KR20160029307A - Medicinal composition contaiing citrulline originated from watermelon - Google Patents

Abstract

The present invention relates to an effective composition for intaking citrulline without a side effect, wherein the citrulline is an active ingredient extracted from watermelon rind and, more specifically, to a composition for preventing or treating male erectile dysfunction symptoms, comprising a mixture of a watermelon rind extract, a cinnamon extract, and a licorice extract. To use the citrulline extracted from watermelon rind as an active ingredient of an erectile dysfunction therapeutic agent, side effects must be controlled and a weak effect must be increased. Alleviation of the side effect and enhancement of the effect which the citrulline has are confirmed, when using a cinnamon extract and a licorice extract together.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for preventing and treating erectile dysfunction, which comprises citrulline as an active ingredient,

The present invention relates to a composition for the prevention and treatment of male erectile dysfunction, wherein the active ingredient contained in the watermelon rind is used but the side effect is remarkably reduced.

Watermelon (Citrullus vulgaris) is native to Africa and is said to have been cultivated from ancient Egyptian times. The length of the stem is 4 to 6 meters, and it grows on the ground, the leaves are staggered, and are deeply divided into three to four. Light yellow flowers bloom in summer. The fruit is large and round and weighs usually 5 ~ 6kg. The inner part of the fruit is red, and it is edible, and the seed is also black and red and also used as tea material. Africa is cultivated from all over the world. Watermelon is composed of the pulp, which is an edible part, and the non-fermented wife, periwinkle. Seedlings account for about 31% of the total weight of watermelon, and most of them are not used as by-products. In addition, the watermelon peel contains about 357 mg / g of citrulline, a kind of special amino acid known as a precursor of arginine, an intermediate metabolite in the urea cycle in the human body. It is known that citrulline is known to be effective for eliminating oxidizing substances and vasodilating function in the body by preventing toxic action during the synthesis of the body components, thus being effective for hypertension, diabetes, kidney disease and constipation. Citrulline acts to remove NOx from the urea circulation system while making the ammonia non-toxic in the body metabolism. Citrulline has been reported to have the effect of improving the body's immune system deficiency and overall physical function, increasing the metabolic rate of the body, aerobic exercise, and reducing athlete's muscle fatigue.

Cinnamon promotes blood circulation, eliminates the coldness of the thoracic region, promotes appetite, promotes digestion, and is used for limb paralysis. It suppresses gastrointestinal spasticity and promotes gastrointestinal motility, thereby releasing gas and improving absorption. There is also a preservative effect that suppresses abnormal fermentation in the intestines. It has been reported that the pharmacological action is to inhibit improving bacteria, to inhibit white spore strain, to act on the surface, and to stimulate saliva and gastric secretion. Its appearance is semi-tubular or corrugated tubular, the outer surface is dark reddish brown, the inner surface is reddish brown and smooth. It is easy to break, and the folded surface is reddish brown, light to light, thin layer and slightly fibrous.

Licorice also has an unusual smell and taste. Licorice harmonizes the toxicity of all medicines and makes the medicinal effect appear, regulates the fever and morale of the book, makes good communication of all blood vessels, and strengthens the muscles and bones. Pharmacological action is effective in detoxification, hepatitis, urticaria, dermatitis, eczema. Jinhae, geomung, muscle relaxation, diuretic, anti-inflammatory action and suppress peptic ulcer. Licorice crust is reddish brown or dark brown with vertical wrinkles and occasionally shrubs, buds and scales. The outer skin of the peeled licorice is pale yellow and fibrous.

Male erectile dysfunction means that the erectile function is not enough or not maintained in sexual life. Generally, this condition is defined as erectile dysfunction if lasted more than 3 months. The causes of impotence are aging, smoking, drinking, diabetes, hypertension, and cerebrovascular disease. In addition, hormone preparations, some of hypertension medications, and psychotropic drugs can cause erectile dysfunction, and surgery and damage to the brain, spinal cord, and pelvis can cause erectile dysfunction. Chronic diseases include multiple sclerosis (chronic neuroimmune system diseases that occur in the central nervous system including brain, spinal cord, and optic nerve), other neurological diseases, depression, chronic renal failure and hepatic failure, chronic obstructive pulmonary disease, skin sclerosis ) Can cause erectile dysfunction. Without these physical causes, psychological factors such as emotional stress, depression or anxiety disorder can cause erectile dysfunction. In addition, lipid metabolism disorders such as diabetes, hypertension, obesity, hypercholesterolemia, and cardiovascular diseases caused by smoking and non-exercise habits may be risk factors for erectile dysfunction.

