KR20130047416A - Composition for promoting the growth of eyebrow or eyelash containing a duckweed - Google Patents

Abstract

The present invention relates to an eyelash and eyelash growth promoter composition comprising duckweed and plant extract as an active ingredient. The composition according to the present invention is excellent in promoting eyebrow and eyelash growth.

Description

Composition for promoting the growth of eyebrow or eyelash containing Bupyeongcho extract

The present invention relates to a composition for promoting eyebrow or eyelash growth.

In modern society that emphasizes beauty rather than functional features of eyelashes, eye care is emphasized to make eyelashes look long and dark, making eyes look big and lively, and expressing facial expressions in abundance. Accordingly, in order to exhibit an abundant volume effect when applying the eye makeup cosmetic composition, interest in long eyebrows or eyelashes is increasing.

These eyebrows or eyelashes have different growth cycles than those of other parts of the hair, such as the hair of the scalp. Characteristics associated with the growth and rest periods of the eyebrows or eyelashes are described in Am Acad Dermatol, 48: S 106-S114 (2003), Disorders of Hair Growth, 2 ^nd ed. 75-76 (2003), Surv Ophthalmol, 47 (Suppl 1): S185-S202 (2002), Br J Dermatol, Epub ahead of print (2009), N Engl J Med, 341: 491-497 (1999), Ophthal Plast Reconstr Surg, 13: 21-25 (1997) and Br J Dermatol, 155: 1170-1176 (2006) and the like.

Am Acad Dermatol, 48: S 106-S114 (2003) and Disorders of Hair Growth, 2 ^nd ed. 75-76 (2003), the hair of the scalp lasts three to four years of growth and a rest period of three to four months. In addition, the growth period accounts for 85 to 93% of the entire cycle, the resting period accounts for 7 to 15% of the entire cycle, and the growth rate is described as 0.3 to 0.4 mm / day.

On the other hand, referring to Ophthal Plast Reconstr Surg, 13: 21-25 (1997) and Br J Dermatol, 155: 1170-1176 (2006), which are associated with the growth of eyebrows or eyelashes, the growth phase is 1 to 2 for eyebrows or eyelashes. Months, with resting periods of 4-9 months, with an overall growth cycle of 5-12 months. In addition, the growth rate occupies 10 to 20% of the entire cycle, the rest period occupies 20 to 90%, and the growth rate is 0.08 to 0.27 mm / day, which is remarkably different from the hair of the scalp.

Since the eyebrows or eyelashes show different growth cycles, growth periods, rest periods, and growth rates than the hairs of the scalp, when the composition or medicament that has been used to promote hair is applied to the eyebrows, the desired eyebrow or eyelash growth effect is desired. It did not represent.

In the present invention, by including the duckweed and plant extract as an active ingredient, it is possible to provide a composition having excellent growth promoting efficacy of the eyebrows or eyelashes.

The present invention relates to an eyelash and eyelash growth promoter composition comprising duckweed and plant extract as an active ingredient.

Hereinafter, the eyebrow and eyelash growth promoter compositions according to the present invention will be described in more detail.

The composition according to the present invention comprises duckweed and plant extracts as described above. The duckweed and plant extract may be used as the extract of Bupyeongcho (spirodela polyrhiza schleider) or the extract of Lepidoptera (Lemna paucicostata Hegelm), preferably may be used Bupyeongcho extract.

Bupyeongcho extract in the present invention activates Wnt / β-catenin, the hair follicle stem cell activator, and activates the intracellular Akt and ERK signal transduction system, the growth phase of the hair growth cycle and difference without causing eye irritation and It is particularly effective for promoting eyelash or eyebrow growth with a resting period.

In the present invention, duckweed and plant extract is dried duckweed and plant outpost purified water, methanol, ethanol, propanol, butanol, glycerin, propylene glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, benzene, hexane, diethyl It may be prepared by extracting with one or more solvents selected from the group consisting of ether, trichloromethane and the like.

