KR20140096431A - Pellet-Type Composition for Prevention of Coccidiosis Symptom of Cattle Using Monensin and Manufacturing Method Thereof - Google Patents

Abstract

The present invention provides a method for manufacturing a pellet-type composition for preventing the coccidiosis symptom of cattle, comprising the steps of: premixing monensin sodium, which is a main material, salt (NaCl), sodium saccharine, propionic acid, and calcium carbonate, which are auxiliary materials, and certain amounts of wheat bran, rumen corn and under-grade wheat flour, which are forming agents; adding moisture to the premix by a spray while mixing the premix with certain amounts of the forming agents, and mixing the premix with the remaining amounts of the forming agents again; making pellets and cutting the pellets into a constant size by mixing the premix, which has been manufactured by mixing the main material, the auxiliary materials and the forming agents, with a water-soluble material, and molding the mixture by an extruder at temperatures of 45 to 50°C; and drying, passing, through an iron-removing sorter, and packing the pellets. The purpose of the present invention is to prevent the coccidiosis symptom of cattle via the pellet-type composition, of which the main component is monensin sodium, to increase the feed efficiency of cattle, to facilitate the growth of cattle, to increase the weight gain of cattle and to increase the milk yield of dairy cattle.

Description

TECHNICAL FIELD The present invention relates to a pellet-type composition for preventing coccidiosis in domestic animals, and to a method for producing the same. More particularly, the present invention relates to a pellet-

The present invention relates to a pellet-like composition for preventing coccidiosis using sodium monensin as a main component and a method for producing the same. More specifically, when a drug for preventing coccidiosis is administered to livestock, the acceptable daily intake (ADI) of only a few mg to several g per kg of body weight is scattered in the feeding process or dispersed in the feed, And the efficiency is lowered. In order to improve the above disadvantages, the present invention has been made for the first time in Korea, and it is manufactured in pellet form so that it can be easily administered to livestock, the loss of product due to scattering upon administration to livestock is reduced, And to prevent the coccidiosis, so as to improve the feed efficiency of livestock such as cattle or chickens, to promote growth, to improve the weight gain, and to increase the milk yield of cows.

The present invention relates to a pharmaceutical composition comprising mononin sodium which is a main raw material and sodium chloride (NaCl), sodium saccharine, propionic acid, calcium carbonate, wheat bran, rumen corn (1/3) of uncoated flour (1/3) is mixed with the raw material and primixed, and a certain amount (1/3) of the excipient is mixed in the mixer for 5 minutes Mixing the remaining amount of the excipient (1/3) and mixing the mixture for 10 minutes; and mixing the premix and the excipient with the water-soluble material for 10 to 30 minutes, Forming a pellet with an extruder at 50 ° C, cutting the pellet into a predetermined size, drying the product for 20 to 40 minutes to dry the product at a moisture content of 13% or less, passing the product through a steel sorting machine, and packaging.

Coccidiosis is a protozoal disease of algae and mammals, and is a pathogen and a parasitic disease of the Eimeria protozoa, which belong to the sporozoites that cause diarrhea, enteritis and stool. Cockcodia is an evolved protozoan of protozoa that has both oily and non-reproductive organs and shows pathogenicity to the asexual genitalia. However, when one type of immunity is formed, antibodies against it are formed, and therefore they can not defend against other types of coccidia.

Cow's coccidiosis is a disease in which coccidiosis is parasitic in the cytoplasm of submucosal tissues in the digestive tract epithelium and causes enteritis by destroying the epithelium. It is generally easy to develop in calves 3-6 months old, has lesions in the small intestine or colon, Causing bleeding diarrhea. Feeding the feed does not increase the weight of the feed because it does not lose weight, and in some cases it can lead to death. Sulfamethoxine, sulfamethazine, sulfaquinoxaline, monensin, and the like are used as medicines for the prevention of coccidiosis. Among them, monensin has a molecular weight of 671 and is a type of transport antibiotic that enhances the permeability of cells produced by microorganisms. It has few side effects and is widely used in rheumatism. Streptomyces cinnaminensis ) is a physiologically active substance. It has been developed as a coccidiotherapeutic agent but is also used as a metabolic regulator for ruminants.

