KR20120042399A - Oral composition containing polyethylene glycol for improving preparation stability - Google Patents

Oral composition containing polyethylene glycol for improving preparation stability Download PDF

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KR20120042399A
KR20120042399A KR1020100104086A KR20100104086A KR20120042399A KR 20120042399 A KR20120042399 A KR 20120042399A KR 1020100104086 A KR1020100104086 A KR 1020100104086A KR 20100104086 A KR20100104086 A KR 20100104086A KR 20120042399 A KR20120042399 A KR 20120042399A
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polyethylene glycol
viscosity
toothpaste
oral composition
composition
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KR1020100104086A
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Korean (ko)
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KR101693732B1 (en
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채상균
김찬호
이병렬
성영은
이존환
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(주)아모레퍼시픽
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

PURPOSE: An oral composition with formulation stability is provided to ensure formulation stability and less viscosity deviation. CONSTITUTION: An oral composition contains 0.001-10.00 wt% of polyethylene glycol with 100-50,000 of molecular weight as a viscosity stabilizing agent. The polyethylene glycol includes polyethylene glycol-6, polyethylene glyol-12, or polyethylene glycol-32. The oral composition is manufactured in the form of a toothpaste or denture cleansing agent.

Description

제형안정성 향상을 위해 폴리에틸렌글리콜을 함유하는 구강용 조성물{Oral composition containing polyethylene glycol for improving preparation stability}Oral composition containing polyethylene glycol for improving preparation stability

본 발명은 제형안정성이 우수한 구강용 조성물에 관한 것으로, 보다 상세하게는 폴리에틸렌글리콜을 점도안정제로 함유함으로써 제조 후 점도 경시변화가 적어 제형안정성이 우수하고 반복 생산에 따른 점도 편차가 적은 구강용 조성물에 관한 것이다.
The present invention relates to a composition for oral cavity having excellent formulation stability, and more particularly to containing a polyethylene glycol as a viscosity stabilizer in the composition for oral cavity having a low viscosity with time variation after manufacture, excellent formulation stability and less variation in viscosity due to repeated production. It is about.

일반적으로 치약 조성물은 불용성 무기 분말의 연마제와, 수용해성 원료과 물을 비롯한 수 친화성 액제의 혼합물을 기본적으로 포함한다. 이때, 상기 성분들의 단순한 혼합물은 혼합 후 방치 시 각 원료의 비중 차이에 의해 불용성 분말과 액상이 분리되면서 불용성 분말이 침전되어 사용성이 매우 나빠진다. 이에 따라, 치약 제조 시 조성물 내에서 점도를 형성시켜 각 성분간의 분리 현상을 막기 위하여 점도안정제나 결합제 등을 첨가한다. In general, the toothpaste composition basically comprises a mixture of an abrasive of insoluble inorganic powder and a water-compatible solution including water-soluble raw materials and water. At this time, the simple mixture of the components are insoluble powder and the liquid phase is separated by the difference in specific gravity of each raw material when left after mixing, insoluble powder precipitates very usability. Accordingly, a viscosity stabilizer, a binder, or the like is added in order to form a viscosity in the composition when the toothpaste is prepared to prevent separation between the components.

종래에는 치약의 점도안정제로서 현탁/분산제로 사용되는 폴리사카라이드계 검류와 점도조절용 실리카를 주로 사용하였다. 그러나, 상기 점도안정제들을 함유하는 치약 조성물은 액상 치약으로서 유동 특성은 양호한 반면에 제품의 안정도가 상대적으로 떨어지는 문제가 있었다. Conventionally, polysaccharide-based gums used as suspension / dispersant and viscosity-adjusting silicas are mainly used as viscosity stabilizers of toothpastes. However, the toothpaste composition containing the viscosity stabilizers is a liquid toothpaste, while having good flow characteristics, there is a problem that the stability of the product is relatively inferior.

또한 경우에 따라 잔탄검(Xanthan Gum)과 폴리아크릴레이트(Sodium polyacrylate)의 혼합물과 같은 결합제를 치약 제조 시 점도조절제로 사용하기도 하였으나, 이러한 치약들은 액체 치약과 세미-파스타제 치약으로서 필요한 유동 특성을 나타내지 않아 전단희석력(Shear Thinning)이나 틱소트로픽 효과(Thixotropic Effect; 액상이나 겔상에 힘(운동)을 가하면 점도가 떨어지는 현상) 측면에서 볼 때, 치약으로서의 사용감 향상에 한계가 따랐을 뿐만 아니라, 디스펜서 용기 타입의 치약으로 사용할 수 있어 치약의 사용 및 휴대 편의성을 가질 수 없는 점 등의 문제점이 있었다.
In some cases, binders such as a mixture of Xanthan Gum and Sodium polyacrylate were used as viscosity modifiers in toothpaste preparation.However, these toothpastes are used as liquid toothpaste and semi-pasta toothpaste. In terms of shear thinning or thixotropic effect, the viscosity of the liquid or gel decreased, resulting in limited use of toothpaste, as well as the dispenser container. It can be used as a type of toothpaste, there is a problem such as not having the use and portability of the toothpaste.

이에, 본 발명자들은 점도안정제로서 분자량(MW) 100?50,000의 폴리에틸렌글리콜을 사용하여 구강용 제형을 제조할 경우 제조 후 점도 변화가 적어 제형안정성이 우수하고, 반복 생산에 따른 점도 편차가 없어 균일한 품질의 제형을 생산할 수 있음을 발견하고 본 발명을 완성하게 되었다.Thus, the inventors of the present invention, when preparing oral formulations using polyethylene glycol having a molecular weight (MW) of 100 to 50,000 as a viscosity stabilizer, there is little change in viscosity after preparation, and thus the formulation stability is excellent, and there is no viscosity deviation due to repeated production. It has been found that the formulation of quality can be produced and the present invention has been completed.

따라서, 본 발명의 목적은 제조 후 점도 변화가 적어 제형안정성이 우수하고 균일한 품질의 제품을 생산할 수 있는 구강용 조성물을 제공하는 것이다.
Accordingly, it is an object of the present invention to provide a composition for oral cavity which can produce a product having excellent formulation stability and uniform quality due to less change in viscosity after manufacture.

상기의 목적을 달성하기 위하여, 본 발명에서는 점도안정제로서 분자량 100?50,000의 폴리에틸렌글리콜을 함유하는 구강용 조성물을 제공한다.
In order to achieve the above object, the present invention provides a composition for oral cavity containing polyethylene glycol having a molecular weight of 100 ~ 50,000 as a viscosity stabilizer.

본 발명에 의한 구강용 조성물은 점도안정제로서 분자량 100?50,000의 폴리에틸렌글리콜을 함유함으로써 제조 후 점도 변화가 적어 제형안정성이 우수하였고, 반복 생산에 따른 점도 편차가 거의 없어 균일한 품질의 제형을 제공할 수 있었다.
The composition for oral cavity according to the present invention is excellent in the stability of formulation due to the low viscosity change after preparation by containing polyethylene glycol having a molecular weight of 100 ~ 50,000 as a viscosity stabilizer, there is almost no viscosity deviation due to repeated production, to provide a formulation of uniform quality. Could.

본 발명은 점도 안정제로서 폴리에틸렌글리콜을 함유하는 구강용 조성물에 관한 것이다.The present invention relates to a composition for oral cavity containing polyethylene glycol as a viscosity stabilizer.

본 발명에서 점도 개선을 위해 사용하는 폴리에틸렌글리콜은 분자량 100?50,000인 것으로, 예를 들면, 폴리에틸렌글리콜-6, 폴리에틸렌글리콜-12 및 폴리에틸렌글리콜-32 등을 들 수 있으나, 이에만 한정되는 것은 아니다. 상기 폴리에틸렌글리콜의 분자량이 100 미만인 경우에는 점도 안정성에 대한 효능이 미미하며, 또한 50,000을 초과하는 경우에는 치약을 제조함에 있어서 고르게 용해시키기 힘든 문제가 있다.The polyethylene glycol used for viscosity improvement in the present invention has a molecular weight of 100 to 50,000, and examples thereof include polyethylene glycol-6, polyethylene glycol-12, and polyethylene glycol-32, but are not limited thereto. When the molecular weight of the polyethylene glycol is less than 100, the efficacy on viscosity stability is insignificant, and when it exceeds 50,000, there is a problem that it is difficult to dissolve evenly in the preparation of toothpaste.

