KR20120125305A - 장기 지속 안압 강하 효과를 지니는 알파?２ 아드레날린 작용제 - Google Patents
장기 지속 안압 강하 효과를 지니는 알파?２ 아드레날린 작용제 Download PDFInfo
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- KR20120125305A KR20120125305A KR1020127021719A KR20127021719A KR20120125305A KR 20120125305 A KR20120125305 A KR 20120125305A KR 1020127021719 A KR1020127021719 A KR 1020127021719A KR 20127021719 A KR20127021719 A KR 20127021719A KR 20120125305 A KR20120125305 A KR 20120125305A
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- intraocular pressure
- bromo
- benzimidazole
- hours
- eye
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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| PCT/US2011/022001 WO2011091225A2 (en) | 2010-01-21 | 2011-01-21 | Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect |
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| KR20120125305A true KR20120125305A (ko) | 2012-11-14 |
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| WO2013016072A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating skin diseases |
| US20130046003A1 (en) * | 2011-07-22 | 2013-02-21 | Mohammed I. Dibas | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating retinal diseases |
| WO2013016073A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye |
| CN105188700A (zh) * | 2013-03-14 | 2015-12-23 | 阿勒根公司 | 通过玻璃体内和前房内途径用于治疗眼内压和眼部疾病的α-2肾上腺素能激动剂 |
| TWI699205B (zh) * | 2014-12-12 | 2020-07-21 | 日商興和股份有限公司 | 用於預防或治療青光眼之藥物療法 |
| WO2019004080A1 (ja) | 2017-06-27 | 2019-01-03 | 国立大学法人東京大学 | 融合遺伝子及び／又はエクソンスキッピングにより生ずる転写産物を検出するためのプローブ及び方法 |
| US11077053B2 (en) | 2018-08-21 | 2021-08-03 | Allergan, Inc. | Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia |
| EP4236932A4 (en) * | 2020-11-02 | 2024-10-09 | Visus Therapeutics, Inc. | Degradant compound in a medicament |
| CN118541148A (zh) * | 2021-11-10 | 2024-08-23 | 视觉治疗股份有限公司 | 增强抗老花眼作用的碳酰胆碱制剂 |
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| EP0775134A4 (en) * | 1994-08-04 | 1997-08-13 | Synaptic Pharma Corp | NEW BENZIMIDAZOLE DERIVATIVES |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| CA2603044A1 (en) * | 2005-06-29 | 2007-01-11 | Allergan, Inc. | Alpha-2 adrenergic agonists for the treatment of pain |
| CA2641501A1 (en) | 2006-02-06 | 2007-08-16 | Nicox S.A. | Nitrooxy-comprising derivatives of apraclonidine and brimodnidine as al pha2 -adrenergic receptor agonists |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
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| US20110178145A1 (en) | 2011-07-21 |
| ZA201205470B (en) | 2013-05-29 |
| CA2787573A1 (en) | 2011-07-28 |
| JP6466504B2 (ja) | 2019-02-06 |
| WO2011091225A2 (en) | 2011-07-28 |
| EP2525793A2 (en) | 2012-11-28 |
| CL2012002038A1 (es) | 2012-11-16 |
| CN102770135A (zh) | 2012-11-07 |
| SG182637A1 (en) | 2012-08-30 |
| JP2013518051A (ja) | 2013-05-20 |
| WO2011091225A3 (en) | 2012-05-18 |
| BR112012018154A2 (pt) | 2016-04-05 |
| MX2012008516A (es) | 2012-10-15 |
| CO6592108A2 (es) | 2013-01-02 |
| EP2525793B1 (en) | 2018-09-05 |
| US9889088B2 (en) | 2018-02-13 |
| JP2016026206A (ja) | 2016-02-12 |
| IL221030A0 (en) | 2012-09-24 |
| TW201141477A (en) | 2011-12-01 |
| RU2012134065A (ru) | 2014-02-27 |
| JP2017125074A (ja) | 2017-07-20 |
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