KR20160034498A - Forming mosquito repellant composition and manufacturing method thereof - Google Patents
Forming mosquito repellant composition and manufacturing method thereof Download PDFInfo
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- KR20160034498A KR20160034498A KR1020140125109A KR20140125109A KR20160034498A KR 20160034498 A KR20160034498 A KR 20160034498A KR 1020140125109 A KR1020140125109 A KR 1020140125109A KR 20140125109 A KR20140125109 A KR 20140125109A KR 20160034498 A KR20160034498 A KR 20160034498A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/48—Zingiberaceae [Ginger family], e.g. ginger or galangal
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
본 발명은 모기 퇴치제 조성물에 관한 것으로, 더욱 상세하게는 발포형 모기 퇴치제 조성물 및 그 제조방법에 관한 것이다.The present invention relates to a mosquito repellent composition, and more particularly, to a foamable mosquito repellent composition and a method of manufacturing the same.
지구 온난화로 인한 기후변화로 모기 개체수가 증가하고 이로 인한 피해 역시 증가하고 있다. 전 세계적으로 뎅기열, 황열병, 말라리아 및 일본뇌염 등으로 매년 200만의 인구가 사망하고 있으며 우리나라도 환자수가 급증하는 추세에 있다. 국내 살충제의 유효 살충성분은 접촉성 기피제로서 모기의 신경계에 독성을 나타내는 퍼메트린(permethrin) 등 피레스로이드(pyrethroid)계 살충제가 대부분을 차지하는데 피레스로이드계는 비교적 낮은 농도에서 모기, 파리, 진드기 등에 유효한 기피제 및 살충제로 사용되는 대표적 화학합성제로 퍼메트린, 알러트린, 델타메트린, 싸이퍼메트린 등이 있다. 살충제의 사용이 증가하였으나 종래 사용하던 합성살충제의 경우 약제 저항성, 유용생물의 살해, 인간과 가축에 대한 독성, 잔류성 및 각종 환경오염 등 부작용이 따르는 문제가 있었다. 그러므로 인간 및 생태계에 미치는 영향을 최소화하면서 인간을 모기로부터 효과적으로 보호할 수 있는 새로운 대체약제 및 방제법의 개발이 시급한 실정이다.
Climate change due to global warming has increased mosquito populations and the damage caused by them has also increased. Globally, 2 million people die annually from dengue fever, yellow fever, malaria and Japanese encephalitis, and the number of patients in Korea is also on the rise. The effective insecticides of domestic insecticides are mostly contact insect repellents, which are pyrethroid insecticides such as permethrin which is toxic to the nervous system of mosquitoes. The pyrethroid type is effective at mosquitoes, flies and mites at relatively low concentrations Representative chemical synthesizers used as repellents and pesticides include permethrin, allotin, deltamethrin, and cypermethrin. The use of insecticides has been increased, but conventional synthetic pesticides have been associated with side effects such as drug resistance, killing of useful organisms, toxicity to humans and livestock, persistence and various environmental pollution. Therefore, it is urgent to develop a new alternative medicine and control method that can effectively protect human from mosquitoes while minimizing the impact on human and ecosystem.
모기(Mosquito)는 사람에게서 나오는 젖산, 이산화탄소 등 유인물질을 촉각에 있는 화학물질 수용체에서 감지해 흡혈대상을 찾아낸다. 모기기피제는 이 수용체의 감지를 방해하여 모기의 촉각에 있는 신경에 카이로몬(kairomone:어떤 생물이 생산하는 물질이 다른 종의 생물에 유리하게 작용하는 물질)이 전달되지 못하게 함으로써 사람을 찾지 못하게 하는 것이 원리이다. 디에칠톨루아미드 (N,N-Diethyl-meta-toluamide), 일명 DEET는 어린이 제품 등에 가장 흔하게 쓰이는 살충제 성분 중 하나인데 중추신경과 뇌 신경에 영향을 미쳐 장시간 노출시 발작, 마비 등의 부작용이 나타날 수 있기 때문에 이미 EU에서는 2006년부터 점차 사용을 중지시키고 있으며 WHO는 WHOPES를 통해 살충제 사용을 규제하는 내용을 회원국에 지속해서 발송하고 있는 실정이다.
Mosquito detects lactic acid, carbon dioxide, and other attractants from humans from chemical receptors in the tactile sense, and finds a blood-sucking target. Mosquito repellents prevent the detection of this receptor so that the neurons in the tactile sense of the mosquito do not allow the person to be found by preventing the transmission of kairomones That is the principle. DEET is one of the most commonly used pesticide ingredients in children's products. It affects the central nervous system and brain nerves, causing long-term exposure to side effects such as seizures and paralysis. N-Diethyl-meta-toluamide Since 2006, the EU has been gradually discontinuing its use, and WHO has been continuing to send its Member States regulations governing the use of pesticides through WHOPES.
직접 살포 또는 100배 내지 10,000배의 물에 희석하여 사용하는 발포형 타블렛 타입의 모기유충구제용 살충제에 대하여는 대한민국 공개특허 제10-2013-0107162호에 개시된 바 있고, 살충제의 주성분 퍼메트린에 향료를 첨가한 후 무수에탄올에 용해시킨 에어로졸 용도의 해충 기피제에 대하여는 대한민국 등록특허 제10-0485412호에 개시된 바 있고, 단독의 DEET 물질을 미세 캡슐화하여 사용하거나 DEET 물질에 은계 화합물을 혼합하여 사용할 수 있는 모기 퇴치제에 대하여는 등록특허 제10-0955620호에 개시된 바 있다. 은행잎 또는 은행외종피로부터 알콜 용매로 추출 후 농축, 분획분리 추출을 통하여 얻은 천연살충성분에 대하여는 공개공보 제10-2013-0026742호에 개시된 바 있다. 그러나 상기 특허문헌 어디에도 모기 유인 및 살충 기능을 동시에 하는 모기 살충제는 전혀 개시되거나 암시된 바 없다. For the insecticide for the mosquito larvae of the foamable tablet type used by direct spraying or diluted in water of 100 to 10,000 times, it is disclosed in Korean Patent Laid-Open Publication No. 10-2013-0107162, and a perfume is added to the main component permethrin of the insecticide The insect repellent for aerosol use dissolved in anhydrous ethanol is disclosed in Korean Patent Registration No. 10-0485412. The insect repellent for aerosol use is disclosed in Korean Patent No. 10-0485412. The insect repellent for aerosol is prepared by microencapsulation of a DEET material alone or a mosquito repellent agent Have been disclosed in Patent Registration No. 10-0955620. The natural insecticidal component obtained by extracting from a ginkgo leaf or bank exonucus with an alcohol solvent, followed by concentration and fractional extraction, is disclosed in Japanese Laid-Open Publication No. 10-2013-0026742. However, no mosquito insecticides have been disclosed or implied at all in the above-mentioned patent documents simultaneously causing mosquito invasive and insecticidal functions.
따라서 본 발명의 목적은 발포형 모기 퇴치제의 제조방법을 제공하는 데 있다.Accordingly, an object of the present invention is to provide a process for producing a foamable mosquito repellent agent.
본 발명의 다른 목적은 상기 방법에 의해 제조된 발포형 모기 퇴치제를 제공하는 데 있다.Another object of the present invention is to provide a foamable mosquito repellent prepared by the above method.
본 발명의 상기 목적은 땀의 성분으로 구성된 모기 유인성분 및 천연 모기 살충성분을 혼합하여 본 발명 모기 퇴치제를 제조하는 단계와; 상기 단계에서 얻은 모기 퇴치제의 살충력 및 모기 유인효과를 실험 및 평가하는 단계와; 본 발명 모기 퇴치제를 발포형 타블렛으로 제조하는 단계를 통하여 달성하였다.
The above object of the present invention is achieved by a method for producing a mosquito repellent composition, comprising the steps of: preparing a mosquito repellent agent of the present invention by mixing a mosquito-attracting component comprising sweat components and a natural mosquito insecticide component; Testing and evaluating the insecticidal and mosquito inducing effects of the mosquito repellent prepared in the above step; The present invention was accomplished through the step of producing a mosquito repellent agent as a foamable tablet.
