WO2022177252A1 - Composition containing composite ion mineral solution as active ingredient for prevention or palliation of coccidiosis - Google Patents
Composition containing composite ion mineral solution as active ingredient for prevention or palliation of coccidiosis Download PDFInfo
- Publication number
- WO2022177252A1 WO2022177252A1 PCT/KR2022/002186 KR2022002186W WO2022177252A1 WO 2022177252 A1 WO2022177252 A1 WO 2022177252A1 KR 2022002186 W KR2022002186 W KR 2022002186W WO 2022177252 A1 WO2022177252 A1 WO 2022177252A1
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- WO
- WIPO (PCT)
- Prior art keywords
- coccidiosis
- feed
- present
- active ingredient
- mineral solution
- Prior art date
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- 235000009566 rice Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008107 starch Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- GDANWVKBBCWCIJ-UHFFFAOYSA-N sulfachlorpyrazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CN=C(Cl)C=N1 GDANWVKBBCWCIJ-UHFFFAOYSA-N 0.000 description 1
- 229960002135 sulfadimidine Drugs 0.000 description 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
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- 229960000898 toltrazuril Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/40—Mineral licks, e.g. salt blocks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Definitions
- the present invention relates to a composition for preventing or improving coccidiosis containing a complex ionic mineral solution as an active ingredient.
- Coccidiosis is a disease in which protozoa belonging to the genus Eimeria belonging to sporangia in general livestock such as poultry, cattle, and pigs parasitize in the cytoplasm of submucosal tissue in the epithelium of the digestive tract of the host animal, destroying the epithelium and causing enteritis.
- it is a protozoal disease that causes enormous economic damage, such as soft stool, diarrhea, bloody stool, decreased weight gain, increased shipping date, and decreased egg laying rate.
- Aymeria protozoa a protozoan that evolved among protozoa, has both sexual and asexual genitalia and is pathogenic to the asexual genitalia. Cases caused by one species of protozoa are rare, and mixed infection is generally observed outdoors, and immunization against only one species does not protect against other types of protozoa, causing considerable problems in poultry farms.
- coccidiosis is easily infected and spread in the breeding environment of livestock raised collectively in a narrow space due to the nature of modern livestock, and in severe cases, more than 50% of young chicks may die.
- Aimeria since Aimeria has a complex life cycle (intracellular, extracellular, asexual, sexual stage) with intermediate stages necessary for growth in vitro with the host animal chicken, it is a complex that induces specific and non-specific immune responses when infected with a host. is a pathogen
- the oocyst of the protozoan Coccidium is infectious when it matures into sporulated oocysts at high humidity and temperature.
- the egg life history repeats itself. In general, it is known that eggs are infectious for 1 to 2 years in a natural environment. Since the number of coccidium cysts increases by 10,000 times when infected with poultry, even a small amount of cysts increases rapidly, leading to the risk of mass infection.
- sulfa drugs such as sulfaquinoxalin, sulfachlorpyrazine, and sulfamethazine, and amfurorium, toltrazuril, etc. are single or It is used as a combination agent, and for the purpose of preventing more fundamental coccidiosis, it has been successful in suppressing the serious occurrence of coccidiosis by continuously administering various anticoccidiosis drugs by adding them to the feed.
- Korean Patent Application Laid-Open No. 2018-0083818 discloses a 'composition for preventing or treating coccidiosis, manufacturing method thereof, and use thereof', comprising anethol or a pharmaceutically acceptable salt thereof, and a porous adsorbent as active ingredients.
- Korean Patent Application Laid-Open No. 2014-0096431 discloses a pellet-type composition for preventing coccidiosis in livestock containing monensin as a main component and a method for preparing the same, but the present invention 'contains a complex ionic mineral solution as an active ingredient'
- a composition for preventing or improving coccidiosis is no description of a composition for preventing or improving coccidiosis.
- the present invention was derived from the above needs, and the present inventors tested the anticoccidium effect of a complex ionic mineral solution extracted from natural minerals to develop a material that can minimize the impact of the drug, which is a disadvantage of the existing anticoccidium agent. As a result, the present invention was completed by confirming that the anticoccidium efficacy of the complex ionic mineral solution used in the present invention is superior to that of the anticoccidium preparations reported to date, and at the same time there is no impact of the drug on livestock.
- the present invention provides a veterinary composition for preventing or treating coccidiosis containing a complex ionic mineral solution as an active ingredient.
- the present invention provides a feed additive composition for preventing or improving coccidiosis comprising a complex ionic mineral solution as an active ingredient.
- the present invention provides a feed for preventing or improving coccidiosis comprising the feed additive composition.
- the present invention provides a method for preventing or improving coccidiosis of livestock by feeding the feed to livestock.
- the complex ionic mineral solution of the present invention has a very excellent effect of inhibiting the proliferation of coccidium protozoa, is eco-friendly, and economical because it can be mass-produced, and there is no impact of the drug on the livestock to be treated. Feeding not only prevents coccidiosis, but also dramatically improves the intestinal environment, activates the immune system, and improves productivity, as well as enables healthy livestock breeding without the use of various veterinary drugs and antibiotics.
- Eimeria acebulina Eimeria acervulina
- E. tenella E. tenella
- Figure 2 is a chicken fed a feed (K1) containing a complex ionic mineral solution extracted from the natural mineral of the present invention and a chicken fed a feed (Unsupplement) not containing the complex ionic mineral solution Eimeria acebulina ( Eimeria acervulina ) or E. tenella ( E. tenella ) After infection with protozoa, it is a graph analyzing the change in chicken weight in each group. Control: A. acebulira-infected chickens fed a regular diet, EA: chickens infected with A. acebulira after a normal diet, K1+EA: chickens infected with A. acebulira after a K1 diet, ET: normal Chickens infected with A. tenella after feeding, K1+ET: Chickens infected with A. tenella after feeding on K1 diet.
- EA chickens infected with A. acebulira after a normal diet
- K1+EA
- the present invention provides a veterinary composition for preventing or treating coccidiosis containing a complex ionic mineral solution as an active ingredient.
- the complex ionic mineral solution is a natural mineral selected from iron ore, ilmenite, elvan, and sericite, pulverized into a powder in the range of 100 to 300 mesh, and the powder 1- It may be a filtrate filtered after 15-30 wt% of the inorganic acid and 15-30 wt% of the inorganic acid and the remaining amount is 100 wt% water, followed by stirring at 50-80°C for 24 hours to 72 hours.
- the inorganic acid may be sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid, etc., preferably sulfuric acid, but is not limited thereto.
