KR20150136137A - 소수성 탁산 유도체의 조성물 및 그의 용도 - Google Patents

소수성 탁산 유도체의 조성물 및 그의 용도 Download PDF

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Publication number
KR20150136137A
KR20150136137A KR1020157031393A KR20157031393A KR20150136137A KR 20150136137 A KR20150136137 A KR 20150136137A KR 1020157031393 A KR1020157031393 A KR 1020157031393A KR 20157031393 A KR20157031393 A KR 20157031393A KR 20150136137 A KR20150136137 A KR 20150136137A
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KR
South Korea
Prior art keywords
composition
hydrophobic
hydrophobic taxane
nanoparticles
taxane derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020157031393A
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English (en)
Korean (ko)
Inventor
네일 피. 데사이
춘린 타오
타파스 데
쉐리 시아오페이 씨
부옹 트류
Original Assignee
아브락시스 바이오사이언스, 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 아브락시스 바이오사이언스, 엘엘씨 filed Critical 아브락시스 바이오사이언스, 엘엘씨
Publication of KR20150136137A publication Critical patent/KR20150136137A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A61K47/48284
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020157031393A 2008-04-10 2008-09-12 소수성 탁산 유도체의 조성물 및 그의 용도 Ceased KR20150136137A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4400608P 2008-04-10 2008-04-10
US61/044,006 2008-04-10
PCT/US2008/076179 WO2009126175A1 (en) 2008-04-10 2008-09-12 Compositions of hydrophobic taxane derivatives and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107025259A Division KR20100133475A (ko) 2008-04-10 2008-09-12 소수성 탁산 유도체의 조성물 그의 용도

Publications (1)

Publication Number Publication Date
KR20150136137A true KR20150136137A (ko) 2015-12-04

Family

ID=40456809

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020157031393A Ceased KR20150136137A (ko) 2008-04-10 2008-09-12 소수성 탁산 유도체의 조성물 및 그의 용도
KR1020107025259A Ceased KR20100133475A (ko) 2008-04-10 2008-09-12 소수성 탁산 유도체의 조성물 그의 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020107025259A Ceased KR20100133475A (ko) 2008-04-10 2008-09-12 소수성 탁산 유도체의 조성물 그의 용도

Country Status (5)

Country Link
JP (1) JP2011517683A (enrdf_load_stackoverflow)
KR (2) KR20150136137A (enrdf_load_stackoverflow)
RU (1) RU2010145529A (enrdf_load_stackoverflow)
TW (1) TW200942233A (enrdf_load_stackoverflow)
WO (1) WO2009126175A1 (enrdf_load_stackoverflow)

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US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
NO345390B1 (no) 2005-08-31 2021-01-11 Abraxis Bioscience Llc Preparater omfattende dårlig vannløselige farmasøytiske midler og antimikrobielle midler
US20100297243A1 (en) 2009-04-15 2010-11-25 Desai Neil P Prion free nanoparticle compositions and methods of making thereof
US9211283B2 (en) * 2009-12-11 2015-12-15 Biolitec Pharma Marketing Ltd Nanoparticle carrier systems based on human serum albumin for photodynamic therapy
LT2552438T (lt) 2010-03-26 2016-09-26 Abraxis Bioscience, Llc Hepatoceliulinės karcinomos gydymo būdai
JP6242213B2 (ja) 2010-03-29 2017-12-06 アブラクシス バイオサイエンス, エルエルシー 薬物送達および治療用薬剤の有効性を向上させる方法
RU2589513C2 (ru) 2010-03-29 2016-07-10 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Способы лечения онкологических заболеваний
AU2011261685B2 (en) 2010-06-04 2016-02-11 Abraxis Bioscience, Llc Methods of treatment of pancreatic cancer
EP3056201A1 (en) 2010-06-07 2016-08-17 Abraxis BioScience, LLC Combination therapy methods for treating proliferative diseases
EP2447268A1 (en) * 2010-10-29 2012-05-02 INDENA S.p.A. Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III
AU2012318239B2 (en) 2011-11-01 2015-07-09 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs
WO2013085902A1 (en) 2011-12-05 2013-06-13 The University Of Texas M.D. Combination therapy methods for treating an inflammatory breast cancer
HUE045661T2 (hu) 2011-12-14 2020-01-28 Abraxis Bioscience Llc Polimer segédanyagok alkalmazása részecskék liofilizálásához vagy fagyasztásához
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
MX370662B (es) 2013-03-12 2019-12-19 Abraxis Bioscience Llc Composiciones que comprenden nanopartículas de paclitaxel y albúmina para usarse en el tratamiento de cáncer.
MX378934B (es) 2013-03-14 2025-03-11 Abraxis Bioscience Llc Composición de nanopartículas para usarse en el tratamiento de cáncer de vejiga
US20150359810A1 (en) 2014-06-17 2015-12-17 Celgene Corporation Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
US10973806B2 (en) 2015-06-29 2021-04-13 Abraxis Bioscience, Llc Methods of treating epithelioid cell tumors comprising administering a composition comprising nanoparticles comprising an mTOR inhibitor and an albumin
BR112018005200A2 (pt) * 2015-09-16 2018-10-09 Dfb Soria Llc liberação de nanopartículas de fármaco e métodos de uso dos mesmos
MX2020004836A (es) 2017-11-06 2020-10-16 Rapt Therapeutics Inc Agentes anticancerígenos.
WO2019183146A1 (en) 2018-03-20 2019-09-26 Abraxis Bioscience, Llc Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin
JP2022553426A (ja) 2019-10-28 2022-12-22 アブラクシス バイオサイエンス, エルエルシー アルブミンおよびラパマイシンの医薬組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6749868B1 (en) * 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
NZ262679A (en) * 1993-02-22 1997-08-22 Vivorx Pharmaceuticals Inc Compositions for in vivo delivery of pharmaceutical agents where the agents are contained in a polymeric shell
CN1100770C (zh) * 1995-09-12 2003-02-05 利普索姆公司 促进水解的紫杉烷疏水性衍生物
JP4865937B2 (ja) * 1997-06-27 2012-02-01 アブラクシス バイオサイエンス、エルエルシー パクリタキセル製剤
MXPA01009924A (es) * 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos de acetato heteosustituido en c10 como agentes antitumorales.
AU2006214100B2 (en) * 2005-02-18 2012-05-31 Abraxis Bioscience, Llc Drugs with improved hydrophobicity for incorporation in medical devices
JP2008531591A (ja) * 2005-02-24 2008-08-14 エラン・ファルマ・インターナショナル・リミテッド ドセタキセルおよびそれらの類似体のナノ粒子製剤

Also Published As

Publication number Publication date
WO2009126175A1 (en) 2009-10-15
RU2010145529A (ru) 2012-05-20
JP2011517683A (ja) 2011-06-16
KR20100133475A (ko) 2010-12-21
TW200942233A (en) 2009-10-16

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