KR20140023869A - 하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용 - Google Patents

하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용 Download PDF

Info

Publication number
KR20140023869A
KR20140023869A KR1020137012799A KR20137012799A KR20140023869A KR 20140023869 A KR20140023869 A KR 20140023869A KR 1020137012799 A KR1020137012799 A KR 1020137012799A KR 20137012799 A KR20137012799 A KR 20137012799A KR 20140023869 A KR20140023869 A KR 20140023869A
Authority
KR
South Korea
Prior art keywords
methyl
buta
diynyl
hydroxyamino
benzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020137012799A
Other languages
English (en)
Korean (ko)
Inventor
라메쉬 카사르
마틴 셔링엄 린셀
제임스 브래들리 아겐
칭 루 (제인)
댄 왕
팀 처치
하인즈 이. 모저
필립 에이. 패튼
Original Assignee
아카오젠, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아카오젠, 인코포레이티드 filed Critical 아카오젠, 인코포레이티드
Publication of KR20140023869A publication Critical patent/KR20140023869A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020137012799A 2010-11-10 2011-11-04 하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용 Withdrawn KR20140023869A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41231110P 2010-11-10 2010-11-10
US61/412,311 2010-11-10
PCT/US2011/059280 WO2012154204A1 (en) 2010-11-10 2011-11-04 Hydroxamic acid derivatives and their use in the treatment of bacterial infections

Publications (1)

Publication Number Publication Date
KR20140023869A true KR20140023869A (ko) 2014-02-27

Family

ID=46317476

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137012799A Withdrawn KR20140023869A (ko) 2010-11-10 2011-11-04 하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용

Country Status (14)

Country Link
EP (1) EP2638006A1 (cg-RX-API-DMAC10.html)
JP (1) JP2014501716A (cg-RX-API-DMAC10.html)
KR (1) KR20140023869A (cg-RX-API-DMAC10.html)
CN (1) CN103298780A (cg-RX-API-DMAC10.html)
AR (1) AR083760A1 (cg-RX-API-DMAC10.html)
AU (1) AU2011367819A1 (cg-RX-API-DMAC10.html)
BR (1) BR112013011693A2 (cg-RX-API-DMAC10.html)
CA (1) CA2817211A1 (cg-RX-API-DMAC10.html)
EA (1) EA201390626A1 (cg-RX-API-DMAC10.html)
IL (1) IL226270A0 (cg-RX-API-DMAC10.html)
MX (1) MX2013005200A (cg-RX-API-DMAC10.html)
SG (1) SG190243A1 (cg-RX-API-DMAC10.html)
TW (1) TW201249786A (cg-RX-API-DMAC10.html)
WO (1) WO2012154204A1 (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2691987C (en) 2007-06-12 2016-08-16 Achaogen, Inc. Antibacterial agents
EP2847162A1 (en) * 2012-05-09 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
KR20160098503A (ko) 2013-12-19 2016-08-18 액테리온 파마슈티칼 리미티드 항균성 1h-인다졸 및 1h-인돌 유도체
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
WO2015173329A1 (en) 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
BR112017010474A2 (pt) 2014-11-19 2017-12-26 Actelion Pharmaceuticals Ltd derivados antibacterianos de benzotiazol
HUE047225T2 (hu) 2014-12-16 2020-04-28 Novartis Ag LpxC inhibitor izoxazol hidroxámsav-vegyületek
AU2017257755B2 (en) 2016-04-25 2021-05-06 Duke University Benzoylglycine derivatives and methods of making and using same
SMT202000524T1 (it) 2016-06-14 2020-11-10 Novartis Ag Forma cristallina di (r)-4-(5-(ciclopropiletinil)isossazol-3-il)-n-idrossi-2-metil-2-(metilsolfonil)butanammide come agente antibatterico
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
KR102868718B1 (ko) * 2018-02-10 2025-10-14 케이비피 바이오사이언시즈 씨오., 엘티디. 항생제로서 작용하는 화합물
CN110563611B (zh) * 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
CN113957098A (zh) * 2021-09-13 2022-01-21 湖南工业大学 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用
CN116730870B (zh) 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
US6716878B1 (en) 1999-04-09 2004-04-06 Vernalis (Oxford) Limited Antimicrobial agents
ES2387803T3 (es) * 2003-01-08 2012-10-02 Novartis Vaccines And Diagnostics, Inc. Agentes antibacterianos
DE102006032709A1 (de) 2006-07-14 2008-01-17 BSH Bosch und Siemens Hausgeräte GmbH Luftschallgedämmte Lebensmittelmühle
CN101209974A (zh) * 2006-12-31 2008-07-02 天津药物研究院 异羟肟酸类衍生物及其用途
CA2691987C (en) * 2007-06-12 2016-08-16 Achaogen, Inc. Antibacterial agents
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
RS59255B1 (sr) * 2010-04-20 2019-10-31 Fujifilm Toyama Chemical Co Ltd Derivat hidroksaminske kiseline

Also Published As

Publication number Publication date
IL226270A0 (en) 2013-07-31
CN103298780A (zh) 2013-09-11
EA201390626A1 (ru) 2013-12-30
MX2013005200A (es) 2013-06-28
EP2638006A1 (en) 2013-09-18
BR112013011693A2 (pt) 2016-08-09
WO2012154204A1 (en) 2012-11-15
SG190243A1 (en) 2013-06-28
AU2011367819A1 (en) 2013-05-02
AR083760A1 (es) 2013-03-20
CA2817211A1 (en) 2012-11-15
TW201249786A (en) 2012-12-16
JP2014501716A (ja) 2014-01-23

Similar Documents

Publication Publication Date Title
WO2012154204A1 (en) Hydroxamic acid derivatives and their use in the treatment of bacterial infections
US9701622B2 (en) Antibacterial agents
JP5550650B2 (ja) 細菌感染症処置に適用するための有機化合物
JP5539864B2 (ja) 抗菌剤
CA2512582C (en) Antibacterial agents
HUP0102901A2 (hu) N-formil-hidroxilamin-származékok alkalmazása antibakteriális szerként
WO2014165075A1 (en) Antibacterial agents
US20150175530A1 (en) Antibacterial agents
US9303027B2 (en) Kappa opioid receptor agonists
US20150203444A1 (en) Polymorphs of n-((s)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1r,2r)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide
TW200524578A (en) Protease inhibitors
JP6034960B2 (ja) フッ素置換（３ｒ、４ｒ、５ｓ）−５−グアニジノ−４−アセトアミド−３−（ペンタン−３−イルオキシ）シクロヘキセン−１−カルボン酸、そのエステル及びその使用
KR20210131329A (ko) 카르바메이트 유도체 및 이의 용도
US20230138583A1 (en) Substituted 2-aminobenzimidazoles analogs as antibiofilm agents
JP2013028536A (ja) 環状アミン−１−カルボン酸エステル誘導体およびそれを含有する医薬組成物
JPH09188631A (ja) Ｆａｓリガンド可溶化抑制薬

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20130516

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid