KR20130032427A - Extract of herbal mixture and phamaceutical composition for treating hbv/hcv infection and hepatocirrhosis and the method for preparing the same - Google Patents
Extract of herbal mixture and phamaceutical composition for treating hbv/hcv infection and hepatocirrhosis and the method for preparing the same Download PDFInfo
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Abstract
Description
본 발명은 간에 독성이 적은 순수 생약제로서, B형, C형 간염 및 간경화에 효과적인 B형/C형 간염 및 간경화 치료를 위한 혼합 생약추출물 및 그 제조방법에 관한 것이다.The present invention relates to a pure herbal medicine with low toxicity to the liver, and to a mixed herbal extract for the treatment of hepatitis B and hepatitis B and hepatic cirrhosis effective for hepatitis B, hepatitis C and cirrhosis, and a preparation method thereof.
간염, 간 기능환자는 전 세계적으로 약 3-4억 명 이상으로서, 간염은 A형, B형, C형, D형, E형 등이 알려져 있고, 그 중 B형과 C형 간염은 만성간염과 간경화, 간암 등으로 악화된다고 알려져 있어, 초기에 예방을 위하여 간염예방주사약을 수입하고 있으나, 약품의 희소성으로 인하여 고가의 가격으로 인해 환자들에게 많은 부담을 주고 있다.Hepatitis and liver function is more than 300 million people worldwide, hepatitis is known as hepatitis A, B, C, D, E, etc. Among them, hepatitis B and C is chronic hepatitis It is known to worsen liver cirrhosis and liver cancer, and hepatitis preventive injection drugs are initially imported for prevention, but due to the scarcity of drugs, they are putting a lot of pressure on patients.
만성 B형 바이러스성 간염(HBV) 및 C형 바이러스성 간염(HCV)은 세계적으로 널리 퍼져있는 질환으로서 특히 아시아에서 만성 B형 간염 발생율이 세계 다른 지역에 비하여 훨씬 많다. 만성 B형 바이러스성 간염(HBV) 및 C형 바이러스성 간염(HCV)의 감염은 일부 환자의 경우 5 ～ 20년의 감염과정 후 간경변증으로 진행될 수 있으며 또한 일차 간세포암의 병인과 연관성이 매우 깊다. 오늘날 많은 약제가 만성 HBV 및 HCV 감염의 치료에 사용되고 있더라도 간염치료제로서 만족스럽지 못하다.Chronic hepatitis B (HBV) and viral hepatitis C (HCV) are widespread in the world, and the incidence of chronic hepatitis B is particularly high in Asia, especially in other parts of the world. Chronic hepatitis B (HBV) and hepatitis C (HCV) infections can progress to cirrhosis after 5 to 20 years of infection in some patients and are highly associated with the pathogenesis of primary hepatocellular carcinoma. Although many drugs today are being used to treat chronic HBV and HCV infections, they are not satisfactory as hepatitis agents.
일반적으로 간기능에 좋은 약제는 민들레, 헛개나무 등 수십가지에 이르고 있으나, 간에는 약을 남용해서는 안되며, 우루사, 홍삼진액 등 약의 과용은 오히려 간 건강을 해칠 수 있다. 효소, 감식초 등 초산 식품이 간에 손상을 덜 입히는 것으로 알려져 있으나, 이 또한 남용해서는 안된다. 우루사 등의 데옥시콜린산은 우황과 답즙(쓸개)의 주성분인데, 생산량도 적고, 고가로서, 생산성이 떨어진다.In general, there are dozens of drugs that are good for liver function, such as dandelion and liana, but the liver should not abuse drugs, and overuse of drugs such as ursa and red ginseng extract may harm liver health. Acetic acid foods such as enzymes and persimmon vinegar are known to cause less damage to the liver, but they should not be abused. Deoxycholic acid, such as ursa, is a major component of sulfur and bile (gallbladder).