A typical example of the treatment of erectile dysfunction is to administer an oral medication. The medication used is one of the primary methods used to treat erectile dysfunction. Viagra, Cialis and Levitra are the representative drugs, and Zydena and M-Vix developed in Korea.

Although they exhibit slight differences in the absorption of the drug, the duration of action, etc., the mechanism of action of the drug is fundamentally the same. These drugs can only be maximally effective if proper sexual stimulation is preceded. Common side effects of Viagra and Cialis are headache, facial flushing, and blurred vision. In particular, oral medications are contraindicated in patients who are hypersensitive to drugs and those who are taking nitrate medications (angina pectoris). Uprima, which has been introduced as another oral drug, is a drug that acts on the brain that activates the inner nucleus of the hypothalamus and the nucleus of the ventricle. It has been recently discontinued due to its unsatisfactory effect and side effects.

Therefore, there is a demand for a remedy for erectile dysfunction without side effects. It is known that citrulline, which is contained in a large amount in the watermelon skin, is helpful for erectile dysfunction treatment and lower blood circulation. However, , It is necessary to consume a large amount of the extract of watermelon peel for a long time in order to have the effect of erectile dysfunction treatment. Therefore, there is a problem that serious ingestion difficulties may occur when ingesting enough to obtain the effect of erectile dysfunction treatment. Regarding citrulline, Korea Patent No. 10-727396 discloses a composition for enhancing stamina containing a mixture of octacosanol by extracting citrulline from watermelon and fatigue. In the 10-1038433, water-soluble dietary fiber and citrulline And a method of extracting using an extrusion molding apparatus.

Korean Patent No. 10-727396 Korean Patent No. 10-1038433

EO. Erhirhie and NE. (1983), " Medicinal Values on Citrullus lanatus (Watermelon): Pharmacological Review ", International Journal of Research in Pharmaceutical and Biomedical Sciences, vol. 4 (4) Oct-Dec 2013, pp1305-1312, ISSN 2229-3701

It is an object of the present invention to provide an effective composition for the ingestion of citrulline, an effective ingredient extracted from watermelon peel, without side effects.

The present invention provides a composition for preventing or treating male erectile dysfunction, comprising a mixture of citrus juice extract, cinnamon extract and licorice extract as an active ingredient.

As known, in order to use citrulline extracted from watermelon peel as an active ingredient of erectile dysfunction treatment, it was necessary to control side effects and increase the weak effect. The present invention confirms the improvement of the side effect of digestive disorder and the enhancement of the effect when cinnamon and licorice extract are added in parallel, rather than citrulline extracted from watermelon peel through clinical test.

Specifically, the composition of the present invention provides a composition for preventing and treating male erectile dysfunction, wherein the volume ratio of the watermelon skin extract, the cinnamon extract, and the licorice extract is 4: 1 to 5: 1. When the content of the watermelon extract is lower than 4: 1, it is not suitable for obtaining the erectile dysfunction. When the content of the watermelon extract is higher than 5: 1, the side effect of the watermelon extract is not improved.

The mixture of cinnamon extract and licorice extract is preferably a mixture of cinnamon extract and licorice extract in a volume ratio of 2: 1 to 5: 1, most preferably 3: 1. When the content of cinnamon extracts is less than 2: 1, there is a disadvantage in not improving indigestion symptoms among side effects of watermelon peel extract. When the content of cinnamon extract is more than 5: 1, side effects such as burning sensation and rash may occur have.

Most preferably, a composition comprising a mixture of 100 ml of citrulline-containing watermelon extract, 15 ml of cinnamon extract, and 5 ml of licorice extract is preferred.

