KR20140003379A - 스핑고신 1-포스페이트(ｓ１ｐ) 수용체들에 대한 리간드들로서의 5-(바이페닐-4-일)-3-페닐-1,2,4-옥사디아졸릴 유도체들 - Google Patents
스핑고신 1-포스페이트(ｓ１ｐ) 수용체들에 대한 리간드들로서의 5-(바이페닐-4-일)-3-페닐-1,2,4-옥사디아졸릴 유도체들 Download PDFInfo
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- KR20140003379A KR20140003379A KR20137003335A KR20137003335A KR20140003379A KR 20140003379 A KR20140003379 A KR 20140003379A KR 20137003335 A KR20137003335 A KR 20137003335A KR 20137003335 A KR20137003335 A KR 20137003335A KR 20140003379 A KR20140003379 A KR 20140003379A
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- methyl
- formula
- tert
- butyl
- ethyl
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- IQDMTAVFQGXHBE-UHFFFAOYSA-N tert-butyl 2-[(4-cyano-2-fluorophenyl)methylamino]-3-[(2-methylpropan-2-yl)oxy]propanoate Chemical compound CC(C)(C)OCC(C(=O)OC(C)(C)C)NCC1=CC=C(C#N)C=C1F IQDMTAVFQGXHBE-UHFFFAOYSA-N 0.000 description 1
- NGCUUWDYTRAPBS-UHFFFAOYSA-N tert-butyl 2-[1-(4-cyanophenyl)ethylideneamino]acetate Chemical compound CC(C)(C)OC(=O)CN=C(C)C1=CC=C(C#N)C=C1 NGCUUWDYTRAPBS-UHFFFAOYSA-N 0.000 description 1
- ACZCUMNKRUGMDJ-UHFFFAOYSA-N tert-butyl 2-[1-[4-(n'-hydroxycarbamimidoyl)phenyl]ethyl-methylamino]acetate Chemical compound CC(C)(C)OC(=O)CN(C)C(C)C1=CC=C(C(N)=NO)C=C1 ACZCUMNKRUGMDJ-UHFFFAOYSA-N 0.000 description 1
- SEMQOVVLEJTZQT-UHFFFAOYSA-N tert-butyl 2-[[1-(4-cyanophenyl)-2-hydroxyethyl]amino]acetate Chemical compound CC(C)(C)OC(=O)CNC(CO)C1=CC=C(C#N)C=C1 SEMQOVVLEJTZQT-UHFFFAOYSA-N 0.000 description 1
- XQJUOTDISDDWTN-UHFFFAOYSA-N tert-butyl 2-[[2-fluoro-4-[(e)-n'-hydroxycarbamimidoyl]phenyl]methylamino]-3-methylbutanoate Chemical compound CC(C)(C)OC(=O)C(C(C)C)NCC1=CC=C(C(N)=NO)C=C1F XQJUOTDISDDWTN-UHFFFAOYSA-N 0.000 description 1
- YAVOOYFWSBKOCK-UHFFFAOYSA-N tert-butyl 2-[[2-fluoro-4-[5-[3-(methoxymethyl)-4-(2-methylphenyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl-methylamino]-2-methylpropanoate Chemical compound COCC1=CC(C=2ON=C(N=2)C=2C=C(F)C(CN(C)C(C)(C)C(=O)OC(C)(C)C)=CC=2)=CC=C1C1=CC=CC=C1C YAVOOYFWSBKOCK-UHFFFAOYSA-N 0.000 description 1
- MLLOMIQNALXXKE-UHFFFAOYSA-N tert-butyl 2-[[2-fluoro-4-[5-[3-(methoxymethyl)-4-(2-methylphenyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methylamino]-2-methylpropanoate Chemical compound COCC1=CC(C=2ON=C(N=2)C=2C=C(F)C(CNC(C)(C)C(=O)OC(C)(C)C)=CC=2)=CC=C1C1=CC=CC=C1C MLLOMIQNALXXKE-UHFFFAOYSA-N 0.000 description 1
- WUEJRAVQKAPIFZ-UHFFFAOYSA-N tert-butyl 2-[[2-methoxy-1-[4-[5-[4-(2-methylphenyl)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-methylamino]acetate Chemical compound C1=CC(C(N(C)CC(=O)OC(C)(C)C)COC)=CC=C1C1=NOC(C=2C=C(C(C=3C(=CC=CC=3)C)=CC=2)C(F)(F)F)=N1 WUEJRAVQKAPIFZ-UHFFFAOYSA-N 0.000 description 1
- KJLWLXSAVXNACT-UHFFFAOYSA-N tert-butyl 2-[[3-fluoro-5-[(e)-n'-hydroxycarbamimidoyl]phenyl]methylamino]-2-methylpropanoate Chemical compound CC(C)(C)OC(=O)C(C)(C)NCC1=CC(F)=CC(C(N)=NO)=C1 KJLWLXSAVXNACT-UHFFFAOYSA-N 0.000 description 1
- CVAWKJKISIPBOD-UHFFFAOYSA-N tert-butyl 2-bromopropanoate Chemical compound CC(Br)C(=O)OC(C)(C)C CVAWKJKISIPBOD-UHFFFAOYSA-N 0.000 description 1
- WMOVHXAZOJBABW-UHFFFAOYSA-N tert-butyl acetate Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 description 1