본 발명자는 3대에 걸쳐 한약업에 종사한 자로서, 상기한 문제점을 인식하여 자연 생야초에서 성분을 채취하여 경제적이면서, 간염바이러스의 증식을 억제하는 성분과 간세포에 독성이 적은 약제를 사용하여 B형/C형 간염 및 간경화 환자를 수십년간 직접 치료한 경험에 의해 본 발명을 개발하게 되었다.The present inventors have been engaged in the Chinese medicine industry for three generations, recognizing the above-mentioned problems, extracting ingredients from natural raw grasses, and using economical and inhibitory ingredients for inhibiting the proliferation of hepatitis virus. Decades of direct treatment of patients with hepatitis B / C and cirrhosis have led to the present invention.
본 발명의 목적은 B형/C형 간염 및 간경화 치료를 위한 혼합 생약추출물 및 그 제조방법을 제공하는 것이다.It is an object of the present invention to provide a mixed herbal extract for the treatment of hepatitis B and C and liver cirrhosis and a method of manufacturing the same.
또한, 본 발명의 목적은 혼합 생약 추출물을 유효성분으로 하는 식음료 및 약학적 조성물을 제공하는 것이다.It is also an object of the present invention to provide a food and beverage and pharmaceutical composition comprising the mixed herbal extract as an active ingredient.
상기와 같은 목적을 달성하기 위하여, 본 발명의 B형/C형 간염 및 간경화 치료를 위한 혼합 생약추출물은 초롱담, 산시호, 백봉령, 화마인, 적하수오, 감초, 오가피, 해동피, 인진, 사삼을 포함하는 것을 특징으로 한다.In order to achieve the above object, the mixed herbal extract for the treatment of hepatitis B and hepatitis C and liver cirrhosis of the present invention is Chorongdam, San Siho, Baekbong-ryeong, Hwamae, Drip Shou, Licorice, Ogapi, Haedongpi, Injin, Samsam Characterized in that it comprises a.
본 발명에 있어서, 초롱담 : 산시호 : 백봉령 : 화마인 : 적하수오 : 감초 : 오가피 : 해동피 : 인진 : 사삼은 1～4 : 2～5 : 1～4 : 1～2 : 1～4 : 1～2 : 1～4 : 1～4 : 1～4 : 1～4의 중량 조성비로 포함하는 것을 특징으로 한다.In the present invention, lantern lantern: Sansi Lake: Baekbong-ryeong: Hwamine: Red sewage: Licorice: Ogapi: Haedongpi: Injin: Sasam 1-4: 2-5: 1-4: 1-2: 1-4: 1 It is characterized by including in the weight ratio of 2 to 1 to 4: 1 to 4: 1 to 4: 1 to 4.
또한, 본 발명의 B형/C형 간염 및 간경화 치료를 위한 혼합 생약추출물의 제조방법은 초롱담, 산시호, 백봉령, 화마인, 적하수오, 감초, 오가피, 해동피, 인진, 사삼에 물을 가하여 중탕기에서 2～5시간 센 불로 가열하고, 8～15시간 중불에서 중탕하는 단계; 및In addition, the preparation method of the mixed herbal extract for the treatment of hepatitis B and C and liver cirrhosis of the present invention by adding water to Chorongdam, Sansiho, Baekbong-ryeong, Hwamine, Red Sewage, Licorice, Ogapi, Haedongpi, Injin, Sasam Heating on a high heat for 2 to 5 hours in a hot water bath and hot water for 8 to 15 hours on medium heat; And
상기 중탕한 혼합물을 2 ～ 5시간 약불로 가열한 후 상기 혼합물이 반으로 줄어들 때까지 농축하는 단계를 포함한다.Heating the heated mixture to low heat for 2 to 5 hours and concentrating until the mixture is reduced to half.
바람직하게는 초롱담 100～300 중량부, 산시호 200～500 중량부, 백봉령 100～300 중량부, 화마인 50～200 중량부, 적하수오 100～300 중량부, 감초 100～300 중량부, 오가피 100～300 중량부, 해동피 100～300 중량부, 인진 100～300 중량부, 사삼 100～300 중량부를 포함하고, 상기 물은 1,000L를 가하여 중탕하고 농축하여 제조한다.Preferably, 100-300 parts by weight of Chorong Dam, 200-500 parts by weight of Sanshi Lake, 100-300 parts by weight of Baekbong-ryeong, 50-200 parts by weight of Hwamine, 100-300 parts by weight of drizzle, 100-300 parts by weight of licorice, Ogapi 100-300 parts by weight, thawed blood 100-300 parts by weight, phosphorus 100-300 parts by weight, four ginseng 100-300 parts by weight, the water is prepared by adding water to 1,000L and hot water.
