KR20100029079A - Gpr12의 저해로 인지 질환을 치료하는 방법 - Google Patents

Gpr12의 저해로 인지 질환을 치료하는 방법 Download PDF

Info

Publication number
KR20100029079A
KR20100029079A KR1020097024747A KR20097024747A KR20100029079A KR 20100029079 A KR20100029079 A KR 20100029079A KR 1020097024747 A KR1020097024747 A KR 1020097024747A KR 20097024747 A KR20097024747 A KR 20097024747A KR 20100029079 A KR20100029079 A KR 20100029079A
Authority
KR
South Korea
Prior art keywords
gpr12
mammal
training
term memory
memory formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020097024747A
Other languages
English (en)
Korean (ko)
Inventor
마르코 페테르스
로데릭 이.엠. 스코트
티모시 피. 툴리
Original Assignee
헬리콘 테라퓨틱스 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 헬리콘 테라퓨틱스 인코퍼레이티드 filed Critical 헬리콘 테라퓨틱스 인코퍼레이티드
Publication of KR20100029079A publication Critical patent/KR20100029079A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020097024747A 2007-05-15 2008-05-15 Gpr12의 저해로 인지 질환을 치료하는 방법 Withdrawn KR20100029079A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93816307P 2007-05-15 2007-05-15
US60/938,163 2007-05-15

Publications (1)

Publication Number Publication Date
KR20100029079A true KR20100029079A (ko) 2010-03-15

Family

ID=40122145

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097024747A Withdrawn KR20100029079A (ko) 2007-05-15 2008-05-15 Gpr12의 저해로 인지 질환을 치료하는 방법

Country Status (11)

Country Link
US (2) US7968524B2 (enExample)
EP (1) EP2162137B1 (enExample)
JP (1) JP2010527375A (enExample)
KR (1) KR20100029079A (enExample)
CN (1) CN101808647A (enExample)
AU (1) AU2008254905A1 (enExample)
BR (1) BRPI0811625A2 (enExample)
CA (1) CA2684920A1 (enExample)
IL (1) IL202091A0 (enExample)
MX (1) MX2009012316A (enExample)
WO (1) WO2008144453A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010118055A1 (en) 2009-04-09 2010-10-14 Cognition Therapeutics, Inc. Inhibitors of cognitive decline
RU2012107457A (ru) 2009-07-31 2013-09-10 Когнишн Терапьютикс, Инк. Ингибиторы ухудшения когнитивных способностей
US20130071330A1 (en) * 2010-02-26 2013-03-21 Susan Catalano Methods of identifying agents effective to treat cognitive decline and diseases associated therewith
SG192596A1 (en) 2011-02-02 2013-09-30 Cognition Therapeutics Inc Isolated compounds from turmeric oil and methods of use
WO2015116923A1 (en) 2014-01-31 2015-08-06 Cognition Therapeutics, Inc. Isoindoline compositions and methods for treating neurodegenerative disease
ES3063712T3 (en) 2017-05-15 2026-04-20 Cognition Therapeutics Inc Compositions for treating neurodegenerative diseases
BR102022009685A2 (pt) * 2022-05-18 2023-11-28 Fundação Oswaldo Cruz Método para triagem de fármacos ou substâncias com potencial neuroprotetor, kit para triagem de fármacos ou substâncias, e, uso de um painel de genes

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6044994A (en) 1993-02-19 1994-09-14 Nippon Shinyaku Co. Ltd. Glycerol derivative, device and pharmaceutical composition
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
US5858988A (en) 1993-02-24 1999-01-12 Wang; Jui H. Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JPH10501686A (ja) 1994-04-13 1998-02-17 ザ ロックフェラー ユニヴァーシティ 神経系の細胞へのdnaのaav仲介送達
US5684143A (en) 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US6653086B1 (en) * 1998-04-14 2003-11-25 Arena Pharmaceuticals, Inc. Endogenous constitutively activated G protein-coupled orphan receptors
JP2003518628A (ja) * 1999-12-10 2003-06-10 アストラゼネカ アクチボラグ 化合物
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
US20060247194A1 (en) 2000-08-30 2006-11-02 Sirna Therapeutics , Inc. Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina)
CN100523215C (zh) * 2000-12-01 2009-08-05 马普科技促进协会 介导rna干涉的小rna分子
US6586524B2 (en) 2001-07-19 2003-07-01 Expression Genetics, Inc. Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
US20040023384A1 (en) * 2002-07-31 2004-02-05 Isis Pharmaceuticals Inc. Antisense modulation of G protein-coupled receptor 12 expression
US20050106731A1 (en) 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
AU2003261449A1 (en) 2002-08-07 2004-02-25 Compositions for rna interference and methods of use thereof
WO2004038407A2 (en) * 2002-10-24 2004-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human g-protein coupled receptor 12 (gpr12)
US7829694B2 (en) * 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US20070104688A1 (en) 2003-02-13 2007-05-10 City Of Hope Small interfering RNA mediated transcriptional gene silencing in mammalian cells
EP1662862A1 (en) * 2003-09-19 2006-06-07 Paradigm Therapeutics Limited Receptor
DK1745295T3 (da) * 2004-04-20 2011-01-31 Galapagos Nv Fremgangsmåder, sammensætninger og forbindelsesanalyser til hæmning af produktionen af amyloid beta-protein

Also Published As

Publication number Publication date
JP2010527375A (ja) 2010-08-12
CN101808647A (zh) 2010-08-18
BRPI0811625A2 (pt) 2014-11-11
US20090022667A1 (en) 2009-01-22
AU2008254905A1 (en) 2008-11-27
EP2162137A1 (en) 2010-03-17
US7968524B2 (en) 2011-06-28
WO2008144453A1 (en) 2008-11-27
EP2162137B1 (en) 2016-11-23
MX2009012316A (es) 2009-12-03
WO2008144453A9 (en) 2010-03-18
US20110281936A1 (en) 2011-11-17
CA2684920A1 (en) 2008-11-27
EP2162137A4 (en) 2011-06-08
IL202091A0 (en) 2010-06-16

Similar Documents

Publication Publication Date Title
KR20100017422A (ko) 작은 간섭 RNA(siRNA)를 이용하여 기억 형성에 관여하는 유전자를 확인하는 방법
TWI543763B (zh) Hsp47表現之調節
CN101557831A (zh) 体内抑制在灵长类亨廷顿基因表达的方法和序列
US20110281936A1 (en) Methods of treating cognitive disorders by inhibition of gpr12
KR20220115995A (ko) 인간 염색체 9 개방 판독 프레임 72 (C9orf72) iRNA 제제 조성물 및 이의 사용 방법
KR20080079264A (ko) 고안압증/녹내장을 치료하기 위한 RHO 키나아제의RNAi-매개 억제
US20250186508A1 (en) Par2 modulation to alter myelination
KR20220025713A (ko) 유전성 신경병증 및 연관 장애의 치료 및 검출
CN102666877A (zh) 治疗神经病理性疼痛的组合物及方法
US20220372492A1 (en) Compounds for modulating fc-epsilon-ri-beta expression and uses thereof
KR101783444B1 (ko) miR-33-5p 를 이용한 뇌신경세포 보호 물질 스크리닝 방법
US20080249038A1 (en) Bone Morphogenetic Protein (Bmp) 2A and Uses Thereof
WO2024251725A1 (en) Oligonucleotides targeting gal3st1
HK1250243A1 (zh) 治疗方法
TW200808328A (en) RNAi-mediated inhibition of stromal cell-derived factor 1-related targets for treatment of neovascularization-related conditions
WO2019047914A1 (zh) 靶向ckip-1的双链rna分子及其用途
KR101088764B1 (ko) Nk1r 단백질 억제제를 포함하는 알코올 의존 예방 및 치료용 조성물
WO2025068557A1 (en) Antisense oligonucleotides for the treatment of canavan disease
HK40103743A (en) Double-stranded rna molecule targeting ckip-1 and use thereof
KR20200131847A (ko) Ttr 아밀로이드증용 병용 요법

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20091127

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid