WO2015018129A1

WO2015018129A1 - Antihypertensive chinese medicine preparation and preparation method therefor

Info

Publication number: WO2015018129A1
Application number: PCT/CN2013/085146
Authority: WO
Inventors: 袁志贤
Original assignee: Yuan Zhixian
Priority date: 2013-08-09
Filing date: 2013-10-12
Publication date: 2015-02-12
Also published as: CN104147385B; CN104147385A; CN103393958A

Abstract

An antihypertensive Chinese medicine preparation and a preparation method therefor. The preparation is a compositional liquid preparation prepared from purified water, Radix Puerariae, Chrysanthemum indicum, Taxillus chinensis, Eucommia ulmoides, Crataegus, Scutellaria baicalensis, Epimedium brevicornum Maxim, Clerodendron trichotomum Thunb leaf, Folium Apocyni Veneti, Pheretima, Gastrodia elata, Uncaria tomentosa, Ligusticum wallichii, Bupleurum, Inula flower, centipede, brown sugar, and a 65% ethanol solution via crushing, decocting, mixing, and stirring processes.

Description

Blood pressure lowering traditional Chinese medicine preparation and preparation method thereof

The invention relates to a traditional Chinese medicine preparation for lowering blood pressure, in particular to a formula and a preparation method of the traditional Chinese medicine preparation relating to the blood pressure lowering effect. Background technique

As a common disease in human body, cardiovascular disease has become one of the major factors threatening the health of today's human beings. In recent years, with the aging of China's population and the improvement of people's living standards, the pace of life and work has accelerated, and the eating habits have developed toward high-heating and high-lipidity. The number of hypertensive patients in the population has been increasing year after year.

At present, in order to reduce blood pressure, the commonly used antihypertensive drugs in domestic hospitals mainly include calcium channel blockers (levels), ACE-I (Puli) and angiotensin-II (sartans). Drug-based, Western medicine lipid-lowering drugs are statins as the leading products. In recent years, traditional Chinese medicine cardiovascular disease treatment preparations have gradually become the best-selling varieties in the domestic market. Compared with western medicine preparations, traditional Chinese medicine preparations have the characteristics of "multi-target, multi-effect". Because Chinese medicine theory believes that the human body is a whole, the traditional Chinese medicine for blood stasis has the ability to remove atherosclerotic plaque, dredge blood vessels and accelerate blood circulation. And a variety of effects, so the Chinese medicine cardiovascular disease preparations are more advantageous than the single Western medicine preparations. This indicates that the majority of patients in China have recognized the clinical effects of traditional Chinese medicine cardiovascular preparations. However, some Chinese medicine treatments on the market are not cured, some use expensive ingredients, many products have no obvious antihypertensive effect, and the effect after decompression is unstable. It is easy to rebound and the defects are worth improving. Summary of the invention

The object of the present invention is to provide a traditional Chinese medicine preparation for preventing and treating hypertension according to the above-mentioned deficiencies, based on the secret recipe of the ancestors, and in combination with modern Chinese and Western medicine technology, in particular to provide a formula and a preparation method for the preparation of the traditional Chinese medicine. The invention belongs to a traditional Chinese medicine compound medicine for clearing heat and calming liver, dissipating blood stasis and promoting blood circulation, treating symptoms such as head vertigo caused by hypertension and liver yang sputum, and the invention can quickly achieve antihypertensive effect, and is non-toxic and has no side effects. The pressure drop is stable, the effect is stable, and the preparation process is simple and easy.

The technical solution of the present invention is as follows:

The preparation of the invention is composed of pure water, puerarin, wild chrysanthemum, mulberry parasitic, eucommia, hawthorn, scutellaria, yinyanghu, stag beetle, apocynum venetum, earthworm, gastrodia, uncaria, chuanxiong, bupleurum, sinensis a liquid preparation of a composition prepared from a solution of hydrazine, brown sugar and 65% ethanol, wherein the mass ratio of each component is:

Pure water 4000-8000g Pueraria 10-30g Wild chrysanthemum 20-40g Mulberry 20-40g Eucommia 25-35g Hawthorn 20-30g Astragalus 15-25g Epimedium 20-30g Sycamore 20-30g Apocynum venetum 20-30g龙20-30g Tianma 30-40g Uncaria 30-40g Chuanxiong 20-30g Bupleurum 20-30g Cyclobalanopsis 20-35g 蜈蚣10-20g Brown sugar 20-30g

65% ethanol solution 15-30g.