본 발명의 혼합 생약추출물을 유효성분으로 하여 약학적 조성물로 제조될 수 있으며, 정제, 캡슐로도 만들어질 수 있고, 이를 포함하는 식음료로도 가공할 수 있으며, 관련 분야의 당업자들은 기타 이의 균등물로 다양하게 제조할 수 있을 것이다.The mixed herbal extract of the present invention as an active ingredient can be prepared as a pharmaceutical composition, can be made into tablets, capsules, and can also be processed into food and beverage containing the same, and those skilled in the art to other equivalents It will be possible to manufacture a variety.
이상에서 살펴본 바와 같이 본 발명에 의한 B형/C형 간염 및 간경화 치료제는 간에 독성이 적은 순수 생약제로서, 간염바이러스의 증식을 억제하고, B형, C형 간염 및 간경화를 효과적으로 다스릴 수 있다.As described above, the hepatitis B / C hepatitis C treatment agent according to the present invention is a pure herbal medicine with less hepatotoxicity, and can inhibit the proliferation of hepatitis virus, and can effectively treat hepatitis B, hepatitis C and cirrhosis.
본 발명에 의한 B형/C형 간염 및 간경화 치료를 위한 혼합 생약추출물은 초롱담, 산시호, 백봉령, 화마인, 적하수오, 감초, 오가피, 해동피, 인진, 사삼을 포함한다.Mixed herbal extracts for the treatment of hepatitis B and C and liver cirrhosis according to the present invention include Chorongdam, Sansiho, Baekbongryeong, Hwamine, Drip Sewage, Licorice, Ogapi, Haedongpi, Injin, Samsam.
초롱담은 용담초라고도 하고, 매우 쓴맛이 나며, 간장에 좋은 약초이다.Choongdam is also known as yongdamcho, has a very bitter taste and is good for soy sauce.
산시호는 미나리과에 속하는 다년초로서 뿌리는 생약 "시호" 라고하여 빈용되고 있다. 성분 중 Saikosaponin b1과 c는 간기능을 강화하여 간장의 치료제로 사용된다. Saikosaponin a, c, d는 부신을 자극하여 부신피질호르몬분비를 촉진함으로써 항염증작용이 있으며 혈소판응고를 억제하고 고지혈증(Cholesterol, Triglyceride)을 개선하여, 만성염증, 간경화, 간염, 지방간(脂肪肝)을 개선한다.Sanshi Lake is a perennial herb belonging to the Araaceae family, and it is often used as a herbal medicine "Shiho". Among the ingredients, Saikosaponin b1 and c enhance liver function and are used as a treatment for liver. Saikosaponin a, c and d have anti-inflammatory effects by stimulating adrenal glands to stimulate adrenal cortex hormone secretion, inhibiting platelet coagulation and improving hyperlipidemia (Cholesterol, Triglyceride), chronic inflammation, cirrhosis, hepatitis, fatty liver To improve.
백봉령은 소나무 뿌리부분에 담자균류인 복령균의 바깥층을 제거한 후 말려서 만든 것으로서, 이뇨작용에 효과가 있고, 질병 후 허약한 심신을 달래고, 자연 강장제로서, 독이 없고, 단맛이 나며, 각종 장기 질병치료에 빈용된다.Baekbongryeong is made by removing the outer layer of Baeknyeong fungi, which is a submerged fungus, on the roots of pine trees. It is effective in diuretic effect, soothes weak body and body after the disease, and is a natural tonic, without poison, sweet taste, and for treating various long-term diseases. It is abused.
화마인은 삼의 열매로서, 건조한 것을 촉촉하게 해주고 활장(滑腸), 통림(通淋)하며 혈액순환을 촉진시키는 효능이 있는 약재이다.Hwamine is the fruit of ginseng, moisturizes dry things, jang (滑腸), canned (通淋) and is effective in promoting blood circulation.