Feeds that are fed diets to animals are made from powdered granulated feed or crude granulated feed under high pressure and high pressure. Pelleting feeds improves digestibility of feed ingredients, increases feed intake, shortens feed intake time And reduce the loss of feed. In addition, pathogenic bacteria and toxic substances that are weak to heat are destroyed, and handling and transportation of feeds becomes easy. However, there is a drawback that it takes a lot of production cost and destroys vitamins which are weak in heat.

Prior art related to the prevention of coccidiosis is disclosed in Korean Patent Laid-Open Publication No. 1998-2538 (Improved Coccidiosis Prevention), which is a method for preventing coccidiosis by continuously administering an effective amount of ionoprotein during the animal's survival period. Korean Patent Laid-Open Publication No. 2005-24400 (Anti-Chicken Coccidiosis Composition) discloses an immunogenic composition having immunogenicity similar to that of A. aeruginosa, A. aeruginosa, C. aeruginosa, C. aeruginosa, C. aeruginosa, C. aeruginosa, Or an antibody obtained from an egg of a chicken immunized with a protein antigen or an immunogenic fragment thereof. Korean Patent Laid-Open Publication No. 2005-10319 (pharmaceutical composition for treating coccidiosis epidermis in animals and a method for producing the same) is a composition comprising ammonium fluoride hydrochloride, sodium sulfamoqualine, ammonia, monoethanol, propylene glycol and purified water. Korean Patent Laid-Open Publication No. 2011-26669 (composition for preventing or treating coccidiosis) is a composition comprising a saponin-containing extract obtained from a plant selected from the group consisting of extracorporeal, plantain, yucca and mugwort or a saponin- And a composition for preventing or treating coccidiosis of poultry.

In addition, Korean Patent Registration No. 100662971 (a granular composition and a production method thereof) includes a core material and a layer covering the core material, and the core material is a saccharide The layer covering the core material is a granular composition comprising a hardened oil and a bioactive component. Korean Patent Laid-Open Publication No. 1994-0008585 (a method for producing a pellet-type feed using a novel binder) is a method for producing a pellet-type feed using a glue or gelatin to prevent wastage or loss of feed due to crumbling, And a process for producing a pellet feed using a high-strength binder such as gelatin scrap powder. Korean Patent Registration No. 10-0209061 (Method for producing a binding agent by micronization of gelatin) relates to a method for producing a binder for micronizing gelatin to 100 mesh or more. Korean Patent Laid-Open No. 2009-0121758 (Method of producing pellet feed additive) Grinding of raw material for grain and forage; step of mixing crushed raw materials of grain and vitamins and mineral additives; Pellet processing step; Spraying when the microorganism is in a liquid phase, and coating in the form of a mixture in the case of a powder. Korean Patent Laid-Open Publication No. 2002-11357 (feed pellet containing coconut dry powder) is produced by incorporating coconut oil into carbohydrate and coated with gelatin, and is used as a fat source and binder of pellet feed to greatly improve the quality and productivity of pelleted feed . Korean Patent No. 630390 (a pellet-shaped tablet having excellent water dispersibility) is a pellet-shaped tablet for animal feeds excellent in water solubility and water dispersibility, containing nutritional ingredients including vitamins,% foaming agent, nonionic surface active agent and hydrophilic porous particles .

However, these prior arts have different technical constructions from the present invention.

When the drug for preventing coccidiosis of livestock is supplied to livestock, since the ADI per kg of body weight is only a few mg to several g, it is disadvantageous in that it is dispersed in the feeding process or dispersed even in the feed, . Also, when livestock is caught in coccidiosis, diarrhea is severe and secondary infection is worried, and weight loss is reduced.

The present invention relates to a pharmaceutical composition comprising mononin sodium which is a main raw material and sodium chloride (NaCl), sodium saccharine, propionic acid, calcium carbonate, wheat bran, rumen corn A step of premixing a certain amount of raw wheat flour with a raw material and a sub ingredient, and a step of adding a certain amount of excipient to the premix with a mixer while adding water to the premix, Mixing the remaining amount of water and a water-soluble material into a premix, mixing the raw material and the excipient, mixing the water-soluble material, molding the mixture into an extruder at 45 ° C to 50 ° C to pelletize, And then wrapping.