- the complex ionic minerals according to the present invention include sulfur, iron, aluminum, zinc, cobalt, copper, vanadium, calcium, potassium, strontium, magnesium, sodium, titanium, manganese, silicon, phosphorus, boron, nickel, chromium, arsenic, lead and A molybdenum component may be included.
- the coccidiosis is not limited thereto, but preferably may be chicken coccidiosis, and the chicken (or chick) coccidiosis is Eimeria tenella , Eimeria ace Bulina ( E. acervulina ), E. necatrix ( E. necatrix ), E. maxima ( E. maxima ) or E. brunetti ( E. brunetti ) It may be caused by a protozoa, but is limited thereto doesn't happen
- prevention refers to an act of improving the immunity of an animal by administering the veterinary composition of the present invention to prevent or alleviate the occurrence of the coccidiosis
- treatment is the veterinary medicine of the present invention. It refers to the act of improving or beneficially changing the coccidiosis occurring in the animal due to the administration of the composition, and it refers to the act of eliminating clinical symptoms or alleviating the degree of occurrence.
- the veterinary composition of the present invention further contains one or more pharmaceutically acceptable carriers or diluents in addition to the complex ionic mineral solution according to the present invention when the veterinary composition is provided in the form of a pharmaceutical composition. can do.
- pharmaceutically acceptable refers to a non-toxic substance that is physiologically acceptable and does not inhibit the action of an active ingredient and does not normally cause gastrointestinal disorders, allergic reactions or similar reactions when administered to animals.
- the pharmaceutically acceptable carrier may include, for example, a carrier for oral administration or a carrier for parenteral administration.
- Carriers for oral administration may include lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like.
- the carrier for parenteral administration may include water, a suitable oil, saline, aqueous glucose and glycol, and the like, and may further include a stabilizer and a preservative. Suitable stabilizers include antioxidants such as sodium hydrogen sulfite, sodium sulfite or ascorbic acid. Suitable preservatives include benzalkonium chloride, methyl- or propyl-paraben and chlorobutanol.
- the pharmaceutical composition of the present invention may further include a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, etc. in addition to the above components.
- the veterinary composition of the present invention may be administered to an animal alone or in combination with a feed.
- a pharmaceutically acceptable edible carrier as is well known in the art to prepare an immediate release or sustained release formulation.
- Such edible carriers can be solid or liquid, for example corn starch, lactose, sucrose, soy flakes, peanut oil, olive oil, sesame oil and propylene glycol, and when a solid carrier is used, the feed can be prepared in tablets, capsules, powders, It may be a troche or sugar-containing tablet or micro-dispersed top dressing, and when a liquid carrier is used, the feed may be in the form of a gelatin soft capsule, syrup, suspension, emulsion, or solution, but is not limited thereto. it is not
- veterinary composition of the present invention When administered to an animal, it may be administered orally or parenterally.
- Parenteral administration methods include, but are not limited to, intravenous, intramuscular, intraarterial, intramedullary, intrathecal, intracardiac, transdermal, subcutaneous, intraperitoneal, intranasal, enteral, topical, sublingual or rectal administration. can be
- the present invention also provides a feed additive composition for preventing or improving coccidiosis comprising a complex ionic mineral solution as an active ingredient.
- the complex ionic mineral solution and coccidiosis are as described above.
- the feed additive composition of the present invention can prevent or alleviate coccidiosis of animals, particularly livestock including poultry.
- the feed additive composition may additionally contain an acceptable carrier for livestock, particularly poultry.
- the feed additive composition may be added with various nutrients such as vitamins, amino acids, minerals, antioxidants, antibiotics, antibacterial agents and other additives as necessary, and the shape thereof is powder, granule, pellet, suspension It may be in a suitable state, such as
- the present invention also provides a feed for preventing or improving coccidiosis comprising the feed additive composition.
- the feed additive may be preferably a complex ionic mineral solution, and the complex ionic mineral solution may be formulated in an amount of 0.000008 to 0.0001 to weight % based on the feed composition, but is not limited thereto.
- the term "feed” refers to any natural or artificial diet, one meal, etc., or a component of the one meal meal, which is suitable for or for the animal to eat, ingest, and digest.
- the feed of the present invention may be prepared in the form of a conventional feed composition such as powder and pellets, but is not limited thereto, and can be prepared in various types of feed known in the art.
- the feed of the present invention may further contain nutritional supplements, digestion and absorption enhancers, growth promoters, and the like, and include grains (eg, milled or crushed wheat, oats, barley, corn, rice), plant proteins (eg, , rape, soybean, and sunflower), animal protein (eg, blood meal, meat meal, bone meal, and fish meal), sugar and dairy products (such as dry ingredients consisting of various milk powder and whey powder, etc.) , there is no particular limitation, and all those commonly used in the art may be used.
- grains eg, milled or crushed wheat, oats, barley, corn, rice
- plant proteins eg, , rape, soybean, and sunflower
- animal protein eg, blood meal, meat meal, bone meal, and fish meal
- sugar and dairy products such as dry ingredients consisting of various milk powder and whey powder, etc.
- the present invention also provides a method for preventing or improving coccidiosis in livestock by feeding the feed according to the present invention to livestock.
- Iron ore a natural mineral
- 10 wt% of the powder is adjusted to 100 wt% with 25 wt% sulfuric acid and the balance is water, stirred at 60°C for 48 hours, and cooled to room temperature. After standing for several hours, the supernatant was taken, and the remaining amount was filtered with filter paper to obtain a filtrate.
- the filtrate was a light yellow transparent solution in appearance, and the filtrate was named a complex ionic mineral solution.
- the complex ionic mineral solution was commissioned by the Korea Basic Science Institute for component analysis.
- the complex ionic mineral solution contains sulfur, iron, and aluminum as main components, and contains zinc, cobalt, copper, vanadium, calcium, potassium, and strontium.
- the anticoccidium effect of the complex ionic mineral solution of the present invention was analyzed.
- the complex ion-mineral solution was diluted 10,000 times with chicken (broiler) feed (fed without antibiotics and anticoccidium), and the experimental group (K1) fed during the test period 2 days before coccidium protozoa inoculation, and complex ions
- the group fed the feed without the mineral solution for the same period was divided into the normal group (control), and the group fed the feed without the complex ionic mineral solution during the test period 2 days before the coccidium protozoa inoculation was divided into the control group (Unsupplement).