In order to obtain a better effect, the preferred raw material quality ratio of the present invention is

Pure water 5000-8000g Pueraria 10-20g wild chrysanthemum 20-30g Eucommia 25-30g Hawthorn 20_25g Astragalus 15-20g Epimedium 20-25g Sycamore 20_25g Apocynum venetum 20_25g Dilong 20-25g Gastrodia 30-35g Uncaria 30-35g Chuanxiong 20_25g Bupleurum 20-25g Cyclobalanopsis 20- 30g 蜈蚣10_20g brown sugar 20-30g

65% ethanol solution 15-25g.

Of course, in order to obtain further good effects, the present invention can also be used as a preferred raw material quality with purified water 6000g Pueraria 15g wild chrysanthemum 25g

Mulberry parasitic 25g Eucommia 25g Hawthorn 20g

黄苓 15g Epimedium 20g Sycamore 20g

Apocynum venetum 25g Earthworm 20g Gastrodia 30g

Uncaria 30g Chuanxiong 20g Bupleurum 20g

Cyclobalcium 25g 蜈蚣 15g brown sugar 30g

205% ethanol solution 20g.

The preparation method of the above blood pressure lowering traditional Chinese medicine preparation comprises the following steps:

1), the pueraria, wild chrysanthemum, mulberry parasitic, Eucommia, Hawthorn, Astragalus, Epimedium, and Sycamore are proportioned well, crushed by a pulverizer and passed through a 80 mesh sieve, and then baked at a high temperature of 50-70 °C. Dry, then naturally dry to room temperature for use;

2), in the above steps, the powder mixture of pueraria, wild chrysanthemum, mulberry parasitic, Eucommia, Hawthorn, Astragalus, Epimedium, and Syzygium sylvestris is added to pure water for three times, and the first time added 10 times the amount of water to cook half a time. Hours, the second time added 5 times the amount of water to cook for 20 minutes, the third time Decoction in 5 times water for 10 minutes, then combine the decoction and filter, and set aside;

3), the Apocynum venetum, Dilong, Tianma, Uncaria, Chuanxiong, Bupleurum, Rotary Flower, and medlar are proportioned, crushed by a pulverizer and passed through a 80 mesh sieve, and then at a high temperature of 50-70 °C. Dry down, then naturally dry to room temperature for use;

4), the above-mentioned powder mixture of Apocynum venetum, Dijon, Gastrodia elata, Uncaria, Chuanxiong, Bupleurum, Rosaceae, and medlar is added to 10 times the amount of pure water for boiling for half an hour, then the decoction is taken and filtered. Standby

5), at room temperature, the above step 2) and the decoction obtained in step 4), and added 65% ethanol solution and stirred evenly, forming a Chinese medicine composition solution preparation;

6), the preparation of the traditional Chinese medicine composition solution in the above step 5) is added to the brown sugar, and stirred for 5 minutes to obtain.

The prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better. The theoretical basis of the present invention is: Pueraria, a legume plant kudzu, is a common vegetable in some provinces and autonomous regions of southern China, and its taste is sweet and delicious, and is often used as a soup. Its main component is starch, and it also contains about 12% of flavonoids, including soybean (soybean) glutinous rice, soybean aglycone, puerarin and other 10 kinds; and contains carrots, amino acids, coumarins and the like. As a traditional Chinese medicine, Pueraria is cool, sweet and pungent. It is a commonly used hurricane solution. Clinical reports have been used to treat high blood pressure with neck pain. The latest data show that Pueraria has a blocking effect on α receptor and angiotensin II receptor, and its curative effect is superior to previous antihypertensive drugs. Especially likely to reverse high Cardiac hypertrophy caused by blood pressure. Puerarin can significantly increase plasma endothelin (ET) levels to return to normal soon. Therefore, one of the mechanisms of puerarin in the treatment of hypertension may be to inhibit the excessive release of ET, promote endothelial recovery, and then stimulate PG12 synthetase activity. Significantly increased EC production of PG inhibits platelet aggregation and improves blood circulation. Large doses of puerarin can lower blood sugar and significantly lower serum cholesterol. However, the use of puerarin to reduce blood pressure is not obvious. However, in the present invention, it is compatible with other traditional Chinese medicines to treat hypertension, and the blood pressure is obvious. The symptoms of headache, dizziness, limb numbness, tinnitus and the like caused by hypertension are effective. Wild chrysanthemum, the head of the perennial herb of the Compositae, is similar to chrysanthemum. It is wild on the hillside grassland and on the side of the road. Wild chrysanthemum can be widely used for detoxification, treatment of acne swelling, sore throat, red eyes, headache and dizziness. At the same time, it has a good antihypertensive effect and can be used for adjuvant treatment of hypertension. The single-flavored decoction has a general effect, but it is very effective in combination with other traditional Chinese medicines of the present invention. Mulberry parasitic, bitter taste; sweet; sex, into the liver, kidney, can be rheumatism, liver and kidney, nourishing blood, and is mainly used for sputum, blood, nourishment, liver and kidney deficiency caused by weak bones, waist Knee acid soft embolism, also commonly used in the treatment of liver and kidney yin deficiency type hypertension. Eucommia ulmoides, the dry bark of Eucommia ulmoides, is a valuable nourishing herb in China. Eucommia ulmoides tea with eucommia ulmoides as raw material has many functions such as nourishing liver and kidney, strengthening bones and muscles, lowering blood pressure and curing fetus. Eucommia ulmoides is sweet and warm, has the functions of nourishing the liver and kidney, strengthening the bones and strengthening the fetus, and reducing the blood pressure with the combination of mulberry parasitic and earthworms, and lowering the blood pressure without coldness and coldness for people with physical weakness. Hawthorn, an edible plant, stone fruit, hard, thin flesh, slightly sour. Hawthorn is a deciduous shrub. Branches dense, with fine thorns, young branches with pilose. Branchlets purple brown, old branches taupe. Hawthorn is a unique combination of fruit and fruit in China. Hawthorn can eliminate product, sputum, stagnation, hawthorn and sour lush, hawthorn can prevent cardiovascular disease, have dilated blood vessels, strong heart, increase coronary blood flow, improve heart vitality, excite the central nervous system, lower blood pressure and Cholesterol, soften blood vessels and diuretic and sedative effects; prevent and cure arteriosclerosis, anti-aging, anti-cancer effect. Hawthorn acid also has a strong heart effect and is also beneficial for senile heart disease. Astragalus, can clear away heat and detoxification, purging fire and detoxification, its taste bitter cold, effect digestion and accumulation, blood circulation, clearing heat and detoxification, purging fire detoxification, dealing with liver heat, high blood pressure, clearing dizziness, headache, mouth The effect of bitterness and upset. Both decoction and infusion have obvious antihypertensive effects. Combined with wild chrysanthemum and Uncaria, it can treat neurological hypertension and arteriosclerosis hypertension, which can lower blood pressure, headache, chest tightness and impetuous symptoms. And disappeared. Epimedium, alias iron arrow, horn flower, long green grass, born in a damp ravine, hillside forest or bamboo clumps, warm, sweet and fragrant, tonifying kidney, strong bones, rheumatism. For impotence and nocturnal emission, muscles and tendons, rheumatism, numbness, numbness; menopausal hypertension and other symptoms. The stinky paulownia is also known as Haizhou Changshan, Taishan Red Five Star, Bubble Flower Tong, Star Aniseed Sycamore, Chasing Wind, Back Court Flower, etc. It is pungent, bitter, sweet, cool, into the liver, gallbladder, spleen. It can treat rheumatic pain, hemiplegia, hypertension, migraine; malaria, dysentery, hemorrhoids, hemorrhoids. After the stagnation of staghorn stalks is heated by high heat, the antihypertensive effect is weakened. However, in combination with other traditional Chinese medicines in the present invention, the efficacy is not affected. Apocynum venetum leaves, leaves of Apocynum venetum, more shrinking and curling, some broken, can treat high blood pressure, Apocynum venetum decoction has antihypertensive effect; Apocynum venetum decoction has a strong heart effect; Apocynum venetum leaf extract has It is sedative, anticonvulsant, and has strong diuretic, lowering blood lipids, regulating immunity, anti-aging and inhibiting influenza virus. Earth dragon, cold, salty. It can clear the heat and calm the convulsions, collaterals, asthma, diuretic; for high fever, convulsions, seizures, joint paralysis, limb numbness, hemiplegia, lung heat and cough, edema and edema, hypertension. Gastrodia elata, a perennial herb, is distributed in most parts of the country. Its dry tubers, also known as gastrodia elata, are commonly used and more expensive traditional Chinese medicines. They are clinically used for headache, dizziness, limb numbness, convulsions in children, epilepsy, convulsions, tetanus, etc., and can be used for liver and yang. Headache, dizziness and other symptoms. Uncaria, also known as the big hooked, double hooked vine, is the hooked vine of the genus Uncaria or the genus Hookus and its genus of various plants with hooked branches, climbing shrubs, unripe vines, sweet and slightly cold, can calm the liver De-fire and heat, can be used with liver yang sputum caused by dizziness, head pass, red eyes and other diseases, hook vine stems contain a variety of steroidal alkaloids, including rhynchophylline, isoflavone, Uncaria , as well as non-alkaloids. The main effective antihypertensive components in Uncaria are rhynchophylline and isoflavone, and the latter has a stronger antihypertensive effect than rhynchophylline. Chuanxiong, a kind of traditional Chinese medicine plant, is often used for promoting blood circulation, relieving pain and relieving pain. It is mainly cultivated in Sichuan, Yunnan, Guizhou, Guangxi, Hubei and other places. Chuanxiong Xin Wenxiang dry, go without keeping, can not only disperse, up to the dome; and into the blood, down to blood. Blood stasis Wide range, suitable for blood stasis to block various diseases; hurricane pain, good effect, can cure head wind headache, rheumatism and pain. In the past, it was said that Chuanxiong was a gas medicine in the blood, and it was said that it had functions such as disintegration, depression, accessibility, and pain relief. Bupleurum, taste and return to the classics: Slightly cold, bitter taste, Xin, return to the liver, gallbladder, with the effect of soothing liver and gallbladder, suffocating and relieving depression, scattered fire. Rotating flowers, also known as sedge grass, shamrock. Herbs perennial, stems with longitudinal edges, green or microstriped purplish red. Leaves alternate, elliptic, elliptical-lanceolate or narrowly oblong. The heads are few or many, terminal, arranged in an umbrella-like shape. The flowers are salty, warm, and slightly toxic. They are used to eliminate phlegm, qi, soft and water. It is a terrestrial arthropod. The body is composed of many body segments. Each section has a foot foot, so it is a multi-legged creature. They are fast and aggressive. In Chinese medicine, 蜈蚣肝肝肝 , , , , , , , 肝肝肝肝肝肝肝肝肝肝肝肝肝肝肝肝For children with convulsions, convulsions, strokes, hemiplegia, tetanus, rheumatism, sores, sputum, snake bites.

