KR20110110624A - Cosmetic composition for reducing skin wrinkle comprising 2-hydroxy-1,4-naphthoquinone - Google Patents

Abstract

The present invention relates to a skin external composition and cosmetic composition for promoting collagen biosynthesis comprising 2-hydroxy-1,4-naphthoquinone as an active ingredient, and the composition can further alleviate skin wrinkles by promoting collagen synthesis. And it can get the effect of keeping skin more firm and elastic.

Description

Cosmetic composition for anti-wrinkle comprising 2-hydroxy-1,4-naphthoquinone as an active ingredient {Cosmetic Composition for Reducing Skin Wrinkle Comprising 2-hydroxy-1,4-naphthoquinone}

The present invention The present invention relates to a skin external composition and a cosmetic composition for promoting collagen production containing 2-hydroxy-1,4-naphthoquinone.

Skin is the largest tissue in the envelope system consisting of a number of epithelial tissues that protect the muscles and organs in the body, and plays an important role in maintaining homeostasis by protecting the body from the external environment. As a result, the skin is degraded due to external physical and chemical stimuli, stress, and nutritional deficiency, and skin aging such as elasticity reduction and wrinkle formation is promoted.

Aging of the skin can be divided into innate age and extrinsic age. The endogenous aging is aging that occurs as the age increases, and aging occurs due to a decrease in the physiological function of the body. In addition, the exogenous aging refers to an aging phenomenon generated by external ultraviolet light, free radicals, stress, and the like. Aging of the skin proceeds by these endogenous and exogenous aging factors, and as a result, wrinkles are formed on the surface of the skin, resulting in rough skin and reduced elasticity.

According to the mechanism by which wrinkles are formed, collagen and elastin in the dermis continue to be degraded and produced. If the supplementation caused by the production after decomposition is not smooth, the skin loses its elasticity and wrinkles Is generated.

Representative anti-wrinkle and skin anti-aging agents studied so far include retinoic acid, retinol, ascorbic acid, and α-hydroxy acid.

Retinoic acid inhibits lipid per-oxidation and ornithine decarboxylase response. However, the side effect of reddening the skin due to the sensitive reaction and high irritation by ultraviolet light has been reported, the use is limited, and there is a problem that the effect appears only after 6 months of continuous use.

Retinol has a weaker wrinkle improvement effect than retinoic acid, but is widely used because of its relatively high safety. However, when retinol is used in high concentrations, skin irritation occurs, skin pigmentation occurs when exposed to ultraviolet rays, and there is a problem in stability because it is easily oxidized by oxygen, heat and light in the air.

Ascorbic acid is easily oxidized by the external environment, such as air, moisture, high temperature, thereby reducing the activity a lot, so the degree of wrinkle improvement is lowered, there is a problem causing discoloration and odor of the formulation.

In addition, α-hydroxy acid is also disclosed as an anti-wrinkle agent, but there are problems in terms of safety of the product, accompanied by side effects of skin irritation such as itching, erythema, and sensitive reaction to ultraviolet rays.

In addition, cosmetics containing sunscreens, moisturizers, antioxidants, etc. are widely used to prevent wrinkles, but the actual wrinkle improvement of these products is insignificant.

On the other hand, balsam is dicotyledon yipanhwa group sapindales balsaminaceae an annual plant with pools "being Patience firing MIA (Impatiens balsamia ) refers to the plant and its leaves. It is native to India and Southeast Asia, grows well in sunny places and grows relatively well in bad environments. In Japanese Patent Application Laid-Open No. 1998-108656, balsam extract shows an antioxidant effect, and Korean Patent No. 10-898308 proposes a cosmetic composition having a skin soothing effect.

Lawsonia inermis is the scientific name for a tropical shrub called henna, and henna refers to the plant and tree leaves. Henna, which has a unique scent of wormwood similar to that of Korea, grows in tropical regions such as India, North Africa, Pakistan, Nepal, Sri Lanka, Iran, and South China. Leaves have been used as a medicine for medical treatments such as skin diseases, and flowers have been used as a raw material for perfumes.

Henna has been used in India and the Middle East as a hair treatment for thousands of years. The leaves have been used as a preventive agent for skin diseases since ancient times, and there is a record of excellent efficacy in jaundice, spleen hypertrophy, and stones. Republic of Korea Patent No. 10-675808 mentions that by collecting the henna extract with nanoparticles can be obtained an excellent effect in the antioxidant effect and antibacterial effect. Korean Patent Publication No. 2010-9394 proposes a hair cosmetic composition, and Patent Registration No. 10-623992 proposes a hair dye coloring composition.