The watermelon extract, cinnamon extract and licorice extract of the present invention can be extracted by a known natural extract method. Preferably, the watermelon extract is prepared according to the method disclosed in Korean Patent No. 10-1038433. The cinnamon and licorice extract may be obtained by conventional extraction methods such as supercritical extraction, subcritical extraction, high temperature extraction, high pressure extraction, and the like, preferably heat extraction or reflux extraction . Most preferably, it can be extracted by using hot water at high temperature and high pressure, and concentrating the water for a predetermined time at a high temperature for a certain period of time.

The present invention provides a food composition for preventing or ameliorating male erectile dysfunction or symptom comprising a mixture of watermelon skin extract, cinnamon extract and licorice extract as an active ingredient.

The present invention also provides a pharmaceutical composition for the prevention and treatment of male erectile dysfunction or symptom comprising a mixture of watermelon skin extract, cinnamon extract and licorice extract as an active ingredient.

The food composition of the present invention includes all forms of natural materials such as foods, functional foods, nutritional supplements, health foods and food additives. Food compositions of this type may be prepared in a variety of forms according to conventional methods known in the art. For example, they may be prepared in the form of tea, juice, extract pouches, and drinks, and may be ingested, granulated, encapsulated and powdered.

In addition, the extract blend of the present invention can be prepared in the form of a composition by mixing with known active ingredients known to be effective for preventing or improving erectile dysfunction.

In order to use the extract mixture of the present invention in the form of a food additive, it may be prepared in the form of liquid or powder. When it is used as a general food additive, the harmfulness is not determined by the capacity of the mixture of the extract of the present invention, but it is usually 1 to 13% by weight, preferably 5 to 10% by weight %. ≪ / RTI > The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health or therapeutic treatment). However, in the case of long-term consumption intended for health and hygiene purposes or for health control purposes, the amount may be less than the above range, and since there is no problem in terms of stability, the active ingredient may be used in an amount exceeding the above range. And more preferably 20% by weight or more of the total weight in the case of a health functional food for therapeutic use.

There is no particular limitation on the kind of the general food. Examples of foods to which the extract can be added include chocolate, candy, snacks, confectionery, ramen, other noodles, gums, dairy products including ice creams, various edible sauces such as ketchup, mustard sauce, mayonnaise, Drinks, tea, drinks, vitamins, and the like, and includes all health foods in a conventional sense.

In addition to the above, the composition according to the present invention may further comprise various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid concentrating agents, pH adjusting agents, stabilizers, Alcohols, carbonating agents used in carbonated drinks, and the like. In addition, the composition according to the invention may contain flesh for the production of natural fruit juices and vegetable drinks. These ingredients can be used independently or in combination. The proportion of the additive is not critical and can be increased or decreased according to the texture. However, if the object of treatment and prevention of male erectile dysfunction according to the present invention is high, Is preferably 80% by weight or less per 100 parts by weight of the polymer.

The pharmaceutical composition for preventing or treating male erectile dysfunction, which comprises the extract mixture according to the present invention as an active ingredient, may be formulated into various oral forms as described below, but is not limited thereto.

Formulations for oral administration include, for example, tablets, pills, light / soft capsules. Liquid. Suspensions, emulsifiers, syrups. Granules, and elixirs. These formulations may contain one or more diluents or excipients such as fillers, extenders, wetting agents, disintegrants, lubricants, binders, surfactants and the like which are commonly used in addition to the above-mentioned effective ingredients. As the disintegrant, agar, starch, alginic acid or its sodium salt, anhydrous calcium monohydrogenphosphate, etc. may be used. As the lubricant, silica, talc, stearic acid or its magnesium salt or calcium salt, polyethylene glycol and the like may be used , Magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidine, and low-substituted hydroxypropylcellulose can be used as the binding agent. In addition, lactose, dextrose, sucrose, mannitol, sorbitol, cellulose. Glycine, etc. may be used as a diluent. In some cases, a generally known boiling mixture, an absorbent, a colorant, a flavoring agent, a sweetening agent, etc. may be used together.

According to the present invention, there can be provided an agent for the prevention and treatment of erectile dysfunction, wherein the ingestion of a natural drug has few side effects. The present invention enables the medicinal utilization of food materials to be discarded by providing a composition with significantly improved digestive disorders, which is a side effect that may occur upon long-term ingestion of watermelon peel extracts known to be effective for erectile dysfunction.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic diagram of the functional grouping between the watermelon skin and the cinnamon and licorice of the present invention.

The present invention will be described in detail with reference to examples. However, the following examples are illustrative of the present invention, and the present invention is not limited by the following examples.

Example 1 < Preparation of Watermelon Peel Extract >

Korean Patent Registration No. 1038433 discloses a method for extracting watermelon peel as a mixture of citrulline and dietary fiber by an extraction method using a twin screw extruder.

In particular, the roots of the watermelon and the blooming green, which are the raw materials of the present invention, must be completely removed, which may cause chronic indigestion in the case of a green surface. After removing the crust, the light green fleshy part was finely crushed at a low temperature as much as possible.

Example 2: < Preparation of cinnamon extract >

The dried cinnamon was extracted with 200 ml of water in 9 g of dried cinnamon, and the mixture was boiled with hot water at high temperature and high pressure while maintaining the temperature at 70 ° C or higher, Prepare the cinnamon extracts after they have melted until they are reduced to 2.

Example 3: <Preparation of licorice extract>

Dried liquorice is prepared by the usual herbal medicine bathing method. To 3 g of dried cinnamon, 200 ml of water is added, and the mixture is boiled with high temperature and high pressure hot water at a temperature of 70 ° C or higher, Prepare the licorice extracts after they are boiled until they are reduced to 2.

Example 4: < Preparation of composition of the present invention >

15 ml of the cinnamon extract according to Example 2 and 5 ml of the licorice extract according to Example 3 per 100 ml of the watermelon peel extract according to Example 1 were prepared in an ampoule form in a dose of 14 times for 40 persons and refrigerated.

Preparation Example 1 < Preparation of composition of extract of watermelon peel and cinnamon extract >

The reagent mixed with 15 ml of the cinnamon extract according to Example 2 per 100 ml of the Watermelon peel extract according to Example 1 was prepared in the form of an ampoule with 14 doses per 40 persons and refrigerated.

Preparation Example 2: Preparation of a composition of <Watermelon skin extract and licorice extract>

The reagent mixed with 5 ml of the licorice extract according to Example 3 per 100 ml of the Watermelon peel extract according to Example 1 is prepared in an ampoule form in 14 doses per 40 persons and is stored in a refrigerator.

Experimental Example

40 healthy adult males were divided into 4 groups as described below and divided into 9 o'clock and 7 o'clock pm for 2 weeks for 2 weeks.

Control (A): Take 100 ml of watermelon peel extract twice a day.

Addition group (B): The composition according to Preparation Example 1 was taken twice a day.

Addition group (C): The composition according to Preparation Example 2 was taken twice a day.

(D): The composition according to Example 4 was taken twice a day.

The clinical results according to the questionnaire after 2 weeks were as follows:

The number of people who participated in the survey Improved erections Number of people who felt side effects Contents of Side Effects A 10 5 8 Symptoms of irritable bowel syndrome include diarrhea, abdominal pain, and abdominal bloating. Symptoms were not felt after defecation. B 10 3 3 Symptoms such as mouth rash, burning sensation, heartburn. C 10 5 4 Side effects similar to control (A). D 10 8 - Side effects No symptoms.

The clinical efficacy of erectile enhancement was confirmed in almost all experimental participants without adverse effects in the administration of the composition according to Example 4.

The present invention provides a natural medicament for improving the erectile dysfunction of a male who has little side effects by using the extract of Watermelon peel, so that the watermelon used as a food waste can be utilized as a raw material for medicines and health functional foods I will open it.

Claims (4)

A composition for preventing or treating male erectile dysfunction, comprising citrus juice extract, cinnamon extract and licorice extract as an active ingredient. The preventive and therapeutic agent for male erectile dysfunction according to claim 1, which comprises a mixture of 4: 1 to 5: 1 as a volume ratio of a mixture of Citrus extract and licorice extract, / RTI &gt; The composition for preventing and treating male erectile dysfunction according to claim 2, wherein the mixture of cinnamon extract and licorice extract is a mixture of cinnamon extracts at a volume ratio of 2: 1 to 5: 1. The composition for preventing and treating male erectile dysfunction according to claim 2, wherein the composition is a mixture of 100 ml of watermelon extract containing citrulline, 15 ml of cinnamon extract, and 5 ml of licorice extract.

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