KR20150064245A - 스핑고신 포스페이트 수용체의 신규한 모듈레이터 - Google Patents

스핑고신 포스페이트 수용체의 신규한 모듈레이터 Download PDF

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Publication number
KR20150064245A
KR20150064245A KR1020157013971A KR20157013971A KR20150064245A KR 20150064245 A KR20150064245 A KR 20150064245A KR 1020157013971 A KR1020157013971 A KR 1020157013971A KR 20157013971 A KR20157013971 A KR 20157013971A KR 20150064245 A KR20150064245 A KR 20150064245A
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KR
South Korea
Prior art keywords
substituted
heteroaryl
alkyl
bond
heterocyclyl
Prior art date
Application number
KR1020157013971A
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English (en)
Korean (ko)
Inventor
에드워드 로버츠
휴 로젠
스티븐 브라운
미구엘 에이. 게레로
수에메이 펭
라물루 포두토리
Original Assignee
더 스크립스 리서치 인스티튜트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 더 스크립스 리서치 인스티튜트 filed Critical 더 스크립스 리서치 인스티튜트
Priority claimed from PCT/US2009/003014 external-priority patent/WO2009151529A1/en
Publication of KR20150064245A publication Critical patent/KR20150064245A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
KR1020157013971A 2008-05-14 2009-05-14 스핑고신 포스페이트 수용체의 신규한 모듈레이터 KR20150064245A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12760308P 2008-05-14 2008-05-14
US61/127,603 2008-05-14
PCT/US2009/003014 WO2009151529A1 (en) 2008-05-14 2009-05-14 Novel modulators of sphingosine phosphate receptors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107028062A Division KR101582910B1 (ko) 2008-05-14 2009-05-14 스핑고신 포스페이트 수용체의 신규한 모듈레이터

Publications (1)

Publication Number Publication Date
KR20150064245A true KR20150064245A (ko) 2015-06-10

Family

ID=43426295

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020107028062A KR101582910B1 (ko) 2008-05-14 2009-05-14 스핑고신 포스페이트 수용체의 신규한 모듈레이터
KR1020157013971A KR20150064245A (ko) 2008-05-14 2009-05-14 스핑고신 포스페이트 수용체의 신규한 모듈레이터

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020107028062A KR101582910B1 (ko) 2008-05-14 2009-05-14 스핑고신 포스페이트 수용체의 신규한 모듈레이터

Country Status (12)

Country Link
KR (2) KR101582910B1 (he)
CN (1) CN102118972B (he)
BR (1) BRPI0912545B1 (he)
CA (1) CA2723904C (he)
DK (1) DK2913326T3 (he)
HR (1) HRP20201316T1 (he)
HU (1) HUE050411T2 (he)
IL (1) IL209306A (he)
LT (1) LT2913326T (he)
MX (1) MX2010012461A (he)
SI (1) SI2913326T1 (he)
ZA (1) ZA201007804B (he)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE025984T2 (hu) 2008-05-14 2016-05-30 Scripps Research Inst Szfingozin foszfát receptor új modulátorai
WO2015196258A1 (en) * 2014-06-26 2015-12-30 Monash University Enzyme interacting agents
EP3470400A1 (en) 2016-06-14 2019-04-17 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal form of ozanimod, crystal form of hydrochloride thereof, and preparation method therefor
CN109563059A (zh) 2016-08-19 2019-04-02 苏州科睿思制药有限公司 奥扎莫德的晶型及其制备方法
CN109640982A (zh) 2016-09-14 2019-04-16 苏州科睿思制药有限公司 奥扎莫德盐酸盐的晶型及其制备方法
CN108137516A (zh) 2016-09-14 2018-06-08 杭州领业医药科技有限公司 奥扎莫德的晶型、其制备方法及药物组合物
CN106749213B (zh) * 2016-11-25 2019-07-02 济南大学 一种具有1,2,4-恶二唑结构的吲哚衍生物及制备方法和在制备抗菌药物中的应用
WO2019042219A1 (zh) 2017-08-31 2019-03-07 苏州科睿思制药有限公司 奥扎莫德盐酸盐的晶型及其制备方法
CN107827837B (zh) * 2017-11-21 2021-09-24 苏州朗科生物技术股份有限公司 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4516430B2 (ja) * 2002-12-20 2010-08-04 メルク・シャープ・エンド・ドーム・コーポレイション １−（アミノ）インダン並びに（１，２−ジヒドロ−３−アミノ）−ベンゾフラン、ベンゾチオフェン及びインドール
CA2648303C (en) * 2006-04-03 2014-07-15 Astellas Pharma Inc. 5-[monocyclic(hetero)arylsubstituted-1,2,4-oxadliazol-3-yl]-(fused heteroaryl substituted) compounds and their use as s1p1 agonists

Also Published As

Publication number Publication date
BRPI0912545B1 (pt) 2022-02-01
LT2913326T (lt) 2020-09-10
CN102118972B (zh) 2015-06-10
IL209306A0 (en) 2011-01-31
BRPI0912545A2 (pt) 2021-04-13
CA2723904C (en) 2017-03-14
KR20110010777A (ko) 2011-02-07
ZA201007804B (en) 2012-01-25
MX2010012461A (es) 2013-07-02
SI2913326T1 (sl) 2020-11-30
IL209306A (he) 2017-02-28
CN102118972A (zh) 2011-07-06
HRP20201316T1 (hr) 2020-11-27
CA2723904A1 (en) 2009-12-17
DK2913326T3 (da) 2020-08-17
HUE050411T2 (hu) 2020-12-28
KR101582910B1 (ko) 2016-01-08

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