KR20160016973A - P38 - map 키나아제 억제제로서 [1, 2, 4] 트리아졸로 [4, 3 - a] 피리딘의 유도체 - Google Patents
P38 - map 키나아제 억제제로서 [1, 2, 4] 트리아졸로 [4, 3 - a] 피리딘의 유도체 Download PDFInfo
- Publication number
- KR20160016973A KR20160016973A KR1020157037285A KR20157037285A KR20160016973A KR 20160016973 A KR20160016973 A KR 20160016973A KR 1020157037285 A KR1020157037285 A KR 1020157037285A KR 20157037285 A KR20157037285 A KR 20157037285A KR 20160016973 A KR20160016973 A KR 20160016973A
- Authority
- KR
- South Korea
- Prior art keywords
- pyridin
- triazolo
- yloxy
- tetrahydro
- naphthalen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2013/061706 WO2014194956A1 (en) | 2013-06-06 | 2013-06-06 | Derivatives of [1, 2, 4] triazolo [4, 3 - a] pyridine as p38 - map kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20160016973A true KR20160016973A (ko) | 2016-02-15 |
Family
ID=48628635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020157037285A KR20160016973A (ko) | 2013-06-06 | 2013-06-06 | P38 - map 키나아제 억제제로서 [1, 2, 4] 트리아졸로 [4, 3 - a] 피리딘의 유도체 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9573949B2 (zh) |
EP (1) | EP3004087B1 (zh) |
KR (1) | KR20160016973A (zh) |
CN (1) | CN105308044A (zh) |
BR (1) | BR112015029504A2 (zh) |
CA (1) | CA2914457A1 (zh) |
HK (1) | HK1219101A1 (zh) |
RU (1) | RU2637944C2 (zh) |
WO (1) | WO2014194956A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2612259T3 (es) | 2011-12-09 | 2017-05-16 | Chiesi Farmaceutici S.P.A. | Inhibidores de cinasa |
AR107164A1 (es) * | 2015-12-23 | 2018-03-28 | Chiesi Farm Spa | INHIBIDORES DE QUINASA p38 |
EP3394059B1 (en) | 2015-12-23 | 2020-11-25 | Chiesi Farmaceutici S.p.A. | 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors |
CN109640970B (zh) * | 2016-06-23 | 2023-05-23 | 马里兰大学巴尔的摩分校 | 选择性p38α特异性MAPK抑制剂 |
US10364245B2 (en) * | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
HRP20221196T1 (hr) | 2017-10-05 | 2022-12-09 | Fulcrum Therapeutics, Inc. | Inhibitori p38 kinaze smanjuju ekspresiju dux4 i nizvodnih gena u cilju liječenja fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
CN108424372B (zh) * | 2018-05-11 | 2021-08-10 | 浙江华贝药业有限责任公司 | 2,2,2-三氟-n-[(s)-4-羰基四氢萘-1-基]-乙酰胺的纯化工艺 |
CN115650824B (zh) * | 2022-10-31 | 2024-01-23 | 合肥工业大学 | 手性二醇及其制备方法、制得的催化剂及制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
EP1392661A1 (en) * | 2001-05-16 | 2004-03-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
CA2576297C (en) * | 2004-08-12 | 2011-01-25 | Pfizer Inc. | Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors |
EP1984363A1 (en) * | 2006-02-09 | 2008-10-29 | Pfizer Limited | Triazolopyridine compounds |
CN102395586A (zh) * | 2009-02-17 | 2012-03-28 | 奇斯药制品公司 | 作为p38map激酶抑制剂的三唑并吡啶衍生物 |
GB201009731D0 (en) | 2010-06-10 | 2010-07-21 | Pulmagen Therapeutics Inflamma | Kinase inhibitors |
ES2612259T3 (es) | 2011-12-09 | 2017-05-16 | Chiesi Farmaceutici S.P.A. | Inhibidores de cinasa |
US9181242B2 (en) * | 2013-06-06 | 2015-11-10 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
-
2013
- 2013-06-06 US US14/895,718 patent/US9573949B2/en active Active
- 2013-06-06 RU RU2015151823A patent/RU2637944C2/ru not_active IP Right Cessation
- 2013-06-06 CN CN201380077185.XA patent/CN105308044A/zh active Pending
- 2013-06-06 KR KR1020157037285A patent/KR20160016973A/ko not_active Application Discontinuation
- 2013-06-06 WO PCT/EP2013/061706 patent/WO2014194956A1/en active Application Filing
- 2013-06-06 BR BR112015029504A patent/BR112015029504A2/pt not_active IP Right Cessation
- 2013-06-06 CA CA2914457A patent/CA2914457A1/en not_active Abandoned
- 2013-06-06 EP EP13729294.2A patent/EP3004087B1/en active Active
-
2016
- 2016-06-21 HK HK16107169.2A patent/HK1219101A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3004087A1 (en) | 2016-04-13 |
HK1219101A1 (zh) | 2017-03-24 |
RU2637944C2 (ru) | 2017-12-08 |
CN105308044A (zh) | 2016-02-03 |
US20160108040A1 (en) | 2016-04-21 |
EP3004087B1 (en) | 2017-08-09 |
RU2015151823A (ru) | 2017-06-13 |
CA2914457A1 (en) | 2014-12-11 |
WO2014194956A1 (en) | 2014-12-11 |
BR112015029504A2 (pt) | 2017-07-25 |
US9573949B2 (en) | 2017-02-21 |
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