KR20110091777A - 폴리펩티드, 항체 가변 도메인 및 길항제 - Google Patents

폴리펩티드, 항체 가변 도메인 및 길항제 Download PDF

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Publication number
KR20110091777A
KR20110091777A KR1020117014479A KR20117014479A KR20110091777A KR 20110091777 A KR20110091777 A KR 20110091777A KR 1020117014479 A KR1020117014479 A KR 1020117014479A KR 20117014479 A KR20117014479 A KR 20117014479A KR 20110091777 A KR20110091777 A KR 20110091777A
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KR
South Korea
Prior art keywords
seq
amino acid
acid sequence
composition
variable domain
Prior art date
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KR1020117014479A
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English (en)
Korean (ko)
Inventor
이안 리차드 캐치폴
피오나 쿡
제랄드 웨인 고프
로렌트 제스퍼스
마이클 스튜어드
Original Assignee
글락소 그룹 리미티드
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Priority claimed from US12/323,632 external-priority patent/US20090148437A1/en
Application filed by 글락소 그룹 리미티드 filed Critical 글락소 그룹 리미티드
Publication of KR20110091777A publication Critical patent/KR20110091777A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
KR1020117014479A 2008-11-26 2009-11-04 폴리펩티드, 항체 가변 도메인 및 길항제 KR20110091777A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/323,632 2008-11-26
US12/323,632 US20090148437A1 (en) 2007-06-06 2008-11-26 Polypeptides, antibody variable domains & antagonists
PCT/EP2009/064654 WO2010060768A1 (fr) 2008-11-26 2009-11-04 Polypeptides, domaines variables d'anticorps et antagonistes

Publications (1)

Publication Number Publication Date
KR20110091777A true KR20110091777A (ko) 2011-08-12

Family

ID=41507943

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117014479A KR20110091777A (ko) 2008-11-26 2009-11-04 폴리펩티드, 항체 가변 도메인 및 길항제

Country Status (11)

Country Link
EP (1) EP2356147A1 (fr)
JP (1) JP2012509852A (fr)
KR (1) KR20110091777A (fr)
CN (1) CN102224169A (fr)
AU (1) AU2009319175A1 (fr)
BR (1) BRPI0921319A2 (fr)
CA (1) CA2744055A1 (fr)
IL (1) IL212333A0 (fr)
MX (1) MX2011005540A (fr)
WO (1) WO2010060768A1 (fr)
ZA (1) ZA201103588B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010100135A1 (fr) 2009-03-05 2010-09-10 Ablynx N.V. Nouveaux complexes dimères de liaison antigénique, méthodes d'obtention/non obtention et leurs utilisations
US9265834B2 (en) 2009-03-05 2016-02-23 Ablynx N.V. Stable formulations of polypeptides and uses thereof
EP2473527B1 (fr) 2009-09-03 2016-11-30 Ablynx N.V. Formulations stables de polypeptides et leurs utilisations
WO2011106697A1 (fr) 2010-02-25 2011-09-01 Schepens Eye Research Institute Compositions thérapeutiques pour le traitement de la maladie de l'œil sec
EP2643351A1 (fr) * 2010-11-24 2013-10-02 Glaxo Group Limited Protéines multispécifique se liant à un antigène et ciblant hgf
SG10201608703SA (en) 2012-11-08 2016-12-29 Eleven Biotherapeutics Inc Il-6 antagonists and uses thereof
EP3071181B1 (fr) 2013-11-18 2021-03-24 Formycon AG Composition pharmaceutique contenant un anticorps anti-vegf
MA51554A (fr) 2014-11-07 2020-11-18 Sesen Bio Inc Anticorps il-6 améliorés

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
GB0521621D0 (en) * 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
EP1957536A2 (fr) * 2005-12-01 2008-08-20 Domantis Limited Formats d'anticorps a domaine non competitif qui lient le recepteur type 1 d'interleukine 1
US20100056439A1 (en) * 2005-12-06 2010-03-04 Domantis Limited Ligands that have binding specificity for egfr and/or vegf and methods of use therefor
CN101400703B (zh) * 2006-02-01 2013-05-08 赛法隆澳大利亚控股有限公司 结构域抗体构建体
GB0724331D0 (en) * 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
MX2009013137A (es) * 2007-06-06 2010-04-30 Domantis Ltd Metodos para seleccionar polipeptidos resistentes a la proteasa.
MX2009012968A (es) * 2007-06-06 2010-04-01 Domantis Ltd Polipeptidos, dominios variables de anticuerpo y antagonistas.

Also Published As

Publication number Publication date
WO2010060768A1 (fr) 2010-06-03
ZA201103588B (en) 2012-01-25
CN102224169A (zh) 2011-10-19
AU2009319175A1 (en) 2010-06-03
JP2012509852A (ja) 2012-04-26
CA2744055A1 (fr) 2010-06-03
BRPI0921319A2 (pt) 2018-10-16
MX2011005540A (es) 2011-06-21
IL212333A0 (en) 2011-06-30
EP2356147A1 (fr) 2011-08-17

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