JP2016507546A - アルツハイマー病を治療する方法において使用するためのヘリカーゼ／プライマーゼ阻害剤 - Google Patents
アルツハイマー病を治療する方法において使用するためのヘリカーゼ／プライマーゼ阻害剤 Download PDFInfo
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- 210000003625 skull Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 230000002739 subcortical effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 230000003976 synaptic dysfunction Effects 0.000 description 1
- 230000003977 synaptic function Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000003478 temporal lobe Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229940107931 zovirax Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13154982 | 2013-02-12 | ||
| EP13154982.6 | 2013-02-12 | ||
| PCT/EP2014/052743 WO2014124978A2 (en) | 2013-02-12 | 2014-02-12 | Helicase-primase inhibitors for use in a method of treating alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016507546A true JP2016507546A (ja) | 2016-03-10 |
| JP2016507546A5 JP2016507546A5 (enExample) | 2016-04-21 |
Family
ID=47709982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556537A Withdrawn JP2016507546A (ja) | 2013-02-12 | 2014-02-12 | アルツハイマー病を治療する方法において使用するためのヘリカーゼ／プライマーゼ阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20150374676A1 (enExample) |
| EP (1) | EP2956134A2 (enExample) |
| JP (1) | JP2016507546A (enExample) |
| KR (1) | KR20150119089A (enExample) |
| CN (1) | CN105101963A (enExample) |
| AU (1) | AU2014217962A1 (enExample) |
| BR (1) | BR112015019220A2 (enExample) |
| CA (1) | CA2898798A1 (enExample) |
| CL (1) | CL2015002241A1 (enExample) |
| EA (1) | EA201500836A1 (enExample) |
| IL (1) | IL240459A0 (enExample) |
| MX (1) | MX2015010339A (enExample) |
| PH (1) | PH12015501762A1 (enExample) |
| SG (1) | SG11201506153TA (enExample) |
| WO (1) | WO2014124978A2 (enExample) |
| ZA (1) | ZA201505243B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022145700A (ja) * | 2016-11-28 | 2022-10-04 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Ｎ－［５－（アミノスルホニル）－４－メチル－１，３－チアゾール－２－イル］－ｎ－メチル－２－［４－（２－ピリジニル）－フェニル］－アセトアミドの遊離塩基形のマレイン酸塩、医薬製剤、製造方法およびヘルペスウイルスの処置のためのその使用 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2573085A1 (en) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
| US11439608B2 (en) | 2017-09-25 | 2022-09-13 | Qun Lu | Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease |
| TW202038947A (zh) * | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| KR102456699B1 (ko) | 2020-11-19 | 2022-10-19 | 주식회사 오에이티씨 | 디다노신을 포함하는 신경염증성 질환 예방 또는 치료용 조성물 |
| EP4580601A1 (en) * | 2022-08-29 | 2025-07-09 | Assembly Biosciences, Inc. | Pharmaceutical compositions for herpes virus |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DOP2000000109A (es) * | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| DE102005014248A1 (de) * | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
| US8299059B2 (en) * | 2009-10-30 | 2012-10-30 | Eli Lilly And Company | Crystalline compound and a process for its preparation |
| EP2573085A1 (en) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
-
2014
- 2014-02-12 EP EP14703891.3A patent/EP2956134A2/en not_active Withdrawn
- 2014-02-12 WO PCT/EP2014/052743 patent/WO2014124978A2/en not_active Ceased
- 2014-02-12 SG SG11201506153TA patent/SG11201506153TA/en unknown
- 2014-02-12 KR KR1020157024625A patent/KR20150119089A/ko not_active Withdrawn
- 2014-02-12 AU AU2014217962A patent/AU2014217962A1/en not_active Abandoned
- 2014-02-12 CN CN201480008550.6A patent/CN105101963A/zh active Pending
- 2014-02-12 BR BR112015019220A patent/BR112015019220A2/pt not_active IP Right Cessation
- 2014-02-12 MX MX2015010339A patent/MX2015010339A/es unknown
- 2014-02-12 CA CA2898798A patent/CA2898798A1/en not_active Abandoned
- 2014-02-12 US US14/767,163 patent/US20150374676A1/en not_active Abandoned
- 2014-02-12 EA EA201500836A patent/EA201500836A1/ru unknown
- 2014-02-12 JP JP2015556537A patent/JP2016507546A/ja not_active Withdrawn
-
2015
- 2015-07-21 ZA ZA2015/05243A patent/ZA201505243B/en unknown
- 2015-08-09 IL IL240459A patent/IL240459A0/en unknown
- 2015-08-11 PH PH12015501762A patent/PH12015501762A1/en unknown
- 2015-08-11 CL CL2015002241A patent/CL2015002241A1/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022145700A (ja) * | 2016-11-28 | 2022-10-04 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Ｎ－［５－（アミノスルホニル）－４－メチル－１，３－チアゾール－２－イル］－ｎ－メチル－２－［４－（２－ピリジニル）－フェニル］－アセトアミドの遊離塩基形のマレイン酸塩、医薬製剤、製造方法およびヘルペスウイルスの処置のためのその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| PH12015501762A1 (en) | 2015-11-09 |
| ZA201505243B (en) | 2017-11-29 |
| WO2014124978A3 (en) | 2014-10-30 |
| AU2014217962A1 (en) | 2015-09-17 |
| BR112015019220A2 (pt) | 2017-07-18 |
| CL2015002241A1 (es) | 2016-02-19 |
| WO2014124978A4 (en) | 2014-12-24 |
| CA2898798A1 (en) | 2014-08-21 |
| MX2015010339A (es) | 2015-11-16 |
| EA201500836A1 (ru) | 2016-02-29 |
| EP2956134A2 (en) | 2015-12-23 |
| US20150374676A1 (en) | 2015-12-31 |
| SG11201506153TA (en) | 2015-09-29 |
| IL240459A0 (en) | 2015-09-24 |
| WO2014124978A2 (en) | 2014-08-21 |
| KR20150119089A (ko) | 2015-10-23 |
| CN105101963A (zh) | 2015-11-25 |
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