There are various naphthoquinone-based compounds such as alkoxy naphthoquinone, hydroxy naphthoquinone, including naphthoquinone, and the like, which are used in various fields including cosmetics.

The inventors of the present invention are developing a substance having an excellent wrinkle improvement effect as an active ingredient of a cosmetic composition for promoting collagen synthesis and improving wrinkles, and 2-hydroxy-1,4-naphthoquinone, which is one of the naphthoquinone compounds, has such an effect. It was confirmed that there is.

In the case of 2-hydroxy-1,4-naphthoquinone, European Patent 0 796 077 and Korean Patent No. 10-699945 are used to manufacture sunscreen products. Has proved effective in [R. Munday, BL Smith, EA Fowke, Haemolytic activity and nephrotoxicity of 2-hydroxy-1,4-naphthoquinone in rats, Journal of Applied Toxicology Volume 11 Issue 2, Pages 85-90, 2006].

Celso A et al. Also suggest that 2-hydroxy-1,4-naphthoquinone can be used as a pesticide due to its mulluscicidal activity [CELSO A et. al ., Molluscicidal activity of 2-hydroxy- [1,4] naphthoquinone and derivatives, Anais da Academia Brasileira de Ciencias (2008) 80 (2): 329-334.

Even in the above studies, there was no study on the skin wrinkle improvement effect of 2-hydroxy-1,4-naphthoquinone as the active ingredient of the present invention.

Japanese Patent Laid-Open No. 1998-108656; Republic of Korea Patent No. 10-898308 Republic of Korea Patent No. 10-675808; Republic of Korea Patent Publication No. 2010-9394 Republic of Korea Patent No. 10-623992; European Patent No. 0 796 077 Republic of Korea Patent No. 10-699945

Haemolytic activity and nephrotoxicity of 2-hydroxy-1,4-naphthoquinone in rats, R. Munday, B. L. Smith, E. A. Fowke, Journal of Applied Toxicology Volume 11 Issue 2, Pages 85 ~ 90, 2006 Molluscicidal activity of 2-hydroxy- [1,4] naphthoquinone and derivatives, CELSO A et al., Anais da Academia Brasileira de Ciencias (2008) 80 (2): 329-334

The present inventors completed the present invention by confirming that 2-hydroxy-1,4-naphthoquinone promotes collagen production and shows an effect of improving skin wrinkles when applied to the skin substantially.

Therefore, an object of the present invention is to provide a composition for external application for promoting collagen synthesis containing 2-hydroxy-1,4-naphthoquinone as an active ingredient.

In addition, another object of the present invention is to provide a cosmetic composition for improving wrinkles comprising 2-hydroxy-1,4-naphthoquinone as an active ingredient.

In order to achieve the above object, the present invention is a skin for promoting collagen synthesis comprising 2-hydroxy-1,4-naphthoquinone represented by the formula (1) as an active ingredient The external preparation composition is provided:

In addition, the present invention provides a cosmetic composition for improving wrinkles comprising 2-hydroxy-1,4-naphthoquinone represented by the formula (1) as an active ingredient.

The external preparation composition and the cosmetic composition according to the present invention act on the fibroblasts of the dermal layer to promote collagen production, and show an excellent effect of promoting collagen production at a lower concentration than the conventional anti-wrinkle agents TGF-β and retinol to improve wrinkles. Not only is the effect exceptional, the formulation stability is excellent and there are few side effects on the skin.

2-hydroxy-1,4-naphthoquinone presented in the present invention is a compound represented by the following formula (1):

[Formula 1]

2-hydroxy-1,4-naphthoquinone represented by Chemical Formula 1 is a known substance having CAS No. 83-72-7, and may be purchased and used from a natural plant.

2-hydroxy-1,4-naphthoquinone which is extracted from natural plants are mainly rosoni ah inner miss (Lawsonia inermis and Impatients It is a compound present in a large amount in the onpogi of balsamia L), and can be extracted from plants including the Lawsonian enamel and Balsam in various ways.

For example, using a conventional method known in the art, that is, a conventional solvent, it can be extracted by hot water extraction, room temperature extraction, warm extraction, ultrasonic extraction, supercritical extraction and the like commonly used.

