KR20110117684A - 항원-특이적 내성의 유도를 위한 조성물 및 방법 - Google Patents

항원-특이적 내성의 유도를 위한 조성물 및 방법 Download PDF

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KR20110117684A
KR20110117684A KR1020117019295A KR20117019295A KR20110117684A KR 20110117684 A KR20110117684 A KR 20110117684A KR 1020117019295 A KR1020117019295 A KR 1020117019295A KR 20117019295 A KR20117019295 A KR 20117019295A KR 20110117684 A KR20110117684 A KR 20110117684A
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antigen
composition
carrier
cells
peptide
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Korean (ko)
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스티븐 밀러
러셀 엘. 브롬리
마이클 에이. 플레이스
다니엘 게츠
아론 마틴
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노쓰웨스턴 유니버시티
마이엘린 리페어 파운데이션, 인크.
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020117019295A 2009-01-20 2010-01-20 항원-특이적 내성의 유도를 위한 조성물 및 방법 Withdrawn KR20110117684A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14594109P 2009-01-20 2009-01-20
US61/145,941 2009-01-20

Publications (1)

Publication Number Publication Date
KR20110117684A true KR20110117684A (ko) 2011-10-27

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KR1020117019295A Withdrawn KR20110117684A (ko) 2009-01-20 2010-01-20 항원-특이적 내성의 유도를 위한 조성물 및 방법

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US (4) US20120076831A1 (enExample)
EP (1) EP2389193A4 (enExample)
JP (1) JP2012515722A (enExample)
KR (1) KR20110117684A (enExample)
CN (1) CN102325546A (enExample)
AU (1) AU2010206854A1 (enExample)
CA (1) CA2750098A1 (enExample)
IL (1) IL214163A0 (enExample)
MX (1) MX2011007559A (enExample)
SG (2) SG173041A1 (enExample)
TW (1) TW201039843A (enExample)
WO (1) WO2010085509A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR011700A0 (en) 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
US20140105980A1 (en) * 2012-10-11 2014-04-17 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
CA2807141C (en) 2010-07-31 2019-02-26 The Scripps Research Institute Compositions and methods for inducing immune tolerance
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
CN108129554A (zh) 2010-08-10 2018-06-08 洛桑聚合联合学院 红细胞结合性治疗剂
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
JP5909745B2 (ja) * 2010-11-12 2016-04-27 クール ファーマシューティカルズ ディベロップメント カンパニー 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬
MX373641B (es) 2011-04-29 2020-05-04 Selecta Biosciences Inc Nanoportadores sintéticos tolerogénicos para la terapia contra alergias.
AU2012304313A1 (en) * 2011-09-08 2014-03-06 University Of Florida Research Foundation, Inc. Materials and methods for modulating immune responses
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
WO2013163176A1 (en) 2012-04-23 2013-10-31 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
US20150150996A1 (en) * 2012-06-06 2015-06-04 Northwestern University Compositions and methods for antigen-specific tolerance
KR20220166879A (ko) 2012-06-21 2022-12-19 노쓰웨스턴유니버시티 펩티드 접합된 입자
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
US11439594B2 (en) 2012-12-04 2022-09-13 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
KR20250076678A (ko) 2013-03-13 2025-05-29 코어 파마슈티칼스 디벨롭먼트 컴퍼니 인크. 염증 치료용 면역-변형된 입자
KR102233251B1 (ko) 2013-04-03 2021-03-26 엔-폴드 엘엘씨 신규 나노입자 조성물
CN105283175A (zh) 2013-05-03 2016-01-27 西莱克塔生物科技公司 用于降低的或增强的药效学作用的致耐受性合成纳米载体和治疗性大分子
EA201592273A1 (ru) 2013-06-04 2016-09-30 Селекта Байосайенсиз, Инк. Повторное введение неиммуносупрессивных антигенспецифических иммунотерапевтических средств
CN105555303A (zh) * 2013-06-28 2016-05-04 贝勒研究院 用于多发性硬化症的树突细胞asgpr靶向免疫治疗剂
HRP20192270T4 (hr) * 2013-08-13 2024-03-01 Northwestern University Konjugirane čestice peptida
SG11201603487YA (en) 2013-11-04 2016-05-30 Uti Limited Partnership Methods and compositions for sustained immunotherapy
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
SG10202010936RA (en) 2014-02-21 2020-12-30 Ecole Polytecnique Fed De Lausanne Epfl Epfl Tto Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
KR20170045344A (ko) * 2014-09-07 2017-04-26 셀렉타 바이오사이언시즈, 인크. 항-바이러스 전달 벡터 면역 반응을 약화시키기 위한 방법 및 조성물
CN107615062B (zh) 2015-02-09 2022-03-18 弹弓生物科学公司 具有可调光学性质的水凝胶颗粒以及使用其的方法
WO2016198932A2 (en) 2015-05-06 2016-12-15 Uti Limited Partnership Nanoparticle compositions for sustained therapy
AU2016379413B2 (en) 2015-12-23 2024-04-04 Cour Pharmaceuticals Development Company Inc. Covalent polymer-antigen conjugated particles
US10898583B2 (en) 2016-04-18 2021-01-26 University Of Maryland, College Park Harnessing quantum dots to study, visualize, and promote immune tolerance
JP7523909B2 (ja) 2017-03-11 2024-07-29 セレクタ バイオサイエンシーズ インコーポレーテッド 抗炎症剤および免疫抑制剤を含む合成ナノキャリアによる組み合わせ処置に関連する方法および組成物
EP3638296A1 (en) 2017-06-16 2020-04-22 The University Of Chicago Compositions and methods for inducing immune tolerance
JP7270946B2 (ja) * 2017-08-08 2023-05-11 国立大学法人浜松医科大学 自己免疫疾患の治療又は予防剤
US12397038B2 (en) 2017-11-29 2025-08-26 Uti Limited Partnership Ubiquitous antigens for treatment of autoimmune or inflammatory diseases
CN112384239A (zh) 2018-05-09 2021-02-19 芝加哥大学 影响免疫耐受的组合物和方法
US20230001010A1 (en) * 2019-07-19 2023-01-05 The Regents Of The University Of Michigan Compositions and methods for treating autoimmune disorders
EP4021909A4 (en) 2019-08-29 2023-08-30 David C. Martin Biofunctional thiophene monomers
WO2021205077A1 (en) * 2020-04-09 2021-10-14 Finncure Oy Mimetic nanoparticles for preventing the spreading and lowering the infection rate of novel coronaviruses
US12194157B2 (en) 2020-04-09 2025-01-14 Finncure Oy Carrier for targeted delivery to a host
WO2022235125A1 (ko) * 2021-05-06 2022-11-10 서울대학교 산학협력단 항체 및 자가항원이 표면에 결합된 지질-생체고분자 나노입자 및 이의 용도
CN119907921A (zh) 2022-05-05 2025-04-29 弹弓生物科学公司 用于血液学的作为红细胞模拟物的工程化颗粒和含有工程化颗粒的组合物
KR20250025383A (ko) 2022-06-02 2025-02-21 슬링샷 바이오사이언시즈 인코포레이티드 아폽토시스 세포 모방체
WO2024182722A1 (en) * 2023-03-01 2024-09-06 Georgia Tech Research Corporation Therapeutic nanoparticles for solid organ immune acceptance

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06157592A (ja) * 1992-11-24 1994-06-03 Hitachi Chem Co Ltd ペプチドもしくはその誘導体、それらとタンパク質との結合体、及びこれらを免疫源とする抗エンドセリン−１抗体の製造方法
US5804201A (en) * 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
ATE491471T1 (de) * 2002-03-19 2011-01-15 Powderject Res Ltd Adjuvantien für dns impstoffe basierend auf imidazochinoline
WO2005046722A2 (en) * 2003-11-05 2005-05-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
US20070041934A1 (en) * 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
US20100028450A1 (en) * 2006-01-25 2010-02-04 The Board Of Trustees Of The University Of Illinoi S Tolerogenic biodegradable artificial antigen presenting system
CN101678090B (zh) * 2007-03-07 2012-04-11 乌第有限合伙公司 用于预防和治疗自身免疫病的组合物和方法
US20080311140A1 (en) * 2007-05-29 2008-12-18 Baylor College Of Medicine Antigen specific immunosuppression by dendritic cell therapy
EP2057998A1 (en) * 2007-10-31 2009-05-13 Universitätsklinikum Hamburg-Eppendorf Use of modified cells for the treatment of multiple sclerosis
EP2123261A1 (en) * 2008-05-20 2009-11-25 Stallergenes S.A. Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance
US8323696B2 (en) * 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
JP2012511516A (ja) * 2008-12-11 2012-05-24 ザ・ガバナーズ・オブ・ザ・ユニバーシティー・オブ・アルバータ 非自己抗原に対する免疫寛容を誘発する方法およびシステム

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