- NBRKLOOSMBRFMH-UHFFFAOYSA-N tert-butyl chloride Chemical compound CC(C)(C)Cl NBRKLOOSMBRFMH-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 229960003433 thalidomide Drugs 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- JMXKSZRRTHPKDL-UHFFFAOYSA-N titanium ethoxide Chemical compound [Ti+4].CC[O-].CC[O-].CC[O-].CC[O-] JMXKSZRRTHPKDL-UHFFFAOYSA-N 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 229940100615 topical ointment Drugs 0.000 description 1
- 230000008359 toxicosis Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- GUYPYYARYIIWJZ-CYEPYHPTSA-N triamcinolone benetonide Chemical compound O=C([C@]12[C@H](OC(C)(C)O1)C[C@@H]1[C@@]2(C[C@H](O)[C@]2(F)[C@@]3(C)C=CC(=O)C=C3CC[C@H]21)C)COC(=O)C(C)CNC(=O)C1=CC=CC=C1 GUYPYYARYIIWJZ-CYEPYHPTSA-N 0.000 description 1
- 229950006782 triamcinolone benetonide Drugs 0.000 description 1
- 229960004320 triamcinolone diacetate Drugs 0.000 description 1
- 229960004221 triamcinolone hexacetonide Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
- 229940086542 triethylamine Drugs 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- WTVXIBRMWGUIMI-UHFFFAOYSA-N trifluoro($l^{1}-oxidanylsulfonyl)methane Chemical group [O]S(=O)(=O)C(F)(F)F WTVXIBRMWGUIMI-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- 238000001946 ultra-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 201000005539 vernal conjunctivitis Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10168833.1 | 2010-07-08 | ||
| EP10168833 | 2010-07-08 | ||
| US36274610P | 2010-07-09 | 2010-07-09 | |
| US61/362,746 | 2010-07-09 | ||
| PCT/EP2011/061372 WO2012004287A1 (en) | 2010-07-08 | 2011-07-06 | 5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate (s1p) receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140003379A true KR20140003379A (ko) | 2014-01-09 |
Family
ID=42341535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20137003335A Withdrawn KR20140003379A (ko) | 2010-07-08 | 2011-07-06 | 스핑고신 1-포스페이트(ｓ１ｐ) 수용체들에 대한 리간드들로서의 5-(바이페닐-4-일)-3-페닐-1,2,4-옥사디아졸릴 유도체들 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9029405B2 (enExample) |
| EP (1) | EP2590956B1 (enExample) |
| JP (1) | JP6014589B2 (enExample) |
| KR (1) | KR20140003379A (enExample) |
| CN (1) | CN103097365B (enExample) |
| AR (1) | AR082132A1 (enExample) |
| AU (1) | AU2011275854B2 (enExample) |
| CA (1) | CA2804473C (enExample) |
| EA (1) | EA201300092A1 (enExample) |
| ES (1) | ES2586145T3 (enExample) |
| IL (1) | IL224071B (enExample) |
| MX (1) | MX2012015021A (enExample) |
| SG (1) | SG186872A1 (enExample) |
| TW (1) | TW201206429A (enExample) |
| WO (1) | WO2012004287A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220142386A (ko) * | 2021-04-14 | 2022-10-21 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조방법 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102250035A (zh) * | 2011-06-10 | 2011-11-23 | 北京富卡生物技术有限公司 | 二芳基取代-1，3，4-噁二唑化合物的合成方法和其药物用途 |
| CN107857760A (zh) * | 2017-11-21 | 2018-03-30 | 南京天翔医药科技有限公司 | 鞘氨醇‑1‑磷酸受体调节剂及其应用 |
| FI4081511T3 (fi) * | 2019-12-23 | 2024-10-24 | Sitryx Therapeutics Ltd | Karboksijohdannaisia, joilla on anti-inflammatorisia ominaisuuksia |
| EP4126827B1 (en) * | 2020-03-27 | 2024-11-20 | Receptos LLC | Sphingosine 1 phosphate receptor modulators |