65% ethanol solution contains alcohol. Liquor is known as "the longest of 100 medicines". Liquor is stable, safe and effective, and because alcohol is a good semi-polar organic solvent, various active ingredients of traditional Chinese medicine are easily soluble. Among them, the medicine exerts its effectiveness by means of alcohol and alcohol to help the drug, and improves the therapeutic effect. As we all know, hypertension is a pathological process in which blood pressure regulation disorders and systemic arterial blood pressure continue to rise. Diagnostic criteria for hypertension refers to a systolic blood pressure in the resting state and / or diastolic blood pressure (140/90 _m mHg), often accompanied by fat and carbohydrate metabolism disorders and heart, brain, Functional or organic changes in organs such as the kidney and retina, systemic diseases characterized by organ remodeling. Resting for more than 5 minutes, the blood pressure of 140/90mmHg measured on 2 different times on the same day can be diagnosed as hypertension. Clinically, many hypertensive patients, especially obese, are often accompanied by diabetes, and diabetes is also associated with high blood pressure, so the two are called homologous diseases. People with diabetes have increased blood sugar, increased blood viscosity, damaged blood vessel walls, and increased vascular resistance, which may cause high blood pressure. It can be seen that both hypertension and diabetes are related to hyperlipidemia. Therefore, both hypertension and diabetes should lower blood pressure and regulate blood lipids. Chinese traditional Chinese medicine believes that hypertension is caused by emotional internal injuries, unhealthy diet, fatigue and fatigue, or due to old age, kidney loss, etc., leading to imbalance of yin and yang, wind and fire endogenous, phlegm and stasis, qi and blood Caused by chaos. Treatment is usually divided into the following types: liver yang upper sputum type, liver and kidney yin deficiency type, yin and yang deficiency type, turbid middle resistance type, congestion block type, rushing disorder type. Western medicine also treats high blood pressure, and Western medicine often has frequent additions and subtractions to achieve the target blood pressure. Therefore, blood pressure fluctuations often occur. The traditional Chinese medicine has a mild antihypertensive effect and a good blood pressure stabilization effect. The invention is particularly suitable for early, middle-aged and elderly hypertensive patients, and the heavier hypertension is combined with the traditional Chinese medicine treatment of the present invention, and can also prevent large blood pressure fluctuations. Clinical Experiment 1:

