KR20100102940A - Composition of external application to the skin for treatment of acne and reduction of wrinkles - Google Patents

Abstract

PURPOSE: An external use skin composition for treating acne and for anti-wrinkle is provided to ensure synergic effect by using triclosan, trichlocarban, and Glycyrrhiza uralensis extract and to prevent wrinkle and aging. CONSTITUTION: An external use skin composition for treating acne and for anti-wrinkle contains 0.01-2 weight% of 2,4,4-trichloro-2-hydroxydiphenyl ether, 0.01-1 weight% of 3,4,4,-trichloro carbanilide, 1-10 weight% of Glycyrrhiza uralensis extract, 1-10 weight% of Pleuropterus multflorus extract, and 5-10 weight% of Scuterllaria baicalensis extract. The composition is used in the form of cosmetic product or soap.

Description

Composition for external application for acne treatment and wrinkle removal {Composition of external application to the skin for treatment of acne and reduction of wrinkles}

The present invention relates to a topical skin composition for treating acne and removing wrinkles, and a topical skin composition that can be used as a soap.

Acne is a common problem in puberty, and many adults also suffer from acne. In general, the cause of acne is not clear, but the most important factor is the propionibacterium acnes, an anaerobic bacterium that breeds in the androgen that stimulates sebaceous glands and breaks down sebum and produces free fatty acids. do. That is, when sebaceous glands are enlarged by androgen stimulation of sebaceous glands, sebum secretion becomes vigorous. Therefore, abnormal seizures occur in the hair follicle wall cells by such sebaceous glands, causing the hair follicles to be blocked and sebum is not discharged. The anaerobic acne bacterium Propionibacterium acne breeds to break down fat to produce free fatty acids. Free fatty acids are known to directly irritate hair follicle walls and enter the dermis and cause inflammation.

In order to treat acne caused by this cause, oral and external preparations are used. Examples thereof include sulfur, resorcinol, salicylic acid, benzoyl peroxide, vitamin A, carbamide peroxide, and antibiotics. Various agents can be mentioned. However, the acne treatment formulations containing the above-described preparations have some results in acne treatment, but have some problems in terms of effects and side effects.

For example, resorcinol is used in small amounts at a concentration of 1 to 2%, and there is a problem of forming dark brown scabs in people with slightly dark skin, and tetracycline-containing antibiotics have the potential for the appearance of resistant bacteria and photosensitization. There is a problem.

On the other hand, although benzoyl peroxide is the most effective substance that can be used for acne, it is toxic, triggers boils, causes extreme dryness, itching, skin irritation, erythema, peeling or swelling of skin. It was forbidden to use.

On the other hand, triclosan was used as a soap and foam cleansing cream for the purpose of treating acne, but it did not reach satisfactory levels in bactericidal power and wrinkle removal for acne bacteria.

The present invention is to solve the above problems, an object of the present invention has the effect of removing the skin wrinkles by the antioxidant effect while effectively preventing and treating acne and at the same time minimize the occurrence of skin wrinkles with excellent moisturizing power And there is no skin irritation or side effects to provide a safe and excellent skin penetration composition.

In order to achieve the above object, in the present invention, 2, 4, 4-trichloro-2-hydroxy diphenyl ether, 3, 4, 4-trichloro carbanide, licorice extract, sewage extract and golden extract Provided is an external preparation composition for treating acne and removing wrinkles, comprising as an active ingredient.

Hereinafter, the present invention will be described in more detail.

The external preparation composition for treating acne and removing wrinkles of the present invention has triclocarban, acne, dermatitis, eczema, and sweat band effect that has excellent bactericidal action against fungal infections of triclosan, skin or scalp, which are effective for disinfecting and removing sebum. The active ingredient is licorice extract, sewage extract with excellent antioxidant and detoxification, and capillary permeability inhibiting.

The 2, 4, 4-trichloro-2-hydroxy diphenyl ether contained in the composition of the present invention is commonly known as triclosan, and its chemical formula is shown below.

[Formula 1]

Triclosan of the formula (1) is known to have an effect on the sterilization and sebum removal, in particular, the antibacterial agent with excellent penetration and stability to the skin has excellent bactericidal and antimicrobial action against acne and Staphylococcus aureus infection.