- Coccidium protozoa E. tenella or E. acervulina
- infected spore-forming eggs (1x10 4 eggs/chicken individual
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Abstract
The present invention relates to a composition comprising a composite ion mineral solution as an active ingredient for prevention of coccidiosis and, more specifically, to a veterinary composition containing composite ion minerals as an active ingredient for prevention or treatment of coccidiosis, a feed additive composition containing composite ion minerals as an active ingredient for prevention or palliation of coccidiosis, a feed, including the feed additive composition, for prevention or palliation of coccidiosis, and a method for prevention or palliation of coccidiosis in livestock by feeding the feed to the livestock.
Description
본 발명은 복합 이온미네랄 용액을 유효성분으로 함유하는 콕시듐증의 예방 또는 개선용 조성물에 관한 것이다.The present invention relates to a composition for preventing or improving coccidiosis containing a complex ionic mineral solution as an active ingredient.
콕시듐증은 가금류, 소, 돼지 등 일반 가축에서 포자충류에 속하는 아이메리아(Eimeria) 속 원충이 숙주동물의 소화관 상피에서 점막 밑 조직의 세포질 내에 기생하며 상피를 파괴시키고 장염을 일으키는 질환이다. 특히, 연변, 설사, 혈변, 증체율 저하, 출하일령 증가, 산란율 저하 등 막대한 경제적 피해를 야기하는 원충성 질병이다.Coccidiosis is a disease in which protozoa belonging to the genus Eimeria belonging to sporangia in general livestock such as poultry, cattle, and pigs parasitize in the cytoplasm of submucosal tissue in the epithelium of the digestive tract of the host animal, destroying the epithelium and causing enteritis. In particular, it is a protozoal disease that causes enormous economic damage, such as soft stool, diarrhea, bloody stool, decreased weight gain, increased shipping date, and decreased egg laying rate.
아이메리아 원충은 원생동물 중에서 진화된 원충으로서 유성 및 무성의 생식기를 가지고 있으며 무성 생식기에 병원성을 나타낸다. 1개종의 원충에 의해 발생되는 예가 드물며, 야외에서는 일반적으로 혼합감염이 관찰되고, 1개종에 대해서만 면역하면 다른 종류의 원충에 대해서는 방어하지 못하므로 양계농장에서 상당한 문제를 야기시킨다.Aymeria protozoa, a protozoan that evolved among protozoa, has both sexual and asexual genitalia and is pathogenic to the asexual genitalia. Cases caused by one species of protozoa are rare, and mixed infection is generally observed outdoors, and immunization against only one species does not protect against other types of protozoa, causing considerable problems in poultry farms.
콕시듐증은 특히, 현대축산의 특성상 좁은 공간에서 집단적으로 사육되는 가축의 사육환경에서 용이하게 감염, 전파되는데 심할 경우 어린 병아리는 50% 이상 폐사할 수 있다.In particular, coccidiosis is easily infected and spread in the breeding environment of livestock raised collectively in a narrow space due to the nature of modern livestock, and in severe cases, more than 50% of young chicks may die.
또한, 아이메리아는 숙주동물인 닭과 체외에서 성장에 필요한 중간단계를 가지는 복잡한 생활사(intracellular, extracellular, asexual, sexual stage)를 가지고 있기 때문에 숙주에 감염 되었을 때 특이 및 비특이 면역반응을 유발하는 복잡한 병원균이다. 콕시듐 원충의 낭포(oocyst)는 높은 습도와 온도에서 포자충(sporulated oocyst)으로 성숙될 경우 감염성이 있으며, 닭의 체내에서 일정한 생활사(life cycle)를 거친 후 분변으로 충란을 배설하면 쉽게 전파가 이루어지고 충란 생활사가 되풀이된다. 일반적으로 충란은 자연환경에서 1~2년 감염성을 보유하고 있다고 알려져 있다. 콕시듐의 낭포가 가금류에 감염되면 10,000 배로 증가하기 때문에 소량의 낭포가 침입하여도 급속도로 증가하여 대량감염의 위험이 따르게 된다.In addition, since Aimeria has a complex life cycle (intracellular, extracellular, asexual, sexual stage) with intermediate stages necessary for growth in vitro with the host animal chicken, it is a complex that induces specific and non-specific immune responses when infected with a host. is a pathogen The oocyst of the protozoan Coccidium is infectious when it matures into sporulated oocysts at high humidity and temperature. The egg life history repeats itself. In general, it is known that eggs are infectious for 1 to 2 years in a natural environment. Since the number of coccidium cysts increases by 10,000 times when infected with poultry, even a small amount of cysts increases rapidly, leading to the risk of mass infection.
이러한 산업적 손실을 초래하는 콕시듐증의 치료제로서는 주로 설파퀴녹살린(sulfaquinoxalin), 설파클로로피라진(sulfachlorpyrazine), 및 설파메타진(sulfamethazine)과 같은 설파제와 암푸로륨, 톨트라주릴(Toltrazuril) 등이 단일 또는 복합제로서 사용되고 있으며, 보다 근원적인 콕시듐증의 방제를 위하여 사전 방지를 목적으로 각종 항콕시듐 약제들을 사료에 첨가하여 지속적으로 투약함으로써 콕시듐증의 심각한 발생을 억제시키는데 성공적이었다.As a treatment for coccidiosis that causes such industrial losses, mainly sulfa drugs such as sulfaquinoxalin, sulfachlorpyrazine, and sulfamethazine, and amfurorium, toltrazuril, etc. are single or It is used as a combination agent, and for the purpose of preventing more fundamental coccidiosis, it has been successful in suppressing the serious occurrence of coccidiosis by continuously administering various anticoccidiosis drugs by adding them to the feed.
그러나 이들 약제를 수십년간에 걸쳐 지속적이고 장기간에 걸쳐 투여함으로써 이들 약제에 내성을 가진 원충이 출현하게 되었으며, 결과적으로 개발된 약제들의 사용 수명을 단축시켜 왔다. 또한, 폐사하지 않고 치유가 된다 하더라도 치유과정에서 체내의 원충 사멸을 위해 사용한 약제의 독한 성분으로 인한 손상이 심대하여 가축이 정상적으로 생육하는 것은 불가능하여 사료효율, 성장속도 등이 현저히 저하되는 문제점이 있다. 이에 따라, 내성이 적으며 인체에도 안전한 항콕시듐제에 대한 요구가 매우 높아지고 있다.However, by continuously and long-term administration of these drugs over several decades, protozoa resistant to these drugs have appeared, and as a result, the useful life of the developed drugs has been shortened. In addition, even if it is cured without dying, the damage caused by the poisonous component of the drug used to kill the protozoa in the body during the healing process is so severe that it is impossible for the livestock to grow normally, so there is a problem that feed efficiency and growth rate are significantly reduced. . Accordingly, there is a very high demand for an anticoccidium agent that has little resistance and is safe for the human body.