1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the three months from January 2013 to March 2013 are selected. 2), Observed subjects: 10 cases were selected in Shenzhen Hospital of Guangdong Province: 5 males and 5 females; age: 5 cases of 45-55 years old, 5 cases of 55-75 years old; Occupation: 5 cases of private business owners, 5 retirees. Course of disease: Blood pressure is not less than 150/100mmHg in the morning, occasionally head vertigo, unclear vision, weakness of limbs.

3), How to use: The oral liquid of the preparation of the present invention is taken 1 hour after the meal, 3 times a day, 300 ml each time, 1 month is a course of treatment, and two courses are observed as therapeutic effects.

4), observation effect:

After two consecutive courses of treatment, 4 of them fell to no more than 120/90 mmHg, 3 to no more than 130/90 mmHg, and 3 to no more than 1 10/90 mmHg. After 7 days of withdrawal, no obvious signs of rebound were observed, blood pressure was stable, head vertigo disappeared, and the visual condition and limb weakness were greatly improved.

Clinical trial 2:

1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the three months from April 2013 to June 2013 are selected.

2), Observed: 10 cases were selected in Futian District Hospital of Shenzhen, Guangdong Province: 6 males and 4 females; age: 55-65 years old 5 cases, 65-75 years old 5 cases; Occupation: served as a post leader There were 5 obese civil servants and 5 obese ordinary retired civil servants. Course of disease: The blood pressure measured in the morning is not less than 170/1 lOmmHg, often accompanied by head vertigo, unclear vision, weakness of limbs.

4), observation effect: After two consecutive courses of treatment, 4 patients fell to no more than 130/100mmHg, 3 patients fell to no more than 120/100mmHg, and 3 patients fell to no more than 110/90mmHgo. After 7 days of withdrawal, no significant observation. Signs of rebound, blood pressure is stable, head vertigo disappears, visual unclearness, and limb weakness are improved.

Combining the above clinical data with the theoretical basis of the present invention, it can be seen that the beneficial effects of the present invention are that the preparation prepared by the invention can achieve the symptoms of clearing heat and calming the liver, removing blood stasis and promoting blood circulation, lowering blood pressure and treating head vertigo caused by liver yang sputum. The invention can quickly achieve the antihypertensive effect, and is non-toxic, has no side effects, has stable blood pressure, stable effect, and the preparation process is simple and easy. detailed description

The present invention will be described in detail below with reference to the embodiments:

Example 1:

Pure water 4000g Pueraria 10g Wild chrysanthemum 20g

Mulberry 20g Eucommia 25g Hawthorn 20g

Yellow tea 15g Epimedium 20g Sycamore 20g

Apocynum venetum 20g Earthworm 20g Gastrodia 30g

Uncaria 30g Chuanxiong 20g Bupleurum 20g

Rotating flower 20g 蜈蚣10g brown sugar 20g 15 g of a 65% ethanol solution.

