KR20140109430A - Casp2에 대한 이중-가닥 rna 화합물 및 그 용도 - Google Patents

Casp2에 대한 이중-가닥 rna 화합물 및 그 용도 Download PDF

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KR20140109430A
KR20140109430A KR1020147019172A KR20147019172A KR20140109430A KR 20140109430 A KR20140109430 A KR 20140109430A KR 1020147019172 A KR1020147019172 A KR 1020147019172A KR 20147019172 A KR20147019172 A KR 20147019172A KR 20140109430 A KR20140109430 A KR 20140109430A
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eye
compound
glaucoma
administered
ocular
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샤이 에를리치
제임스 디. 톰슨
라비아 오즈덴
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쿠아크 파마수티칼스 인코퍼레이티드
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
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    • A61P27/06—Antiglaucoma agents or miotics
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KR1020147019172A 2012-01-04 2013-01-03 Casp2에 대한 이중-가닥 rna 화합물 및 그 용도 Ceased KR20140109430A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261582886P 2012-01-04 2012-01-04
US61/582,886 2012-01-04
US201261596231P 2012-02-08 2012-02-08
US61/596,231 2012-02-08
PCT/US2013/020012 WO2013103632A1 (en) 2012-01-04 2013-01-03 Double-stranded rna compounds to casp2 and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197035560A Division KR102202004B1 (ko) 2012-01-04 2013-01-03 Casp2에 대한 이중-가닥 rna 화합물 및 그 용도

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KR20140109430A true KR20140109430A (ko) 2014-09-15

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KR1020147019172A Ceased KR20140109430A (ko) 2012-01-04 2013-01-03 Casp2에 대한 이중-가닥 rna 화합물 및 그 용도
KR1020197035560A Active KR102202004B1 (ko) 2012-01-04 2013-01-03 Casp2에 대한 이중-가닥 rna 화합물 및 그 용도

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KR1020197035560A Active KR102202004B1 (ko) 2012-01-04 2013-01-03 Casp2에 대한 이중-가닥 rna 화합물 및 그 용도

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US (2) US9382542B2 (enExample)
EP (1) EP2800812A1 (enExample)
JP (2) JP2015507478A (enExample)
KR (2) KR20140109430A (enExample)
CN (1) CN104053776A (enExample)
AU (1) AU2013206951B2 (enExample)
BR (1) BR112014016640A2 (enExample)
CA (1) CA2858627C (enExample)
EA (1) EA036003B1 (enExample)
IL (1) IL233142B (enExample)
NZ (1) NZ625980A (enExample)
WO (1) WO2013103632A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015136255A1 (en) * 2014-03-11 2015-09-17 The University Of Birmingham Combined inhibition of caspase-2 and caspase-6 in neuroprotection and axon regeneration
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents

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US5998203A (en) 1996-04-16 1999-12-07 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
US6444776B1 (en) 1998-12-21 2002-09-03 Novartis Ag Organic polymers
IT1305306B1 (it) * 1999-03-17 2001-05-04 Farmigea Spa Uso della pirenoxina per la protezione dei tessuti corneali ininterventi di fotocheratectomia.
US6444676B1 (en) * 1999-12-20 2002-09-03 Iok-Hou Pang Use of PARP inhibitors in the treatment of glaucoma
AU2002368202B2 (en) * 2001-11-02 2008-06-05 Insert Therapeutics, Inc Methods and compositions for therapeutic use of RNA interference
EP2135948B1 (en) * 2002-11-25 2014-09-17 Masafumi Matsuo ENA nucleic acid drugs modifying splicing in mRNA precursor
US7605249B2 (en) * 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
EP1635763B1 (en) * 2003-06-09 2012-08-08 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
EP1689864A2 (en) * 2003-10-21 2006-08-16 Dyad Pharmaceutical Corporation Method and compositions for treating 5alpha-reductase type 1 and type 2 dependent conditions
GB0403041D0 (en) * 2004-02-11 2004-03-17 Milner Anne J Induction of apoptosis
WO2007031091A2 (en) * 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
US8168584B2 (en) * 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
JP2010507387A (ja) * 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のｓｉＲＮＡおよびその使用方法
WO2008094860A2 (en) * 2007-01-30 2008-08-07 Allergan, Inc. Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists
CA2701845A1 (en) * 2007-10-03 2009-04-09 Quark Pharmaceuticals, Inc. Novel sirna structures
NZ591391A (en) * 2008-10-22 2012-10-26 Quark Pharmaceuticals Inc Non-invasive methods for treating eye disorders using a topical oligonucleotide composition
JP2010260857A (ja) * 2009-04-10 2010-11-18 Santen Pharmaceut Co Ltd シロリムス誘導体を有効成分として含有する網脈絡膜疾患の治療剤
US20120135009A1 (en) * 2009-07-16 2012-05-31 Pascale Giraudon Cleaved and Phosphorylated CRMP2 as Blood Marker of Inflammatory Diseases of the Central Nervous System
WO2011014587A2 (en) * 2009-07-31 2011-02-03 Amira Pharmaceuticals, Inc. Ophthalmic pharmaceutical compositions of dp2 receptor antagonists
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WO2011084193A1 (en) * 2010-01-07 2011-07-14 Quark Pharmaceuticals, Inc. Oligonucleotide compounds comprising non-nucleotide overhangs

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Publication number Publication date
CN104053776A (zh) 2014-09-17
US20140371439A1 (en) 2014-12-18
AU2013206951B2 (en) 2016-11-24
BR112014016640A2 (pt) 2021-03-16
CA2858627C (en) 2020-12-01
KR102202004B1 (ko) 2021-01-12
US9382542B2 (en) 2016-07-05
JP2015507478A (ja) 2015-03-12
AU2013206951A1 (en) 2014-07-03
WO2013103632A1 (en) 2013-07-11
JP6774928B2 (ja) 2020-10-28
KR20190137940A (ko) 2019-12-11
CA2858627A1 (en) 2013-07-11
EP2800812A1 (en) 2014-11-12
EA036003B1 (ru) 2020-09-11
US20160304879A1 (en) 2016-10-20
JP2018099117A (ja) 2018-06-28
IL233142A0 (en) 2014-07-31
IL233142B (en) 2019-01-31
EA201491048A1 (ru) 2015-09-30
NZ625980A (en) 2015-05-29
US10570394B2 (en) 2020-02-25

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