감국(甘菊:Chrysanthemum indicum)은 쌍떡잎식물 초롱꽃목 국화과의 여러해살이풀로서 황국(黃菊)이라고도 한다. 주로 산에서 자라고 풀 전체에 짧은 털이 나 있고 줄기의 높이는 60∼90cm이며 검은색으로 가늘고 길다. 10월에 꽃을 말려서 술에 넣어 마시고 어린 잎은 나물로 쓴다. 제충국(除蟲菊)이라는 국화에서 추출한 피레스 성분이 천연살충제로 사용되는데 산국, 황국, 금국, 소극, 구절초, 쑥부쟁이, 벌개미취 등에도 소량의 피레스 성분이 들어있다.Chrysanthemum indicum is a perennial plant of the perennial herbaceous Chrysanthemum chrysanthemum, also known as 黄菊. It grows mainly in the mountains and has short hairs on the whole grass. The height of the stem is 60 ~ 90cm, it is black and thin and long. In October, the flowers are dried and drunk, and young leaves are used as herbs. Pyrrhenic acid extracted from chrysanthemum, called Chrysanthemum japonica, is used as a natural insecticide. It contains a small amount of pyrethane in the country, kingdom, kingdom,
울금은 생강과의 다년생 식물로 우리나라에서는 진도 등 남쪽지방에서 많이 생산되고, 황색의 결정성분인 디케톤 화합물 쿠르쿠민(curcumin)과 그 유도체 p-히드록시신나모일페루로일메탄(p-hydroxycinnamoylferuloylmethane) 및 p,p'-디히드록시디신나모일메탄(p,p'-dihydroxydicinnamoylmethane)으로 된 황색색소를 0.3중량% 함유하는데 상기 성분들은 모기 등의 곤충 기피제 효능이 있는 것으로 확인되었다.Uleum is a perennial plant with ginger. It is produced mainly in the southern provinces such as Jindo in Korea. It is produced by using the diketone compound curcumin and its derivative p-hydroxycinnamoylferuloylmethane, p, p'-dihydroxydicinnamoylmethane, and 0.3% by weight of a yellow pigment of p, p'-dihydroxydicinnamoylmethane. These components were confirmed to have an insect repellent effect such as a mosquito.
제피나무(Zanthoxylum piperitum)는 쌍떡잎식물 운향과의 낙엽관목으로서 초피나무라고도 하며 산 중턱 및 산골짜기에서 높이 3∼5m로 자란다. 제피나무의 매운 성분과 향기는 사람한테는 거의 독성이 없지만 모기, 파리 같은 곤충이나 물고기, 돼지, 오리 같은 동물에게는 매우 독성이 있다. Zanthoxylum piperitum is a deciduous shrub of the dicotyledonous plant, and is known as a primavera. It grows up to 3 ~ 5m in the middle of the mountain and valley. Spicy ingredients and fragrance of the berry tree are almost non-toxic to humans, but are extremely toxic to insects such as mosquitoes and flies and to animals such as fish, pigs and ducks.
세신은 족두리풀의 뿌리를 건조시킨 약재로서 뿌리가 지극히 가늘고 몹시 매운 맛을 띠고 있다. 족두리풀은 쥐방울과에 속하는 다년생 초본식물로서 근경에 마디가 많으며 원줄기 끝에서 2개의 잎이 나와 마주 퍼진다. 감기로 열이 심하고 특히 두통이 심하여 견딜 수 없을 때에 긴요하며 진해작용도 한다. 민간에서는 이가 아픈 곳에 물고 있으면 곧 진통이 된다고 하여 진통제로 이용한다.Seisin is a medicinal herb that dried the roots of bamboo shoots. Its roots are very thin and very spicy. It is a perennial herbaceous plant belonging to the rat and bellflower. There are many nodes in rhyme and two leaves come out from the end of the main stem. It is severe when it is cold with fever, especially when headache is severe and can not withstand. In the private sector, it is used as an analgesic because it becomes pain when it is bitten in a sick place.
신이화(辛夷花)는 산목련꽃으로 신(莘)이라는 이름은 약간 매운 맛이 난다하여 붙여진 이름이다. 신이화의 맛은 맵고 성질은 따뜻하며 꽃, 열매, 잎, 뿌리, 껍질 모두 약으로 사용한다. 신이화의 효능은 풍사를 통하게 하여 막힌 것을 뚫어주는 역할을 하고 머리를 맑게 하여 얼굴에 난 기미나 주근깨를 치료한다.Shin Yi Hwa is a mountain magnolia flower, and the name "Shin" is a name given to it that it tastes a little spicy. The flavor of Shinhwa is spicy, its quality is warm, and flowers, fruits, leaves, roots and bark are all used as medicine. The efficacy of Shinhwa is through the enchantment and serves to pierce the blinds, cleanses the head and treats stains and freckles on the face.
본 발명은 물에 용해하여 간편하게 사용하는 신규한 모기 퇴치제를 제공하는 효과가 있으며 이동이 용이하고 액체 상태 제품의 불편성을 배재한 안정적으로 친환경적인 모기 퇴치제를 제공할 수 있는 뛰어난 효과가 있다.The present invention has an effect of providing a novel mosquito repellent agent which is easily dissolved by dissolving in water, and has an excellent effect of providing a stable and eco-friendly mosquito repellent agent which is easy to move and discomfort of a liquid state product is excluded.
도 1은 본 발명 발포형 모기 퇴치제의 제조과정을 나타낸 도면이다.BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a view showing a manufacturing process of a foamed mosquito repellent of the present invention. FIG.
본 발명은 감국, 울금, 제피나무, 세신 및 신이화 각각을 미세분쇄한 후 체질하는 단계와; 상기 단계의 체질한 감국, 울금, 제피나무, 세신 및 신이화 미세분말을 혼합한 혼합분말을 50℃에서 2시간 건조한 후 포도당, 2-페닐에탄올, 락트산, 옥타날, 미리스트산, 2-노네날, 트리메틸아민 및 이산화탄소의 혼합물과 혼합하는 단계; 및 상기 단계의 혼합분말에 부형제 및 활택제를 첨가한 후 타정기에 넣고 성형하는 단계를 포함하는 발포형 모기 퇴치제의 제조방법을 제공한다.The present invention relates to a method for producing a microorganism, The mixed powder obtained by mixing the spermatogonium, spermatogonium, cedarwood, sicin and syngeneic fine powder sieved in the above step was dried at 50 ° C for 2 hours, and then the mixture was treated with glucose, 2-phenylethanol, lactic acid, octanal, , A mixture of trimethylamine and carbon dioxide; And a step of adding an excipient and a lubricant to the mixed powder of the above step and then molding the resultant into a tablet machine and molding the mixture.
본 발명의 부형제는 약제에 적당한 굳기나 형상을 주기 위해서, 또는 주제의 양이 적은 경우에 일정 용량, 중량을 주어 취급하기 쉬운 크기로 할 목적으로 첨가되는 것으로 과립 및 타블렛의 형성과 유지를 위한 부형제로는 유당, 히드록시프로필셀룰로오스 및 탈크 등이 주로 이용된다. 물에 용해되면서 기포가 생기게 할 부형제로는 탄산수소나트륨 및 구연산이 이용된다.The excipient of the present invention is added for the purpose of imparting a suitable hardness or shape to the medicine or to make it easy to handle with a certain volume and weight when the amount of the subject is small. The excipient for forming and maintaining the granule and the tablet Lactose, hydroxypropyl cellulose and talc are mainly used. As an excipient to be dissolved in water and causing bubbles, sodium hydrogencarbonate and citric acid are used.
본 발명은 상기 제조방법에 의해 제조된 발포형 모기 퇴치제를 제공한다.
The present invention provides a foamable mosquito repellent prepared by the above production method.
이하, 본 발명의 구체적인 내용을 실시 예 및 실험 예를 들어 상세히 설명한다.
Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples.
실시 예: 본 발명 모기 퇴치제의 제조Examples: Preparation of mosquito repellent agent of the present invention
본 발명에 사용된 포도당, 2-페닐에탄올, 락트산, 옥타날, 미리스트산, 2-노네날, 트리메틸아민 및 이산화탄소는 시그마-알드리치 인터넷 홈페이지에서 구입하였다. 본 발명에 사용된 감국, 울금, 제피나무, 세신 및 신이화는 전문 매장에서 구입하였고 Circoplex impact mill(Model 50-ZPS, Alpine Aktiengesellschaft)을 이용하여 미세분쇄하였다. 상기 분쇄물을 -80℃에서 냉동보관하면서 시료로 사용하였다. The glucose, 2-phenylethanol, lactic acid, octanal, myristic acid, 2-nonenyl, trimethylamine and carbon dioxide used in the present invention were purchased from the Sigma-Aldrich website. The gingko, gingko, zinnia, zinnia, and cinnamon used in the present invention were purchased from specialty stores and finely pulverized using a Circoplex impact mill (Model 50-ZPS, Alpine Aktiengesellschaft). The pulverized material was used as a sample while being kept frozen at -80 ° C.
