JP 35484093 A JP35484093 A JP 35484093A JP 35484093 A JP35484093 A JP 35484093A JP H07185363 A JPH07185363 A JP H07185363A
- Authority
- JP
- Japan
- Prior art keywords
- heating
- cooling
- cooling device
- hole
- heated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Devices For Use In Laboratory Experiments (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、医学、化学、生物工学
の分野における各種サンプルを、迅速に加熱および冷却
することができ、そして、サンプルの精密温度制御が可
能であり、かつ、温度分布精度の良好な加熱冷却器であ
り、被加熱冷却物用の光学的測定用の観察用貫通孔の構
造を有する加熱冷却器の構造に関する。BACKGROUND OF THE INVENTION The present invention is capable of rapidly heating and cooling various samples in the fields of medicine, chemistry and biotechnology, and enables precise temperature control of samples and temperature distribution. The present invention relates to a structure of a heating / cooling device having a good accuracy and having a structure of an observation through hole for optical measurement for an object to be heated.
【0002】[0002]
【従来の技術】従来の理科学向け恒温水槽においては、
水を熱媒体としていたために、サンプル容器が水と接触
してしまう。また、サンプルの迅速な昇温と降温が不可
能であった。一定の温度へ到達するまでに長時間がかか
り、かつ設定温度を変更する場合、応答速度が遅かっ
た。また、精密な温度プログラムコントロールをしなが
ら被加熱冷却物の光学的測定用の観察用貫通孔の構造を
備えたものが存在しなかった。2. Description of the Related Art In a conventional constant temperature water tank for science and science,
Since water was used as the heat medium, the sample container comes into contact with water. Moreover, it was impossible to rapidly raise and lower the temperature of the sample. It took a long time to reach a certain temperature, and when the set temperature was changed, the response speed was slow. Further, there has been no one having a structure of an observation through hole for optical measurement of a cooled object while controlling a precise temperature program.
【0003】[0003]
【発明が解決しようとする課題】本発明は、このような
従来の欠点を解決して、各種サンプルを所定の温度まで
すばやく昇温あるいは降温し、かつ温度変更に対しても
迅速に対応し、かつ温度分布も良好で精密なプログラマ
ブル温度コントロールが可能であり、被加熱冷却物の光
学的測定用の観察用貫通孔の構造を備えた迅速な昇温お
よび降温が可能な加熱冷却器を提供するために成された
ものである。DISCLOSURE OF THE INVENTION The present invention solves the above-mentioned drawbacks of the prior art, quickly raises or lowers the temperature of various samples to a predetermined temperature, and quickly responds to temperature changes, Provided is a heating / cooling device having a good temperature distribution, capable of precise programmable temperature control, and having a structure of a through hole for observation for optical measurement of an object to be heated and capable of rapid heating and cooling. It was made for the purpose.
【0004】[0004]
【課題を解決するための手段】上記の課題を解決するた
めに成された本発明は、構造体の任意の面に被加熱冷却
物支持用の面、孔、溝を有するとともに、その構造体内
部に熱伝導率の良好な液体金属からなる熱媒体を充填
し、ヒーターを設置すると共に、降温に関しては、熱放
散性の良好なフィン、ハニカム構造あるいはパイプから
なる冷却部を設置し、冷気あるいは冷媒等に接触するこ
とにより降温させ、任意の部分に所望の形状の被加熱冷
却物用の光学的測定用の観察用貫通孔の構造を備えて、
各種サンプルの測定を可能にすると言う技術的手段を採
用した。DISCLOSURE OF THE INVENTION The present invention, which has been made to solve the above-mentioned problems, has a structure for supporting a material to be heated, a hole, and a groove on an arbitrary surface of the structure, and the structure thereof. The inside is filled with a heat medium made of a liquid metal having good thermal conductivity, and a heater is installed.Finally, for cooling the temperature, a fin having good heat dissipation properties, a cooling unit made of a honeycomb structure or a pipe is installed, and cold air or The temperature is lowered by coming into contact with a refrigerant or the like, and an arbitrary portion is provided with a structure of an observation through hole for optical measurement for a heated object having a desired shape,
We adopted the technical means of enabling measurement of various samples.