Preferably it is extracted using a solvent selected from the group consisting of water, lower glycols having 1 to 6 carbon atoms, lower alcohols having 1 to 4 carbon atoms, and mixtures thereof. Most preferably, 1,3-butylene glycol is used as the extraction solvent, and extracted with an ultrasonic extractor at room temperature for 1 to 12 hours. The time of the ultrasonic extraction may vary depending on the amount of sample to be extracted, and may undergo a process of filtering or purifying the extraction result.

In addition, in the case of 2-hydroxy-1,4-naphthoquinone, a commercially available compound is purchased and used after purification. The purification method used at this time may be a method commonly used in this field. Liquid-liquid extraction using a mixture of various organic solvents, purification methods such as column chromatography and high-speed liquid chromatography filled with various synthetic resins such as silica gel and activated alumina are possible, but are not limited to the above purification methods.

Experimental Example 1 according to the present invention to test the collagen synthesis effect of 2-hydroxy-1,4-naphthoquinone, as compared to the conventional TGF-β and retinol used a lot as a substance for promoting collagen production The collagen biosynthetic effect of 2-hydroxy-1,4-naphthoquinone was demonstrated to be better.

Through these results, the 2-hydroxy-1,4-naphthoquinone proposed in the present invention can be applied as a skin external preparation composition and a cosmetic composition, and promotes collagen synthesis when applied to the skin, thereby further relieving skin wrinkles. You can do this, and you can get the effect of keeping your skin firmer and more elastic.

2-hydroxy-1,4-naphthoquinone may comprise 0.0001 to 1.0% by weight relative to the total weight of the external preparation composition, preferably may comprise 0.001 to 1.0% by weight. If the content of the compound is less than the proposed range can not be expected a clear effect, on the contrary, if the content exceeds the proposed range, the increase in effect is less than the increase of the content may cause some cytotoxicity.

The external preparation composition is not particularly limited in its formulation, and may be, for example, an external preparation composition having a formulation of body lotion, ointment, gel, cream, patch or spray. At this time, in the external preparation composition of each formulation, other components than the above 2-hydroxy-1,4-naphthoquinone can be appropriately selected by those skilled in the art according to the formulation or purpose of use of other external preparations.

In particular, 2-hydroxy-1,4-naphthoquinone according to the present invention can be applied as a cosmetic composition comprising it as an active ingredient through the collagen synthesis promoting effect.

As a result of applying a cream containing 2-hydroxy-1,4-naphthoquinone to the skin in Experimental Example 2 according to the present invention, it showed a high wrinkle improvement effect, and the skin irritation was measured in Experimental Example 3, and the compound was It was confirmed that it does not cause skin irritation.

2-hydroxy-1,4-naphthoquinone may be included in an amount of 0.0001 to 1.0% by weight, and preferably 0.001 to 1.0% by weight based on the total weight of the cosmetic composition. If the content of the compound is less than the proposed range, it is not expected to have a distinct effect, on the contrary, if the content exceeds the above range, the effect may not be increased compared to an increase in the amount of inclusion, and may exhibit some cytotoxicity.

The cosmetic composition is not particularly limited in the formulation thereof, for example, lotion, milky lotion, cream, foam, essence, serum, softening water, milky lotion, foundation, makeup base, soap, sunscreen cream and sun oil It may be prepared in a dosage form.

In addition, the compositions of each formulation may contain various bases and additives necessary and appropriate for the formulation of the formulation, and nonionic surfactants, silicone polymers, extender pigments, fragrances, preservatives, Fungicides, oxidation stabilizers, organic solvents, ionic or nonionic thickeners, softeners, antioxidants, free radical destroying agents, opacifying agents, stabilizers, emollients, silicones, α-hydroxy acids, defoamers, humectants, And known compounds such as vitamins, insect repellents, fragrances, preservatives, surfactants, anti-inflammatory agents, substance P antagonists, fillers, polymers, propellants, basicizing or acidifying agents, or coloring agents.

Hereinafter, preferred examples and experimental examples are presented to help understand the present invention. However, the following examples are merely provided to more easily understand the present invention, and the contents of the present invention are not limited by the examples.

Experimental Example  One: Type  I collagen  Biosynthesis promoting effect

In order to investigate the collagen synthesis effect of 2-hydroxy-1,4-naphthoquinone according to the present invention, it was purchased from Sigma Aldrich and used for purification.