Since the excipient used as the feed composition is mixed with the preventive agent for coccidiosis, the dietary supplement is easy and the dispersibility in the livestock body is good, so that the bodily growth rate can be improved and the feed efficiency can be improved.

The present invention has the effect of preventing the coccidiosis of livestock, improving feed efficiency, promoting growth, improving the amount of gain, and increasing the milk yield of dairy cows, based on monensin sodium.

1 is a manufacturing process diagram of the present invention.

The present invention shows a pellet-like composition for preventing coccidiosis of livestock.

The present invention relates to a pharmaceutical composition containing mononezine sodium as a main component and at least one component selected from salt, saccharide, propionic acid and calcium carbonate as a sub ingredient; As the excipient, any one or more ingredients selected from among wheat flour, lumen cone, and the like; Wherein the water-soluble material comprises at least one selected from the group consisting of alpha starch, sugar, starch sugar, sugar alcohols, gum, and alginic acid.

In the above, 3 to 3.4 wt% of monensin sodium, 2 to 4 wt% of sodium chloride, 0.4 to 0.6 wt% of saccharides, 0.1 to 0.2 wt% of propionic acid, 23 to 25 wt% of melanin, 3 to 5 wt% of calcium carbonate, %, 40 to 42 wt% of the unevenness and 0.5 to 1.5 wt% of the water-soluble substance.

Among the above materials, the saccharide may be any one or two or more selected from saccharin, saccharide, new water, stevioside, aspartame or acesulfame K.

The water-soluble substance may be any one or more components selected from starch sugar, sugar alcohol and gum.

The starch sugar in the water-soluble substance may be at least one selected from glucose, fructose, and lactose.

The sugar alcohol in the water-soluble substance may be any one or more selected from sorbitol and xylitol.

The gums among the water-soluble substances may be at least one selected from gum arabic, guar gum and xanthan gum.

The present invention shows a method for producing a pellet-like composition for preventing coccidiosis of livestock.

The present invention relates to a method for producing a fermented milk, comprising the steps of: mixing monensin sodium as a raw material; salt, saccharide, calcium carbonate, propionic acid as a raw material; and a part of wheat flour, lumen cone, A step of adding water with spraying while a part of the mixture is mixed in a primary mixer, and then mixing the remaining amount of the uncharged fraction into a secondary mixture, and a step of mixing the water-soluble material with the premix, which is a mixture of the raw material, the filler and the excipient, And cutting the pellets into a uniform size, followed by drying and packaging through a steel sorting machine.

The temperature at the time of extrusion may be 45 ° C to 50 ° C.

The present invention premixes a certain amount of sodium monomnsuch as a main raw material, a saccharide such as salt and saccharin as a sub ingredient, propionic acid, calcium carbonate, excipients such as wheat bran, lumen cone and excipients as raw materials with raw materials. Here, wheat bran is wheat bran, which is a by-product of wheat turning, lumen cone is crushed wheat grain, and the off-balance wheat is wheat flour other than wheat flour. The water-soluble substances are alpha starch, sugar, starch sugar, glucose, fructose, fructose, sugar alcohols are sorbitol and xylitol, and the gums consist of one or more selected from gum arabic, guar gum, xanthan gum and alginic acid.

Adding 1% of water by spraying while mixing a predetermined amount of the unspecified part with the above premix in the mixer for 5 minutes, mixing the remaining amount of the unspecified part with the excipient and mixing for 10 minutes, and mixing the raw material and excipient Mixing the pre-mix with water-soluble materials for 10 to 30 minutes, shaping the mixture into an extruder at 45 ° C to 50 ° C, pelletizing and then cutting to a predetermined size, and drying for 20 to 40 minutes to dry And passing through the steel sorting machine and packaging.

The water-soluble substance is composed of one or more of alpha starch, sugar, starch sugar, sugar alcohols, gum, alginic acid, gum arabic and guar gum.

1) Preparation of main ingredients, substitute materials and excipients

The main ingredient of the present invention, monensin sodium, was purchased from EI LANCO Animal Pharmaceutical Co., Ltd., and 3 to 3.4 wt% of 100 wt% of the pellet composition was used.

Salt and saccharides (saccharin, etc.) are used for good eating because the livestock recognizes the taste. The salty taste of 100 wt% of the pelletized composition is 2 to 4 wt% of salt (NaCl) and 0.4 to 0.6 wt% of saccharin do. They are used because they are relatively inexpensive, but other alternatives can be used. Propionic acid and calcium carbonate are used in amounts of 0.1 ~ 0.2wt% and 3 ~ 5wt% for sterilizing agent and mineral feed, respectively. Salt was purchased from the Second Coming Co., sodium saccharin was purchased from Eunjin Bio Co., sodium propionate was purchased from Daeho, and calcium carbonate was purchased from Sanmaru Korea.

Wheat bran is a by-product of wheat bran, which is a mixture of wheat husks, embryos and wheat flour. It has good palatability and high content of phosphorus and fiber. Purchased from Shinwoo Feed Co., Ltd. and used in an amount of 23 to 25 wt% based on 100 wt% of the pellet-like composition.

The lumen cone is obtained by crushing the corn husk and is purchased from Hengsung Feed Co., and is used in an amount of 21 to 24 wt% based on 100 wt% of the pelletized composition. The finely divided wheat flour is purchased from Shinwoo Industries and used in an amount of 40 to 42 wt% based on 100 wt% of the pellet-like composition.

2) water-soluble substance

The water soluble substances are sorbitol and xylitol, and the gums are gum arabic, guar gum, xanthan gum and alginic acid (imported from CJ), sugar (CJ), starch sugar Product). ≪ / RTI > 0.1 to 0.5 wt% is used relative to 100 wt% of the pellet-like composition.

3) Mix of raw materials, sub-materials, excipients, and water-soluble substances

Mix a certain amount (1/3) of raw material and excipient to the raw material and premix it. A predetermined amount (1/3) of the excipient is mixed with the above-mentioned premix in a mixer for 5 minutes, and 1% of water is added by spraying, and the remaining amount of the excipient (1/3) is mixed and mixed for 10 minutes. The excipient is divided three times to mix a small amount of the raw material evenly in the mixture and the excipient.

4) Forming, cutting and drying

The water-soluble materials were mixed in a premix containing the raw materials, the filler and the excipient for 10 to 30 minutes, put into a pellet mill, added with a pressure (15 N) and heated at 45 to 50 ° C to form a pellet- Then, it is dried for 30 minutes. The extruded pellets are cut to a predetermined size and dried by hot air at 45 to 50 캜.

5) Seasonal and packaging

Dry pelletized product is selected by particle size, passed through metal detector, then tested for properties and content, and after checking the appearance, markings and contents, pack.

≪ Examples 1 to 4 >

34 grams of monensin sodium, 30 grams of salt, 5 grams of saccharin, 2 grams of propionic acid, 40 grams of calcium carbonate, 250 grams of wheat bran, 230 grams of lumencone, and 137 grams of unspecified minute were premixed. To this premix was added 137 g of the unmodified starch and 1% of water by spraying while mixing in a mixer for 5 minutes for the first time, and then the remaining amount of 136 g of the unmodified starch was mixed with the excipient and mixed for 10 minutes. A water-soluble material is mixed with a premix containing a raw material and an excipient for 10 to 30 minutes, molded into an extruder at 45 ° C to 50 ° C, pelletized, cut to a predetermined size, and dried for 20 to 40 minutes to obtain a water content of 13% Dried, passed through a steel sorting machine, inspected according to the standard, and packed. The packaging is made by standard and stored in a sealed container at room temperature in a shaded area.

* Black guar gum and Arabia gum were used.

<Comparative Example>

The pelletized product was prepared in the same manner as in Example 1, and the mixing ratio was as shown in Table 1. However, a pellet-like product was prepared in the same manner as the control 1 except that the arabic gum was used in the control 2 of the comparative example.

