KR20100101601A - 이온 채널의 조절제로서의 헤테로사이클릭 유도체 - Google Patents
이온 채널의 조절제로서의 헤테로사이클릭 유도체 Download PDFInfo
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- KR20100101601A KR20100101601A KR1020107012966A KR20107012966A KR20100101601A KR 20100101601 A KR20100101601 A KR 20100101601A KR 1020107012966 A KR1020107012966 A KR 1020107012966A KR 20107012966 A KR20107012966 A KR 20107012966A KR 20100101601 A KR20100101601 A KR 20100101601A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Pyridine Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98749007P | 2007-11-13 | 2007-11-13 | |
| US60/987,490 | 2007-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100101601A true KR20100101601A (ko) | 2010-09-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020107012966A Withdrawn KR20100101601A (ko) | 2007-11-13 | 2008-11-12 | 이온 채널의 조절제로서의 헤테로사이클릭 유도체 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8097636B2 (https=) |
| EP (1) | EP2220080B1 (https=) |
| JP (1) | JP2011503191A (https=) |
| KR (1) | KR20100101601A (https=) |
| CN (1) | CN101910166A (https=) |
| AT (1) | ATE540036T1 (https=) |
| AU (1) | AU2008321142A1 (https=) |
| CA (1) | CA2705547A1 (https=) |
| ES (1) | ES2377172T3 (https=) |
| IL (1) | IL205696A0 (https=) |
| MX (1) | MX2010005307A (https=) |
| NZ (1) | NZ585729A (https=) |
| RU (1) | RU2010123876A (https=) |
| WO (1) | WO2009064752A2 (https=) |
| ZA (1) | ZA201003352B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| ATE527251T1 (de) * | 2005-05-16 | 2011-10-15 | Vertex Pharma | Bicyclische derivate als modulatoren von ionenkanälen |
| MX2008003337A (es) | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| AU2008256937A1 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| EP2231655B1 (en) | 2007-11-13 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain |
| RU2011103451A (ru) * | 2008-07-01 | 2012-08-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
| JP6215230B2 (ja) * | 2012-01-16 | 2017-10-18 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | イオンチャネルのモジュレーターとしてのピラン−スピロ環式ピペリジンアミド |
| CN106045908B (zh) * | 2016-06-14 | 2018-09-28 | 郑州轻工业学院 | 一种新型化合物6,7-二溴-1,2,3,4-四氢异喹啉及其制备方法 |
| CN115745910B (zh) | 2017-07-21 | 2025-05-27 | 安塔比奥公司 | 化学化合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CH666623A5 (de) * | 1985-05-17 | 1988-08-15 | Idc Chemie Ag | Vorrichtung zur behandlung von brandwunden oder verbruehungen. |
| US8202861B2 (en) * | 2003-08-08 | 2012-06-19 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20080015102A (ko) * | 2005-05-10 | 2008-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| ATE527251T1 (de) * | 2005-05-16 | 2011-10-15 | Vertex Pharma | Bicyclische derivate als modulatoren von ionenkanälen |
| MX2007015726A (es) * | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| RU2008118350A (ru) * | 2005-10-12 | 2009-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| NZ593074A (en) * | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| AU2008256937A1 (en) * | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| EP2231655B1 (en) * | 2007-11-13 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain |
| RU2011103451A (ru) * | 2008-07-01 | 2012-08-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
-
2008
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- 2008-11-12 CA CA2705547A patent/CA2705547A1/en not_active Abandoned
- 2008-11-12 ES ES08848685T patent/ES2377172T3/es active Active
- 2008-11-12 KR KR1020107012966A patent/KR20100101601A/ko not_active Withdrawn
- 2008-11-12 JP JP2010534132A patent/JP2011503191A/ja not_active Withdrawn
- 2008-11-12 AT AT08848685T patent/ATE540036T1/de active
- 2008-11-12 WO PCT/US2008/083173 patent/WO2009064752A2/en not_active Ceased
- 2008-11-12 EP EP08848685A patent/EP2220080B1/en not_active Not-in-force
- 2008-11-12 AU AU2008321142A patent/AU2008321142A1/en not_active Abandoned
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- 2008-11-12 RU RU2010123876/04A patent/RU2010123876A/ru not_active Application Discontinuation
- 2008-11-12 NZ NZ585729A patent/NZ585729A/en not_active IP Right Cessation
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2010
- 2010-05-11 IL IL205696A patent/IL205696A0/en unknown
- 2010-05-12 ZA ZA2010/03352A patent/ZA201003352B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010123876A (ru) | 2011-12-20 |
| IL205696A0 (en) | 2010-11-30 |
| ES2377172T3 (es) | 2012-03-23 |
| NZ585729A (en) | 2012-04-27 |
| EP2220080B1 (en) | 2012-01-04 |
| MX2010005307A (es) | 2010-07-28 |
| CN101910166A (zh) | 2010-12-08 |
| EP2220080A2 (en) | 2010-08-25 |
| ZA201003352B (en) | 2011-08-31 |
| US8097636B2 (en) | 2012-01-17 |
| AU2008321142A8 (en) | 2010-06-24 |
| CA2705547A1 (en) | 2009-05-22 |
| US20090124655A1 (en) | 2009-05-14 |
| JP2011503191A (ja) | 2011-01-27 |
| AU2008321142A1 (en) | 2009-05-22 |
| ATE540036T1 (de) | 2012-01-15 |
| WO2009064752A3 (en) | 2009-08-27 |
| WO2009064752A2 (en) | 2009-05-22 |
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| PA0105 | International application |
Patent event date: 20100611 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |