KR20150028299A - 야누스 키나제 (ｊａｋ) 억제제 투여요법 - Google Patents
야누스 키나제 (ｊａｋ) 억제제 투여요법 Download PDFInfo
- Publication number
- KR20150028299A KR20150028299A KR1020157001085A KR20157001085A KR20150028299A KR 20150028299 A KR20150028299 A KR 20150028299A KR 1020157001085 A KR1020157001085 A KR 1020157001085A KR 20157001085 A KR20157001085 A KR 20157001085A KR 20150028299 A KR20150028299 A KR 20150028299A
- Authority
- KR
- South Korea
- Prior art keywords
- therapeutically effective
- jak
- effective dose
- days
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261674289P | 2012-07-20 | 2012-07-20 | |
| US61/674,289 | 2012-07-20 | ||
| US201361815803P | 2013-04-25 | 2013-04-25 | |
| US61/815,803 | 2013-04-25 | ||
| PCT/US2013/051015 WO2014015107A1 (en) | 2012-07-20 | 2013-07-18 | Dosing regimen for janus kinase (jak) inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177007913A Division KR20170034949A (ko) | 2012-07-20 | 2013-07-18 | 야누스 키나제 (ｊａｋ) 억제제 투여요법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150028299A true KR20150028299A (ko) | 2015-03-13 |
Family
ID=48901189
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157001085A Ceased KR20150028299A (ko) | 2012-07-20 | 2013-07-18 | 야누스 키나제 (ｊａｋ) 억제제 투여요법 |
| KR1020177007913A Ceased KR20170034949A (ko) | 2012-07-20 | 2013-07-18 | 야누스 키나제 (ｊａｋ) 억제제 투여요법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177007913A Ceased KR20170034949A (ko) | 2012-07-20 | 2013-07-18 | 야누스 키나제 (ｊａｋ) 억제제 투여요법 |
Country Status (25)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2713052T3 (es) | 2013-02-22 | 2019-05-17 | Pfizer | Combinación de derivados de pirrolo[2,3-d]pirimidina con uno o más agentes adicionales como inhibidores de janus cinasas (JAK) |
| ES2750655T3 (es) | 2014-08-12 | 2020-03-26 | Pfizer | Derivados de pirrolo[2,3-d]pirimidina útiles para inhibir la Janus cinasa |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CA3251507A1 (en) | 2015-10-16 | 2025-05-21 | Abbvie Inc. | Use of a solid dosage form comprising (3s,4r)-3-ethyl-4-(3h-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide for treating rheumatoid arthritis |
| US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| WO2017143014A1 (en) | 2016-02-16 | 2017-08-24 | Brian Kim | Jak inhibitors and uses thereof |
| CN107098908B (zh) * | 2016-02-23 | 2021-01-08 | 欣凯医药科技(上海)有限公司 | 一种吡咯并嘧啶类化合物的制备方法和应用 |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| JP7278649B6 (ja) * | 2019-01-30 | 2024-02-15 | 格格巫（珠海）生物科技有限公司 | Ｊａｋ阻害剤及びその製造方法 |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| EP4263559A1 (en) | 2020-12-18 | 2023-10-25 | Boehringer Ingelheim Animal Health USA Inc. | Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof |
| AU2022239128B2 (en) * | 2021-03-16 | 2024-09-05 | Hk Inno.N Corporation | Novel salts of heterocyclic compound as protein kinase inhibitor and uses thereof |
| WO2022222948A1 (zh) * | 2021-04-22 | 2022-10-27 | 深圳微芯生物科技股份有限公司 | 包含jak3/jak1/tbk1选择性抑制剂的药物组合物及其医药用途 |
| WO2024259429A2 (en) * | 2023-06-16 | 2024-12-19 | The University Of Chicago | Methods and compositions for pharmaceutically relevant interactions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20004727A3 (cs) * | 1998-06-19 | 2002-03-13 | Pfizer Products Inc. | Deriváty pyrrolo[2,3-d] pyrimidinu |
| EP2384326B1 (en) * | 2008-08-20 | 2014-04-23 | Zoetis LLC | Pyrrolo[2,3-d]pyrimidine compounds |
-
2013
- 2013-07-18 JP JP2015523243A patent/JP6022063B2/ja active Active
- 2013-07-18 AU AU2013292547A patent/AU2013292547B2/en active Active
- 2013-07-18 MX MX2015000871A patent/MX360857B/es active IP Right Grant
- 2013-07-18 CN CN201380038563.3A patent/CN104470525A/zh active Pending
- 2013-07-18 NZ NZ703152A patent/NZ703152A/en unknown
- 2013-07-18 EP EP13742573.2A patent/EP2874630B1/en not_active Revoked
- 2013-07-18 IN IN370DEN2015 patent/IN2015DN00370A/en unknown
- 2013-07-18 SI SI201331328T patent/SI2874630T1/sl unknown
- 2013-07-18 LT LTEP13742573.2T patent/LT2874630T/lt unknown
- 2013-07-18 WO PCT/US2013/051015 patent/WO2014015107A1/en not_active Ceased
- 2013-07-18 HR HRP20182088TT patent/HRP20182088T1/hr unknown