한편, 한국공개특허 제2018-0083818호에는 아네톨(Anethol) 또는 이의 약학적으로 허용 가능한 염, 및 다공성 흡착제를 유효성분으로 포함하는, '콕시듐증 예방 또는 치료용 조성물, 이의 제조방법 및 이의 이용'이 개시되어 있고, 한국공개특허 제2014-0096431호에는 모넨신을 주성분으로 하는 가축의 콕시듐증 예방용 펠릿형 조성물 및 그의 제조방법'이 개시되어 있으나, 본 발명의 '복합 이온미네랄 용액을 유효성분으로 함유하는 콕시듐증의 예방 또는 개선용 조성물'에 대해서는 기재된 바가 없다.On the other hand, Korean Patent Application Laid-Open No. 2018-0083818 discloses a 'composition for preventing or treating coccidiosis, manufacturing method thereof, and use thereof', comprising anethol or a pharmaceutically acceptable salt thereof, and a porous adsorbent as active ingredients. This is disclosed, and Korean Patent Application Laid-Open No. 2014-0096431 discloses a pellet-type composition for preventing coccidiosis in livestock containing monensin as a main component and a method for preparing the same, but the present invention 'contains a complex ionic mineral solution as an active ingredient' There is no description of a composition for preventing or improving coccidiosis.
본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 본 발명자들은 기존 항콕시듐제의 단점인 약제의 충격을 최소화할 수 있는 물질을 개발하고자 천연광물로부터 추출된 복합 이온미네랄 용액의 항콕시듐 효과를 테스트한 결과, 본 발명에서 사용된 복합 이온미네랄 용액의 항콕시듐 효능이 현재까지 보고된 항콕시듐 제제보다 우수하고 동시에 가축에 약제의 충격이 없는 것을 확인함으로써, 본 발명을 완성하였다.The present invention was derived from the above needs, and the present inventors tested the anticoccidium effect of a complex ionic mineral solution extracted from natural minerals to develop a material that can minimize the impact of the drug, which is a disadvantage of the existing anticoccidium agent. As a result, the present invention was completed by confirming that the anticoccidium efficacy of the complex ionic mineral solution used in the present invention is superior to that of the anticoccidium preparations reported to date, and at the same time there is no impact of the drug on livestock.
상기 과제를 해결하기 위해, 본 발명은 복합 이온미네랄 용액을 유효성분으로 함유하는 콕시듐증의 예방 또는 치료용 수의학적 조성물을 제공한다.In order to solve the above problems, the present invention provides a veterinary composition for preventing or treating coccidiosis containing a complex ionic mineral solution as an active ingredient.
또한, 본 발명은 복합 이온미네랄 용액을 유효성분으로 포함하는 콕시듐증의 예방 또는 개선용 사료첨가제 조성물을 제공한다.In addition, the present invention provides a feed additive composition for preventing or improving coccidiosis comprising a complex ionic mineral solution as an active ingredient.
또한, 본 발명은 상기 사료첨가제 조성물을 포함하는 콕시듐증의 예방 또는 개선용 사료를 제공한다.In addition, the present invention provides a feed for preventing or improving coccidiosis comprising the feed additive composition.
또한, 본 발명은 상기 사료를 가축에 급여하여 가축의 콕시듐증을 예방 또는 개선하는 방법을 제공한다.In addition, the present invention provides a method for preventing or improving coccidiosis of livestock by feeding the feed to livestock.
본 발명의 복합 이온미네랄 용액은 콕시듐 원충의 증식 억제 효과가 매우 우수하며, 친환경적이고, 대량 생산이 가능하여 경제적이며, 처리 대상 가축에 약제의 충격이 없어, 사료첨가제로 사료에 혼합하여 상시적으로 급이하면 콕시듐증 예방은 물론 장내 환경을 획기적으로 개선하고, 면역체계를 활성화시켜 생산성을 향상시길 수 있을 뿐만 아니라, 각종 동물약품과 항생제의 사용 없이도 가축을 건강하게 사육할 수 있을 것이다.The complex ionic mineral solution of the present invention has a very excellent effect of inhibiting the proliferation of coccidium protozoa, is eco-friendly, and economical because it can be mass-produced, and there is no impact of the drug on the livestock to be treated. Feeding not only prevents coccidiosis, but also dramatically improves the intestinal environment, activates the immune system, and improves productivity, as well as enables healthy livestock breeding without the use of various veterinary drugs and antibiotics.
도 1은 본 발명의 천연광물로부터 추출된 복합 이온미네랄 용액을 함유한 사료(K1)를 급식한 닭과 복합 이온미네랄 용액을 포함하지 않는 사료(Unsupplement)를 급식한 닭에 아이메리아 아세불리나(Eimeria acervulina) 또는 아이메리아 테넬라(E. tenella) 원충을 감염시킨 후, 분변으로 배설된 충란의 수를 분석한 그래프이다. Control: 일반 사료를 식이한 아이메리아 원충 비감염 닭. **: p < 0.01.1 is a chicken fed a feed (K1) containing a complex ionic mineral solution extracted from a natural mineral of the present invention and a chicken fed a feed (Unsupplement) that does not contain a complex ionic mineral solution Eimeria acebulina ( Eimeria acervulina ) or E. tenella ( E. tenella ) After infection with protozoa, it is a graph analyzing the number of eggs excreted in feces. Control: Aemeria protozoa uninfected chickens fed a regular diet. **: p < 0.01.
도 2는 본 발명의 천연광물로부터 추출된 복합 이온미네랄 용액을 포함하는 사료(K1)를 급식한 닭과 복합 이온미네랄 용액을 포함하지 않는 사료(Unsupplement)를 급식한 닭에 아이메리아 아세불리나(Eimeria acervulina) 또는 아이메리아 테넬라(E. tenella) 원충을 감염시킨 후, 각 그룹의 닭 체중 변화를 분석한 그래프이다. Control: 일반 사료를 식이한 아이메리아 원충 비감염 닭, EA: 일반 사료 식이 후 아이메리아 아세불리라를 감염시킨 닭, K1+EA: K1 사료 식이 후 아이메리아 아세불리라를 감염시킨 닭, ET: 일반 사료 식이 후 아이메리아 테넬라를 감염시킨 닭, K1+ET: K1 사료 식이 후 아이메리아 테넬라를 감염시킨 닭.Figure 2 is a chicken fed a feed (K1) containing a complex ionic mineral solution extracted from the natural mineral of the present invention and a chicken fed a feed (Unsupplement) not containing the complex ionic mineral solution Eimeria acebulina ( Eimeria acervulina ) or E. tenella ( E. tenella ) After infection with protozoa, it is a graph analyzing the change in chicken weight in each group. Control: A. acebulira-infected chickens fed a regular diet, EA: chickens infected with A. acebulira after a normal diet, K1+EA: chickens infected with A. acebulira after a K1 diet, ET: normal Chickens infected with A. tenella after feeding, K1+ET: Chickens infected with A. tenella after feeding on K1 diet.
