KR20110088598A - 혈관 질환 및 대사 질환 치료용 실로스타졸의 니트레이트 유도체 - Google Patents

혈관 질환 및 대사 질환 치료용 실로스타졸의 니트레이트 유도체 Download PDF

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Publication number
KR20110088598A
KR20110088598A KR1020117015258A KR20117015258A KR20110088598A KR 20110088598 A KR20110088598 A KR 20110088598A KR 1020117015258 A KR1020117015258 A KR 1020117015258A KR 20117015258 A KR20117015258 A KR 20117015258A KR 20110088598 A KR20110088598 A KR 20110088598A
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KR
South Korea
Prior art keywords
compound
formula
vascular
metabolic diseases
cilostazol
Prior art date
Application number
KR1020117015258A
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English (en)
Korean (ko)
Inventor
디르크 사르토르
아르민 쉐르하크
Original Assignee
카르디올린크스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 카르디올린크스 아게 filed Critical 카르디올린크스 아게
Publication of KR20110088598A publication Critical patent/KR20110088598A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020117015258A 2008-12-02 2009-12-01 혈관 질환 및 대사 질환 치료용 실로스타졸의 니트레이트 유도체 KR20110088598A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08170435A EP2194048A1 (en) 2008-12-02 2008-12-02 Nitrate esters for the treatment of vascular and metabolic diseases
EP08170435.5 2008-12-02

Publications (1)

Publication Number Publication Date
KR20110088598A true KR20110088598A (ko) 2011-08-03

Family

ID=40456966

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117015258A KR20110088598A (ko) 2008-12-02 2009-12-01 혈관 질환 및 대사 질환 치료용 실로스타졸의 니트레이트 유도체

Country Status (14)

Country Link
US (1) US8426597B2 (US07846941-20101207-C00217.png)
EP (2) EP2194048A1 (US07846941-20101207-C00217.png)
JP (1) JP2012510502A (US07846941-20101207-C00217.png)
KR (1) KR20110088598A (US07846941-20101207-C00217.png)
CN (1) CN102245583A (US07846941-20101207-C00217.png)
AU (1) AU2009324123A1 (US07846941-20101207-C00217.png)
BR (1) BRPI0923300A2 (US07846941-20101207-C00217.png)
CA (1) CA2745252A1 (US07846941-20101207-C00217.png)
IL (1) IL213214A0 (US07846941-20101207-C00217.png)
MX (1) MX2011005744A (US07846941-20101207-C00217.png)
RU (1) RU2011126607A (US07846941-20101207-C00217.png)
SG (1) SG171423A1 (US07846941-20101207-C00217.png)
WO (1) WO2010063724A1 (US07846941-20101207-C00217.png)
ZA (1) ZA201104011B (US07846941-20101207-C00217.png)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013525323A (ja) 2010-04-19 2013-06-20 カーディオリンクス・アーゲー 血管性及び代謝性疾患の処置のための酸化窒素ドナー担持バルサルタン誘導体
AR081268A1 (es) 2010-06-02 2012-07-18 Cardiolynx Ag Derivados de nitrato de pioglitazona
PL2888286T3 (pl) 2012-08-21 2018-07-31 Janssen Pharmaceutica Nv Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie
CN104736565B (zh) 2012-08-21 2019-03-12 詹森药业有限公司 利培酮半抗原的抗体及其用途
ES2666000T3 (es) 2012-08-21 2018-04-30 Janssen Pharmaceutica, N.V. Anticuerpos para aripiprazol y uso de los mismos
AU2013305938B2 (en) 2012-08-21 2017-08-17 Saladax Biomedical Inc. Antibodies to paliperidone haptens and use thereof
ES2669565T3 (es) 2012-08-21 2018-05-28 Janssen Pharmaceutica Nv Haptenos de risperidona y paliperidona
US9303041B2 (en) 2012-08-21 2016-04-05 Janssen Pharmaceutica Nv Haptens of olanzapine
EP2888590B1 (en) 2012-08-21 2020-07-08 Janssen Pharmaceutica NV Antibodies to olanzapine and use thereof
AU2013305935B2 (en) 2012-08-21 2017-08-24 Saladax Biomedical Inc. Haptens of quetiapine for use in immunoassays
JP6389176B2 (ja) 2012-08-21 2018-09-12 ヤンセン ファーマシューティカ エヌ．ベー． アリピプラゾールハプテンに対する抗体及びその使用
CN104736561B (zh) 2012-08-21 2018-06-12 詹森药业有限公司 帕潘立酮的抗体及其用途
JP6389177B2 (ja) 2012-08-21 2018-09-12 ヤンセン ファーマシューティカ エヌ．ベー． オランザピンハプテンに対する抗体及びその使用
CN107043424B (zh) 2012-08-21 2021-03-16 詹森药业有限公司 利培酮的抗体及其用途
US9504682B2 (en) 2012-08-21 2016-11-29 Janssen Pharmaceutica Nv Haptens of aripiprazole
PL2888258T3 (pl) 2012-08-21 2019-10-31 Janssen Pharmaceutica Nv Hapteny paliperydonu
CA2882615C (en) 2012-08-21 2019-07-09 Ortho-Clinical Diagnostics, Inc. Antibodies to quetiapine and use thereof
JP6949025B2 (ja) 2015-12-17 2021-10-13 ヤンセン ファーマシューティカ エヌ．ベー． リスペリドンに対する抗体及びその使用
US10435478B2 (en) 2015-12-17 2019-10-08 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
CN114044766B (zh) * 2021-10-09 2022-12-27 张北北九食品检验技术有限公司 放射性同位素碳-14标记的呋虫胺和中间体及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535019A (en) 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
ATE134624T1 (de) 1990-02-19 1996-03-15 Ciba Geigy Ag Acylverbindungen
US6148496A (en) 1999-04-09 2000-11-21 The Procter & Gamble Company Method for making a seamless apertured metal belt
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
ES2299861T3 (es) 2003-07-31 2008-06-01 Nicox S.A. Derivados nitroxi de losartan y de otros bloqueadores similares del receptor de angiotensina ii para el tratamiento de enfermedades cardiovasculares.
WO2006079610A1 (en) * 2005-01-31 2006-08-03 Nicox S.A. Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases
EP1922069A2 (en) * 2005-08-08 2008-05-21 Nitromed, Inc. Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use

Also Published As

Publication number Publication date
MX2011005744A (es) 2011-06-20
EP2194048A1 (en) 2010-06-09
IL213214A0 (en) 2011-07-31
SG171423A1 (en) 2011-07-28
EP2367803A1 (en) 2011-09-28
BRPI0923300A2 (pt) 2019-07-16
CN102245583A (zh) 2011-11-16
WO2010063724A1 (en) 2010-06-10
AU2009324123A1 (en) 2011-07-21
CA2745252A1 (en) 2010-06-10
RU2011126607A (ru) 2013-01-10
US8426597B2 (en) 2013-04-23
US20110230520A1 (en) 2011-09-22
ZA201104011B (en) 2012-02-29
JP2012510502A (ja) 2012-05-10

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