KR20150119089A - 알츠하이머병 치료 방법에 사용하기 위한 헬리카제-프리마제 억제제 - Google Patents
알츠하이머병 치료 방법에 사용하기 위한 헬리카제-프리마제 억제제 Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Medicinal Preparation (AREA)
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| PCT/EP2014/052743 WO2014124978A2 (en) | 2013-02-12 | 2014-02-12 | Helicase-primase inhibitors for use in a method of treating alzheimer's disease |
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| KR20150119089A true KR20150119089A (ko) | 2015-10-23 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11918599B2 (en) | 2020-11-19 | 2024-03-05 | Daegu Gyeongbuk Institute Of Science And Technology | Composition for preventing or treating neuroinflammatory disease comprising didanosine |
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| EP2573085A1 (en) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
| ES2877854T3 (es) * | 2016-11-28 | 2021-11-17 | Aicuris Gmbh & Co Kg | Una sal de maleato de la base libre de N-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)-fenil]-acetamida, formulaciones farmacéuticas, procedimientos de fabricación y usos de las mismas para el tratamiento de los virus del herpes |
| US11439608B2 (en) | 2017-09-25 | 2022-09-13 | Qun Lu | Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease |
| TW202038947A (zh) * | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| EP4580601A1 (en) * | 2022-08-29 | 2025-07-09 | Assembly Biosciences, Inc. | Pharmaceutical compositions for herpes virus |
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| DOP2000000109A (es) * | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| DE102005014248A1 (de) * | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
| US8299059B2 (en) * | 2009-10-30 | 2012-10-30 | Eli Lilly And Company | Crystalline compound and a process for its preparation |
| EP2573085A1 (en) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11918599B2 (en) | 2020-11-19 | 2024-03-05 | Daegu Gyeongbuk Institute Of Science And Technology | Composition for preventing or treating neuroinflammatory disease comprising didanosine |
Also Published As
| Publication number | Publication date |
|---|---|
| PH12015501762A1 (en) | 2015-11-09 |
| ZA201505243B (en) | 2017-11-29 |
| WO2014124978A3 (en) | 2014-10-30 |
| AU2014217962A1 (en) | 2015-09-17 |
| BR112015019220A2 (pt) | 2017-07-18 |
| CL2015002241A1 (es) | 2016-02-19 |
| WO2014124978A4 (en) | 2014-12-24 |
| CA2898798A1 (en) | 2014-08-21 |
| MX2015010339A (es) | 2015-11-16 |
| EA201500836A1 (ru) | 2016-02-29 |
| EP2956134A2 (en) | 2015-12-23 |
| JP2016507546A (ja) | 2016-03-10 |
| US20150374676A1 (en) | 2015-12-31 |
| SG11201506153TA (en) | 2015-09-29 |
| IL240459A0 (en) | 2015-09-24 |
| WO2014124978A2 (en) | 2014-08-21 |
| CN105101963A (zh) | 2015-11-25 |
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