상기 [표 1] 조성에 따라 모기 유인성분(A)과 모기 살충성분(B)을 10:90 중량비율로 혼합하여 본 발명 모기 퇴치제 혼합분말을 제조하였다.
The mosquito attractant component (A) and the mosquito insecticide component (B) were mixed in a weight ratio of 10:90 according to the composition of Table 1 to prepare a mosquito repellent agent powder of the present invention.
실험 예 1: 본 발명 모기 퇴치제의 Experimental Example 1: Preparation of mosquito repellent of the present invention 살충력Insecticide 실험 Experiment
상기 실시 예에서 제조한 모기 퇴치제를 가지고 세계보건기구(WHO)에서 정한 다음의 규정대로 살충활성을 시험하여 다음과 같은 반수치사량(LD50)을 측정하여 하기 [표 2]에 나타내었다. The insecticidal activity of the mosquito repellent prepared in the above Example was tested according to the following criteria set by the World Health Organization (WHO), and the following lethal dose (LD 50 ) was measured and shown in Table 2 below.
모기 퇴치제 혼합분말 10g에 아세톤 100mL를 가하여 충분히 용해하여 각각 실험에 사용하였다. 빨간집 모기(Culex pipiens pallens) 성충 60마리를 세 개의 군으로 나누어 첫 번째 군은 국부적용(Tropical application: 이산화탄소 기체로 마취시킨 모기를 micro applicator를 이용하여 시료용액 0.5μL를 흉부에 살포함) 처리하고 두번째 군은 물먹임(Water feeding: 시료를 아세톤: 5% 수크로스 수용액을 1:9의 비율로 조제하여 면 patch에 적신 후 20cm×20cm×20cm의 공간에서 아세톤을 날린 후 모기를 넣어 항온 배양함) 처리하고 성충을 방사한 후 30분간 접촉시킨 다음 관찰용 망으로 옮겨 담아 24시간 후에 치사율을 조사하였다. 각 실험은 3회 반복 실시하였고 약품을 처리하지 않은 대조군 실험을 병행 비교하였다. 결과는 [표 2]와 같았다.100 g of acetone was added to 10 g of the mosquito repellent mixed powder to dissolve sufficiently and used in the experiments. Red house mosquito ( Culex pipiens pallens) dividing the adult 60 into three groups The first group is the local application (Tropical application: including a live mosquitoes were anesthetized with carbon dioxide gas to the sample solution using a 0.5μL to micro applicator chest) process and the second group being our ass (Water feeding: Prepare the sample in a ratio of 1: 9 of acetone: 5% aqueous sucrose, wet the cotton patch, and then spray the acetone in a 20 cm × 20 cm × 20 cm space and incubate with the mosquito) After being irradiated, the cells were contacted for 30 minutes, and transferred to an observation network. After 24 hours, the mortality was examined. Each experiment was repeated three times and the control experiments without drug treatment were compared in parallel. The results are shown in Table 2.
Number of experiments
실험 예 2: 본 발명 모기 퇴치제의 유인효과 확인실험Experimental Example 2: Invention test of the mosquito repellent of the present invention
50cm×50cm×50cm 크기의 투명 아크릴 상자 한쪽에는 실시 예에 의해 제조한 모기 퇴치제 혼합분말 0.5g을 500mL 정제수에 넣어 용해하였다. 상자의 다른 한쪽에는 500mL 정제수만 넣고 50마리의 빨간집 모기(Culex pipiens pallens) 성충을 방사하여 모기의 활동성향을 24시간 관찰함으로써 모기의 유인율(%)를 조사하였다. 0.5 g of the mosquito repellent mixed powder prepared in the Example was dissolved in 500 ml of purified water in one side of a transparent acrylic box of a size of 50 cm x 50 cm x 50 cm. On the other side of the box, only 500 mL of purified water was added and 50 red mosquitoes ( Culex pipiens The rate of mosquito invasion (%) was investigated by observing the activity propensity of mosquitoes for 24 hours by radiating adults.