상기 폴리에틸렌글리콜은 치약 조성물 총 중량에 대하여 0.001?10.00 중량%로 함유될 수 있으며, 보다 바람직하게는 0.50?2.00 중량%의 양으로 함유될 수 있다. 상기 폴리에틸렌글리콜의 함량이 0.001 중량% 미만에서는 점도 변화에 대한 효능을 얻을 수 없고, 10.00 중량%를 초과하는 경우에는 제형안정성에 문제가 발생할 수 있다. 본 발명에 의한 치약 조성물은 폴리에틸렌글리콜을 함유함으로써 제형 안정성이 우수하였으며, 반복 생산에 따른 점도 편차가 거의 없어서 소비자들에게 균일한 품질의 구강용 제형을 제공할 수 있었다. The polyethylene glycol may be contained in an amount of 0.001 to 10.00% by weight based on the total weight of the toothpaste composition, more preferably in an amount of 0.50 to 2.00% by weight. If the content of the polyethylene glycol is less than 0.001% by weight can not obtain the effect on the viscosity change, if it exceeds 10.00% by weight may cause problems in formulation stability. Toothpaste composition according to the present invention was excellent in formulation stability by containing polyethylene glycol, there was little variation in viscosity due to repeated production was able to provide a formulation for oral cavity to consumers with a uniform quality.

본 발명에 의한 구강용 조성물은 그 제형에 있어 특별히 한정되지 않으며, 예를 들면, 치약, 구강청정제, 틀니세정제, 또는 구취제 등으로 제형화될 수 있으나 이에만 한정되는 것은 아니다.
The composition for oral cavity according to the present invention is not particularly limited in the formulation, for example, but may be formulated as a toothpaste, mouthwash, denture cleaner, or bad breath, but is not limited thereto.

이하, 본 발명의 내용을 실시예 및 시험예를 통하여 보다 구체적으로 설명한다. 이들 실시예는 본 발명의 내용을 이해하기 위해 제시되는 것일 뿐 본 발명의 권리 범위가 이들 실시예와 시험예로 한정되는 것은 아니고, 당업계에서 통상적으로 주지된 변형, 치환 및 삽입 등을 수행할 수 있으며, 이에 대한 것도 본 발명의 범위에 포함된다.
Hereinafter, the present invention will be described more specifically with reference to examples and test examples. These examples are provided only for understanding the contents of the present invention, but the scope of the present invention is not limited to these examples and test examples, and modifications, substitutions, and insertions commonly known in the art may be performed. It may be included in the scope of the present invention.

[실시예 1?5 및 비교예 1]  [Examples 1-5 and Comparative Example 1]

하기 표 1에 기재된 조성에 따라 통상적인 방법으로 실시예 1?5 및 비교예 1의 치약을 제조하였다(단위: 중량%). 비교예 1에는 폴리에틸렌글리콜을 사용하지 않았으며, 실시예 1에서는 폴리에틸렌글리콜-6, 실시예 2에서는 폴리에틸렌글리콜-12, 실시예 3에서는 폴리에틸렌글리콜-32을 각각 2 중량%씩 첨가하였고, 실시예 4와 5에서는 폴리에틸렌글리콜-32를 각각 0.5 중량% 및 4 중량%로 첨가하여 치약을 제조하였다.Toothpastes of Examples 1 to 5 and Comparative Example 1 were prepared in a conventional manner according to the compositions shown in Table 1 below (unit: wt%). Polyethyleneglycol was not used in Comparative Example 1, polyethyleneglycol-6 in Example 1, polyethyleneglycol-12 in Example 2, and polyethyleneglycol-32 in Example 3 were added by 2% by weight, respectively. In and 5, the toothpaste was prepared by adding 0.5 wt% and 4 wt% of polyethylene glycol-32, respectively.

성분ingredient 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 비교예 1Comparative Example 1 향료Spices 1.001.00 1.001.00 1.001.00 1.001.00 1.001.00 1.001.00 메틸파라벤Methyl paraben 0.200.20 0.200.20 0.200.20 0.200.20 0.200.20 0.200.20 카르복시메틸셀룰로오스나트륨Carboxymethyl Cellulose Sodium 0.700.70 0.700.70 0.700.70 0.700.70 0.700.70 0.700.70 정제수Purified water 잔량Balance 잔량Balance 잔량Balance 잔량Balance 잔량Balance 잔량Balance 불화나트륨Sodium fluoride 0.760.76 0.760.76 0.760.76 0.760.76 0.760.76 0.760.76 폴리에틸렌글리콜-6Polyethylene Glycol-6 2.002.00 -- -- -- -- -- 폴리에틸렌글리콜-12Polyethylene Glycol-12 -- 2.002.00 -- -- -- -- 폴리에틸렌글리콜-32Polyethylene Glycol-32 -- -- 2.002.00 0.500.50 4.004.00 -- 삭카린나트륨Zaccarin Sodium 0.150.15 0.150.15 0.150.15 0.150.15 0.150.15 0.150.15 솔비톨액Sorbitol Liquid 30.0030.00 30.0030.00 30.0030.00 30.0030.00 30.0030.00 30.0030.00 함수규산Function 6.506.50 6.506.50 6.506.50 6.506.50 6.506.50 6.506.50 탄산칼슘Calcium carbonate 35.0035.00 35.0035.00 35.0035.00 35.0035.00 35.0035.00 35.0035.00 소듐 라우릴 설페이트Sodium Lauryl Sulfate 1.501.50 1.501.50 1.501.50 1.501.50 1.501.50 1.501.50

[시험예 1] 폴리에틸렌글리콜 종류 및 함량에 따른 점도 경시변화[Test Example 1] Viscosity with time according to the type and content of polyethylene glycol

상기 실시예 1?5 및 비교예 1에서 제조한 치약들에 대한 점도 경시변화를 하기와 같이 측정하였다. Viscosity change with respect to the toothpaste prepared in Examples 1 to 5 and Comparative Example 1 was measured as follows.

먼저, 실시예 1?5 및 비교예 1의 치약 제조직후 각각의 치약들을 100 ml씩 점도병에 넣은 후 점도계(Brookfield Helipath Stand viscometer)로 점도를 측정하였다. 그런 다음, 각각의 치약들을 30℃ 항온조에 일주일간 보관하면서 1일 후 및 7일 후의 점도를 각각 측정하였으며, 그 결과를 하기 표 2에 나타내었다(단위: cps). First, immediately after preparation of the toothpaste of Examples 1 to 5 and Comparative Example 1, each toothpaste was put into a viscous bottle by 100 ml, and the viscosity was measured by a viscometer (Brookfield Helipath Stand viscometer). Then, each toothpaste was stored for 1 week in a 30 ℃ thermostat was measured for viscosity after 1 day and 7 days, respectively, the results are shown in Table 2 (unit: cps).

평가 항목Evaluation items 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 비교예 1Comparative Example 1 초기점도Initial viscosity 220000220000 380000380000 600000600000 540000540000 600000600000 160000160000 1일 후 점도Viscosity after 1 day 920000920000 10000001000000 10400001040000 11800001180000 10800001080000 880000880000 7일 후 점도Viscosity after 7 days 16800001680000 17200001720000 16400001640000 17600001760000 16800001680000 17400001740000 점도 경시변화
초기점도 - 7일 후 점도 차이Viscosity change over time
Initial viscosity-difference in viscosity after 7 days 14600001460000 13400001340000 10400001040000 12200001220000 10500001050000 15800001580000

상기 표 2의 결과에서, 폴리에틸렌글리콜을 함유한 실시예 1?5에서 제조한 치약이 비교예 1과 비교하여 점도 경시변화가 현저히 적음을 확인할 수 있었다. 특히, 폴리에틸렌글리콜의 분자량이 커질수록 점도 경시변화를 축소하는데 더욱 효과적이었으며, 또한 폴리에틸렌글리콜의 함량에 의존하여 점도 경시변화가 축소되는 것을 확인하였다. 그러나, 폴리에틸렌글리콜 2 중량% 이상에서는 함량 증가 비율 대비 점도 경시변화 축소 비율이 미미함을 확인할 수 있었다. 따라서, 상기 결과를 통해 분자량이 큰 폴리에틸렌글리콜을 2 중량% 이하로 사용할 경우 구강용 조성물의 제형 안정성이 최적 상태로 유지될 수 있음을 알 수 있다.
In the results of Table 2, it was confirmed that the toothpaste prepared in Examples 1 to 5 containing polyethylene glycol was significantly less change in viscosity over time compared to Comparative Example 1. In particular, the higher the molecular weight of polyethylene glycol was more effective in reducing the viscosity change with time, and also it was confirmed that the viscosity change over time depending on the content of polyethylene glycol. However, in the polyethylene glycol 2% by weight or more, it was confirmed that the rate of change in viscosity over time compared to the content increase rate is insignificant. Therefore, it can be seen from the above results that the formulation stability of the composition for oral cavity can be maintained in an optimal state when using a polyethylene glycol having a large molecular weight of 2 wt% or less.

[시험예 2] 반복 생산에 따른 점도 편차[Test Example 2] Viscosity deviation due to repeated production

상기 실시예 1?5 및 비교예 1의 조성을 갖는 치약을 각각 30번씩 반복 생산한 후 30℃ 항온조에 7일간 보관 다음 그 점도를 각각 측정한 후, 측정된 점도의 표준편차를 각각 구하였으며, 그 결과를 하기 표 3에 나타내었다(단위: cps). After repeated production of the toothpaste having the composition of Examples 1 to 5 and Comparative Example 1 each 30 times and stored in a 30 ℃ thermostat for 7 days and then measured the viscosity of each, and then obtained the standard deviation of the measured viscosity, respectively The results are shown in Table 3 below (unit: cps).

평가 항목Evaluation items 비교예 1Comparative Example 1 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 7일 후 점도 표준 편차Viscosity standard deviation after 7 days 196000196000 100000100000 7000070000 5200052000 6400064000 5600056000

상기 표 3의 결과에서, 실시예 1?5의 조성으로 제조한 치약들이 비교예 1의 조성을 갖는 치약들보다 반복 생산에 따른 점도 편차가 적은 것을 확인하였으며, 특히 실시예 3의 조성을 갖는 치약의 점도 편차가 가장 적은 것을 확인하였다.In the results of Table 3, it was confirmed that the toothpaste prepared in the composition of Examples 1 to 5 less variation in viscosity due to repeated production than the toothpaste having the composition of Comparative Example 1, in particular, the viscosity of the toothpaste having the composition of Example 3 The least deviation was confirmed.

상기 결과를 통해 본 발명에 의한 구강용 조성물이 반복 생산에 따른 점도 편차가 거의 없어 소비자들에게 균일한 품질의 제품을 제공할 수 있음을 확인하였다.
Through the above results, it was confirmed that the composition for oral cavity according to the present invention has almost no viscosity deviation due to repeated production, thereby providing a product of uniform quality to consumers.

Claims (3)

점도안정제로서 분자량 100?50,000의 폴리에틸렌글리콜을 함유하는 구강용 조성물.An oral composition containing polyethylene glycol having a molecular weight of 100 to 50,000 as a viscosity stabilizer. 제 1항에 있어서, 상기 폴리에틸렌글리콜은 폴리에틸렌글리콜-6, 폴리에틸렌글리콜-12 및 폴리에틸렌글리콜-32로 이루어진 군에서 선택된 1종 이상임을 특징으로 하는 구강용 조성물.The oral composition according to claim 1, wherein the polyethylene glycol is at least one selected from the group consisting of polyethylene glycol-6, polyethylene glycol-12, and polyethylene glycol-32. 제 1항에 있어서, 상기 폴리에틸렌글리콜은 조성물 총 중량에 대하여 0.001?10.00 중량%로 함유됨을 특징으로 하는 구강용 조성물.
The oral composition according to claim 1, wherein the polyethylene glycol is contained in an amount of 0.001 to 10.00% by weight based on the total weight of the composition.
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US10231910B2 (en) 2014-05-15 2019-03-19 The Procter & Gamble Company Oral care compositions having improved freshness
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US10285921B2 (en) 2014-05-15 2019-05-14 The Procter & Gable Company Dentrifrice compositions having dental plaque mitigation or improved fluoride uptake
US9913783B2 (en) 2014-05-15 2018-03-13 The Procter & Gamble Company Dentifrice compositions having optimized preservatives
US10039697B2 (en) 2014-05-15 2018-08-07 The Procter & Gamble Company Dentifrice compositions having improved fluoride ion stability or fluoride uptake
US10130569B2 (en) 2014-05-15 2018-11-20 The Procter & Gamble Company Dentifrice compositions having dental plaque mitigation or improved fluoride uptake
US10149806B2 (en) 2014-05-15 2018-12-11 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US10226414B2 (en) 2014-05-15 2019-03-12 The Procter & Gamble Company Dentifrice compositions with improved fluoride stability
US10231910B2 (en) 2014-05-15 2019-03-19 The Procter & Gamble Company Oral care compositions having improved freshness
US9364419B2 (en) 2014-05-15 2016-06-14 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US10835477B2 (en) 2014-05-15 2020-11-17 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US10213370B2 (en) 2015-11-13 2019-02-26 The Procter & Gamble Company Dentifrice compositions with improved fluoride stability
US10226410B2 (en) 2015-11-13 2019-03-12 The Procter & Gamble Company Dentifrice compositions with improved fluoride uptake
US10463583B2 (en) 2015-11-13 2019-11-05 The Procter & Gamble Company Dentifrice compositions with dual fluoride source with improved fluoride uptake
US11096876B2 (en) 2015-11-13 2021-08-24 The Procter & Gamble Company Dentifrice compositions with dual fluoride source with improved fluoride update

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