【0005】[0005]
【作 用】上記のように構成された加熱冷却器によれば
被加熱冷却物は、構造体に設けられた面、孔、溝に接し
ているため迅速に加熱冷却器の温度と等しくなる。ま
た、ヒーターが液体金属の熱伝導率の良好な熱媒体の中
に設置してあるため、精密に温度を制御する事が可能と
なり、被加熱冷却物用の光学的測定用の観測用貫通孔の
構造を備えることにより各種サンプルの測定が可能とな
る。[Operation] According to the heating / cooling device configured as described above, since the object to be heated is in contact with the surface, the hole, and the groove provided in the structure, the temperature of the heating / cooling device quickly becomes equal to that of the heating / cooling device. In addition, since the heater is installed in a heat medium with good thermal conductivity of liquid metal, it is possible to precisely control the temperature, and an observation through hole for optical measurement of the object to be heated. With the structure described above, various samples can be measured.
【0006】[0006]
【実施例1】図1は、本発明の構成を示す。1は、熱伝
導率の良い銅合金製の中空構造の被加熱冷却物支持容器
であり、その中空内部には、水銀が封入されている。
2、3、4は被加熱冷却物を支持するための孔である。
1の内部には、冷却用パイプ5が通っており、冷却部7
によって冷却された冷媒がポンプ6によって送り込まれ
る。8も冷却用のパイプであり、効率を上げるため構造
体の外部に設置されている。9は、1に封入された水銀
を熱するために設置されたヒーターであり、13は、外
部ヒーターである。撹拌翼10によって、水銀の温度分
布を均一にするために撹拌する。11は、温度センサー
であり、加熱手段および冷却手段にフィードバックされ
る。12は、被加熱冷却物の光学的測定の観測用貫通孔
である。以上の構成で、恒温槽を組み立て、実験を行っ
た。図1の2、3、4に試験管をセットし、それぞれの
試験管に熱電対を取り付け、2の位置の熱電対でPID
制御で行った。その時、2の位置の熱電対の出力をチェ
ックした。この時の実験の温度範囲は−20℃から10
0℃の範囲で、昇温速度12℃/秒を達成し、降温速度
6.2℃/秒を達成し、温度分布精度±0.1℃以内を
達成することができた。Embodiment 1 FIG. 1 shows the structure of the present invention. Reference numeral 1 denotes a hollow-structured object supporting object to be cooled which is made of a copper alloy having a good thermal conductivity, and mercury is enclosed in the hollow inside thereof.
2, 3 and 4 are holes for supporting the object to be heated.
A cooling pipe 5 passes through the inside of 1, and a cooling unit 7
The coolant cooled by is pumped by the pump 6. Reference numeral 8 is also a cooling pipe, and is installed outside the structure to improve efficiency. Reference numeral 9 is a heater installed to heat the mercury enclosed in 1, and 13 is an external heater. The stirring blade 10 stirs to make the temperature distribution of mercury uniform. A temperature sensor 11 is fed back to the heating means and the cooling means. Reference numeral 12 is a through hole for observation of optical measurement of the object to be heated. An experiment was conducted by assembling a constant temperature bath with the above configuration. Set the test tubes to 2, 3 and 4 in Fig. 1, attach thermocouples to each test tube, and use the PID with the thermocouple at the 2 position.
Controlled. At that time, the output of the thermocouple at the position 2 was checked. The temperature range of the experiment at this time was from -20 ° C to 10
In the range of 0 ° C., the temperature rising rate of 12 ° C./second was achieved, the temperature decreasing rate of 6.2 ° C./second was achieved, and the temperature distribution accuracy of ± 0.1 ° C. or less was achieved.
