KR20140116054A - 다발성 경화증의 치료를 위한 ａｐｃ-매개 관용 유도 - Google Patents
다발성 경화증의 치료를 위한 ａｐｃ-매개 관용 유도 Download PDFInfo
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- KR20140116054A KR20140116054A KR1020147010794A KR20147010794A KR20140116054A KR 20140116054 A KR20140116054 A KR 20140116054A KR 1020147010794 A KR1020147010794 A KR 1020147010794A KR 20147010794 A KR20147010794 A KR 20147010794A KR 20140116054 A KR20140116054 A KR 20140116054A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US61/573,200 | 2011-11-14 | ||
| PCT/EP2012/068954 WO2013045488A1 (en) | 2011-09-26 | 2012-09-26 | Apc-mediated tolerance induction for therapy of multiple sclerosis |
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| WO (1) | WO2013045488A1 (enExample) |
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| EP3013362B1 (en) | 2013-06-28 | 2021-08-04 | Baylor Research Institute | Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis |
| DK3133923T3 (da) * | 2014-04-24 | 2020-08-10 | Univ Florida | Aav-based gene therapy for multiple sclerosis |
| US12485186B2 (en) | 2017-03-31 | 2025-12-02 | The Children's Medical Center Corporation | Antibody-mediated conditioning with immunosuppression to enable allogeneic transplantation |
| AU2020289326A1 (en) * | 2019-06-04 | 2022-01-27 | Thomas Jefferson University | Oligodendrocyte-derived extracellular vesicles for therapy of multiple sclerosis |
| CN111089972B (zh) * | 2019-12-18 | 2021-05-14 | 天津天海新域生物科技有限公司 | 一种用于检测抗人体髓鞘碱性蛋白抗体的试剂盒及其应用 |
| EP4135777A4 (en) | 2020-04-14 | 2025-03-12 | University Of Florida Research Foundation, Incorporated | AAV-BASED GENE THERAPIES FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
| WO2023240274A1 (en) * | 2022-06-10 | 2023-12-14 | The Medical College Of Wisconsin, Inc. | Immune tolerance induction for auto-immune diseases through platelet targeted gene therapy involving myelin oligodendrocyte glycoprotein (mog) polypeptide. |
| CN116200414B (zh) * | 2022-08-31 | 2024-10-18 | 天津华科泰生物技术有限公司 | 一种重组人髓鞘少突胶质细胞糖蛋白及其制备方法和应用 |
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| US7090982B2 (en) * | 1991-10-22 | 2006-08-15 | The Governors Of The University Of Alberta | Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patient |
| HUP0303930A3 (en) * | 2001-01-26 | 2012-09-28 | Univ Emory | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
| IL141813A (en) * | 2001-03-05 | 2010-04-15 | Hadasit Med Res Service | Mixture comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the preparation of compositions for the treatment of hematopoietic dusirders |
| US20030049797A1 (en) * | 2001-04-16 | 2003-03-13 | Yoshikazu Yuki | Hybrid proteins for autoimmune disease |
| EP1753455A2 (en) * | 2004-06-04 | 2007-02-21 | Genentech, Inc. | Method for treating multiple sclerosis |
| EP2368973A1 (en) * | 2005-10-13 | 2011-09-28 | Anthrogenesis Corporation | Production Of Oligodendrocytes From Placenta-Derived Stem Cells |
| JP5010220B2 (ja) * | 2006-09-11 | 2012-08-29 | 三菱化学メディエンス株式会社 | 造血幹細胞移植療法の施行患者の病態把握方法 |
| US8188218B2 (en) * | 2006-10-27 | 2012-05-29 | University Of Kansas | Bi-functional peptides for multiple sclerosis treatment and diagnosis |
| US8673286B2 (en) | 2007-04-09 | 2014-03-18 | Northwestern University | DOPA-functionalized, branched, poly(aklylene oxide) adhesives |
| DE102007039429A1 (de) * | 2007-08-21 | 2009-02-26 | Imtm Gmbh | Verfahren zur Aktivierung regulatorischer T-Zellen |
| KR101103423B1 (ko) | 2009-09-04 | 2012-01-06 | 아주대학교산학협력단 | 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도 |
| US20130053594A1 (en) | 2009-12-17 | 2013-02-28 | The University Of Chicago | Methods of making self-healing polymer and gel compositions |
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| US9592259B2 (en) | 2017-03-14 |
| JP2015502135A (ja) | 2015-01-22 |
| US20140242037A1 (en) | 2014-08-28 |
| CN104010664A (zh) | 2014-08-27 |
| WO2013045488A1 (en) | 2013-04-04 |
| EP2760478A1 (en) | 2014-08-06 |
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