1), the pueraria, wild chrysanthemum, mulberry parasitic, Eucommia, Hawthorn, Astragalus, Epimedium, and Syzygium sylvestris are proportioned well, crushed by a pulverizer and passed through a 80 mesh sieve, and then at a high temperature of 50-70 ° C Dry, then naturally dry to room temperature for use;

2), in the above steps, the powder mixture of pueraria, wild chrysanthemum, mulberry parasitic, Eucommia, Hawthorn, Astragalus, Epimedium, and Syzygium sylvestris is added to pure water for three times, and the first time added 10 times the amount of water to cook half a time. Hour, add 5 times the amount of water for 20 minutes, add 5 times the amount of water for 10 minutes, then combine the decoction and filter, set aside;

5), at room temperature, the decoction obtained in the above step 2) and step 4), and added 65% ethanol solution and stirred uniformly to form a solution of the traditional Chinese medicine composition solution;

6), the preparation of the traditional Chinese medicine composition solution in the above step 5) is added to brown sugar, and stirred for 5 minutes to obtain.

The preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.

Example 2; The preferred raw material quality of the present invention is (g):

Pure water 8000g Pueraria 30g Wild chrysanthemum 40g Mulberry parasitic 40g Eucommia 35g Hawthorn 30g Astragalus 25g Epimedium 30g Sycamore 30g Apocynum venetum 30g Earthworm 30g Gastrodia 40g Uncaria 40g Chuanxiong 30g Bupleurum 30g Cyclobalanopsis 35g 蜈蚣20g Brown sugar 30g 65% ethanol solution 15g<

The preparation method is as in Example 1.

Example 3;

The mass of each component is (g):

Pure water 5000g Pueraria 15g Wild chrysanthemum 25g Mulberry parasitic 25g Eucommia 30g Hawthorn 25g Astragalus 20g Epimedium 25g Sycamore 25g Apocynum venetum 25g Earthworm 25g Gastrodia 35g Uncaria 35g Chuanxiong 25g Bupleurum 25g Cyclobalanopsis 25g 蜈蚣 15g Brown sugar 25g

205% ethanol solution 20g.

The preparation method is as in Example 1.

Embodiment 4;

The mass of each component is (g):

Pure water 6000g Pueraria 20g wild chrysanthemum 30g Mulberry parasitic 30g Eucommia 35g Hawthorn 30g Astragalus 25g Epimedium 30g Sycamore 30g Apocynum venetum 30g Earthworm 30g Gastrodia 35g Uncaria 35g Chuanxiong 30g Bupleurum 30g Rotary flower 30g 蜈蚣20g Brown sugar 30g

65% ethanol solution 25g.

The preparation method is as in Example 1.

Example 5

The mass of each component is (g):

Pure water 7000g Pueraria 10g Wild chrysanthemum 20g Mulberry 20g Eucommia 25g Hawthorn 20g Astragalus 25g Epimedium 30g Tung 30g Apocynum venetum 30g Earthworm 30g Gastrodia 30g Uncaria 30g Chuanxiong 20g Bupleurum 20g Cyclobalanopsis 35g 蜈蚣 20g Brown sugar 20g

65% ethanol solution 30g.

The preparation method is as in Example 1.

Example 6:

The mass of each component is (g):

Pure water 4500g Pueraria 12g Wild chrysanthemum 28g Mulberry parasitic 28 Eucommia 28g Hawthorn 26g Astragalus 18g Epimedium 22g Sycamore 22g Apocynum venetum 22g Earthworm 22g Gastrodia 38g Uncaria 38g Chuanxiong 21g Bupleurum 21g

Cyclobalanthine 23g 蜈蚣 12g brown sugar 28g

65% ethanol solution 18g.

The preparation method is as in Example 1.

The above embodiments are only a few of the various embodiments of the present invention. For example, if the formula is increased or decreased according to the ratio in the technical solution, the curative effect of the blood pressure lowering preparation prepared is not affected, and will also fall on It is within the scope of the claims of the present invention.