【0007】[0007]
【発明の効果】以上のように、本発明は、構造体の任意
の面に被加熱冷却物支持用の面、孔、溝を有するととも
に、その構造体内部に熱伝導率の良好な水銀からなる熱
媒体を充填し、ヒーターを設置する、このように構成さ
れた加熱冷却器によれば被加熱冷却物は、構造体に設け
られた面、孔、溝に接しているため迅速に加熱冷却器の
温度と等しくなる。降温に関しては、フィン、ハニカム
構造あるいはパイプからなる冷却部を設置し、冷気ある
いは冷媒等に接触することにより降温させる。この結果
温度分布も良好となり、精密なプログラマブル温度コン
トロールが可能となる。したがって、従来の技術では、
なしえなっかた各種の温度パターンの精密温度制御が可
能となり、被加熱冷却物用の光学的測定用の観測用貫通
孔の構造を備えることにより各種サンプルの測定が可能
にした。医学、化学、生物工学の分野等においては、新
しい用途が開け、複雑な温度プログラム制御が可能とな
り、新規な操作方法かできるようになった。INDUSTRIAL APPLICABILITY As described above, according to the present invention, a structure for supporting a material to be heated, a hole, and a groove are provided on any surface of the structure, and mercury having good thermal conductivity is formed inside the structure. According to the heating / cooling device configured as described above, the heating target is filled with a heat medium, and the object to be heated is quickly heated and cooled because it is in contact with the surface, hole, or groove provided in the structure. It becomes equal to the temperature of the vessel. Regarding cooling, a cooling unit composed of fins, a honeycomb structure, or a pipe is installed, and the temperature is lowered by contacting cold air or a refrigerant. As a result, the temperature distribution becomes good and precise programmable temperature control becomes possible. Therefore, in the conventional technology,
Precise temperature control of various temperature patterns has become possible, and various samples can be measured by providing the structure of the observation through hole for optical measurement of the object to be heated. In the fields of medicine, chemistry, biotechnology, etc., new applications have opened up, complicated temperature program control has become possible, and new operation methods have become possible.
【図1】実施例1の構成図FIG. 1 is a configuration diagram of a first embodiment.
1 構造体 2、3、4 被加熱冷却物支持用の穴 5 内部冷却パイプ 6 ポンプ 7 冷却用熱交換部 8 外部冷却パイプ 9 内部ヒーター 10 撹拌翼 11 温度センサー 12 光学観測穴 13 外部ヒーター 1 Structure 2, 3, 4 Hole for Supporting Heated Cooled Material 5 Internal Cooling Pipe 6 Pump 7 Cooling Heat Exchange Section 8 External Cooling Pipe 9 Internal Heater 10 Stirrer Blade 11 Temperature Sensor 12 Optical Observation Hole 13 External Heater
───────────────────────────────────────────────────── フロントページの続き (72)発明者 加藤 圭一 神奈川県川崎市宮前区馬絹1634−1 コス モ宮崎台 アバンシード305号 (72)発明者 栗田 洋 神奈川県鎌倉市西鎌倉4−16−15 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Keiichi Kato 163-1 Makinagi, Miyamae-ku, Kawasaki-shi, Kanagawa Cosmo Miyazakidai Avanced 305 (72) Inventor Hiro Kurita 4-16-15 Nishi-Kamakura, Kamakura-shi, Kanagawa
Claims (7)
持用の被加熱冷却物の所望の形状の少なくとも1つの
孔、少なくとも1つの凹部および少なくとも1つの貫通
孔、少なくとも1つの溝を有する構造体とその内部に熱
媒体を充填するための中空構造になっている構造体に、
少なくとも1つのヒーターを構造体の内部、外部に有す
る事を特徴とする加熱冷却器。1. A planar shape, and at least one hole, at least one recess and at least one through hole, and at least one groove of a desired shape of the object to be cooled for supporting the object to be heated, which are provided on a surface and on an arbitrary surface. To the structure having a hollow structure for filling the heat medium with the structure having,
A heating / cooling device having at least one heater inside and outside the structure.
特徴とする特許請求範囲第1項記載の加熱冷却器。2. The heating / cooling device according to claim 1, wherein the structure has a cooling means.
けられた冷媒供給機と、そして、各々、熱交換を行うた
めの前記構造体の外部の面の一部、前記構造体の内部、
外部の面の一部の上に形成された凹凸部、前記構造体の
内部、外部に形成された、その中を前記冷媒が通過する
少なくとも1つの冷却パイプ、前記構造体の内部、外部
に設けられた、フィンを有する放熱板、および前記構造
体の内部、外部に設けられた、ハニカム構造を有する放
熱板のうち少なくとも1つからなっている構造を特徴と
する特許請求範囲第2項記載の加熱冷却器。3. The cooling means is a refrigerant supply device provided outside the structure, and a part of an outer surface of the structure for heat exchange, and an inside of the structure. ,
Concavo-convex portion formed on a part of the outer surface, at least one cooling pipe formed inside or outside the structure, through which the refrigerant passes, provided inside or outside the structure The heat dissipation plate having a fin, and the heat dissipation plate having a honeycomb structure, which is provided inside or outside of the structure, and has a structure including at least one of the heat dissipation plates. Heating cooler.
