JP2013518051A - 長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト - Google Patents
長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト Download PDFInfo
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- JP2013518051A JP2013518051A JP2012550140A JP2012550140A JP2013518051A JP 2013518051 A JP2013518051 A JP 2013518051A JP 2012550140 A JP2012550140 A JP 2012550140A JP 2012550140 A JP2012550140 A JP 2012550140A JP 2013518051 A JP2013518051 A JP 2013518051A
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- benzimidazole
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- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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| JP2017086952A Expired - Fee Related JP6466504B2 (ja) | 2010-01-21 | 2017-04-26 | 長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト |
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| US20130046003A1 (en) * | 2011-07-22 | 2013-02-21 | Mohammed I. Dibas | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating retinal diseases |
| WO2013016072A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating skin diseases |
| BR112014001501A2 (pt) * | 2011-07-22 | 2017-02-14 | Allergan Inc | moduladores alfa-2 adrenérgicos para tratamento de distúrbios visuais mediados por projeções visuais centrais do olho |
| WO2014159576A1 (en) * | 2013-03-14 | 2014-10-02 | Allergan, Inc. | Alpha-2 adrenergic agonist for treating intraocular pressure and ocular diseases through intravitreal and intracameral routes |
| TWI699205B (zh) * | 2014-12-12 | 2020-07-21 | 日商興和股份有限公司 | 用於預防或治療青光眼之藥物療法 |
| WO2019004080A1 (ja) | 2017-06-27 | 2019-01-03 | 国立大学法人東京大学 | 融合遺伝子及び／又はエクソンスキッピングにより生ずる転写産物を検出するためのプローブ及び方法 |
| US11077053B2 (en) | 2018-08-21 | 2021-08-03 | Allergan, Inc. | Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia |
| PT4236932T (pt) * | 2020-11-02 | 2026-02-23 | Visus Therapeutics Inc | Composto degradante num medicamento |
| WO2023086878A1 (en) * | 2021-11-10 | 2023-05-19 | Visus Therapeutics, Inc. | Carbachol formulations to enhance anti-presbyopia effects |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004270A1 (en) * | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Novel benzimidazole derivatives |
| JPH09507216A (ja) * | 1993-12-17 | 1997-07-22 | ザ、プロクター、エンド、ギャンブル、カンパニー | ５−（２−イミダゾリニルアミノ）ベンゾイミダゾール誘導体、それらの製法及びα−２−アドレノセプター作動剤としてのそれらの用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495583B1 (en) * | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| CA2603044A1 (en) * | 2005-06-29 | 2007-01-11 | Allergan, Inc. | Alpha-2 adrenergic agonists for the treatment of pain |
| CA2641501A1 (en) | 2006-02-06 | 2007-08-16 | Nicox S.A. | Nitrooxy-comprising derivatives of apraclonidine and brimodnidine as al pha2 -adrenergic receptor agonists |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
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2011
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- 2011-01-21 KR KR1020127021719A patent/KR20120125305A/ko not_active Withdrawn
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- 2011-01-21 CN CN2011800111530A patent/CN102770135A/zh active Pending
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- 2011-01-21 EP EP11702342.4A patent/EP2525793B1/en not_active Not-in-force
- 2011-01-21 RU RU2012134065/15A patent/RU2012134065A/ru unknown
- 2011-01-21 BR BR112012018154A patent/BR112012018154A2/pt not_active IP Right Cessation
- 2011-01-21 WO PCT/US2011/022001 patent/WO2011091225A2/en not_active Ceased
- 2011-01-21 CA CA2787573A patent/CA2787573A1/en not_active Abandoned
- 2011-01-21 US US13/010,958 patent/US9889088B2/en not_active Expired - Fee Related
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2012
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- 2017-04-26 JP JP2017086952A patent/JP6466504B2/ja not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09507216A (ja) * | 1993-12-17 | 1997-07-22 | ザ、プロクター、エンド、ギャンブル、カンパニー | ５−（２−イミダゾリニルアミノ）ベンゾイミダゾール誘導体、それらの製法及びα−２−アドレノセプター作動剤としてのそれらの用途 |
| WO1996004270A1 (en) * | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Novel benzimidazole derivatives |
Also Published As
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| SG182637A1 (en) | 2012-08-30 |
| ZA201205470B (en) | 2013-05-29 |
| CA2787573A1 (en) | 2011-07-28 |
| WO2011091225A3 (en) | 2012-05-18 |
| JP6466504B2 (ja) | 2019-02-06 |
| CO6592108A2 (es) | 2013-01-02 |
| KR20120125305A (ko) | 2012-11-14 |
| US9889088B2 (en) | 2018-02-13 |
| JP2017125074A (ja) | 2017-07-20 |
| BR112012018154A2 (pt) | 2016-04-05 |
| AU2011207301A1 (en) | 2012-08-09 |
| TW201141477A (en) | 2011-12-01 |
| EP2525793A2 (en) | 2012-11-28 |
| WO2011091225A2 (en) | 2011-07-28 |
| IL221030A0 (en) | 2012-09-24 |
| US20110178145A1 (en) | 2011-07-21 |
| CN102770135A (zh) | 2012-11-07 |
| JP2016026206A (ja) | 2016-02-12 |
| MX2012008516A (es) | 2012-10-15 |
| RU2012134065A (ru) | 2014-02-27 |
| EP2525793B1 (en) | 2018-09-05 |
| CL2012002038A1 (es) | 2012-11-16 |
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