KR20140088887A - mGluR2-음성 알로스테릭 조절제로서의 퀴놀린 카르복스아미드 및 퀴놀린 카르보니트릴 유도체, 조성물, 및 그의 용도 - Google Patents

mGluR2-음성 알로스테릭 조절제로서의 퀴놀린 카르복스아미드 및 퀴놀린 카르보니트릴 유도체, 조성물, 및 그의 용도 Download PDF

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KR20140088887A
KR20140088887A KR1020147014513A KR20147014513A KR20140088887A KR 20140088887 A KR20140088887 A KR 20140088887A KR 1020147014513 A KR1020147014513 A KR 1020147014513A KR 20147014513 A KR20147014513 A KR 20147014513A KR 20140088887 A KR20140088887 A KR 20140088887A
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alkyl
group
phenyl
compound
stereoisomer
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크리스토퍼 제임스 번가드
안토넬라 콘베르소
파블로 드 레옹
바바라 헤니
티모시 존 하팅
제시 조셉 마니코브스키
피터 제이. 맨리
로버트 마이스너
쟈오양 멍
제임스 제이. 퍼킨스
마이클 티. 루드
요우헝 슈
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머크 샤프 앤드 돔 코포레이션
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
KR1020147014513A 2011-11-03 2012-10-26 mGluR2-음성 알로스테릭 조절제로서의 퀴놀린 카르복스아미드 및 퀴놀린 카르보니트릴 유도체, 조성물, 및 그의 용도 Withdrawn KR20140088887A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161555227P 2011-11-03 2011-11-03
US61/555,227 2011-11-03
US201261672334P 2012-07-17 2012-07-17
US61/672,334 2012-07-17
PCT/US2012/062027 WO2013066736A1 (en) 2011-11-03 2012-10-26 QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Publications (1)

Publication Number Publication Date
KR20140088887A true KR20140088887A (ko) 2014-07-11

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KR1020147014513A Withdrawn KR20140088887A (ko) 2011-11-03 2012-10-26 mGluR2-음성 알로스테릭 조절제로서의 퀴놀린 카르복스아미드 및 퀴놀린 카르보니트릴 유도체, 조성물, 및 그의 용도

Country Status (16)

Country Link
US (3) US9278960B2 (enrdf_load_stackoverflow)
EP (1) EP2775841B1 (enrdf_load_stackoverflow)
JP (2) JP5857136B2 (enrdf_load_stackoverflow)
KR (1) KR20140088887A (enrdf_load_stackoverflow)
CN (1) CN104010504B (enrdf_load_stackoverflow)
AR (1) AR088611A1 (enrdf_load_stackoverflow)
AU (2) AU2012332895B2 (enrdf_load_stackoverflow)
CA (1) CA2853923A1 (enrdf_load_stackoverflow)
CO (1) CO6950474A2 (enrdf_load_stackoverflow)
IL (1) IL232291A0 (enrdf_load_stackoverflow)
IN (1) IN2014CN03234A (enrdf_load_stackoverflow)
MX (1) MX344308B (enrdf_load_stackoverflow)
MY (1) MY167423A (enrdf_load_stackoverflow)
RU (1) RU2610262C2 (enrdf_load_stackoverflow)
TW (1) TWI605040B (enrdf_load_stackoverflow)
WO (1) WO2013066736A1 (enrdf_load_stackoverflow)

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JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
MX370438B (es) * 2014-03-24 2019-12-13 Guangdong Zhongsheng Pharmaceutical Co Ltd Derivados quinolina como inhibidores smo.
JP6661605B2 (ja) 2014-08-01 2020-03-11 ヤンセン ファーマシューティカ エヌ．ベー． ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
ES2707525T3 (es) 2014-08-01 2019-04-03 Janssen Pharmaceutica Nv Compuestos de 6,7-dihidropirazolo[1,5-a]pirazin-4(5H)-ona y su uso como moduladores alostéricos negativos de receptores de mGlu2
JO3601B1 (ar) 2014-08-01 2020-07-05 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
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EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
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RU2711382C2 (ru) * 2014-12-03 2020-01-16 Янссен Фармацевтика Нв 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2
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