KR20100017102A - 광학 조영제 - Google Patents

광학 조영제 Download PDF

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Publication number
KR20100017102A
KR20100017102A KR1020097023747A KR20097023747A KR20100017102A KR 20100017102 A KR20100017102 A KR 20100017102A KR 1020097023747 A KR1020097023747 A KR 1020097023747A KR 20097023747 A KR20097023747 A KR 20097023747A KR 20100017102 A KR20100017102 A KR 20100017102A
Authority
KR
South Korea
Prior art keywords
group
contrast agent
formula
btm
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020097023747A
Other languages
English (en)
Korean (ko)
Inventor
알란 커스버트슨
에드빈 빌헬름 요한슨
마이클 에드워드 쿠퍼
Original Assignee
지이 헬스케어 에이에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0709441A external-priority patent/GB0709441D0/en
Priority claimed from GB0715682A external-priority patent/GB0715682D0/en
Priority claimed from GB0716175A external-priority patent/GB0716175D0/en
Application filed by 지이 헬스케어 에이에스 filed Critical 지이 헬스케어 에이에스
Publication of KR20100017102A publication Critical patent/KR20100017102A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
KR1020097023747A 2007-05-16 2008-05-16 광학 조영제 Ceased KR20100017102A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0709441.0 2007-05-16
GB0709441A GB0709441D0 (en) 2007-05-16 2007-05-16 Peptide imaging agents
GB0715682A GB0715682D0 (en) 2007-08-13 2007-08-13 Peptide imaging agents
GB0715682.1 2007-08-13
GB0716175.5 2007-08-20
GB0716175A GB0716175D0 (en) 2007-08-20 2007-08-20 Optical imaging agents

Publications (1)

Publication Number Publication Date
KR20100017102A true KR20100017102A (ko) 2010-02-16

Family

ID=39870387

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097023747A Ceased KR20100017102A (ko) 2007-05-16 2008-05-16 광학 조영제

Country Status (12)

Country Link
US (1) US20100303727A1 (enExample)
EP (1) EP2148702A2 (enExample)
JP (1) JP2010527922A (enExample)
KR (1) KR20100017102A (enExample)
CN (1) CN101743022A (enExample)
AU (1) AU2008249820A1 (enExample)
BR (1) BRPI0811588A2 (enExample)
CA (1) CA2686089A1 (enExample)
IL (1) IL201794A0 (enExample)
MX (1) MX2009012358A (enExample)
NZ (1) NZ581161A (enExample)
WO (1) WO2008139206A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100291706A1 (en) * 2009-05-15 2010-11-18 Millipore Corporation Dye conjugates and methods of use
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
WO2012001063A1 (en) 2010-06-29 2012-01-05 Ge Healthcare As Dye compositions and dye syntheses
CN103813713A (zh) * 2011-07-20 2014-05-21 乔治亚州大学研究基金会 细胞识别缀合物及使用maldi-ms成像对癌症组织进行组织学分析的方法
CN104540819B (zh) * 2012-08-28 2019-04-19 皮尔斯生物科技有限公司 苯并吡喃鎓化合物
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
JP6793122B2 (ja) * 2014-12-19 2020-12-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 術中イメージング
JP7017410B2 (ja) * 2015-01-22 2022-02-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ｉｎ ｖｉｖｏ画像化のためのプロテアーゼ活性化コントラスト剤
WO2016127150A1 (en) * 2015-02-08 2016-08-11 Nanohybrids Methods of detecting biological activity, cellular behavior and drug delivery using encapsulated polymethine aggregates
CN104804463B (zh) * 2015-03-10 2016-08-24 西安交通大学第一附属医院 用于靶向肿瘤组织的近红外荧光染色剂及制备方法和应用
CN107739528A (zh) * 2017-09-30 2018-02-27 武汉工程大学 一种五肽改性菁染料化合物及其制备方法和应用
US20240131199A1 (en) * 2020-12-17 2024-04-25 Bracco Imaging S.P.A. Ph responsive cyanine dyes and conjugates thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627027A (en) * 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US6593148B1 (en) * 1994-03-01 2003-07-15 Li-Cor, Inc. Cyanine dye compounds and labeling methods
IT1276833B1 (it) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US7175953B2 (en) * 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE10018199A1 (de) * 2000-04-12 2001-10-31 Few Chemicals Gmbh Fluoreszenzmarker
EP2258776A1 (en) * 2002-05-10 2010-12-08 Carnegie Mellon University Fluorescent cyanine dyes containing functional groups
EP1594551A2 (en) * 2003-02-19 2005-11-16 Sicel Technologies, Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
US7750163B2 (en) * 2003-10-31 2010-07-06 GE Healthcare U.K. Limited Cyanine dye labelling reagents
WO2006073314A1 (en) * 2005-01-06 2006-07-13 Ge Healthcare As Optical imaging
US8053415B2 (en) * 2005-01-21 2011-11-08 Washington University In St. Louis Compounds having RD targeting motifs
GB2425315B (en) * 2005-04-22 2009-10-07 Ge Healthcare Uk Ltd Water-soluble fluoro-substituted cyanine dyes as reactive fluorescence labelling reagents
ES2612738T3 (es) * 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
DE102006029454A1 (de) * 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
ATE480596T1 (de) * 2005-12-05 2010-09-15 Dyomics Gmbh Hydrophile marker auf der basis von diastereomeren cyaninen
US8273325B2 (en) * 2006-12-20 2012-09-25 Ge Healthcare As Contrast agents
EP2146749B1 (en) * 2007-05-16 2012-03-28 GE Healthcare AS Labelled hgf binding peptides for imaging

Also Published As

Publication number Publication date
WO2008139206A3 (en) 2009-04-16
IL201794A0 (en) 2010-06-16
CN101743022A (zh) 2010-06-16
BRPI0811588A2 (pt) 2014-10-21
NZ581161A (en) 2012-06-29
US20100303727A1 (en) 2010-12-02
EP2148702A2 (en) 2010-02-03
AU2008249820A1 (en) 2008-11-20
JP2010527922A (ja) 2010-08-19
WO2008139206A2 (en) 2008-11-20
MX2009012358A (es) 2010-02-17
CA2686089A1 (en) 2008-11-20

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Patent event date: 20091113

Patent event code: PA01051R01D

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Patent event date: 20130516

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