KR20110044166A - 통증 및 소양증 치료용 방법, 조성물 및 키트 - Google Patents

통증 및 소양증 치료용 방법, 조성물 및 키트 Download PDF

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Publication number
KR20110044166A
KR20110044166A KR1020107022652A KR20107022652A KR20110044166A KR 20110044166 A KR20110044166 A KR 20110044166A KR 1020107022652 A KR1020107022652 A KR 1020107022652A KR 20107022652 A KR20107022652 A KR 20107022652A KR 20110044166 A KR20110044166 A KR 20110044166A
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South Korea
Prior art keywords
compound
channels
pain
voltage
receptor
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KR1020107022652A
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English (en)
Korean (ko)
Inventor
브루스 피. 벤
클리포드 제이. 울프
Original Assignee
프레지던트 앤드 펠로우즈 오브 하바드 칼리지
더 제너럴 하스피탈 코포레이션
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Application filed by 프레지던트 앤드 펠로우즈 오브 하바드 칼리지, 더 제너럴 하스피탈 코포레이션 filed Critical 프레지던트 앤드 펠로우즈 오브 하바드 칼리지
Publication of KR20110044166A publication Critical patent/KR20110044166A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107022652A 2008-03-11 2009-03-11 통증 및 소양증 치료용 방법, 조성물 및 키트 Withdrawn KR20110044166A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6901808P 2008-03-11 2008-03-11
US61/069,018 2008-03-11

Publications (1)

Publication Number Publication Date
KR20110044166A true KR20110044166A (ko) 2011-04-28

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Family Applications (1)

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KR1020107022652A Withdrawn KR20110044166A (ko) 2008-03-11 2009-03-11 통증 및 소양증 치료용 방법, 조성물 및 키트

Country Status (11)

Country Link
US (1) US20110086818A1 (cg-RX-API-DMAC7.html)
EP (1) EP2271329A4 (cg-RX-API-DMAC7.html)
JP (1) JP2011513484A (cg-RX-API-DMAC7.html)
KR (1) KR20110044166A (cg-RX-API-DMAC7.html)
CN (1) CN102112121A (cg-RX-API-DMAC7.html)
AU (1) AU2009223739A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0909627A2 (cg-RX-API-DMAC7.html)
CA (1) CA2717042A1 (cg-RX-API-DMAC7.html)
IL (1) IL208027A0 (cg-RX-API-DMAC7.html)
MX (1) MX2010009951A (cg-RX-API-DMAC7.html)
WO (1) WO2009114139A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101867779B1 (ko) * 2017-12-08 2018-06-19 서울대학교산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법
KR101877002B1 (ko) * 2017-03-06 2018-07-12 서울대학교 산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법

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AU2007322033B2 (en) 2006-11-20 2013-07-11 President And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritis
WO2010085589A2 (en) 2009-01-22 2010-07-29 G&H Brands Llc Desensitizing drug product
JP6205133B2 (ja) * 2009-07-10 2017-09-27 プレジデント アンド フェローズ オブ ハーバード カレッジ 抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
JP5832856B2 (ja) * 2010-12-15 2015-12-16 久光製薬株式会社 局所鎮痛作用増強剤及び局所鎮痛キット
MX386293B (es) 2011-02-18 2025-03-18 Libertas Bio Inc Compuestos de aminoindano y su uso en el tratamiento del dolor.
JP6495654B2 (ja) 2011-10-24 2019-04-03 アサナ バイオサイエンシズ，リミティド ライアビリティ カンパニー シクロヘキシルアミン類
US8779003B2 (en) 2011-12-29 2014-07-15 Mackay Memorial Hospital Method and composition for prolonging analgesic effect of local anesthetic
WO2014028675A1 (en) 2012-08-15 2014-02-20 Endo Pharmaceuticals Inc. Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
CA2900710C (en) * 2013-02-08 2023-08-08 General Mills, Inc. Reduced sodium food products
EP3131541A4 (en) * 2014-04-14 2018-02-14 Flex Pharma, Inc. Ion channel activators and methods of use
KR20180069782A (ko) 2015-08-03 2018-06-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 하전 이온 채널 블록커 및 이용 방법
CN106214678B (zh) * 2016-07-26 2020-12-29 上海璃道医药科技有限公司 苯酮类药物的用途
WO2018136943A1 (en) 2017-01-23 2018-07-26 Flex Pharma, Inc. Compositions and methods affecting exercise performance
US11591375B2 (en) * 2018-01-22 2023-02-28 Oregon State University Immunogenic compositions comprising Mycobacterium bovis surface proteins and uses thereof
EP3762034B1 (en) 2018-03-05 2025-08-27 Wylder Nation Foundation A fatty acid amide hydrolase (faahi) inhibitor for use in inhibiting the cellular accumulation of a sphingolipid in a subject that has lysosomal storage disease or disorder
AU2019322187A1 (en) * 2018-08-15 2021-03-25 Pharmacyl Ab Substituted benzamides and their use in therapy
CN109498604A (zh) * 2018-12-24 2019-03-22 复旦大学 香叶醇新用途，预防和治疗非疾病引起的瘙痒症的配制品及方法
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
MX2021010869A (es) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueadores de canales iónicos sustituidos por éster y métodos para su uso.
AU2020235888A1 (en) 2019-03-11 2021-09-30 Nocion Therapeutics, Inc. Charged ION channel blockers and methods for use
US10934263B2 (en) 2019-03-11 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN114828845A (zh) 2019-11-06 2022-07-29 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2021173916A1 (en) * 2020-02-27 2021-09-02 President And Fellows Of Harvard College Nociceptor neurons control cancer immunosurveillance
CN115243683A (zh) * 2020-03-04 2022-10-25 纽克尔斯有限公司 Qx314防止与施用trpv1调节剂相关的交感神经兴奋的用途
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN119118953A (zh) * 2020-03-11 2024-12-13 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
CN113509457B (zh) * 2020-09-07 2023-03-21 四川昇嘉科技有限公司 山椒素在制备治疗湿疹的药物中的用途
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

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US6413961B1 (en) * 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
CZ20022095A3 (cs) * 1999-12-15 2003-02-12 Ucb Farchim S. A. Cyklická kvarterní amoniová sloučenina pro použití při léčbě a/nebo prevenci kašle u teplokrevného živočicha a farmaceutický prostředek ji obsahující
CA2446060A1 (en) * 2001-05-07 2002-11-14 Corium International Compositions and delivery systems for administration of a local anesthetic agent
ES2535045T3 (es) * 2003-04-10 2015-05-04 Vanderbilt Royalty Sub L.P. Usos y composiciones para administración de capsaicina
ES2223277B1 (es) * 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
RU2380092C2 (ru) * 2004-01-30 2010-01-27 Кориум Интернэшнл, Инк. Быстро растворяющаяся пленка для доставки активного агента
JP5148271B2 (ja) * 2004-06-02 2013-02-20 ニューロジズエックス，インコーポレーテッド 疼痛処置のためのカプサイシノイド、局所麻酔薬および／または鎮痒薬を含有する処方物
AU2007322033B2 (en) * 2006-11-20 2013-07-11 President And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101877002B1 (ko) * 2017-03-06 2018-07-12 서울대학교 산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법
KR101867779B1 (ko) * 2017-12-08 2018-06-19 서울대학교산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법

Also Published As

Publication number Publication date
WO2009114139A3 (en) 2009-12-23
US20110086818A1 (en) 2011-04-14
JP2011513484A (ja) 2011-04-28
AU2009223739A1 (en) 2009-09-17
CA2717042A1 (en) 2009-09-17
MX2010009951A (es) 2011-09-01
WO2009114139A2 (en) 2009-09-17
EP2271329A4 (en) 2013-01-09
CN102112121A (zh) 2011-06-29
IL208027A0 (en) 2010-12-30
EP2271329A2 (en) 2011-01-12
BRPI0909627A2 (pt) 2018-04-10

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20101011

Patent event code: PA01051R01D

Comment text: International Patent Application

N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20110316

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid