KR20120050493A - Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 - Google Patents

Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 Download PDF

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KR20120050493A
KR20120050493A KR1020127007529A KR20127007529A KR20120050493A KR 20120050493 A KR20120050493 A KR 20120050493A KR 1020127007529 A KR1020127007529 A KR 1020127007529A KR 20127007529 A KR20127007529 A KR 20127007529A KR 20120050493 A KR20120050493 A KR 20120050493A
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ras
raf
mutant
tumor
inhibitor
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Korean (ko)
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조지아 하치바실리오우
시바 말렉
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제넨테크, 인크.
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127007529A 2009-08-24 2010-08-24 Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 Ceased KR20120050493A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23646609P 2009-08-24 2009-08-24
US61/236,466 2009-08-24
US30114910P 2010-02-03 2010-02-03
US61/301,149 2010-02-03

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KR20120050493A true KR20120050493A (ko) 2012-05-18

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KR1020127007529A Ceased KR20120050493A (ko) 2009-08-24 2010-08-24 Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정

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US (2) US20120214828A1 (https=)
EP (1) EP2470898A4 (https=)
JP (1) JP2013502236A (https=)
KR (1) KR20120050493A (https=)
CN (1) CN102859355B (https=)
AU (1) AU2010289794B2 (https=)
BR (1) BR112012003926A2 (https=)
CA (1) CA2771369A1 (https=)
IL (2) IL218099A0 (https=)
IN (1) IN2012DN01403A (https=)
MX (1) MX338856B (https=)
MY (1) MY165154A (https=)
RU (2) RU2553379C2 (https=)
SG (2) SG178866A1 (https=)
WO (1) WO2011028540A1 (https=)

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AU2008337286B2 (en) 2007-12-19 2014-08-07 Cancer Research Technology Limited Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
NZ601085A (en) 2010-02-01 2015-04-24 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
US8709419B2 (en) 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
AU2012312515A1 (en) * 2011-09-19 2014-03-13 Genentech, Inc. Combination treatments comprising c-met antagonists and B-raf antagonists
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
US20150017261A1 (en) * 2012-01-11 2015-01-15 Duke University Methods of Treating and Preventing Cancer by Disrupting the Binding of Copper in the Map Kinase Pathway
US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
TR201904980T4 (tr) 2012-08-07 2019-05-21 Novartis Ag Bir B-Raf inhibitörü, bir EGFR inhibitörü ve isteğe bağlı olarak bir PI3K-alfa inhibitörü içeren farmasötik kombinasyonlar.
DK2884979T3 (da) 2012-08-17 2019-09-02 Hoffmann La Roche Kombinationsbehandlinger mod melanom omfattende indgivelse af cobimetinib og vemurafenib
US20150273057A1 (en) * 2012-10-25 2015-10-01 Glaxosmithkline Llc Combination
EP2786764B1 (en) 2013-04-01 2017-03-08 Samsung Electronics Co., Ltd. Combination therapy using anti-c-met antibody and sorafenib
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
EP3805404A1 (en) 2014-05-13 2021-04-14 Board of Regents, The University of Texas System Gene mutations and copy number alterations of egfr, kras and met
ES2827024T3 (es) * 2014-12-23 2021-05-19 Dot Therapeutics 1 Inc Combinación de inhibidores de Raf y de taxanos
WO2017066664A1 (en) * 2015-10-16 2017-04-20 Millennium Pharmaceuticals, Inc. Combination therapy including a raf inhibitor for the treatment of colorectal cancer
EP3450555B1 (en) * 2016-04-28 2020-11-18 Denka Company Limited Method for determining tolerance of cancer cell to epidermal growth factor receptor inhibitor
JP7341060B2 (ja) 2017-02-10 2023-09-08 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｍａｐｋ経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物
EP3732285A1 (en) 2017-12-28 2020-11-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
BR112020025764A2 (pt) 2018-06-19 2021-05-11 Biontech Us Inc. neoantígenos e usos dos mesmos
IL297650A (en) * 2020-04-27 2022-12-01 Verastem Inc Methods of treating abnormal cell growth
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor

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EP1766068A4 (en) * 2004-06-04 2010-03-03 Genentech Inc EGFR Mutations
EP1874342B1 (en) * 2005-04-26 2018-06-06 Eisai R&D Management Co., Ltd. Compositions and methods for cancer immunotherapy
PL1913157T5 (pl) * 2005-06-28 2017-09-29 Genentech Inc Mutacje EGFR i KRAS do prognozowania reakcji pacjenta na leczenie inhibitorem EGFR
ATE520979T1 (de) * 2005-08-24 2011-09-15 Bristol Myers Squibb Co Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptors
ES2426814T3 (es) * 2007-03-13 2013-10-25 Amgen Inc. Mutaciones de K-ras y B-raf y terapia con anticuerpos anti-EGFr

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US20150164895A1 (en) 2015-06-18
EP2470898A1 (en) 2012-07-04
RU2012111231A (ru) 2013-10-10
MY165154A (en) 2018-02-28
RU2553379C2 (ru) 2015-06-10
SG10201402917XA (en) 2014-08-28
CN102859355B (zh) 2015-10-07
WO2011028540A1 (en) 2011-03-10
US20120214828A1 (en) 2012-08-23
CN102859355A (zh) 2013-01-02
AU2010289794B2 (en) 2014-10-02
HK1175248A1 (zh) 2013-06-28
RU2015104058A (ru) 2015-06-10
IL235398A0 (en) 2014-12-31
MX338856B (es) 2016-05-03
IN2012DN01403A (https=) 2015-06-05
BR112012003926A2 (pt) 2020-08-11
MX2012002292A (es) 2012-03-19
AU2010289794A1 (en) 2012-04-05
IL218099A0 (en) 2012-04-30
CA2771369A1 (en) 2011-03-10
JP2013502236A (ja) 2013-01-24
SG178866A1 (en) 2012-04-27
EP2470898A4 (en) 2013-03-13

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