On the other hand, the 3, 4, 4-trichloro carbanide is commonly referred to as triclocarban, the chemical formula is as follows.

[Formula 2]

Triclocarban of the formula (2) is excellent in the absorption and stability to the skin shows an excellent bactericidal action against the fungal infection of the skin or scalp.

Skin external preparation composition for acne treatment and wrinkle removal should firstly have excellent antimicrobial effect against acne bacteria, secondly, have anti-aging and capillary permeability inhibitory ability, and third, have no skin irritation. In order to achieve the above object, the composition according to the present invention should contain licorice extract, sewage extract and golden extract which are extracts obtained from plants.

The licorice of the present invention is a herbal material with acne, dermatitis, eczema, sweat belt effect, whitening effect, and skin soothing action, contains glycyrrhizin, which has antiallergic effect, and glycyrrhetinic acid derivative. (glycyrrhetinic acid) contains anti-inflammatory, adrenal cortex hormone action. It is a derivative of iso-flavonoid, which protects extra cellular matrix (ECM), which acts as a cushion of cells, and contains a lot of flavanone glycosides. It has an antimuscular action such as papaverine.

 The sewage has an excellent effect to show the body when taking, antioxidants, nervous breakdowns, anorexia, fatigue recovery, and when worn, the muscles are strong, the color is good and the gray hair is black to prevent aging. Extracting white sewage and using it as a bath solvent improves the complexion of the skin and has a shine.

 The gold contains a flavonone derivative, antioxidants, whitening effect, anti-aging, detoxification and capillary permeability inhibiting action, in oriental medicine, the root is also used as antipyretic, diuretic, branch, edema and anti-inflammatory.

The method of extracting licorice, sewage and gold is according to methods known in the art. For example, licorice, sewage, and gold are crushed with a grinder, and then, they are added to a solution containing 50% of water and ethanol, extracted for 5-6 hours at a temperature of 80-100 ° C, and concentrated to concentrate a thick solution of 30-40 brix. use. Sewage and gold are also extracted and used in the same way as licorice.

The licorice extract in the present invention includes not only the extract extracted from licorice, but also the active ingredient itself to inhibit the growth and activity of acne bacteria. In addition, the sewage extract in the present invention includes not only the extract extracted from the sewage but also the active ingredient itself to prevent oxidation and skin aging. In addition, the golden extract contains not only the extract extracted from the gold, but also the active ingredient itself to act as anti-aging, detoxification and capillary permeability inhibitory action.

The external preparation composition for treating acne and removing wrinkles of the present invention preferably contains 1 to 10% by weight licorice extract, 1 to 10% by weight sewage extract and 5 to 10% by weight golden extract as active ingredients. Do. Licorice extract is less than 1% by weight, it is difficult to cure acne, eczema, sweat band and whitening effect, if it exceeds 10% by weight, there may be a problem of formulation stability, sewage extract is less than 1% by weight to prevent skin aging It is difficult to exert sufficient capacity, and when it exceeds 10% by weight, there may be a problem in coordination with other active ingredients. Gold extract is less than 5% by weight of the antioxidant, whitening effect and capillary permeability inhibitory effect is insufficient, if it exceeds 10% by weight may have a problem in the stability of the product.

On the other hand, when the triclocarban is less than 0.01% by weight, it is difficult to achieve the effect, and when it exceeds 1% by weight, problems with coordination, stability and safety with other active ingredients occur. On the other hand, when the content of triclosan is less than 0.01% by weight, it is also difficult to achieve the effect, more than 2% by weight causes a problem in the stability of the product.

When the composition according to the present invention is a cosmetic soap, in addition to licorice extract, sewage extract golden extract, triclocarban and triclosan in the cosmetic soap base, in addition to fragrances, pigments, fungicides, anti-inflammatory agents, antioxidants, preservatives, moisturizers or physical properties improvement In order to mix the inorganic salts, synthetic polymers and the like can be easily prepared by a conventional manufacturing method.