In the present invention, the duckweed and plant extracts may be included in an amount of 0.01 to 50 parts by weight, and preferably 1.0 to 20 parts by weight based on the total weight of the composition. If the content of the composition is less than 0.01 parts by weight, there is a fear that the effect of promoting the growth of the eyelashes and eyelashes are insignificant, if it exceeds 50 parts by weight, it is excellent in promoting the growth of the eyebrows and eyelashes, but there is a fear that there may be irritation by the solvent, There is a difficulty.

The composition according to the present invention is vitamin B3 (nicotinic acid amide), vitamin B5 (panthenol), vitamin E (tocopherol), vitamin H (biotin), licorice extract, green tea extract, sugar extract, sessin extract, ginseng extract, adenosine, isoflavone It may further comprise at least one additive selected from the group consisting of, pentadecane glycerides, benzylaminopurine, eugenol, hinokthiol, benzyl nicotinic acid and acids, salts and derivatives of the above substances.

The additives may enhance the eyelash or eyebrow growth promoting effect of duckweed and plant extracts.

In the present invention, vitamin B3 (nicotinic acid amide) is one of the vitamin B complexes, and mainly exists as nicotinic acid amide coenzyme (NAD, NADP) in vivo, and is mainly involved in oxidation and reduction reactions. The vitamin B3 may serve to assist the health of the digestive system to restore gastrointestinal disorders and to create healthy skin.

In the present invention, vitamin B5 (panthenol) is a provitamin of pantothenic acid to improve skin moisturizing function, stimulate skin regeneration, and is effective in preventing inflammation and itching.

Vitamin H (biotin) is a complex of vitamin B. The vitamin H helps the production of fatty acids, oxidation of fatty acids and carbohydrates, and can increase the utilization of protein, folic acid, pantothenic acid and B12.

Other vitamin E, licorice extract, green tea extract, medicinal extract, sessin extract, red ginseng extract, adenosine, isoflavone, pentadecaneglycerides, benzylaminopurine, eugenol, hinokithiol, benzylnicotinic acid, Efficacy in activating hair follicle cells.

The above-mentioned additives are not particularly limited in content unless there is a problem in terms of safety of the additives, for example, may be included in 0.0001 to 10 parts by weight, preferably 0.001 to 5 parts by weight based on the total weight of the composition. Can be. If the content of the additive is less than 0.0001 parts by weight, the growth promoting effect of the eyelashes and eyelashes may be insignificant. If it exceeds 10 parts by weight, the eyebrow and eyelash growth promotion is excellent, but there is a fear that the solvent may be stimulated, There is difficulty.

The composition according to the present invention is not particularly limited in formulation, but may be formulated with one or more selected from the group consisting of liquid, spray, gel, paste, emulsion, cream, conditioner and shampoo.

In addition, the composition is not particularly limited, but may be in the form of a cosmetic composition used for eye makeup, in order to easily apply to eyebrows or eyelashes, one selected from the group consisting of mascara, eyeliner, eyeshadow and eyebrow, etc. It may be in the form of the above eye makeup products.

In some cases, the composition may further comprise one or more coloring materials. At this time, an inorganic pigment or an organic pigment can be used as a coloring substance. The inorganic pigment may be a surface treatment of iron oxide, chromium oxide, zinc oxide, titanium oxide, ultramarine, ferric ferrocyanide, ferric ammonium ferrocyanide, manganese violet, etc., and the organic pigment may be carbon black and D & C type. The pigment and these may be laked by the base materials, such as barium, calcium, aluminum.

In addition, pearl may be further included in the composition to prepare the composition in the form of a cosmetic composition.

In the present invention, the coloring material may be included in an amount of 0.1 to 50 parts by weight, and preferably 1 to 30 parts by weight, based on the total composition.

The composition containing duckweed and plant extract according to the present invention as an active ingredient is excellent in eyebrow and eyelash growth promoting effect.

1 is a graph showing the eyelash growth effect of Bupyeongcho extract.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, embodiments according to the present invention can be modified in many different forms, the scope of the invention should not be construed as limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Examples and Comparative Examples

1. Preparation of Extract

The Bupyeongcho outpost was washed, powdered, and cooled for 5 days in 10 times the amount of the extraction solvent, and then the extract was filtered and concentrated to obtain an extract. A mixed solution of purified water and ethanol was added thereto, dissolved, and filtered to prepare a final extract. Purified water, ethanol, 1,3-butylene glycol or a mixture thereof was used as the extraction solvent used at this time.

2. Preparation of Growth Accelerator Composition

As shown in Table 1, each of the raw materials (1,3 butylene glycol, carbomer, xanthan gum, ethanol, arginine, sodium hyaluronate aqueous solution, Bupyeongcho extract, panthenol, biotin, nicotinic acid amide, purified water, preservatives and pigments) The mixture was stirred and stirred to prepare a growth accelerator composition.

ingredient Example 1 Example 2 Example 3 Example 4 Comparative Example 1 1,3 butylene glycol (by weight) 6.0 6.0 6.0 6.0 6.0 Carbomer (part by weight) 0.25 0.25 0.25 0.25 0.25 Xanthan gum (parts by weight) 0.2 0.2 0.2 0.2 0.2 Ethanol (parts by weight) 5.0 5.0 5.0 5.0 5.0 Arginine (parts by weight) 0.4 0.4 0.4 0.4 0.4 Sodium hyaluronate aqueous solution (1%) (part by weight) 5.0 5.0 5.0 5.0 5.0 Bupyeongcho extract (part by weight) 1.0 5.0 10.0 5.0 - Panthenol (parts by weight) - - - 0.5 - Biotin (parts by weight) - - - 0.1 - Niacinamide (parts by weight) - - - 0.3 - Purified water (parts by weight) Too 100 Too 100 Too 100 Too 100 Too 100 antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Pigment Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount

Experimental Example 1. Test for promoting hair growth of Bupyeongcho extract

Hair growth promoting test was used 42 to 49 days old mice (C57BL / 6, female). First, the hair on the back was removed using an electric razor, and each mouse was weighed and divided into eight pieces so that the weight was evenly distributed. After one day of adaptation, 100 microliters (0.1% w / v) of Bupyeongcho extract was applied to the hair removal site once a day for 20 days. As a result, the degree of hair growth was visually determined, and the ratio of the area where the newborn hair was grown to the area from which hair was removed was determined.

As shown in Table 2, in the case of sample group 3 using 1.0 parts by weight of Bupyeongcho extract, there was a remarkable hair growth effect compared to the control group. No findings were found.

sample Effective area% Control group Composition of Comparative Example 1 20 Sample group 1 Composition of Example 1 30 Sample group 2 Composition of Example 2 45 Sample group 3 Composition of Example 3 60 Sample group 4 Composition of Example 4 70

Experimental Example 2. Eyelash growth promotion test of Bupyeongcho extract

Healthy women were applied to the compositions of Examples and Comparative Examples of Table 1 for 8 weeks. Each group was applied to the root of the eyelashes before going to bed once a day, and the front and sides of the eyelashes were taken with a digital camera at week 0, week 1, week 4 and week 8 with close-ups of the eyelashes. Eyelash lengths were analyzed in an Image-Pro 4.5 program.

According to eyelash length and density, the eyelash grade was divided into 7 levels from 0 to 6 levels, and randomized images taken by digital cameras were evaluated by 3 evaluators through 3 evaluations. .

The measurement was made after waiting 20 minutes at constant temperature and humidity conditions (25 ± 2 ° C., 40 ± 2%) after washing the face.

