JP2019099503A - Oral composition - Google Patents

Abstract

To provide methods for preparing oral compositions stably containing active ingredients (especially β-glycyrrhetinic acid and cetylpyridinium chloride).SOLUTION: Provided is a method for producing an oral composition comprising the following steps (A) to (D) in this order. The method comprises: (A) mixing water and an organic acid or a salt thereof; (B) blending β-glycyrrhetinic acid, propylene glycol, and polyoxyethylene hydrogenated castor oil; (C) combining cetyl pyridinium chloride; and (D) blending hydroxyethyl cellulose, the liquid oral composition satisfying formula (1), when the polyoxyethylene hydrogenated castor oil is X mass% and the β-glycyrrhetinic acid and tocopherol are Y mass%. Y/X-0.543X+0.495 (provided that 0.1≤X, 0<Y) (1) preferably, Y/X<0.543X+0.47 (1) preferably, 0.05≤Y≤0.1 and is 0.25≤X≤0.45.SELECTED DRAWING: None

Description

  The present invention relates to an oral composition and the like.

  β-Glycyrrhetinic acid is an oil-soluble component having an excellent anti-inflammatory effect. For this reason, although it is mix | blended in order to provide an anti-inflammatory effect to the composition for oral cavity etc., since it is oil solubility (namely, it is poorly water-soluble), stability in a composition is bad and it is easy to precipitate. For this reason, research and development have been made for the purpose of preparing an oral composition which stably contains β-glycyrrhetinic acid.

  Tocopherol has an excellent effect as an antioxidant, but it is also an oil-soluble component and has poor stability in the composition.

  In addition, cetyl pyridinium chloride is a component that exhibits a bactericidal effect, and is a component that is used relatively frequently in oral compositions.

Patent No. 5952986 JP, 2010-024227, A

  An object of the present invention is to provide a liquid composition for oral cavity, which contains β-glycyrrhetinic acid and tocopherol dissolved therein for long-term stability, and in which adsorption of cetylpyridinium chloride is less likely to be inhibited.

  A surfactant can usually be used to dissolve the oil-soluble component. In order to stably blend β-glycyrrhetinic acid and tocopherol into the oral composition, it has been considered to use a surfactant. However, in order to suppress adsorption of cetyl pyridinium chloride to the teeth, it is preferable to use a surfactant as small as possible.

  In consideration of the above circumstances, polyoxyethylene hydrogenated castor oil, which is a surfactant that does not suppress the adsorption of cetyl pyridinium chloride to teeth so strongly, is used to impart some viscosity to the composition for oral cavity. The composition for oral cavity was prepared by blending hydroxyethyl cellulose as a thickener. More specifically, citric acid and glycerin are dissolved in water (A), to which β-glycyrrhetinic acid, tocopherol, propylene glycol, and polyoxyethylene hydrogenated castor oil (B) and hydroxyethyl cellulose (D) are blended. Finally, cetyl pyridinium chloride (C) was blended to prepare a liquid oral composition. However, the composition for oral cavity produced precipitation after preparation.

  Therefore, as a result of further investigations, it has been found that by changing the composition order of the components, it is possible to prepare a composition for liquid oral cavity where precipitation does not occur after preparation, and further improvement is made to complete the present invention. The

