KR20130107162A - Manufacturing method and composition in effervescent tablets of mosquito larvacide - Google Patents

Manufacturing method and composition in effervescent tablets of mosquito larvacide Download PDF

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Publication number
KR20130107162A
KR20130107162A KR1020120029032A KR20120029032A KR20130107162A KR 20130107162 A KR20130107162 A KR 20130107162A KR 1020120029032 A KR1020120029032 A KR 1020120029032A KR 20120029032 A KR20120029032 A KR 20120029032A KR 20130107162 A KR20130107162 A KR 20130107162A
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Prior art keywords
powder
mosquito
compound
larvae
water
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KR1020120029032A
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Korean (ko)
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고정길
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고정길
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/14—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing aromatic radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A20/00—Water conservation; Efficient water supply; Efficient water use
    • Y02A20/40—Protecting water resources
    • Y02A20/402—River restoration

Abstract

The present invention relates to a method and composition for preparing insecticides for mosquito repellents of the effervescent tablet type. Inventive agent for making foamable tablet type as a product used to make insecticide for mosquito larvae of the foamable tablet type and directly spray or dilute with water from 100 to 10,000 times. Tablet type foaming agent according to the present invention is a stable and environmentally friendly product that excludes the convenience of use, ease of logistics movement and inconvenience of the liquid product as a product using a direct spray and a solvent to make a chemical solution simply used to be.

Description

Manufacturing method and composition in Effervescent tablets of mosquito larvacide}

Method and composition of effervescent tablet insecticide for mosquito larvae

Conventional mosquito control adopts adult-oriented control method, dilute insecticides in kerosene and smoke control using smoke screen or spray control using nebulizer. The larvae control method was introduced and 70% of mosquito control was converted to the larvae control method, and the ratio of the larvae control method is increasing from year to year.

According to the characteristics of mosquitoes, most of the lives of the larvae in the water and the end of life after the adult larvae, if the activity radius of the larvae in the water 1m 2 in the water, when the adult is winged wings fly the activity radius is self-flying It is 4 km long and has an adult spreading area of about 10,000,000 times. In this respect, it is reasonable to choose a larval control method rather than an efficiency of adult control.

The caterpillar products have been released in various formulations, mainly liquid products, which are limited in terms of logistics movement and use organic solvents and excess surfactants. They are emulsion type, EC type (Emulsion Concentration) and Suspension Concentration and Powder type formulations have been used. For example, in case of EC Type (Emulsion Concentration) insecticides, diluting the stock solution with water according to the proper dilution ratio and putting it in the spray bottle is sprayed and used as an insecticide for larvae control. It was used after an inconvenient dilution process with ecological threat in mind. The study was made to compensate for these defects and reached the point where next-generation eco-friendly larvae control was required.

The origin of the effervescent tablet of the present invention is used as a product such as the use of soft vitamins or denture cleansers such as pharmaceuticals, and existing pharmaceutical preparations do not have a great difficulty in preparing effervescent tablets because most of the main ingredients are water-soluble components. Most insecticides are insoluble in water, so only the formulations of emulsion type, EC Type (Emulsion Concentration), Suspension Concentration and Granule Type, have been developed.

Mosquito repellent insecticide of the effervescent tablet of the present invention development of safe supplementary ingredients for protecting the ecosystem of aquatic organisms due to environmental degradation due to the use of toxic solvents and excessive surfactants and insecticides are insoluble Therefore, the method of converting the physical properties to high concentration of water-soluble and mosquito larvae foam foam tablets must be completed a unique manufacturing method.

The present invention is to minimize the economic burden and inconvenience in use by improving the efficiency to provide the effect of larval control is necessary to develop an eco-friendly formulation.

One. High concentration  Method for preparing water-soluble main ingredient powder

Organophosphorus compound, benzoylphenylurea compound, benzoylurea compound, 35-55 parts by weight of natural insecticide international, 0.1-5.0 parts by weight of sodium or potassium hydroxide, metal magnesium, which are insecticides of the highly concentrated water-soluble main ingredient powder of the present invention 0.1-5.0 parts by weight, triethanolamine 0.1-5.0 parts by weight, 40-65 parts by weight of silicon dioxide, to prepare a metal complex or amine compound in methanol or ethanol, and then adsorbed to silicon dioxide powder and dried between 30 degrees and 40 degrees To prepare a highly concentrated water-soluble powder main ingredient.