| WO2022212769A1 (en) * | 2021-03-31 | 2022-10-06 | Washington University | Compositions for binding sphingosine-1-phosphate receptor 1 (s1p1), imaging of s1p1, and processes for preparation thereof |
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| ATE177439T1 (de) | 1994-11-05 | 1999-03-15 | Basf Ag | Melaminharze |
| CA2547198A1 (en) * | 2003-12-17 | 2005-06-30 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists |
| US20060223866A1 (en) * | 2004-08-13 | 2006-10-05 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
| GB0511684D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| EP1893591A1 (en) | 2005-06-08 | 2008-03-05 | Novartis AG | POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| GB0601744D0 (en) * | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| CA2664268A1 (en) * | 2006-09-29 | 2008-04-03 | Novartis Ag | Diaryl oxadiazol derivatives |
| KR20100075608A (ko) * | 2007-10-04 | 2010-07-02 | 메르크 세로노 에스. 에이. | 옥사다이졸 유도체 |
| TW201000099A (en) * | 2008-06-20 | 2010-01-01 | Amgen Inc | S1P1 receptor agonists and use thereof |
| EP2241558A1 (en) * | 2009-04-03 | 2010-10-20 | Merck Serono SA | Oxadiazole derivatives |
-
2011
- 2011-07-01 TW TW100122179A patent/TW201206429A/zh unknown
- 2011-07-06 CA CA2804473A patent/CA2804473C/en not_active Expired - Fee Related
- 2011-07-06 JP JP2013517372A patent/JP6014589B2/ja not_active Expired - Fee Related
- 2011-07-06 EP EP11729318.3A patent/EP2590956B1/en not_active Not-in-force
- 2011-07-06 AU AU2011275854A patent/AU2011275854B2/en not_active Ceased
- 2011-07-06 EA EA201300092A patent/EA201300092A1/ru unknown
- 2011-07-06 WO PCT/EP2011/061372 patent/WO2012004287A1/en not_active Ceased
- 2011-07-06 CN CN201180033823.9A patent/CN103097365B/zh not_active Expired - Fee Related
- 2011-07-06 MX MX2012015021A patent/MX2012015021A/es not_active Application Discontinuation
- 2011-07-06 SG SG2012096533A patent/SG186872A1/en unknown
- 2011-07-06 ES ES11729318.3T patent/ES2586145T3/es active Active
- 2011-07-06 US US13/809,013 patent/US9029405B2/en not_active Expired - Fee Related
- 2011-07-06 KR KR20137003335A patent/KR20140003379A/ko not_active Withdrawn
- 2011-07-08 AR ARP110102449 patent/AR082132A1/es not_active Application Discontinuation
-
2012
- 2012-12-31 IL IL224071A patent/IL224071B/en active IP Right Grant
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220142386A (ko) * | 2021-04-14 | 2022-10-21 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201300092A1 (ru) | 2013-06-28 |
| CA2804473A1 (en) | 2012-01-12 |
| EP2590956B1 (en) | 2016-05-04 |
| AR082132A1 (es) | 2012-11-14 |
| JP6014589B2 (ja) | 2016-10-25 |
| EP2590956A1 (en) | 2013-05-15 |
| AU2011275854B2 (en) | 2015-08-27 |
| CN103097365A (zh) | 2013-05-08 |
| CN103097365B (zh) | 2016-02-24 |
| SG186872A1 (en) | 2013-02-28 |
| MX2012015021A (es) | 2013-04-03 |
| WO2012004287A1 (en) | 2012-01-12 |
| AU2011275854A1 (en) | 2013-02-21 |
| US20130116289A1 (en) | 2013-05-09 |
| IL224071B (en) | 2018-06-28 |
| TW201206429A (en) | 2012-02-16 |
| CA2804473C (en) | 2019-04-02 |
| US9029405B2 (en) | 2015-05-12 |
| ES2586145T3 (es) | 2016-10-11 |
| JP2013530202A (ja) | 2013-07-25 |
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