본 발명의 목적을 달성하기 위하여, 본 발명은 복합 이온미네랄 용액을 유효성분으로 함유하는 콕시듐증의 예방 또는 치료용 수의학적 조성물을 제공한다.In order to achieve the object of the present invention, the present invention provides a veterinary composition for preventing or treating coccidiosis containing a complex ionic mineral solution as an active ingredient.
본 발명의 수의학적 조성물에 있어서, 상기 복합 이온미네랄 용액은 철광석, 일메라이트(Ilmenite), 맥반석, 견운모 중에서 선택되는 천연 광물을 100~300 매쉬(mesh) 범위의 분말로 분쇄하고, 그 분말 1-15 중량%에 무기산 15-30 중량%와 잔량은 물로 하여 100 중량%를 이룬 후, 50-80℃ 범위에서 24시간 내지 72시간 동안 교반한 후 여과한 여액(filtrate)일 수 있다.In the veterinary composition of the present invention, the complex ionic mineral solution is a natural mineral selected from iron ore, ilmenite, elvan, and sericite, pulverized into a powder in the range of 100 to 300 mesh, and the powder 1- It may be a filtrate filtered after 15-30 wt% of the inorganic acid and 15-30 wt% of the inorganic acid and the remaining amount is 100 wt% water, followed by stirring at 50-80°C for 24 hours to 72 hours.
상기 무기산은 황산, 염산, 질산, 인산 등일 수 있으며, 바람직하게는 황산일수 있으나, 이에 제한되지 않는다.The inorganic acid may be sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid, etc., preferably sulfuric acid, but is not limited thereto.
본 발명에 따른 복합 이온미네랄은 황, 철, 알루미늄, 아연, 코발트, 구리, 바나듐, 칼슘, 칼륨, 스트론튬, 마그네슘, 나트륨, 티타늄, 망간, 규소, 인, 붕소, 니켈, 크롬, 비소, 납 및 몰리브덴 성분이 포함될 수 있다.The complex ionic minerals according to the present invention include sulfur, iron, aluminum, zinc, cobalt, copper, vanadium, calcium, potassium, strontium, magnesium, sodium, titanium, manganese, silicon, phosphorus, boron, nickel, chromium, arsenic, lead and A molybdenum component may be included.
또한, 본 발명의 수의학적 조성물에 있어서, 상기 콕시듐증은 이로 한정되는 것은 아니나, 바람직하게는 닭 콕시듐증일 수 있고, 상기 닭(또는 병아리)의 콕시듐증은 아이메리아 테넬라(Eimeria tenella), 아이메리아 아세불리나(E. acervulina), 아이메리아 네카트릭스(E. necatrix), 아이메리아 멕시마(E. maxima) 또는 아이메리아 브루네티(E. brunetti)의 원충에 의해 유발되는 것일 수 있으나, 이에 제한되지 않는다.In addition, in the veterinary composition of the present invention, the coccidiosis is not limited thereto, but preferably may be chicken coccidiosis, and the chicken (or chick) coccidiosis is Eimeria tenella , Eimeria ace Bulina ( E. acervulina ), E. necatrix ( E. necatrix ), E. maxima ( E. maxima ) or E. brunetti ( E. brunetti ) It may be caused by a protozoa, but is limited thereto doesn't happen
본 발명에서 용어 "예방"은 본 발명의 수의학적 조성물의 투여로 인하여 동물의 면역력을 향상시켜 상기 콕시듐증이 발생하지 않거나 발생 정도를 완화시키는 행위를 의미하며, 상기 "치료"는 본 발명의 수의학적 조성물의 투여로 인하여 동물에게 발생된 상기 콕시듐증이 호전 또는 이롭게 변경하는 행위를 의미하며, 임상적 증상을 없애거나 발생 정도를 완화하는 행위를 의미한다.In the present invention, the term "prevention" refers to an act of improving the immunity of an animal by administering the veterinary composition of the present invention to prevent or alleviate the occurrence of the coccidiosis, and the "treatment" is the veterinary medicine of the present invention. It refers to the act of improving or beneficially changing the coccidiosis occurring in the animal due to the administration of the composition, and it refers to the act of eliminating clinical symptoms or alleviating the degree of occurrence.
또한, 본 발명의 수의학적 조성물은 상기 수의학적 조성물이 약학적 조성물의 형태로 제공이 되는 경우에는, 본 발명에 따른 상기 복합 이온미네랄 용액 이외에 하나 이상의 약학적으로 허용되는 담체 또는 희석제를 추가로 함유할 수 있다. 용어 "약학적으로 허용되는"이란 생리학적으로 허용되고 동물에게 투여될 때, 활성성분의 작용을 저해하지 않으며 통상적으로 위장 장애, 알레르기 반응 또는 이와 유사한 반응을 일으키지 않는 비독성의 물질을 말한다.In addition, the veterinary composition of the present invention further contains one or more pharmaceutically acceptable carriers or diluents in addition to the complex ionic mineral solution according to the present invention when the veterinary composition is provided in the form of a pharmaceutical composition. can do. The term "pharmaceutically acceptable" refers to a non-toxic substance that is physiologically acceptable and does not inhibit the action of an active ingredient and does not normally cause gastrointestinal disorders, allergic reactions or similar reactions when administered to animals.
상기 약학적으로 허용되는 담체로는 예컨대, 경구 투여용 담체 또는 비경구 투여용 담체를 포함할 수 있다. 경구 투여용 담체는 락토스, 전분, 셀룰로스 유도체, 마그네슘 스테아레이트, 스테아르산 등을 포함할 수 있다. 또한, 비경구 투여용 담체는 물, 적합한 오일, 식염수, 수성 글루코오스 및 글리콜 등을 포함할 수 있으며, 안정화제 및 보존제를 추가로 포함할 수 있다. 적합한 안정화제로는 아황산수소나트륨, 아황산나트륨 또는 아스코르브산과 같은 항산화제가 있다. 적합한 보존제로는 벤즈알코늄 클로라이드, 메틸- 또는 프로필-파라벤 및 클로로부탄올이 있다. 본 발명의 약학적 조성물은 상기 성분들 이외에 윤활제, 습윤제, 감미제, 향미제, 유화제, 현택제 등을 추가로 포함할 수 있다.The pharmaceutically acceptable carrier may include, for example, a carrier for oral administration or a carrier for parenteral administration. Carriers for oral administration may include lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like. In addition, the carrier for parenteral administration may include water, a suitable oil, saline, aqueous glucose and glycol, and the like, and may further include a stabilizer and a preservative. Suitable stabilizers include antioxidants such as sodium hydrogen sulfite, sodium sulfite or ascorbic acid. Suitable preservatives include benzalkonium chloride, methyl- or propyl-paraben and chlorobutanol. The pharmaceutical composition of the present invention may further include a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, etc. in addition to the above components.
본 발명의 수의학적 조성물은 동물에게 단독으로 투여하거나 사료와 조합하여 투여할 수도 있다. 상기 수의학적 조성물을 동물 사료와 별도로 투여할 경우, 당해 기술분야에 잘 알려진 바와 같이 약제학적으로 허용 가능한 식용 담체와 조합하여, 즉시 방출 또는 서방성 제형으로 제조할 수 있다. 이러한 식용 담체는 고체 또는 액체, 예를 들어 옥수수 전분, 락토오스, 수크로오스, 콩 플레이크, 땅콩유, 올리브유, 참깨유 및 프로필렌 글리콜일 수 있고, 고체 담체가 사용될 경우, 사료는 정제, 캡슐제, 산제, 트로키제 또는 함당정제 또는 미분산성 형태의 탑 드레싱일 수 있으며, 액체 담체가 사용될 경우, 사료는 젤라틴 연질 캡슐제, 또는 시럽제나 현탁액, 에멀젼제, 또는 용액제의 제형일 수 있으나, 이에 한정되는 것은 아니다.The veterinary composition of the present invention may be administered to an animal alone or in combination with a feed. When the veterinary composition is administered separately from the animal feed, it can be combined with a pharmaceutically acceptable edible carrier as is well known in the art to prepare an immediate release or sustained release formulation. Such edible carriers can be solid or liquid, for example corn starch, lactose, sucrose, soy flakes, peanut oil, olive oil, sesame oil and propylene glycol, and when a solid carrier is used, the feed can be prepared in tablets, capsules, powders, It may be a troche or sugar-containing tablet or micro-dispersed top dressing, and when a liquid carrier is used, the feed may be in the form of a gelatin soft capsule, syrup, suspension, emulsion, or solution, but is not limited thereto. it is not
본 발명의 수의학적 조성물이 동물에게 투여 시, 경구 또는 비경구적으로 투여할 수 있다. 비경구적인 투여방법으로는 이에 한정되지는 않으나, 정맥내, 근육내, 동맥내, 골수내, 경막내, 심장내, 경피, 피하, 복강내, 비강내, 장관, 국소, 설하 또는 직장내 투여일 수 있다.When the veterinary composition of the present invention is administered to an animal, it may be administered orally or parenterally. Parenteral administration methods include, but are not limited to, intravenous, intramuscular, intraarterial, intramedullary, intrathecal, intracardiac, transdermal, subcutaneous, intraperitoneal, intranasal, enteral, topical, sublingual or rectal administration. can be
본 발명은 또한, 복합 이온미네랄 용액을 유효성분으로 포함하는 콕시듐증의 예방 또는 개선용 사료첨가제 조성물을 제공한다.The present invention also provides a feed additive composition for preventing or improving coccidiosis comprising a complex ionic mineral solution as an active ingredient.
본 발명의 사료첨가제 조성물에 있어서, 상기 복합 이온미네랄 용액 및 콕시듐증은 전술한 바와 같다.In the feed additive composition of the present invention, the complex ionic mineral solution and coccidiosis are as described above.
본 발명의 사료첨가제 조성물은 동물 특히, 가금류를 포함하는 가축의 콕시듐증을 예방 또는 완화시킬 수 있다.The feed additive composition of the present invention can prevent or alleviate coccidiosis of animals, particularly livestock including poultry.
본 발명의 일 구현 예에서, 상기 사료첨가제 조성물은 추가적으로 가축 특히, 가금류 등에 허용되는 담체를 함유할 수 있다. 본 발명에 있어서는 상기 사료첨가제 조성물은 필요에 따라 비타민, 아미노산류, 미네랄 등의 각종 양분, 항산화제, 항생물질, 항균제 및 기타의 첨가제 등을 가할 수도 있으며, 그 형상으로서는 분체, 과립, 펠릿, 현탁액 등의 적당한 상태일 수 있다.In one embodiment of the present invention, the feed additive composition may additionally contain an acceptable carrier for livestock, particularly poultry. In the present invention, the feed additive composition may be added with various nutrients such as vitamins, amino acids, minerals, antioxidants, antibiotics, antibacterial agents and other additives as necessary, and the shape thereof is powder, granule, pellet, suspension It may be in a suitable state, such as
본 발명은 또한, 상기 사료첨가제 조성물을 포함하는 콕시듐증의 예방 또는 개선용 사료를 제공한다.The present invention also provides a feed for preventing or improving coccidiosis comprising the feed additive composition.
본 발명의 일 구현 예에서, 상기 사료첨가제는 바람직하게는 복합 이온미네랄 용액일 수 있고, 상기 복합 이온미네랄 용액은 사료 조성물 기준으로 0.000008 내지 0.0001 내지 중량 % 배합되는 것일 수 있으나, 이에 제한되지 않는다.In one embodiment of the present invention, the feed additive may be preferably a complex ionic mineral solution, and the complex ionic mineral solution may be formulated in an amount of 0.000008 to 0.0001 to weight % based on the feed composition, but is not limited thereto.
본 발명에 있어서, 용어 "사료"는 동물이 먹고, 섭취하며, 소화시키기 위한 또는 이에 적당한 임의의 천연 또는 인공 규정식, 한끼식 등 또는 상기 한끼식의 성분을 의미한다.In the present invention, the term "feed" refers to any natural or artificial diet, one meal, etc., or a component of the one meal meal, which is suitable for or for the animal to eat, ingest, and digest.
본 발명의 사료는 가루 및 펠릿과 같은 종래의 사료 조성물의 형태로 제조될 수 있으나, 이에 제한되지 않고, 당업계에 알려진 다양한 형태의 사료로 제조가 가능하다.The feed of the present invention may be prepared in the form of a conventional feed composition such as powder and pellets, but is not limited thereto, and can be prepared in various types of feed known in the art.