For the composition of Example 3 containing 1.0 parts by weight of Bupyeongcho extract as shown in Table 3, there was an effect of eyelash growth of about 1 mm or more compared to the control group to which the composition of the comparative example was applied, and the growth period of the eyelashes was 20 As it is around%, it was confirmed that it is effective for promoting eyelash growth. As a result of comparing the state of eye and eye around the eye during the 8-week experiment, no unusual skin irritation was found in the control group and all treatment groups.

sample Eyelash Length mm Control group Composition of Comparative Example 1 6.6 ± 0.8 Sample group 1 Composition of Example 1 7.1 ± 0.7 Sample group 2 Composition of Example 2 7.5 ± 0.8 Sample group 3 Composition of Example 3 7.7 ± 0.9 Sample group 4 Composition of Example 4 7.6 ± 0.7

1 in the present invention is a graph showing the effect of eyelash growth of Bupyeongcho extract. Specifically, a) is a graph showing the results when the eyelash length effects of the sample group and the control group were visually determined, and b) shows the comparison result between the samples (sample group and control group).

As shown in Figure 1, when using the composition of Example 3 after 8 weeks in the visual evaluation according to the length and density of the eyelashes, compared to the case of using the composition according to the comparative example, the step is increased significantly Can be. This can be confirmed that the composition of the example containing the Bupyeongcho extract is effective in promoting eyelash or eyebrow growth compared to the composition of the comparative example does not contain the Bupyeongcho extract.

Formulation Example. Mascara manufacturer

When preparing a mascara containing the composition according to the invention, the formulation can be prepared as shown in Table 4.

ingredient weight % paraffin 5.0 Wax 8.0 Stearic acid 5.0 Carnauba Wax 5.0 Candelilla lead 2.0 Polysorbate 20 1.0 Sorbitan stearate 1.0 Isododecane 3.0 Black iron oxide 8.0 Acrylate Copolymer 9.0 1,3-butylene glycol 3.0 Triethanolamine 1.0 Gum arabic 1.0 Aminomethylpropanediol 0.4 Hydroxyethyl Cellulose 0.3 Magnesium aluminum silicate 0.2 Polyvinyl alcohol 5.0 Bupyeongcho Extract 1.0 Hinokitinol 0.1 Sessin Extract 0.2 Panthenol 0.5 Biotin 0.1 Nicotinic Acid 0.3 antiseptic Suitable amount Purified water Too 100

Claims (8)

Eyebrow and eyelash growth promoter composition comprising duckweed and plant extract as an active ingredient.
The method of claim 1,
Duckweed and plants are Bupyeongcho (spirodela polyrhiza schleider) or rice frog (Lemna paucicostata Hegelm) eyebrow and eyelash growth promoter composition.
The method of claim 1,
An eyelash and eyelash growth promoter composition comprising 0.01 to 50 parts by weight of the plant extract, based on the total weight of the composition.
The method of claim 1,
The plant extract is at least one solvent selected from the group consisting of purified water, methanol, ethanol, propanol, butanol, glycerin, propylene glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, benzene, hexane, diethyl ether and dichloromethane Eyebrow and eyelash growth promoter composition that is extracted with.
The method of claim 1,
Vitamin B3, Vitamin B5, Vitamin E, Vitamin H, Licorice Extract, Green Tea Extract, Sugar Extract, Sessin Extract, Red Ginseng Extract, Adenosine, Isoflavones, Pentadecaneglycerides, Benzylaminopurine, Eugenol, Hinokithiol, Benzynicotinic Acid and An eyelash and eyelash growth promoter composition further comprising at least one additive selected from the group consisting of acids, salts and derivatives of the substance.
The method of claim 5, wherein
An eyelash and eyelash growth promoter composition comprising 0.0001 to 10 parts by weight, based on the weight of the total composition.
The method of claim 1,
The eyebrow and eyelash growth promoter compositions are formulated into one or more selected from the group consisting of liquids, sprays, gels, pastes, emulsions, creams, conditioners and shampoos.
The method of claim 1,
The composition of the eyebrow and eyelash growth promoter used in at least one selected from the group consisting of mascara, eyeliner, eyeshadow and eyebrow.

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