Human normal fibroblasts were seeded in each well of a 48-well microplate to a concentration of 1 × 10 ⁶ and incubated for 24 hours at 37 ° C. in DMEM medium. Subsequently, the experimental group in which each sample was replaced with serum-free DMEM medium and the control group in which the sample was not treated with serum-free DMEM medium were further incubated for 24 hours. In this case, the final concentration of 2-hydroxy-1,4-naphthoquinone was used at concentrations of 50, 100, 150, and 200 ppm, and TGF-β and retinol, which are widely used as a substance for promoting collagen production, are known for comparison. Was used.

After incubation with each sample, the supernatant of each well was collected and the amount of newly synthesized collagen was measured by measuring the amount of procollagen type IC-peptide (PICP) using a kit (Takara, Japan). . PICP amount was converted to ng / ml, and the results are shown in Table 1 below.

Sample (concentration) Collagen amount (ng / ml) Increase Control group 0.748 100% 2-hydroxy-1,4-naphthoquinone (50 ppm) 1.072 143.3% 2-hydroxy-1,4-naphthoquinone (100 ppm) 1.278 170.9% 2-hydroxy-1,4-naphthoquinone (150 ppm) 1.319 176.3% 2-hydroxy-1,4-naphthoquinone (200 ppm) 1.351 180.6% TGF-β (200 ppm) 1.031 137.8% Retinol (200ppm) 1.044 139.6%

As shown in Table 1, 2-hydroxy-1,4-naphthoquinone showed up to 180% higher collagen production than the control group, and showed an improved effect compared to TGF-β and retinol. These results show that 2-hydroxy-1,4-naphthoquinone according to the present invention has the effect of promoting collagen synthesis of fibroblasts.

Experimental Example  2: wrinkle improvement effect

In order to confirm the anti-wrinkle effect of 2-hydroxy-1,4-naphthoquinone according to the present invention, a sensory test was performed after the preparation of the cream formulation.

A cream prepared in Formulation Example 3 below (prescription) and a cream prepared in the absence of 2-hydroxy-1,4-naphthoquinone (comparative example) were used. At this time, the comparative example was replaced with purified water instead of 2-hydroxy-1,4-naphthoquinone in the composition of Formulation Example 3.

In the experiment, 20 women aged 30 to 50 years were selected, and the creams of the prescription and the comparative example were washed twice every morning, and then the appropriate amount of the cream was corrected continuously for 8 weeks mainly around the eyes. Wrinkle improvement effect of each subject was evaluated through visual evaluation and the results are shown in Table 2 below.

Wrinkle improvement effect (visual evaluation) Test Sample Excellent wrinkle improvement Wrinkle improvement effect slightly No wrinkle improvement Prescription Example 9 7 4 Comparative example 2 4 14

Through the experimental results of Table 2, it can be seen that the cosmetic formulation of the prescription example containing 2-hydroxy-1,4-naphthoquinone according to the present invention has a higher wrinkle improvement effect than the comparative example. Moreover, skin irritation could not be observed in the subjects who applied the prescription example of this invention to skin.

Experimental Example  3: Check skin irritation

The degree of skin irritation of the cosmetic containing 2-hydroxy-1,4-naphthoquinone according to the present invention was evaluated.

A cream prepared in Formulation Example 3 below (prescription) and a cream prepared in the absence of 2-hydroxy-1,4-naphthoquinone (comparative example) were used. To test the skin irritation of the cosmetics, a patch test was carried out on 20 adult men and women aged 20 to 39 years using the Jordan's Draize method. The test site was wiped with ethanol and dried, and a 10 μl dropping chamber (Finn chamber, 100 × 10, EPITEST, Finland) of the prepared material was hermetically sealed to the inside of the forearm of the test subject. After the closed patch for 24 hours, the patch was removed, and the test site was marked with a marker pen. 2 hours, 22 hours, 46 hours (2 hours, 22 hours, 46 hours after removal of the patch = 26 hours, 48 hours, 72 hours including patch attachment) using a magnifying glass to observe the test site for erythema and edema Was observed.

The criterion is based on the criteria of the International Contact Dermatitis Research Group (ICDRG) (Tables 3 and 4), and the average skin reactivity was calculated by Equation 1 below, and the results are shown in Table 5.

Evaluation criteria and score of skin reaction sign Symptom weight - No response 0 + - Faint erythema One + Boundary but mild erythema 2 ++ Edema and papules 3 +++ Pronounced erythema, papules and vesicles 4 ++++ Clear erythema and edema 5 +++++ Blisters, necrosis 6

Estimation standard for skin irritation Skin responsiveness Irritation degree 0.0-0.99 No stimulation 1.0 to 2.99 Light stimulation 3.0-4.99 Heavy stimulation 5.0 or more Strong stimulation

24 hours 48 hours Average skin reactivity
(n = 20) + - + ++ + - + ++ Prescription Example One - - - - - 0.416 Comparative example One - -One One - -One 0.833

As shown in Table 5, the skin reactivity of the cream of the comparative example does not contain 2-hydroxy-1,4-naphthoquinone of the present invention is very low does not cause skin irritation by the other components of the cream I could see that it doesn't. In addition, it was found that the skin irritation did not occur even when 2-hydroxy-1,4-naphthoquinone was added.

Experimental Example  4: raw material stability evaluation

To confirm the formulation stability of the composition containing 2-hydroxy-1,4-naphthoquinone according to the present invention was carried out as follows.

Test Examples The examples used were creams prepared in the following Example 3, 1 week, 2 weeks, 4 weeks, 8 weeks, 12 weeks, in a thermostat of 5 ° C, 25 ° C, 45 ° C and 5-45 ° C cycles. Stability test of 2-hydroxy-1,4-naphthoquinone was carried out in units of 24 weeks. For stability measurement, high pressure liquid chromatography (HPLC, HPLC Column: Agilent ZORBAX Eclipse XDB C18, 4.6X150㎜, 5㎛) was used. The amount of 2-hydroxy-1,4-naphthoquinone was measured and the results are shown in Table 6 below.

Evaluation of stability of raw materials Term / Condition Standard (NQ 200 ppm) 5 ℃ 25 ℃ 45 ℃ 5 ~ 45 ℃ cycle 1 week 100% 99.95% 98.84% 98.35% 98.65% 2 weeks 100% 99.95% 98.79% 96.71% 98.79% 4 Weeks 100% 99.58% 98.45% 98.10% 98.23% 8 Weeks 100% 99.01% 97.78% 97.23% 97.49% 12 Weeks 100% 99.12% 98.28% 97.63% 97.76% 24 Weeks 100% 99.50% 98.52% 97.98% 97.10%

From the experimental results in Table 6, for the cosmetic composition of the formulation containing 2-hydroxy-1,4-naphthoquinone according to the present invention the formulation of the formulation at 5 ℃, 25 ℃, 45 ℃ and 5 to 45 ℃ cycle There was almost no change in form or separation, and the stability of the raw materials in the formulation was found to be excellent.

Experimental Example  5: Formulation stability evaluation

To confirm the formulation stability of the composition containing 2-hydroxy-1,4-naphthoquinone according to the present invention was carried out as follows.

In the example used for the test, the cream prepared in the following Example 3 and the cream (comparatively) which did not contain 2-hydroxy-1,4-naphthoquinone were used. Evaluation criteria for long-term preservation stability of the cosmetics in units of 1 week, 1 month and 6 months in a thermostat and room temperature of 4 ℃, 45 ℃, 50 ℃ and 4 ℃ to 45 ℃ cycle (Cycle) Was evaluated, and the results are shown in Table 8.

Good ○ Instability × detach △

Preservation conditions Prescription Example Comparative example
4 ℃ 1 week ○ ○ 1 month ○ ○ 6 months ○ ○
45 ℃ 1 week ○ ○ 1 month ○ ○ 6 months ○ ○
50 ℃ 1 week ○ ○ 1 month ○ ○ 6 months ○ ○
cycle 1 week ○ ○ 1 month ○ ○ 6 months ○ ○

As shown in Table 8, the stability of the cream of the comparative example does not contain the active ingredient 2-hydroxy-1,4-naphthoquinone, the stability of the other components of the cosmetics It can be seen that there is no.

In addition, long-term storage stability also appears in the cosmetic formulations containing 2-hydroxy-1,4-naphthoquinone, so there is no problem in stability even by the addition of the active ingredient 2-hydroxy-1,4-naphthoquinone. And it was found.

Hereinafter, preferred formulation examples are provided to aid the understanding of the present invention. However, the following formulation examples are merely provided to more easily understand the present invention, and the contents of the present invention are not limited by the formulation examples. At this time, as the kava extract was used Kava extract extracted in Preparation Example 1.