&Lt; Test Example 1 > Quality comparison

The pelletized product prepared at the blending ratio of the examples and the comparative examples was subjected to the visual observation of pellets (visual observation), moisture (Karl Fischer method), raw materials (HPLC method), and disintegration (Disintegration test apparatus, test for confirming whether the pellet is disintegrated within the specified time in the test solution under specified conditions), appearance and the like were tested and classified into excellent, excellent, normal, and insufficient, and the results are shown in Table 2 below.

From the above results, the properties, appearance and appearance of the starch and gum in the control 1 of Examples 1, 2 and 4 and Comparative Example 1 using the starch and gum as water-soluble substances were excellent. In addition, moisture and raw materials were also excellent.

&Lt; Test Example 2 > Weight gain comparison

The pelletized products prepared by the methods of Examples 1-4 and 1-2 were fed to the feed of the cattle, and the groups in which the pelletized product was not fed and the amount of weight gain were compared according to the general test method, (Unit: body weight gain, kg / day).

  * Body weight gain per day (kg / day): average body weight gain during the day

Commercially available feeds were feedstuffs for cattle feed (Cargill products) that did not contain monensin sodium. When the pelletized product of the present invention was fed, the weight gain was 5-10% as compared with the commercially available feed.

&Lt; Test Example 3 > Prevention of coccidiosis

The preventive effect of coccidiosis was measured according to the rearing period of the group fed diets fed with the monenesin-containing parenteral composition of the present invention and the group fed with the general feeds (Purina), and the results are shown in Table 4 below. Fecal calf feces were collected at regular intervals (1-5 months) to identify coccidiosis.

Coccidial bulgeing was not observed in the group of Example 1-4 of the pellet composition containing monensin sodium. However, in the case of the comparative example, coccidiosis was observed occasionally and diarrhea was observed. Therefore, the diarrhea was stopped by treating with monensin every time and the dietary supplement was again performed.

INDUSTRIAL APPLICABILITY The present invention can be industrially used because it can prevent the coccidiosis of livestock, improve feed efficiency, promote growth, improve the weight gain and increase milk yield of dairy cows, based on monensin sodium.

Claims (6)

A monosynthin sodium as a main component and at least one component selected from the group consisting of salt, saccharide, propionic acid and calcium carbonate as a sub ingredient; As the excipient, any one or more ingredients selected from among wheat flour, lumen cone, and the like; A pellet-shaped composition for preventing coccidiosis in domestic animals, which comprises at least one selected from the group consisting of alpha starch, sugar, starch sugar, sugar alcohols, gum, and alginic acid as a water-soluble substance The method according to claim 1, further comprising the steps of: 3 to 3.4 wt% of monensin sodium, 2 to 4 wt% of sodium chloride, 0.4 to 0.6 wt% of saccharides, 0.1 to 0.2 wt% of propionic acid, 23 to 25 wt% Wherein the composition is composed of 21 to 23 wt% of corn, 40 to 42 wt% of unevenness and 0.5 to 1.5 wt% of water-soluble substance. The pellet-shaped composition for prevention of coccidiosis in domestic animals according to claim 1, wherein the saccharide is at least one selected from the group consisting of saccharin, saccharide, new water, stevioside, aspartame and acesulfame K The method of claim 1, wherein the water-soluble substance is at least one selected from the group consisting of starch sugar, sugar alcohol and gum, wherein the starch sugar is at least one selected from glucose, fructose, and lactose, and the sugar alcohol is at least one selected from sorbitol and xylitol , And the gum is at least one selected from gum arabic, guar gum and xanthan gum. A step of premixing sodium monosyne as a raw material and a salt, a saccharide, calcium carbonate, and propionic acid as a sub ingredient and a part of wheat bran, lumen cone and alginate as an excipient, and a step of premixing A step of adding water with a spray while mixing with a residual amount of unexpected minutes, and a step of mixing the remaining amount of the unspecified minute by a secondary mixing step, and a step of mixing a water-soluble substance into a premix containing a raw material, a parting agent and an excipient, molding the mixture into an extruder, And separating the pellet-shaped composition from the pellet-shaped composition for preventing coccidiosis in domestic animals. The method for producing a pellet-like composition for preventing coccidiosis in domestic animals according to claim 5, wherein the temperature at the time of extrusion is 45 ° C to 50 ° C

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