적하수오는 쓰고 달며 떫은 맛을 가지며, 간, 신경에 효과가 있고, 해독작용을 한다. 강장, 강정 작용을 한다.Dripping water is bitter and sweet and has a bitter taste, and is effective on the liver and nerves and detoxification. Tonic, Gangjeong acts.
오가피는 또 다른 인삼이라 불릴 정도로 효능이 다양하며, 강장, 강정성분이 있음이 보고되고 있으며, 이를 이용한 음료도 나오고 있다. 본초강목에 의하면, 오래 장복하면 늙는 것을 방지하고(항산화작용, 노화방지기능)이 있고, 숙취해소에 좋으며, 인체의 기를 높이고, 가려움증과 거의 모든 질병에 활용된다.Ogapi is so varied that it is called another ginseng, it is reported that there are tonic, Gangjeong ingredients, and drinks using it are also coming out. According to the herbaceous tree, long-wearing prevents old age (antioxidative action, anti-aging function), is good for relieving hangovers, improves the body's spirit, itching and almost all diseases.
해동피는 엄나무 줄기 껍질로서, 쓰고, 독성이 없다. 관절염, 만성간염 등 간장 질환에 효과가 크고, 강장작용을 하고 신장에도 효과가 있다.Thawing blood is a bark of oak stems, bitter and nontoxic. Arthritis, chronic hepatitis, such as hepatic diseases, the effect is great, tonic effect and kidney is effective.
인진의 약성(藥性)은 맛은 쓰고 매우며 성질은 매우 차다. 방광경, 비경, 위경에 작용한다. 열을 내리고 습을 없애며, 소변을 잘 보게 한다". "약리(藥理)실험에서 담즙분비 촉진작용, 이뇨작용, 해열작용 등이 있다는 것이 밝혀졌다. 향기 성분과 스코풀게틴 성분도 담즙분비 촉진작용을 한다. 황달, 급성 및 만성 간염, 위염, 소변을 잘 못보는 장애 등에 쓴다(동의학사전).Injin's weakness is very bitter and very cold. It acts on the bladder, parenteral and stomach. Lowers the heat, removes the humidity, and urine well. "" The pharmacological (藥理) experiments have been found to promote bile secretion, diuretic, fever. Fragrant ingredients and scopulgetin ingredients also promote bile secretion. It is used for jaundice, acute and chronic hepatitis, gastritis, and impaired urine.
사삼은 맛이 달고 성질은 서늘하며, 폐, 간, 비경에 작용하며, 강장, 청폐, 진해, 거단, 소종 작용을 한다.Samsam tastes sweet and cool, and acts on the lungs, liver, parenteral, tonic, cinnabar, Jinhae, leech, small saegon.
본 발명에 의한 B형/C형 간염 및 간경화 치료를 위한 상기 혼합 생약추출물은 초롱담 : 산시호 : 백봉령 : 화마인 : 적하수오 : 감초 : 오가피 : 해동피 : 인진 : 사삼을 1～4 : 2～5 : 1～4 : 1～2 : 1～4 : 1～2 : 1～4 : 1～4 : 1～4 : 1～4 의 중량 조성비로 혼합한 후, 여기에 물을 가하여 중탕기에서 1～3시간 센 불로 가열하고, 5～15시간 중불에서 중탕한 후, 상기 중탕한 혼합물을 2 ～ 5시간 약불로 가열한 후 상기 혼합물이 반으로 줄어들 때까지 농축하여 제조된다.The mixed herbal extracts for the treatment of hepatitis B and C according to the present invention is Chorongdam: Sansiho: Baekbongryeong: Hwamine: Drip Shou: Licorice: Ogapi: Haedongpi: Injin: Sasam 1 ~ 4: 2 ～ 5: 1 ~ 4: 1 ～ 2: 1 ～ 4: 1 ～ 2: 1 ～ 4: 1 ～ 4: 1 ～ 4: 1 ～ 4 After mixing in a weight ratio of 1 ~ 4, water is added to it The mixture is heated to high heat for 3 hours, heated to medium heat for 5 to 15 hours, heated to low heat for 2 to 5 hours, and concentrated until the mixture is reduced to half.
바람직하게는 초롱담 100～300 중량부, 산시호 200～500 중량부, 백봉령 100～300 중량부, 화마인 50～200 중량부, 적하수오 100～300 중량부, 감초 100～300 중량부, 오가피 100～300 중량부, 해동피 100～300 중량부, 인진 100～300 중량부, 사삼 100～300 중량부를 포함하고, 물은 1,000L를 가하여 중탕하여 물이 500L가 될 때까지 가열하여 제조한다.Preferably, 100-300 parts by weight of Chorong Dam, 200-500 parts by weight of Sanshi Lake, 100-300 parts by weight of Baekbong-ryeong, 50-200 parts by weight of Hwamine, 100-300 parts by weight of drizzle, 100-300 parts by weight of licorice, Ogapi 100 to 300 parts by weight, thawed blood 100 to 300 parts by weight, phosphorus 100 to 300 parts by weight, four ginseng 100 to 300 parts by weight. Water is prepared by adding 1,000 liters of water and heating until water reaches 500 liters.
상기와 같이 제조된 혼합 생약추출물을 1일 2～3회 식전에 복용하고, 1회에 100CC를 복용하여 15일 이상이 지나면 호전반응이 온다.Take the mixed herbal extract prepared as described above 2-3 times a day before meals, take 100CC at a time to improve the response after 15 days or more.
상기와 같이 제조된 혼합 생약추출물을 유효성분으로 하여 정제하거나, 캡슐화하여 약학적 조성물로 이용하거나, 이를 포함한 식음료로 이용할 수 있다.The mixed herbal extract prepared as described above may be purified as an active ingredient, encapsulated to be used as a pharmaceutical composition, or as a food and beverage containing the same.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention, and it will be apparent to those skilled in the art that the scope of the present invention is not to be construed as being limited by these examples.
본 발명의 혼합 생약추출물을 제조하기 위해 하기 표 1의 약재를 다음의 용량에 따라 준비한다.In order to prepare the mixed herbal extract of the present invention, the medicines of Table 1 are prepared according to the following doses.
상기 약재의 혼합물 1,900g을 중탕기에 넣은 후, 물 1,000L를 넣는다. 2시간 센 불에서 가열한 후, 중불에서 10시간 가열한다. 상기 원액을 중불에서 가열하면서 원액이 500L가 될 때까지 약 3시간 가열한다.1900 g of the mixture of the medicine is put in a water bath, and then 1,000 L of water is added. Heat on high heat for 2 hours, then heat on medium heat for 10 hours. The stock solution is heated on medium heat and heated for about 3 hours until the stock solution reaches 500 liters.
본 발명의 혼합 생약추출물을 제조하기 위해 하기 표 2의 약재를 다음의 용량에 따라 준비한다. 상기 약재의 혼합물 1,900g을 중탕기에 넣은 후, 물 1,000L를 넣는다. 2시간 센 불에서 가열한 후, 중불에서 10시간 가열한다. 상기 원액을 중불에서 가열하면서 원액이 500L가 될 때까지 약 4시간 가열한다.In order to prepare the mixed herbal extract of the present invention, the medicines of Table 2 are prepared according to the following doses. 1900 g of the mixture of the medicine is put in a water bath, and then 1,000 L of water is added. Heat on high heat for 2 hours, then heat on medium heat for 10 hours. The stock solution is heated on medium heat and heated for about 4 hours until the stock solution reaches 500 liters.
Claims (6)
상기 중탕한 혼합물을 2 ～ 5시간 약불로 가열한 후 상기 혼합물이 반으로 줄어들 때까지 농축하는 단계를 포함하는 것을 특징으로 하는 B형/C형 간염 및 간경화 치료를 위한 혼합 생약추출물의 제조방법.Adding water to Choe Lan Dam, Shaanxi Lake, Baekbong-ryeong, Hwamine, Red Sewage, Licorice, Ogapi, Haedongpi, Injin, Samsam and heating them in a hot water bath for 2 to 5 hours, and heating them in heavy heat for 8 to 15 hours; And
Method of producing a mixed herbal extract for the treatment of hepatitis B and hepatitis C and liver cirrhosis characterized in that it comprises the step of heating the heated mixture to low heat for 2 to 5 hours until the mixture is reduced by half.