Formulation example  1: lotion skin , toner)

As shown in Table 9, a lotion containing 2-hydroxy-1,4-naphthoquinone was prepared according to a conventional method.

ingredient Content (% by weight) Purified water 88.14 glycerin 1.50 Dipropylene glycol 2.00 Fiji-400 0.30 Diel-Pantenol 0.20 Disodium ID 0.02 Sodium Hyaluronate Liquid 2.00 ethanol 5.00 Methylparaben 0.12 incense 0.10 Fiji-60 Hydrogenated Castor Oil 0.60 2-hydroxy-1,4-naphthoquinone 0.02

Formulation example  2: emulsion (Lotion)

As shown in Table 10, an emulsion (lotion) containing 2-hydroxy-1,4-naphthoquinone was prepared according to a conventional method.

ingredient Content (% by weight) Purified water 74.10 Methylparaben 0.20 Disodium ID 0.03 glycerin 5.00 Butylene Glycol 5.00 Carbomer 0.50 Glycerin Stearate 2.4 Sorbitan stearate 0.60 Cetearyl Stearate 1.70 Stearic acid 1.00 Beads wax 0.80 Squalane 3.00 Butylene Glycol Dicaprylate 2.50 Cyclomethicone 1.50 Dimethicone 0.50 Profile paraben 0.10 Triethanolamine 0.50 Phenoxyethanol 0.30 incense 0.25 2-hydroxy-1,4-naphthoquinone 0.02

Formulation example  3: nutrition cream

As shown in Table 11, a nutrition cream containing 2-hydroxy-1,4-naphthoquinone was prepared according to a conventional method.

ingredient Content (% by weight) Purified water 67.40 Methylparaben 0.20 Disodium ID 0.03 glycerin 5.00 Butylene Glycol 5.00 Carbomer 0.10 Glyceryl stearate 2.80 Sorbitan stearate 1.20 Cetemaryl stearate 1.70 Stearic acid 1.00 Beads wax 0.80 Squalane 5.00 Butylene Glycol Dicaprylate 4.00 Cyclomethicone 4.00 Dimethicone 0.50 Profile paraben 0.10 Tocopherol acetate 0.20 Triethanolamine 0.10 Thickener 0.30 Phenoxyethanol 0.30 incense 0.25 2-hydroxy-1,4-naphthoquinone 0.02

Formulation example  4: ointment

An ointment containing 2-hydroxy-1,4-naphthoquinone was prepared according to a conventional method as shown in Table 12 below.

ingredient Content (% by weight) Purified water Remainder Cetostearyl alcohol 3.0 Hard flow paraffin 5.0 Tocopherol acetate 2.0 Seteareth-20 3.0 Panthenol 0.5 Methyl paraoxybenzoate Quantity Paraoxybenzoic Acid Profiles Quantity 2-hydroxy-1,4-naphthoquinone 0.02

Claims (7)

Skin external composition for promoting collagen biosynthesis comprising 2-hydroxy-1,4-naphthoquinone represented by Formula 1 as an active ingredient:
[Formula 1]

The composition of claim 1, wherein the composition comprises 2-hydroxy-1,4-naphthoquinone in an amount of 0.0001 to 1.0% by weight based on the total weight of the composition. The external preparation composition for promoting collagen biosynthesis according to claim 1, wherein the external preparation composition for promoting collagen production is an ointment, gel, cream, patch or spray formulation. A cosmetic composition for improving wrinkles comprising 2-hydroxy-1,4-naphthoquinone represented by Formula 1 as an active ingredient:
[Formula 1]

The cosmetic composition for improving wrinkles according to claim 4, wherein the 2-hydroxy-1,4-naphthoquinone has a collagen synthesis promoting effect. The cosmetic composition for improving wrinkles according to claim 4, wherein the composition comprises 2-hydroxy-1,4-naphthoquinone in an amount of 0.0001 to 1.0% by weight based on the total weight of the composition. The cosmetic composition for improving wrinkles according to claim 4, wherein the cosmetic composition for improving wrinkles is one selected from the group consisting of lotion, milky lotion, cream, foam, essence, serum, softening water, milky lotion, foundation, makeup base, soap, sunscreen cream and sun oil. Wrinkle improvement cosmetic composition, characterized in that having a formulation.