본 발명의 사료는 영양 보충제, 소화 및 흡수 향상제, 성장 촉진제 등을 더 포함할 수 있으며, 곡물(예를 들면. 분쇄 또는 파쇄된 밀, 귀리, 보리, 옥수수, 쌀), 식물성 단백질(예를 들면, 평지, 콩, 및 해바라기), 동물성 단백질(예를 들면, 혈분, 육분, 골분 및 생선분), 당분 및 유제품(예를 들면 각종 분유 및 유장 분말로 이루어지는 건조 성분 등)을 더 포함할 수 있으나, 특별히 제한되는 바가 없으며, 당 분야에서 통상적으로 사용되는 것은 모두 사용 가능하다.The feed of the present invention may further contain nutritional supplements, digestion and absorption enhancers, growth promoters, and the like, and include grains (eg, milled or crushed wheat, oats, barley, corn, rice), plant proteins (eg, , rape, soybean, and sunflower), animal protein (eg, blood meal, meat meal, bone meal, and fish meal), sugar and dairy products (such as dry ingredients consisting of various milk powder and whey powder, etc.) , there is no particular limitation, and all those commonly used in the art may be used.
본 발명은 또한, 본 발명에 따른 사료를 가축에 급여하여 가축의 콕시듐증을 예방 또는 개선하는 방법을 제공한다.The present invention also provides a method for preventing or improving coccidiosis in livestock by feeding the feed according to the present invention to livestock.
이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail by way of Examples. However, the following examples are only illustrative of the present invention, and the content of the present invention is not limited to the following examples.
제조예 1. 복합 이온미네랄Preparation Example 1. Complex Ion Minerals
용액의 제조Preparation of solution
천연광물인 철광석을 150 매쉬 이하의 분말로 분쇄하고, 그 분말 10 중량%를 황산 25 중량%와 잔량은 물로하여 100 중량%로 조정한 후, 60℃에서 48시간 교반하고, 상온으로 냉각한 후 수 시간 정치 후 상등액을 취하고 잔량은 여과지로 여과하여 여액을 취하였다. 상기 여액은 외관은 연한 노랑색 투명 용액상태로 상기 여액을 복합 이온미네랄 용액으로 명명하였다.Iron ore, a natural mineral, is pulverized into a powder of 150 mesh or less, 10 wt% of the powder is adjusted to 100 wt% with 25 wt% sulfuric acid and the balance is water, stirred at 60°C for 48 hours, and cooled to room temperature. After standing for several hours, the supernatant was taken, and the remaining amount was filtered with filter paper to obtain a filtrate. The filtrate was a light yellow transparent solution in appearance, and the filtrate was named a complex ionic mineral solution.
상기 복합 이온미네랄 용액을 한국기초과학지원연구원에 의뢰하여 성분 분석을 실시하였고, 그 결과 복합 이온미네랄 용액은 황, 철 및 알루미늄을 주성분으로 하여, 아연, 코발트, 구리, 바나듐, 칼슘, 칼륨, 스트론튬, 마그네슘, 나트륨, 티타늄, 망간, 규소, 인, 붕소, 니켈, 크롬, 비소, 납 및 몰리브덴의 성분으로 구성되어 있음을 알 수 있었다.The complex ionic mineral solution was commissioned by the Korea Basic Science Institute for component analysis. As a result, the complex ionic mineral solution contains sulfur, iron, and aluminum as main components, and contains zinc, cobalt, copper, vanadium, calcium, potassium, and strontium. , magnesium, sodium, titanium, manganese, silicon, phosphorus, boron, nickel, chromium, arsenic, lead and molybdenum.
또한, 한국화학융합시험연구원과 한국화학연구원(안전성평가연구소)에서 수행한 독성시험 결과 본 발명의 복합 이온미네랄 용액은 생체에 무해한 것으로 확인되었다.In addition, as a result of toxicity tests conducted by the Korea Research Institute of Chemical Convergence Testing and the Korea Research Institute for Chemical Safety (Safety Evaluation Research Institute), it was confirmed that the complex ionic mineral solution of the present invention is harmless to the living body.
| 구분division | 반수치사량 (㎎/㎏)Half lethal dose (mg/kg) |
자극성 평가점수pepper evaluation score |
비고note |
| 급성경구독성Acute oral toxicity | > 5,000> 5,000 | -- | 사망 실험동물 "0"death test animal "0" |
| 급성경피독성Acute dermal toxicity | > 4,000> 4,000 | -- | 사망 실험동물 "0"death test animal "0" |
| 피부자극성skin irritation | -- | 0.00.0 | |
| 피부감작성skin sensitization | -- | 0.00.0 | |
| 안점막자극eye mucous membrane irritation | -- | 0.00.0 | |
| 어류독성Fish toxicity | > 10> 10 | -- | 사망 실험동물 "0"death test animal "0" |
| 물벼룩 급성유영저해Daphnia acute swimming inhibition | > 100> 100 | -- | 사망 실험동물 "0"death test animal "0" |
| 조류경구독성Avian Oral Toxicity | > 2,000> 2,000 | -- | 사망 실험동물 "0"death test animal "0" |
| 아급성경구독성Subacute oral toxicity | > 1,000> 1,000 | -- | 사망 실험동물 "0"death test animal "0" |
| 아급성경피독성Subacute dermal toxicity | > 1,000> 1,000 | -- | 사망 실험동물 "0"death test animal "0" |
| 유전독성(복귀돌연변이시험)Genotoxicity (reversion mutation test) | > 5,000> 5,000 | -- | 유전자 변이 "0"genetic mutation "0" |
실시예 1. 복합 이온미네랄 용액의 항콕시듐 효과Example 1. Anticoccidium effect of complex ionic mineral solution
본 발명의 복합 이온미네랄 용액의 항콕시듐 효과를 분석하였다. 실험은 복합 이온미네랄 용액을 닭(육계) 사료(항생제, 항콕시듐제가 포함되지 않은 사료)에 10,000배로 희석하여 섞어준 후 콕시듐 원충 접종 2일 전부터 시험기간 동안 급여한 실험군(K1)과, 복합 이온미네랄 용액을 섞지 않은 사료를 동일기간 급여한 그룹을 정상군(control), 복합 이온미네랄 용액을 섞지 않은 사료를 콕시듐 원충 접종 2일 전부터 시험기간 동안 급여한 그룹을 비교군(Unsupplement)으로 나누어 수행하였다. 콕시듐 원충 (E. tenella 또는 E. acervulina)은 구강으로, 포자가 형성된 충란(1x104 개 충란/닭 개체)을 감염시켰다. 충란을 감염시킨 후 6-9일 사이에 각각의 분변으로 배출되는 충란 수를 분석하였다. The anticoccidium effect of the complex ionic mineral solution of the present invention was analyzed. For the experiment, the complex ion-mineral solution was diluted 10,000 times with chicken (broiler) feed (fed without antibiotics and anticoccidium), and the experimental group (K1) fed during the test period 2 days before coccidium protozoa inoculation, and complex ions The group fed the feed without the mineral solution for the same period was divided into the normal group (control), and the group fed the feed without the complex ionic mineral solution during the test period 2 days before the coccidium protozoa inoculation was divided into the control group (Unsupplement). . Coccidium protozoa ( E. tenella or E. acervulina ) infected spore-forming eggs (1x10 4 eggs/chicken individual) orally. The number of eggs excreted in each feces between 6 and 9 days after infection was analyzed.