The cosmetic soap base is C12-18 fatty acid salt 20 to 50% by weight of oleic acid, isostearic acid, animal and vegetable fatty acid sodium or potassium salt, 5-30% by weight of amino acid surfactant such as acyl glutamate, cationic surfactant Preferably comprises 5 to 20% by weight of alkylbetaine or amidopropylbetaine. In addition, it is preferable to include natural oils, wax fatty alcohols, hydrocarbons, natural plant extracts, etc. in order to give the skin softening effect, and at least one of glycerin, propylene glycol, sorbitol, etc. to give skin moisturizing effect. It includes, it is preferable to include salicylic acid, citric acid as a sterilizing aid, one of titanium dioxide as an antioxidant, alkyl paraben as a preservative. In addition, a fragrance | flavor, a pigment, and a metal ion blocking agent can use what is normally used. The composition may also be prepared in a foam cleansing cosmetic formulation.

Since the composition according to the present invention can see the synergistic effect of the mixed use of triclosan, triclocaban, licorice extract and sewage extract, it is possible to effectively prevent acne and to obtain an excellent effect on skin wrinkle removal. In addition, the anti-aging, detoxification and capillary permeability inhibitory action of the golden extract is added, as well as the removal of the skin wrinkles can be prevented in advance. The licorice extract, sewage extract and golden extract is a natural material obtained from a natural source, there is no skin irritation or side effects without the user's sense of rejection and has the advantage of excellent skin penetration.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.

Example 1 and Comparative Example 1

To prepare a composition of the soap formulation according to the invention according to the composition shown in Table 1. The following concentrations all represent weight percent.

Raw material name Example 1 Comparative Example 1 Triclosan 1.5 1.0 Triclocaban 1.5 - Licorice Extract 3.0 - Sewage Extract 2.5 - Golden Extract 7.0 - Cocamidopropyl Betaine 5.0 5.0 Cocoyl diethanolamide 5.0 5.0 Disodium Ethylenediaminetetraacetic Acid 0.1 0.1 Propylene glycol 4.0 4.0 glycerin 10.0 10.0 Lauric acid 6.0 6.0 Myristic acid 5.0 5.0 Stearic acid 15.0 15.0 Polyethylene Glycol (Molecular Weight 4500) 4.0 4.0 Polypropylene glycol methyl glucose ether 0.5 0.5 Polyoxyethylene sorbitan monolaurate 0.5 0.5 Titanium dioxide 0.04 0.04 Glycerol Monostearate 3.0 3.0 Propylparaben 0.1 0.1 Squalene 1.0 1.0 Caustic carry 5.0 5.0 Salicylic acid 6.0 6.0 Purified water to 100 to 100

[Test Example 1]

30 men and women with acne aged 15 to 35 years using the soap prepared according to Example 1 and Comparative Example 1 for 30 days according to the user's opinion according to the evaluation criteria of Table 2 Determined. The resulting value is shown in Table 3.

Item score  Very good 3  Great 2  no effect One

division Example 1 Comparative Example 2 Cleaning power 2.3 2.1 Moisturizing 2.5 2.2 Bubble generation force 2.2 1.8 Acne Reduction Effect 2.4 2.1 Side Effect Not Occurred Not Occurred

As shown in Table 3, triclosan alone did not achieve satisfactory results for acne, but when triclocaban, licorice extract, sewage extract and golden extract were treated together, synergistic effects were seen at the same concentration, and moisturizing power was obtained. As it is excellent, it has an excellent effect on skin wrinkle removal.

Claims (3)

2, 4, 4-trichloro-2-hydroxy diphenyl ether, 3, 4, 4-trichloro carbanide, licorice extract, sewage extract and golden extract is characterized in that it contains as an active ingredient and Skin external composition for wrinkle removal. The method of claim 1, wherein the total weight of the composition, 0.01 to 2% by weight of 2, 4, 4-trichloro-2-hydroxy diphenyl ether, 0.01 to 1% by weight of 3, 4, 4-trichlorocarbanilide, 1 to 10% by weight licorice extract, sewage extract 1 Skin external composition for acne treatment and wrinkle removal, characterized in that containing 10 to 10% by weight and 5 to 10% by weight of golden extract as an active ingredient. According to claim 1, wherein the composition is an external composition for treating acne and wrinkles, characterized in that the cosmetic formulation or soap formulation.