Claims

Rights request

1. A formula of a traditional Chinese medicine preparation for lowering blood pressure, characterized in that the preparation of the present invention is made of purified water, kudzu root, wild chrysanthemum, locust, eucommia, hawthorn, astragalus, epimedium, sycamore, apocynum leaves, ground A liquid preparation of a composition prepared from Asparagus, Gastrodia elata, Uncaria, Ligusticum chuanxiong, Bupleurum, Inula, Centipede, brown sugar and 65% ethanol solution, in which the mass ratio of each component is 4000-8000g purified water, 10-30g Pueraria lobata, wild Chrysanthemum 20-40g, Loranth 20-40g, Eucommia 25-35g, Hawthorn 20-30g, Astragalus 15-25g, Epimedium 20-30g, Wutong 20-30g, Apocynum leaves 20-30g, Earthworm 20-30g Gastrodia 30-40g, Uncaria 30-40g Chuanxiong 20-30g Bupleurum 20-30g Inula 20-35g Centipede 10-20g Brown sugar 20-30g

65% ethanol solution 15-30g.

2. The formula of the traditional Chinese medicine preparation for lowering blood pressure according to claim 1, further characterized in that the mass ratio of each component is:

Purified water 5000-8000g Pueraria lobata 10-20g Wild chrysanthemum 20-30g Lobra 20-30g Eucommia 25-30g Hawthorn 20-25g Astragalus 15-20g Epimedium 20-25g Smelly Wutong 20-25g Apocynum leaves 20-25g Ground Dragon 20-25g Gastrodia elata 30-35g Uncaria 30-35g Chuanxiong 20-25g Bupleurum 20-25g Inula 20-30g Centipede 10-20g Brown sugar 20-30g

65% ethanol solution 15-25g.

3. The formula of the traditional Chinese medicine preparation for lowering blood pressure according to claim 1 or 2, further characterized in that the mass ratio of each component is

Purified water 6000g Pueraria lobata 15g Wild chrysanthemum 25g

Locust 25g Eucommia 25g Hawthorn 20g

Astragalus 15g Epimedium 20g Smelly Wutong 20g

Apocynum leaves 25g Dilong 20g Gastrodia elata 30g

Uncaria 30g, Ligusticum chuanxiong 20g, Bupleurum 20g

Inula 25g Centipede 15g Brown sugar 30g

65% ethanol solution 20g.

4. A preparation method of a traditional Chinese medicine preparation for lowering blood pressure, characterized in that it includes the following: 1), mixing kudzu root, wild chrysanthemum, locust, eucommia, hawthorn, astragalus, epimedium and odoriferous sycamore in proportion, and Crush it with a pulverizer and pass it through an 80-mesh sieve, then dry it at a high temperature of 50-70°C, and then let it naturally dry to room temperature for later use;

2). Add the powder mixture of kudzu root, wild chrysanthemum, locust, eucommia, hawthorn, astragalus, epimedium, and sycamore in the above steps to purified water and boil for three times. For the first time, add 10 times the amount of water and boil half of it. hour, add 5 times the amount of water for the second time and cook for 20 minutes, add 5 times the amount of water for the third time and cook for 10 minutes, then combine the decoctions and filter, set aside;

3). Mix Apocynum leaves, Dilong, Gastrodia, Uncaria, Ligusticum chuanxiong, Bupleurum, Inula, and Centipede in proportion, grind them through a crusher and pass through an 80-mesh sieve, and then grind them at a high temperature of 50-70°C. Tumble dry, then let it air to room temperature for later use;

4). Combine the above-mentioned Apocynum leaves, Dilong, Gastrodia, Uncaria, Ligusticum chuanxiong, Bupleurum and Inula - Add 10 times the amount of purified water to the centipede powder mixture and boil for half an hour, then take the decoction and filter it and set aside;

5), at room temperature, mix the decoction obtained in the above steps 2) and 4), add 65% ethanol solution and stir evenly to form a Chinese medicine composition solution preparation;

6). Add brown sugar to the Chinese medicine composition solution in the above step 5), and stir for 5 minutes to prepare. The prepared Chinese medicine composition solution can be taken orally, if it can be drunk once in the morning, noon and evening. And if you drink it for a long time, the effect will be better.