入れるための、前記少なくとも1つの孔、前記少なくと
も1つの凹物、前記少なくとも1つの貫通孔前記少なく
とも1つの溝に連通する、前記被加熱冷却物を観察およ
び光学的測定をするための少なくとも1つの観察用貫通
孔を有する構造を有する事を特徴とする特許請求範囲第
1項記載の加熱冷却器。4. The sintered body communicating with the at least one hole, the at least one recess, the at least one through hole, and the at least one groove for receiving the object to be cooled. The heating / cooling device according to claim 1, wherein the heating / cooling device has a structure having at least one observation through hole for observing and optically measuring the object to be heated.
透光性セラミックス、透光性ガラス、および透光性樹脂
のうち何れか1つによって充填されている事を特徴とす
る特許請求範囲第4項記載の加熱冷却器。5. The at least one observation through hole comprises:
The heating / cooling device according to claim 4, wherein the heating / cooling device is filled with any one of translucent ceramics, translucent glass, and translucent resin.
率の良好な液体金属である事を特徴とする特許請求範囲
第1項記載の加熱冷却器。6. The heating / cooling device according to claim 1, wherein the heat medium filled in the structure is a liquid metal having good thermal conductivity.
ある事を特徴とする特許請求範囲第1項記載の加熱冷却
器。7. The heating / cooling device according to claim 1, wherein the heat medium filled in the structure is mercury.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP35484093A JPH07185363A (en) | 1993-12-27 | 1993-12-27 | Heating and cooling device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP35484093A JPH07185363A (en) | 1993-12-27 | 1993-12-27 | Heating and cooling device |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH07185363A true JPH07185363A (en) | 1995-07-25 |
Family
ID=18440264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP35484093A Pending JPH07185363A (en) | 1993-12-27 | 1993-12-27 | Heating and cooling device |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH07185363A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2027251A2 (en) * | 2006-05-17 | 2009-02-25 | California Institute of Technology | Thermal cycling system |
US20100279299A1 (en) * | 2009-04-03 | 2010-11-04 | Helixis, Inc. | Devices and Methods for Heating Biological Samples |
US8003370B2 (en) * | 2006-05-17 | 2011-08-23 | California Institute Of Technology | Thermal cycling apparatus |
US8987685B2 (en) | 2009-09-09 | 2015-03-24 | Pcr Max Limited | Optical system for multiple reactions |
-
1993
- 1993-12-27 JP JP35484093A patent/JPH07185363A/en active Pending
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2027251A2 (en) * | 2006-05-17 | 2009-02-25 | California Institute of Technology | Thermal cycling system |
JP2009537152A (en) * | 2006-05-17 | 2009-10-29 | カリフォルニア インスティテュート オブ テクノロジー | Temperature cycle system |
EP2027251A4 (en) * | 2006-05-17 | 2010-05-05 | California Inst Of Techn | Thermal cycling system |
US8003370B2 (en) * | 2006-05-17 | 2011-08-23 | California Institute Of Technology | Thermal cycling apparatus |
US8008046B2 (en) * | 2006-05-17 | 2011-08-30 | California Institute Of Technology | Thermal cycling method |
US8232091B2 (en) * | 2006-05-17 | 2012-07-31 | California Institute Of Technology | Thermal cycling system |
EP2535427A3 (en) * | 2006-05-17 | 2013-04-24 | California Institute of Technology | Thermal cycling system |
US9316586B2 (en) | 2006-05-17 | 2016-04-19 | California Institute Of Technology | Apparatus for thermal cycling |
US20100279299A1 (en) * | 2009-04-03 | 2010-11-04 | Helixis, Inc. | Devices and Methods for Heating Biological Samples |
EP2414504A2 (en) * | 2009-04-03 | 2012-02-08 | Helixis Inc. | Devices and methods for heating biological samples |
EP2414504A4 (en) * | 2009-04-03 | 2013-08-28 | Illumina Inc | Devices and methods for heating biological samples |
US8987685B2 (en) | 2009-09-09 | 2015-03-24 | Pcr Max Limited | Optical system for multiple reactions |
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