In the method of the present invention, since the pesticidal component is an insoluble component, first, sodium hydroxide or potassium hydroxide, metal magnesium, triethanolamine are dissolved in alcohols, mixed with the pesticidal component to prepare a metal compound, and quickly added silicon dioxide to powder The dried alcohol component is dried to 30 ° to 40 ° to prepare a dry accommodating ingredient powder.

Conventional technology has been a technique for emulsifying or dispersing an insoluble pesticidal ingredient using a large amount of surfactant using an organic solvent or water solvent, and in this process, non-environmentally friendly raw materials such as surfactant and organic solvent were used.

Subsidiary materials during the manufacturing process of the present invention using raw materials used in the manufacture of pharmaceuticals is a raw material harmless to the human body and can be said to be an environmentally friendly manufacturing method that does not threaten the ecosystem of aquatic organisms.

2. Foamability Tablet  Manufacturing method

5-15 parts by weight of highly concentrated main ingredient powder, 2-10 parts by weight of sodium bicarbonate or sodium carbonate, 2-10 parts by weight of citric acid or adipic acid, 10-20 parts by weight of lactose, 2-5 parts by weight of talc, magnesium stearate 1-5 parts by weight of hydroxypropyl cellulose and 2-5 parts by weight of microcrystalline cellulose are mixed uniformly, and tableted in a tablet tableting machine in an appropriate size of 0.1 g to 50 g to prepare a foamable tablet.

Conventional effervescent tablets naturally disintegrate after tablet compression by moisture in the air, and in the process of neutralizing reactions of acidic and alkaline ingredients in the tablet, there are disadvantages that are less commercially viable. Expensive manufacturing costs are required in the manufacturing process for producing humidity under dry conditions.

In order to solve this difficulty, the present invention blocks acidic citric acid or adipic acid with magnesium stearate in a mixer, and coats the coating to block the effects of humidity in the air. We developed the technology to block the moisture in the air by applying the powder coating. In the case of tableting with the raw material coated with the powder coating, it was not possible to observe the change of properties even when packaged and stored at room temperature.

Insecticides for mosquito repellents of the effervescent tablet type of the present invention does not affect aquatic organisms by using subsidiary materials used in the manufacture of pharmaceuticals, and mainly applied to toilet septic tanks, puddle pools, bushes, wetlands, rivers, and reclaimed land. Or because aquatic plants such as wetlands or reeds, which are easy to inhabit the larvae of the funnel, are hard to reach the water surface by the spraying method. Even in lush places such as marshes and reeds, they reach the water surface and foam themselves.In the case of puddles, the foamed foam is distributed evenly in the upper and lower layers of water, so that the larvae are effectively extinguished with the appropriate amount, and the larvae have little effect on aquatic ecology. Made it possible. It is an eco-friendly product that guarantees ease of operation, economic feasibility and ecological stability due to proper spreading.

In the following examples will be described the present invention in detail. All percentages used below are% by weight.

One. High concentration  Method for preparing water-soluble main ingredient powder

Example  One

Benzoylurea compounds such as or

Benzoylphenylurea compounds such as or

Organophosphorus compounds such as or

Pyrethrum

Novaluron, Diflubenzuron, or Chlorfluazuron, Teflubenzuron. Flufenoxuron,

Temephos or Pyrethrum 35 ~ 55%

Sodium or potassium hydroxide 0.1-5%

Silicon dioxide 40 ~ 65%

Alcohol

Example  2

Benzoylurea compounds such as or

Benzoylphenylurea compounds such as or

Organophosphorus compounds such as or

Pyrethrum

Novaluron, Diflubenzuron, or Chlorfluazuron, Teflubenzuron. Flufenoxuron,

Temephos or Pyrethrum 35 ~ 55%

Metal Magnesium 0.1 ~ 5%

Silicon dioxide 40 ~ 65%

Alcohol

Example  3

Benzoylurea compounds such as or

Benzoylphenylurea compounds such as or

Organophosphorus compounds such as or

Pyrethrum

Novaluron, Diflubenzuron, or Chlorfluazuron, Teflubenzuron. Flufenoxuron,

Temephos or Pyrethrum 35 ~ 55%

Triethanolamine 0.1-5%

Silicon dioxide 40 ~ 65%

Alcohol

2. Foamability Tablet  Manufacturing method

Example  One

 Highly Concentrated Water Soluble Main Ingredient Powder 5-15%

 Sodium bicarbonate or sodium carbonate 2-20%

 Citric acid or adipic acid 2-20%

 Lactose 10-20%

 Hydroxypropylcellulose 2- 5%

 Talc 2-5%

 Magnesium Stearate 1-5%

Microcrystalline Cellulose Rest

3. Foamability Tablet  Type of For mosquito larvae relief  Pesticide Experimental Example

               (Insecticidal ingredient: Novaluron )

1) Photo tableting and foaming process of effervescent tablet mosquito larvae insecticide

  (1) tableting

Figure pat00001

Figure pat00002

Figure pat00003

  (2) foaming step

Figure pat00004

Figure pat00005

Figure pat00006

4. Foamability Tablet  Type of For mosquito larvae relief  Effect test of pesticide

Test agent Drug efficacy test Remarks Product Content (%) Disclosure Larva Emulsion
( EC type ) 10g / 100 ml (10%) Second generation  Terminal healthy larvae Existing Distribution Products Caterpillar control Effervescent tablet
( Effervescenttablet ) 16 mg / Tablet (5%) Second generation  Terminal healthy larvae Development product
No treatment Second generation  Terminal healthy larvae

 ---- All experiments were repeated 5 times. division Treated water Number of repeats Total number per treatment Efficacy 2 3 90

Investigation method division Survey item Count Investigation method About Mortality rate 5 times Investigation of the number of larvae until the allegory of adult red larvae larvae after 24 hours, 2 days, 3 days, 4 days and 5 days after treatment

Drug efficacy test density
(ppm) Treatment Pharmaceutical Total population
(Mari) 24 hours 48 hours 72 hours 96 hours 120 hours Remarks Number of mosquito
(Mari) Number of mosquito
(Mari) Number of mosquito
(Mari) Number of mosquito
(Mari) Number of mosquito
(Mari) Death rate (%) 0.025 emulsion 90 9 13 20 32 45 50 Effervescent tablet 90 10 12 20 31 46 51 Development 0.05 emulsion 90 13 18 28 42 54 60 Effervescent tablet 90 13 17 29 43 54 60 Development 0.1 emulsion 90 17 23 38 57 68 75 Effervescent tablet 90 17 24 38 58 70 78 Development 0.25 emulsion 90 20 28 58 76 80 88 Effervescent tablet 90 20 28 57 77 81 90 Development 0.5 emulsion 90 25 33 87 88 90 100 Effervescent tablet 90 23 33 79 87 90 100 Development No treatment 90 0 One One 2 3

Drug Control Effects on Red Mosquito Larvae

In this experiment, emulsion and effervescent tablet are insecticides of the same ingredient.

Summary of results

        In both emulsion and effervescent tablets, the growth inhibition rate was over 80% at the concentration of 0.25ppm.

       Have excellent insecticidal effects against mosquito larvae

Indicated.

conclusion

        Effervescent tablet mosquito larvae insecticide can be used to control mosquito larvae

It is judged that practicality is recognized.

Claims (4)

Organophosphorus compound, benzoylphenylurea compound, benzoylurea compound, novaluron, Diflubenzuron, Diflubenzuron, which is a natural pesticide compound Chlorfluazuron, Teflubenzuron, Flufenoxuron,
A composition for preparing a highly concentrated water-soluble main ingredient powder containing Temephos and Pyrethrum as pesticides
Sodium hydroxide or potassium hydroxide, metal magnesium and triethanolamine are dissolved in alcohols, mixed with pesticides to prepare a metal compound, and rapidly added to silicon dioxide to powder to dry the remaining alcohol components to dry at 30 ~ 40 degrees. A water-soluble powder is prepared.
Method for powder coating by magnesium stearate or calcium stearate to block the moisture in the air of acidic and alkaline materials during the manufacturing process of effervescent tablet
0.1 g to 50 g of effervescent tablet containing highly concentrated water-soluble main ingredient powder and containing sodium bicarbonate, sodium carbonate and citric acid, adipic acid, lactose, hydroxypropyl cellulose, talc, magnesium stearate and microcrystalline cellulose Composition prepared by

KR1020120029032A 2012-03-21 2012-03-21 Manufacturing method and composition in effervescent tablets of mosquito larvacide KR20130107162A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160034498A (en) * 2014-09-19 2016-03-30 하성섭 Forming mosquito repellant composition and manufacturing method thereof
KR102577638B1 (en) * 2023-03-28 2023-09-13 (주)국보싸이언스 floating type's insecticidal composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160034498A (en) * 2014-09-19 2016-03-30 하성섭 Forming mosquito repellant composition and manufacturing method thereof
KR102577638B1 (en) * 2023-03-28 2023-09-13 (주)국보싸이언스 floating type's insecticidal composition

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