Number of experiments
Total number of mosquitoes
실험결과, 95% 이상 모기들이 모기 퇴치제가 용해된 지역으로 유인되었다.
More than 95% of the mosquitoes were attracted to the area where the mosquito repellent was dissolved.
제조 예: 발포형 Manufacturing example: foam type 타블렛의Tablet 제조방법 Manufacturing method
실시 예에서 제조한 모기 퇴치제 혼합분말 중량대비 탄산나트륨, 구연산, 유당, 히드록시프로필셀룰로오스 및 탈크의 혼합물로 이루어진 부형제를 10중량%로 혼합한 후 20 메쉬의 크기를 갖는 과립체를 통과시켜 체질한 다음 60℃에서 2시간 건조하여 과립을 건조하였다. 상기 과립 50g에 활택제(스테아린산 마그네슘 100%) 1.5g을 첨가한 후 타정기(Tablet Press Making Machine, KTP-12, KoreaMedi)에 0.5g씩 넣고 200kg/㎠의 압력으로 성형하여 타블렛을 제조하였다.
An excipient consisting of a mixture of sodium carbonate, citric acid, lactose, hydroxypropylcellulose and talc was mixed in an amount of 10% by weight based on the weight of the mosquito repellent prepared in Example, and the mixture was sieved through a granule having a size of 20 mesh And dried at 60 ° C for 2 hours to dry the granules. After adding 1.5 g of a lubricant (100% magnesium stearate) to 50 g of the granules, 0.5 g of the tablet was put into a tablet press machine (KTP-12, KoreaMedi) and the tablet was molded at a pressure of 200 kg / cm2.
본 발명은 친환경적인 모기 퇴치제를 제공하는 뛰어난 효과가 있으므로 해충방제산업상 매우 유용한 발명인 것이다.The present invention is an extremely useful invention in the pest control industry because it has an excellent effect of providing an environmentally friendly mosquito repellent.
Claims (3)
상기 단계의 체질한 감국, 울금, 제피나무, 세신 및 신이화 미세분말을 혼합한 혼합분말을 건조한 후 포도당, 2-페닐에탄올, 락트산, 옥타날, 미리스트산, 2-노네날, 트리메틸아민 및 이산화탄소의 혼합물과 1:9(w/w)의 비율로 혼합하는 단계; 및
상기 단계의 혼합분말에 부형제 및 활택제를 첨가한 후 타정기에 넣고 성형하여 타블렛을 제조하는 것을 특징으로 하는 발포형 모기 퇴치제의 제조방법.Finely crushing and finely crushing each of the mulberry, wool, mulberry, persica, and dehisnation;
The mixed powder obtained by mixing the spermatogonium, spermatogonium, cedarwood, sicin and syngeneic fine powder sieved in the above step is dried and then mixed with glucose, 2-phenylethanol, lactic acid, octanal, myristic acid, 2-nonenal, trimethylamine and carbon dioxide At a ratio of 1: 9 (w / w); And
Wherein the tablet is prepared by adding an excipient and a lubricant to the mixed powder of the step and then molding the tablet into a tablet machine to form a tablet.
A foamable mosquito repellent prepared by the method of any one of claims 1 to 2.
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| KR20130107162A (en) * | 2012-03-21 | 2013-10-01 | 고정길 | Manufacturing method and composition in effervescent tablets of mosquito larvacide |
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| KR20120102099A (en) * | 2004-06-08 | 2012-09-17 | 아메리칸 바이오피직스 코포레이션 | System for trapping flying insects with attractant lures |
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| KR101090052B1 (en) * | 2011-04-14 | 2011-12-07 | 김미옥 | Natural mosquito repellent composition containing the turmeric-leaf and method for manufacturing the same |
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| KR20130107162A (en) * | 2012-03-21 | 2013-10-01 | 고정길 | Manufacturing method and composition in effervescent tablets of mosquito larvacide |
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