- 2013-07-18 DK DK13742573.2T patent/DK2874630T3/en active
- 2013-07-18 KR KR1020157001085A patent/KR20150028299A/ko not_active Ceased
- 2013-07-18 RS RS20190051A patent/RS58242B1/sr unknown
- 2013-07-18 CA CA2878867A patent/CA2878867C/en active Active
- 2013-07-18 CN CN201810369706.3A patent/CN108354938A/zh active Pending
- 2013-07-18 US US14/415,047 patent/US9522151B2/en active Active
- 2013-07-18 KR KR1020177007913A patent/KR20170034949A/ko not_active Ceased
- 2013-07-18 PL PL13742573T patent/PL2874630T3/pl unknown
- 2013-07-18 PT PT13742573T patent/PT2874630T/pt unknown
- 2013-07-18 ES ES13742573T patent/ES2707627T3/es active Active
- 2013-07-18 SM SM20190044T patent/SMT201900044T1/it unknown
- 2013-07-18 BR BR112015000808A patent/BR112015000808A2/pt not_active Application Discontinuation
- 2013-07-18 HU HUE13742573A patent/HUE042771T2/hu unknown
- 2013-07-18 HK HK15109423.1A patent/HK1209314A1/xx unknown
-
2015
- 2015-01-08 ZA ZA2015/00134A patent/ZA201500134B/en unknown
-
2016
- 2016-08-05 JP JP2016154135A patent/JP2017019816A/ja active Pending
-
2018
- 2018-08-23 HK HK18110906.2A patent/HK1252083A1/zh unknown
-
2019
- 2019-02-14 CY CY20191100203T patent/CY1121436T1/el unknown
Also Published As
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| PA0105 | International application |
Patent event date: 20150115 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PA0201 | Request for examination | ||
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Comment text: Notification of reason for refusal Patent event date: 20160519 Patent event code: PE09021S01D |
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| PE0601 | Decision on rejection of patent |
Patent event date: 20161108 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20160519 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |
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Patent event code: PX09011S01I Patent event date: 20161108 Comment text: Decision to Refuse Application Patent event code: PX09012R01I Patent event date: 20160718 Comment text: Amendment to Specification, etc. Patent event code: PX09012R01I Patent event date: 20150115 Comment text: Amendment to Specification, etc. |
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| PX0601 | Decision of rejection after re-examination |
Comment text: Decision to Refuse Application Patent event code: PX06014S01D Patent event date: 20170220 Comment text: Amendment to Specification, etc. Patent event code: PX06012R01I Patent event date: 20170206 Comment text: Decision to Refuse Application Patent event code: PX06011S01I Patent event date: 20161108 Comment text: Amendment to Specification, etc. Patent event code: PX06012R01I Patent event date: 20160718 Comment text: Notification of reason for refusal Patent event code: PX06013S01I Patent event date: 20160519 Comment text: Amendment to Specification, etc. Patent event code: PX06012R01I Patent event date: 20150115 |
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Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20170322 |
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| PJ0201 | Trial against decision of rejection |
Patent event date: 20170322 Comment text: Request for Trial against Decision on Refusal Patent event code: PJ02012R01D Patent event date: 20170220 Comment text: Decision to Refuse Application Patent event code: PJ02011S01I Patent event date: 20161108 Comment text: Decision to Refuse Application Patent event code: PJ02011S01I Appeal kind category: Appeal against decision to decline refusal Appeal identifier: 2017101001393 Request date: 20170322 |
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Free format text: TRIAL NUMBER: 2017101001393; TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20170322 Effective date: 20180612 |
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Patent event code: PJ13011S01D Patent event date: 20180612 Comment text: Trial Decision on Objection to Decision on Refusal Appeal kind category: Appeal against decision to decline refusal Request date: 20170322 Decision date: 20180612 Appeal identifier: 2017101001393 |