The present invention includes, for example, the subject matters described in the following sections.
Item 1.
(I) polyoxyethylene hydrogenated castor oil, and (ii) β-glycyrrhetinic acid and tocopherol,
And water, cetyl pyridinium chloride, hydroxyethyl cellulose, and propylene glycol,
When content of (i) component and (ii) component is made into X mass% and Y mass%, following Formula (1):
Y / X <−0.543X + 0.495 (however, 0.1 ≦ X, 0 <Y) [Formula (1)]
Meet
(Ii) A composition for liquid oral cavity in which the components are dissolved.
Item 2.
Formula (1) is
Y / X <−0.543X + 0.47 (however, 0.1 ≦ X, 0 <Y)
The composition for liquid oral cavity according to item 1, which is
Item 3.
The range of X in equation (1) is
0.25 ≦ X ≦ 0.45
The liquid oral cavity composition according to Item 1 or 2, which is
Item 4.
The range of Y in equation (1) is
0.05 ≦ Y ≦ 0.1
The liquid oral cavity composition according to any one of Items 1 to 3, which is
Item 5.
The liquid oral composition according to any one of Items 1 to 4, which contains 50 to 90% by mass of water.
Item 6.
The liquid oral cavity composition according to any one of Items 1 to 5, wherein the liquid oral cavity composition in which the component (ii) is dissolved is a liquid oral cavity composition in which the component (ii) is not precipitated.
Item 7.
A method for producing the liquid oral composition according to any one of items 1 to 6, wherein
The following steps (B) to (D):
(B) blending β-glycyrrhetinic acid, tocopherol, propylene glycol, and polyoxyethylene hydrogenated castor oil into water;
(C) combining cetyl pyridinium chloride,
(D) blending hydroxyethyl cellulose,
, In this order, how.
Item 8.
8. The method according to item 7, comprising the step of mixing (A) water and an organic acid or a salt thereof prior to step (B).
Item 9.
As a hydroxyethyl cellulose of a process (D), a hydroxyethyl cellulose dispersion glycerol liquid is used,
9. The method according to item 7 or 8.
Item 10.
Step (B) is a step of blending a mixture containing β-glycyrrhetinic acid, tocopherol, propylene glycol, and polyoxyethylene hydrogenated castor oil.
Item 10. The method according to any one of Items 7 to 9.

  According to the present invention, it is possible to prepare a liquid oral composition which contains β-glycyrrhetinic acid and tocopherol in solution for long-term stability.

In the examination of the blending amounts of β-glycyrrhetinic acid, tocopherol and polyoxyethylene hydrogenated castor oil in the composition for oral cavity, a sample considered to be a blending amount near the limit where precipitation does not occur is selected, and polyoxyethylene hydrogenated castor oil In the graph, X is plotted on the horizontal axis, and Y / X is plotted on the vertical axis, where X is the mass ratio of X and Y mass% is the total amount of β-glycyrrhetinic acid and tocopherol.

  Hereinafter, each embodiment of the present invention will be described in more detail.

The composition for oral cavity included in the present invention (hereinafter referred to as "the composition for oral cavity of the present invention") comprises (i) polyoxyethylene hydrogenated castor oil, and (ii) β-glycyrrhetinic acid and tocopherol, And water, cetyl pyridinium chloride, hydroxyethyl cellulose, and propylene glycol, and when the contents of the component (i) and the component (ii) are X mass% and Y mass%, the following formula (1):
Y / X <−0.543X + 0.495 (however, 0.1 ≦ X, 0 <Y) [Formula (1)]
(Ii) a liquid oral composition in which the component is dissolved. In the present specification, mass% indicates w / w%.

Formula (1) is preferably, for example, Y / X <−0.543X + 0.49 (where 0.1 ≦ X, 0 <Y),
Y / X <−0.543X + 0.48 (however, 0.1 ≦ X, 0 <Y),
Y / X <−0.543X + 0.47 (however, 0.1 ≦ X, 0 <Y),
Y / X <−0.543X + 0.46 (however, 0.1 ≦ X, 0 <Y),
Y / X <−0.543X + 0.45 (where 0.1 ≦ X, 0 <Y), or Y / X <−0.543X + 0.445 (where 0.1 ≦ X, 0 <Y) May be

  Furthermore, although the range of X in the formula (1) is 0.1 ≦ X, the lower limit is preferably, for example, 0.15 or more, 0.2 or more, 0.25 or more, or 0.3 or more, and The upper limit is preferably, for example, 0.8 or less, 0.75 or less, 0.7 or less, 0.65 or less, 0.6 or less, 0.55 or less, 0.5 or less, 0.45 or less, or 0.4 It is below. The lower limit value and the upper limit value may be arbitrarily combined to determine the range of X. For example, 0.15 ≦ X ≦ 0.8, 0.2 ≦ X ≦ 0.6, 0.25 ≦ X ≦ 0.45, or 0.3 ≦ X ≦ 0.4. Ru.