그 결과, 본 발명의 복합 이온미네랄 용액이 사료와 함께 처리된 실험군(K1)에서 비교군(Unsupplement) 대비 분변으로 배설되는 충란의 수가 현저하게 감소되었음을 확인할 수 있었다(도 1). 또한, 정상군(control)과 비교하여 실험군 및 비교군 모두에서 시험기간 동안 체중 변화에는 차이가 없음을 확인할 수 있었다(도 2). 상기 결과를 통해 본 발명에 따른 복합 이온미네랄 용액은 닭에 독성을 보이지 않으면서, 콕시듐 원충의 증식을 효과적으로 억제하는 것임을 알 수 있었다.As a result, it was confirmed that the number of eggs excreted in feces was significantly reduced in the experimental group (K1) treated with the compound ionic mineral solution of the present invention as compared to the control group (Unsupplement) (FIG. 1). In addition, it was confirmed that there was no difference in body weight change during the test period in both the experimental group and the control group compared with the control group ( FIG. 2 ). From the above results, it was found that the complex ionic mineral solution according to the present invention effectively inhibits the proliferation of coccidium protozoa without showing toxicity to chickens.
Claims (6)
- 복합 이온미네랄을 유효성분으로 함유하는 콕시듐증의 예방 또는 치료용 수의학적 조성물.A veterinary composition for preventing or treating coccidiosis containing complex ionic minerals as an active ingredient.
- 제1항에 있어서, 상기 복합 이온미네랄은 철광석, 일메라이트, 맥반석, 견운모 중에서 선택되는 천연 광물을 100~300 매쉬(mesh) 범위의 분말로 분쇄하고, 그 분말 1-15 중량%에 무기산 15-30 중량%와 잔량은 물로 하여 100 중량%를 이룬 후, 50-80℃ 범위에서 24시간 내지 72시간 동안 교반한 후 여과한 여액(filtrate)인 것을 특징으로 하는 수의학적 조성물.The method according to claim 1, wherein the complex ionic mineral is obtained by pulverizing a natural mineral selected from iron ore, ilmerite, elvanite, and sericite into a powder in the range of 100 to 300 mesh, and 1-15 wt% of the powder contains inorganic acid 15- A veterinary composition, characterized in that 30% by weight and the remaining amount is 100% by weight of water, and then the filtrate is filtered after stirring at 50-80°C for 24 hours to 72 hours.
- 제1항에 있어서, 상기 콕시듐증은 닭 콕시듐증인 것을 특징으로 하는 수의학적 조성물.The veterinary composition according to claim 1, wherein the coccidiosis is chicken coccidiosis.
- 복합 이온미네랄을 유효성분으로 포함하는 콕시듐증의 예방 또는 개선용 사료첨가제 조성물.A feed additive composition for preventing or improving coccidiosis comprising complex ionic minerals as an active ingredient.
- 제4항의 사료첨가제 조성물을 포함하는 콕시듐증의 예방 또는 개선용 사료.A feed for preventing or improving coccidiosis comprising the feed additive composition of claim 4.
- 제5항의 사료를 가축에 급여하여 가축의 콕시듐증을 예방 또는 개선하는 방법.A method for preventing or improving coccidiosis of livestock by feeding the feed of claim 5 to livestock.
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| KR1020210020924A KR102259950B1 (en) | 2021-02-17 | 2021-02-17 | Composition for preventing or reducing Coccidiosis comprising complex ionized mineral as effective component |
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Citations (5)
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|---|---|---|---|---|
| WO2014086959A1 (en) * | 2012-12-07 | 2014-06-12 | Ceva Sante Animale | Treatment of coccidiosis with intramuscular triazine compositions |
| KR20140096431A (en) * | 2013-01-25 | 2014-08-06 | 대한뉴팜(주) | Pellet-Type Composition for Prevention of Coccidiosis Symptom of Cattle Using Monensin and Manufacturing Method Thereof |
| KR101705319B1 (en) * | 2016-06-03 | 2017-02-14 | 주식회사 에이엠바이오 | Additive composition for livestock feed and manufacturing method of functional feed using thereof |
| KR20190062142A (en) * | 2017-11-28 | 2019-06-05 | (주)비티엔 | Amino acid mineral complex with immune enhancing activities and food, drug or feed compositon comprising it |
| KR102259950B1 (en) * | 2021-02-17 | 2021-06-02 | 경상국립대학교산학협력단 | Composition for preventing or reducing Coccidiosis comprising complex ionized mineral as effective component |
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| WO2014086959A1 (en) * | 2012-12-07 | 2014-06-12 | Ceva Sante Animale | Treatment of coccidiosis with intramuscular triazine compositions |
| KR20140096431A (en) * | 2013-01-25 | 2014-08-06 | 대한뉴팜(주) | Pellet-Type Composition for Prevention of Coccidiosis Symptom of Cattle Using Monensin and Manufacturing Method Thereof |
| KR101705319B1 (en) * | 2016-06-03 | 2017-02-14 | 주식회사 에이엠바이오 | Additive composition for livestock feed and manufacturing method of functional feed using thereof |
| KR20190062142A (en) * | 2017-11-28 | 2019-06-05 | (주)비티엔 | Amino acid mineral complex with immune enhancing activities and food, drug or feed compositon comprising it |
| KR102259950B1 (en) * | 2021-02-17 | 2021-06-02 | 경상국립대학교산학협력단 | Composition for preventing or reducing Coccidiosis comprising complex ionized mineral as effective component |
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