KR20120050493A - Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 - Google Patents

Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 Download PDF

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KR20120050493A
KR20120050493A KR1020127007529A KR20127007529A KR20120050493A KR 20120050493 A KR20120050493 A KR 20120050493A KR 1020127007529 A KR1020127007529 A KR 1020127007529A KR 20127007529 A KR20127007529 A KR 20127007529A KR 20120050493 A KR20120050493 A KR 20120050493A
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ras
raf
mutant
tumor
inhibitor
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Korean (ko)
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조지아 하치바실리오우
시바 말렉
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제넨테크, 인크.
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
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    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020127007529A 2009-08-24 2010-08-24 Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 Ceased KR20120050493A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23646609P 2009-08-24 2009-08-24
US61/236,466 2009-08-24
US30114910P 2010-02-03 2010-02-03
US61/301,149 2010-02-03

Publications (1)

Publication Number Publication Date
KR20120050493A true KR20120050493A (ko) 2012-05-18

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KR1020127007529A Ceased KR20120050493A (ko) 2009-08-24 2010-08-24 Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정

Country Status (15)

Country Link
US (2) US20120214828A1 (https=)
EP (1) EP2470898A4 (https=)
JP (1) JP2013502236A (https=)
KR (1) KR20120050493A (https=)
CN (1) CN102859355B (https=)
AU (1) AU2010289794B2 (https=)
BR (1) BR112012003926A2 (https=)
CA (1) CA2771369A1 (https=)
IL (2) IL218099A0 (https=)
IN (1) IN2012DN01403A (https=)
MX (1) MX338856B (https=)
MY (1) MY165154A (https=)
RU (2) RU2015104058A (https=)
SG (2) SG178866A1 (https=)
WO (1) WO2011028540A1 (https=)

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JP5760010B2 (ja) 2010-02-01 2015-08-05 キャンサー・リサーチ・テクノロジー・リミテッド １−（５−ｔｅｒｔ−ブチル−２−フェニル−２Ｈ−ピラゾール−３−イル）−３−［２−フルオロ−４−（１−メチル−２−オキソ−２，３−ジヒドロ−１Ｈ−イミダゾ［４，５−Ｂ］ピリジン−７−イルオキシ）−フェニル］−尿素および関連化合物ならびに治療におけるそれらの使用
US8709419B2 (en) 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
SG11201400724SA (en) * 2011-09-19 2014-04-28 Genentech Inc Combination treatments comprising c-met antagonists and b-raf antagonists
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
US20150017261A1 (en) * 2012-01-11 2015-01-15 Duke University Methods of Treating and Preventing Cancer by Disrupting the Binding of Copper in the Map Kinase Pathway
US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
JP6342396B2 (ja) * 2012-08-07 2018-06-13 ノバルティス アーゲー Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬
KR20190057421A (ko) 2012-08-17 2019-05-28 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
WO2014066606A2 (en) * 2012-10-25 2014-05-01 Glaxosmithkline Llc Combination
EP2786764B1 (en) 2013-04-01 2017-03-08 Samsung Electronics Co., Ltd. Combination therapy using anti-c-met antibody and sorafenib
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
ES2844229T3 (es) * 2014-05-13 2021-07-21 Univ Texas Mutaciones génicas y alteraciones en el número de copias de EGFR, KRAS y MET
CN107405348B (zh) * 2014-12-23 2021-06-11 点疗法-1公司 Raf抑制剂与紫杉烷的组合
WO2017066664A1 (en) * 2015-10-16 2017-04-20 Millennium Pharmaceuticals, Inc. Combination therapy including a raf inhibitor for the treatment of colorectal cancer
KR102367595B1 (ko) * 2016-04-28 2022-02-25 덴카 주식회사 상피성 세포 성장 인자 수용체 저해제에 대한 암세포의 내성을 판정하는 방법
WO2018146253A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
WO2019133810A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
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JP2009505658A (ja) * 2005-08-24 2009-02-12 ブリストル−マイヤーズ スクイブ カンパニー 上皮増殖因子受容体モデュレーターに対する感受性を決定するためのバイオマーカーおよび方法
PT2412828E (pt) * 2007-03-13 2013-08-02 Amgen Inc Mutações k-ras e b-raf e terapia com anticorpos anti-egfr

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HK1175248A1 (zh) 2013-06-28
CN102859355A (zh) 2013-01-02
IN2012DN01403A (https=) 2015-06-05
CA2771369A1 (en) 2011-03-10
SG10201402917XA (en) 2014-08-28
IL218099A0 (en) 2012-04-30
MX338856B (es) 2016-05-03
RU2012111231A (ru) 2013-10-10
MX2012002292A (es) 2012-03-19
RU2553379C2 (ru) 2015-06-10
EP2470898A4 (en) 2013-03-13
IL235398A0 (en) 2014-12-31
AU2010289794B2 (en) 2014-10-02
MY165154A (en) 2018-02-28
SG178866A1 (en) 2012-04-27
US20120214828A1 (en) 2012-08-23
JP2013502236A (ja) 2013-01-24
WO2011028540A1 (en) 2011-03-10
RU2015104058A (ru) 2015-06-10
US20150164895A1 (en) 2015-06-18
CN102859355B (zh) 2015-10-07
BR112012003926A2 (pt) 2020-08-11
EP2470898A1 (en) 2012-07-04
AU2010289794A1 (en) 2012-04-05

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