  The range of Y in the formula (1) is 0 <Y, but the lower limit is preferably, for example, 0.02 or more, 0.03 or more, 0.04 or more, 0.05 or more, or 0.06 or more. The upper limit is preferably, for example, 0.12 or less, 0.11 or less, 0.1 or less, or 0.09 or less. The lower limit value and the upper limit value may be combined arbitrarily to determine the range of Y. Although not limited, for example, 0.02 ≦ Y ≦ 0.12, 0.03 ≦ Y ≦ 0.11, 0.05 ≦ Y ≦ 0.1, or 0.06 ≦ Y ≦ 0.09, etc. are exemplified. Ru.

  The polyoxyethylene hydrogenated castor oil is not limited, but the average addition mole number of ethylene oxide (EO) is preferably 15 to 100, more preferably 20 to 80, and further preferably 40 to 60. preferable. The polyoxyethylene hydrogenated castor oil is preferably contained in the composition for oral cavity in an amount of 0.1 to 2% by mass, more preferably 0.2 to 1.5% by mass, still more preferably 0.3 to 1% by mass. Preferably, 0.3 to 0.5% by mass is more preferable.

  The content of β-glycyrrhetinic acid is preferably 0.01 to 0.5% by mass, more preferably 0.02 to 0.4% by mass, and more preferably 0.03 to 0.2% by mass in the composition for oral cavity. Is more preferred. In addition, the upper limit of the range may be 0.15% by mass or less, or 0.1% by mass.

  Tocopherol is a component also known as vitamin E. As tocopherol, more specifically, for example, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, tocopherol acetate (eg, dl-α-tocopherol acetate), tocopherol nicotinate, tocopherol succinate etc. It can be mentioned. More preferred are α-tocopherol, tocopherol acetate and tocopherol nicotinate, and more preferred is tocopherol acetate. Tocopherols can be used singly or in combination of two or more. The content of tocopherol in the composition for oral cavity is preferably 0.01 to 0.5% by mass, more preferably 0.02 to 0.4% by mass, and still more preferably 0.03 to 0.3% by mass. And 0.04 to 0.2% by mass are more preferable.

  However, the content of the polyoxyethylene hydrogenated castor oil, β-glycyrrhetinic acid, and tocopherol is premised to satisfy the formula (1).

  Water is not particularly limited, and distilled water, deionized water, tap water, etc. can be appropriately selected and used. Water is preferably contained in the composition for oral cavity at 50 to 90% by mass, more preferably 60 to 90% by mass, still more preferably 70 to 90% by mass, and still more preferably 80 to 90% by mass.

  The content of cetylpyridinium chloride in the composition for oral cavity is preferably 0.01 to 5% by mass, more preferably 0.02 to 4% by mass, still more preferably 0.03 to 3% by mass, and 0.04 -2 mass% or 0.05 to 1 mass% is further more preferable.

  The content of hydroxyethyl cellulose (HEC) in the composition for oral cavity is preferably 0.05 to 0.5% by mass, more preferably 0.1 to 0.4% by mass, and 0.2 to 0.3% by mass. % Is more preferred.

  The content of propylene glycol in the composition for oral cavity is preferably 1 to 5% by mass, and more preferably 2 to 4% by mass.

  Moreover, the composition for oral cavity may also contain another component in the range which does not impair the effect of this invention besides these.

  For example, an organic acid or a salt thereof can be preferably included. As an organic acid or its salt, the well-known organic acid or its salt mix | blended with the composition for oral cavity can be selected suitably, and can be used. As an organic acid, a hydroxycarboxylic acid is mentioned, for example, More specifically, a citric acid, a sulfuric acid, malic acid etc. are illustrated preferably. Preferred examples of salts of organic acids include potassium salts and sodium salts. Particularly preferred examples include sodium citrate and citric acid anhydride. The organic acids or salts thereof can be used singly or in combination of two or more. The organic acid or a salt thereof is preferably contained in the composition for oral cavity in an amount of 0.01 to 0.2% by mass, more preferably 0.02 to 0.17% by mass, and 0.03 to 0.15 More preferably,% by mass, 0.04 to 0.13% by mass, or 0.05 to 0.1% by mass.

  Moreover, it is preferable that pH of the said composition for oral cavity is about 5.0-8.0, and it is more preferable that it is about 5.5-7.5.

  For example, preservatives can be preferably blended. As the preservative, preferred is p-hydroxybenzoic acid ester, and more specifically, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, butyl p-hydroxybenzoate, isobutyl p-hydroxybenzoate and the like are exemplified. Ru. Among them, methyl parahydroxybenzoate is preferred. These can be used 1 type or in combination of 2 or more types. It is preferable that 0.05 to 0.5 mass% is contained in the whole composition for oral cavity, and, as for a preservative (especially paraoxybenzoic acid ester), 0.1 to 0.4 mass% is more preferable, 0.2 -0.3 mass% is further more preferable.

  For example, as components that can be used as other components, for example, surfactants, abrasives, caking agents, flavoring agents, sweetening agents, wetting agents, conditioning agents and the like can be mentioned.

  As the surfactant, a nonionic surfactant, an anionic surfactant or an amphoteric surfactant can be blended. Specific examples of the anionic surfactant include alkyl sulfate, polyoxyethylene alkyl ether sulfate, alkyl phosphate, polyoxyalkyl ether phosphate, fatty acid soap, polyoxyethylene alkyl ether carboxylic acid Salts, polyoxyethylene alkyl ether sulfate, α-olefin sulfonate, alkyl sulfosuccinate, polyoxyalkyl ether sulfosuccinate, acyl amino acid salt, glycerin fatty acid ester sulfate, alkyl ether phosphate, alkyl glutamate and the like Can be mentioned. As a cationic surfactant, monoalkyl trimethyl ammonium salt, dialkyl dimethyl ammonium salt, alkylamine salt etc. are mentioned. As the nonionic surfactant, sugar fatty acid ester, fatty acid alkanolamide, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polypropylene alkyl ether, polyoxy Ethylene alkyl phenyl ether, alkyl glucoside, polyoxyethylene polyoxypropylene block copolymer, lecithin, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester and the like can be mentioned. The amphoteric surfactant includes alkyl dimethylaminoacetic acid betaine, fatty acid amidopropyl dimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, alkyl sulfobetaine, alkyl betaine and the like. These surfactants can be used alone or in combination of two or more.

  As the polishing agent, abrasive silica, calcium hydrogen phosphate, calcium phosphate, tribasic calcium phosphate, tribasic magnesium phosphate, calcium pyrophosphate, hydroxyapatite, insoluble sodium metaphosphate, aluminum silicate, zirconium silicate, calcium silicate, carbonate Examples thereof include calcium, magnesium carbonate, magnesium oxide, alumina, aluminum hydroxide, calcium sulfate, polymethyl methacrylate, pumice (pumice stone), bentonite, synthetic resin and the like. These abrasives can be used alone or in combination of two or more.

  As a binder, carboxymethyl cellulose sodium, carboxymethyl ethyl cellulose salt, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, ethyl cellulose, crystalline cellulose, cellulose derivatives other than hydroxyethyl cellulose such as crystalline cellulose and carmellose sodium, microbial production of xanthan gum and the like Polymers, tragacanth gum, karaya gum, arabia gum, carrageenan, dextrin, agar, pectin, pullulan, gellan gum, locust bean gum, natural polymers such as sodium alginate or natural gums, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, polyvinyl methyl ether , Synthetic polymers such as sodium polyacrylate, Sex silica, inorganic binder, such as Veegum, cationic caking agent such as chloride O- [2- hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose and the like. These caking agents can be used alone or in combination of two or more.

  Examples of flavoring agents (including flavoring agents) include menthol, carboxylic acid, methyl salicylate, vanillin, benzyl succinate, methyl eugenol, anethole, limonene, oscimene, n-decyl alcohol, methyl acetate, citronenyl acetate, cineole, ethyl linalool , Allirin, thyme, nutmeg, cinnamic aldehyde, benzaldehyde, spearmint oil, peppermint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, sciatic oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento Oil, tea tree oil, tabana oil, star anise oil, fennel oil, diatom oil, basil oil and the like. These perfumes can be used alone or in combination of two or more.

  As a sweetening agent, saccharin, saccharin sodium, acesulfame potassium, stevia extract, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, soumatin, aspartyl phenylalanine methyl ester, methoxycinnamic aldehyde, palatinose, palatinit, erythritol, maltitol , Xylitol, lactitol and the like. These sweetening agents can be used alone or in combination of two or more.

  Wetting agents include ethanol, dipropylene glycol, 1,3-butylene glycol, isoprene glycol, diglycerin, sorbit, polyethylene glycol and the like. These can be used alone or in combination of two or more.

  Examples of the conditioning agent include silicone derivatives, cationically modified water-soluble polymers, fatty acid esters, trimethylglycine, protein hydrolysates, amino acids and their derivatives, urea, phospholipids, glycolipids, ceramides and the like. These can be used alone or in combination of two or more.

  Other components include animal and vegetable fats and oils, powders, preservatives / preservatives, dyes, pH adjusters, UV absorbers, animal and plant extracts and the like.

  Moreover, the form of the composition for oral cavity of this invention will not be restrict | limited in particular, if it is a liquid. For example, it can be used as a form (dosage form) such as liquid dentifrice, liquid dentifrice, mouthwash, spray, coating agent and the like. Among these, liquid toothpaste, liquid toothpaste, mouthwash and coating agents are more preferable.

  The composition for oral cavity of the present invention can contain β-glycyrrhetinic acid and tocopherol in a stable manner for a long period of time. For example, precipitation does not occur even when left at room temperature (25 ° C.) for at least one week.

  As described above, in order to produce the composition for oral cavity of the present invention, the order in which each component is blended is also important. If the order is not appropriate, precipitation occurs and a long-term stable composition can not be obtained.

In order to manufacture the composition for oral cavity of this invention, the manufacturing method which contains the following process (B)-(D) in this order can be used, for example.
(B) Step of blending β-glycyrrhetinic acid, tocopherol, propylene glycol, and polyoxyethylene hydrogenated castor oil with water (C) Step of blending cetylpyridinium chloride (D) Step of blending hydroxyethyl cellulose Further, water-soluble component When preparing the composition for oral cavity which further contains (especially organic acid or its salt), (A) water and a water-soluble ingredient (for example, organic acid or its salt) are mixed before a process (B). And b.

  There are no particular limitations on the order of blending of the components blended in step (B), and β-glycyrrhetinic acid, tocopherol, propylene glycol, and polyoxyethylene hydrogenated castor oil may be blended in any order. Among them, it is preferable to mix β-glycyrrhetinic acid, tocopherol and polyoxyethylene hydrogenated castor oil into propylene glycol in advance and then mix them into the composition obtained by the process performed before the process (B). . In the steps (A) to (D), other components may be further blended within the range not impairing the effects of the present invention, but in the case of using an oil-soluble component as the other components, the step (B) It is preferable to mix the oil-soluble component together with polyoxyethylene hydrogenated castor oil in propylene glycol in advance, and then mix it in water or the composition obtained by the process performed before the process (B). Is preferred. That is, step (B) is a step of blending a liquid mixture containing propylene glycol, polyoxyethylene hydrogenated castor oil, and an oil-soluble component, and β-glycyrrhetinic acid and tocopherol are also preferable oil-soluble components. it can.