상기 혼합물을 중탕기에서 2～5시간 센 불로 가열하고, 8～15시간 중불에서 중탕하는 단계; 및
상기 중탕한 혼합물을 2 ～ 5시간 약불로 가열한 후 상기 혼합물이 반으로 줄어들 때까지 농축하는 단계를 포함하는 것을 특징으로 하는 B형/C형 간염 및 간경화 치료를 위한 혼합 생약추출물의 제조방법.Choongdam Dam 100 ~ 300 parts by weight, Sanshi Lake 200 ~ 500 parts by weight, Baekbong-ryeong 100 ~ 300 parts by weight, Hwamine 50 ~ 200 parts by weight, Dracao 100 ~ 300 parts by weight, Licorice 100 ~ 300 parts by weight, Ogapi 100 ~ 300 parts by weight Adding 1,000 L of water to 100 parts by weight, 100 to 300 parts by weight of thawed blood, 100 to 300 parts by weight of phosphorus, and 100 to 300 parts by weight of samsam;
Heating the mixture on a high heat for 2 to 5 hours in a hot water bath and hot water for 8 to 15 hours on medium heat; And
Method of producing a mixed herbal extract for the treatment of hepatitis B and hepatitis C and liver cirrhosis characterized in that it comprises the step of heating the heated mixture to low heat for 2 to 5 hours until the mixture is reduced by half.
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| CN103961604A (en) * | 2014-04-07 | 2014-08-06 | 刘新江 | Chinese patent medicine pill for treating serious hepatitis, cirrhosis and liver ascites |
| CN103961607A (en) * | 2014-05-07 | 2014-08-06 | 苏玉琴 | Traditional Chinese medicine formula prepared and processed for curing hepatitis B patients |
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| CN104547852A (en) * | 2014-09-26 | 2015-04-29 | 董向坤 | Pharmaceutical composition for treating liver diseases |
| CN104645247A (en) * | 2015-03-16 | 2015-05-27 | 陈为志 | Traditional Chinese medicine preparation for treating hepatolenticular degeneration and preparation method of traditional Chinese medicine preparation |
| CN104707107A (en) * | 2015-03-19 | 2015-06-17 | 吴玉生 | Traditional Chinese medicine for curing liver diseases |
| CN104825896A (en) * | 2015-05-25 | 2015-08-12 | 张天义 | Pharmaceutical composition for treating biliary cirrhosis |
| CN105535345A (en) * | 2016-01-05 | 2016-05-04 | 成都富豪斯生物科技有限公司 | Traditional Chinese medicine composition for treating chronic hepatitis B and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103961604A (en) * | 2014-04-07 | 2014-08-06 | 刘新江 | Chinese patent medicine pill for treating serious hepatitis, cirrhosis and liver ascites |
| CN103961604B (en) * | 2014-04-07 | 2016-09-07 | 刘新江 | A kind of treat heavy type hepatitis, cirrhosis, the Chinese patent pills of liver ascites |
| CN103961607A (en) * | 2014-05-07 | 2014-08-06 | 苏玉琴 | Traditional Chinese medicine formula prepared and processed for curing hepatitis B patients |
| CN104435267A (en) * | 2014-06-26 | 2015-03-25 | 南京华宽信息咨询中心 | Anti-inflammatory soft capsule as well as preparation method and application of anti-inflammatory soft capsule |
| CN104547852A (en) * | 2014-09-26 | 2015-04-29 | 董向坤 | Pharmaceutical composition for treating liver diseases |
| CN104645247A (en) * | 2015-03-16 | 2015-05-27 | 陈为志 | Traditional Chinese medicine preparation for treating hepatolenticular degeneration and preparation method of traditional Chinese medicine preparation |
| CN104707107A (en) * | 2015-03-19 | 2015-06-17 | 吴玉生 | Traditional Chinese medicine for curing liver diseases |
| CN104825896A (en) * | 2015-05-25 | 2015-08-12 | 张天义 | Pharmaceutical composition for treating biliary cirrhosis |
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