  In addition, hydroxyethyl cellulose may be directly blended into the composition obtained by the step performed before step (D), but the form of a dispersion dispersed in glycerin (ie, hydroxyethyl cellulose dispersed glycerin solution) Is preferably used. That is, in the step (D), it is preferable to blend, as the hydroxyethyl cellulose, a hydroxyethyl cellulose-dispersed glycerin solution into the composition obtained by the step performed before the step (D). In this case, the weight ratio of hydroxyethyl cellulose and glycerin in the hydroxyethyl cellulose-dispersed glycerin solution is preferably about 1:10 to about 150, more preferably about 1:20 to about 100, and still more preferably about 1:30 to about 70. The amount of glycerin used here is preferably 5 to 15% by mass in the composition for oral cavity, more preferably 7 to 13% by mass, and still more preferably 8 to 12% by mass.

  In each step, each component is blended and mixed. The mixing can be carried out by known methods. For example, it can be carried out using a mixer (dispa mixer, anchor mixer, homo mixer, etc.).

  In the present specification, the term "comprising" also includes "consisting essentially of" and "consisting of" (The term "comprising" includes "consisting essentially of" and "consisting of.").

  Hereinafter, the present invention will be described more specifically, but the present invention is not limited to the following examples. In addition, the usage-amount (%) of each component described by the manufacturing method of the composition for liquid oral cavity of each case shows the mass% with respect to the composition whole quantity obtained unless it refuses in particular.

Example 1
A stainless steel can was charged with water, and sodium citrate (0.07%) and anhydrous citric acid (0.01%) were dissolved to prepare work in process A. Then dissolve methyl parahydroxybenzoate (0.2%) and polyoxyethylene hydrogenated castor oil (0.4%) in propylene glycol (3%) warmed in a separate container, and then add tocopherol acetate (0.05%) Mix with dissolved perfume (0.1%), add β-glycyrrhetinic acid (0.04% or 0.05%) to prepare work-in-process B, and place it in work-in-process A (stainless steel can) Mix and dissolve. Thereafter, cetyl pyridinium chloride (0.05%) was charged into the mixed solution (stainless steel can) and dissolved. Finally, a product D prepared by dispersing hydroxyethyl cellulose (0.2%) in concentrated glycerin (10%) was charged into the mixed solution (stainless steel can) and dissolved. The average added mole number of ethylene oxide (EO) of the polyoxyethylene hydrogenated castor oil used was 60.

Comparative Example 1
A stainless steel can was charged with water, and sodium citrate (0.07%), anhydrous citric acid (0.01%), and concentrated glycerin (10%) were dissolved to prepare weight A. Thereafter, methyl parahydroxybenzoate (0.2%) and polyoxyethylene hydrogenated castor oil (0.4%) are dissolved in propylene glycol (3%) warmed in a separate container, and this is dissolved in tocopherol acetate (0.05%) B) was prepared by mixing with the dissolved perfume and further adding β-glycyrrhetinic acid (0.04% or 0.05%). Further, hydroxyethyl cellulose (0.2%) was dispersed in in-process B, and then charged in in-process A (stainless steel can) and dissolved. Finally, cetyl pyridinium chloride (0.05%) was charged into a stainless steel can and dissolved.

  In Example 1, the case where the amount of β-glycyrrhetinic acid used is 0.4% is described as Example 1-1, and the case where 0.5% is described as Example 1-2. In Comparative Example 1, the case where the amount of β-glycyrrhetinic acid used is 0.4% is referred to as Comparative Example 1-1, and the case where it is 0.5% is referred to as Comparative Example 1-2.

  The liquid compositions of Example 1-1 and Example 1-2 were all transparent without precipitation. On the other hand, all of the liquid compositions of Comparative Example 1-1 and Comparative Example 1-2 were deposited. (Checked visually)

  From the results, the step of blending (B) β-glycyrrhetinic acid, tocopherol, propylene glycol and polyoxyethylene hydrogenated castor oil, the step of blending (C) cetylpyridinium chloride, the step of blending (D) hydroxyethyl cellulose, It was found that by carrying out the procedure in this order, .beta.-glycyrrhetinic acid can be stably incorporated into the liquid composition without precipitation. It has also been confirmed that a step of mixing (A) water and an organic acid or a salt thereof may be included before the step (B).

  Furthermore, a liquid oral composition was prepared in the same manner as in Example 1 except that the amounts of β-glycyrrhetinic acid, tocopherol acetate and polyoxyethylene hydrogenated castor oil were changed. In addition, the amount of the composition for oral cavity obtained by adjusting the amount of water for the change was made the same. The amounts of β-glycyrrhetinic acid, tocopherol acetate and polyoxyethylene hydrogenated castor oil used are shown in Table 1. After the composition for a liquid oral cavity obtained is allowed to stand still at 25 ° C. for one week, it is observed visually, and if there is no precipitation, it will be "○" if it is transparent, but there will be no precipitation, but if it is slightly whitened, "Δ "," Was evaluated as "x" if precipitation occurred. The evaluation is also shown in Table 1. The composition evaluated as し な い does not precipitate but is slightly whitened, so it was considered difficult to further increase the blending amount of β-glycyrrhetinic acid and tocopherol acetate. In addition, what is not evaluated for manufacture is shown by "-". Further, in the following table, β-glycyrrhetinic acid is expressed as βGR, tocopherol acetate is expressed as VEA, and polyoxyethylene hydrogenated castor oil is expressed as HCO.

  The greater the blending amount of the oil-soluble component, β-glycyrrhetinic acid and tocopherol acetate, the easier it is to precipitate, and the greater the blending amount of polyoxyethylene hydrogenated castor oil, which is a surfactant, the more the oil-soluble component dissolves and precipitation becomes difficult. From the results of Table 1 above, the evaluation of the composition for liquid oral cavity ("-") not evaluated for production was predicted. The predicted evaluation results are shown in Table 2 in Table 2. Moreover, in each compounding quantity of polyoxyethylene hydrogenated castor oil, the thing with the largest compounding quantity of (beta)-glycyrrhetic acid and tocopherol acetate is shown by black triangle "(triangle | delta)" among what obtained the evaluation of (triangle | delta).

  Furthermore, for the composition for which the evaluation of “▲” was obtained in Table 2, the blending amount of polyoxyethylene hydrogenated castor oil is X mass%, and the total blending amount of β-glycyrrhetinic acid and tocopherol is Y mass%, the horizontal axis Was plotted on X and Y / X was plotted on the vertical axis. The graph is shown in FIG.

Four points were nearly plotted on the straight line represented by Y / X = −0.5429X + 0.4952 (R ² = 0.957). From this, it was found that if the composition for a liquid oral cavity is such that each component is blended so as to fill the region below the straight line, precipitation does not occur and long-term stability.

  From the above, when the compounding amount of polyoxyethylene hydrogenated castor oil is X mass%, and the total compounding amount of β-glycyrrhetinic acid and tocopherol is Y mass%, Y is produced by the specific manufacturing method described above. It was considered that if the composition for liquid oral cavity satisfying /X<−0.543X+0.495, precipitation did not occur and long-term stability.

Claims (6)

(I) polyoxyethylene hydrogenated castor oil, and (ii) β-glycyrrhetinic acid and tocopherol,
And water, cetyl pyridinium chloride, hydroxyethyl cellulose, and propylene glycol,
When content of (i) component and (ii) component is made into X mass% and Y mass%, following Formula (1):
Y / X <−0.543X + 0.495 (however, 0.1 ≦ X, 0 <Y) [Formula (1)]
Meet
(Ii) A composition for liquid oral cavity in which the components are dissolved. Formula (1) is
Y / X <−0.543X + 0.47 (however, 0.1 ≦ X, 0 <Y)
The composition for liquid oral cavity according to claim 1, which is The range of X in equation (1) is
0.25 ≦ X ≦ 0.45
The composition for liquid oral cavity according to claim 1 or 2, wherein The range of Y in equation (1) is
0.05 ≦ Y ≦ 0.1
The composition for liquid oral cavity according to any one of claims 1 to 3, which is The liquid oral composition according to any one of claims 1 to 4, which contains 50 to 90% by mass of water. The liquid oral cavity composition according to any one of claims 1 to 5, wherein the liquid oral cavity composition in which the component (ii) is dissolved is a liquid oral cavity composition in which the component (ii) is not precipitated.