CN101743022A - 光学成像剂 - Google Patents

光学成像剂 Download PDF

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Publication number
CN101743022A
CN101743022A CN200880024835A CN200880024835A CN101743022A CN 101743022 A CN101743022 A CN 101743022A CN 200880024835 A CN200880024835 A CN 200880024835A CN 200880024835 A CN200880024835 A CN 200880024835A CN 101743022 A CN101743022 A CN 101743022A
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CN
China
Prior art keywords
group
preparation
btm
formula
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880024835A
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English (en)
Chinese (zh)
Inventor
A·卡思伯特森
E·W·约翰内森
M·E·库珀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0709441A external-priority patent/GB0709441D0/en
Priority claimed from GB0715682A external-priority patent/GB0715682D0/en
Priority claimed from GB0716175A external-priority patent/GB0716175D0/en
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN101743022A publication Critical patent/CN101743022A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN200880024835A 2007-05-16 2008-05-16 光学成像剂 Pending CN101743022A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0709441.0 2007-05-16
GB0709441A GB0709441D0 (en) 2007-05-16 2007-05-16 Peptide imaging agents
GB0715682A GB0715682D0 (en) 2007-08-13 2007-08-13 Peptide imaging agents
GB0715682.1 2007-08-13
GB0716175.5 2007-08-20
GB0716175A GB0716175D0 (en) 2007-08-20 2007-08-20 Optical imaging agents
PCT/GB2008/001693 WO2008139206A2 (en) 2007-05-16 2008-05-16 Optical imaging agents

Publications (1)

Publication Number Publication Date
CN101743022A true CN101743022A (zh) 2010-06-16

Family

ID=39870387

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880024835A Pending CN101743022A (zh) 2007-05-16 2008-05-16 光学成像剂

Country Status (12)

Country Link
US (1) US20100303727A1 (enExample)
EP (1) EP2148702A2 (enExample)
JP (1) JP2010527922A (enExample)
KR (1) KR20100017102A (enExample)
CN (1) CN101743022A (enExample)
AU (1) AU2008249820A1 (enExample)
BR (1) BRPI0811588A2 (enExample)
CA (1) CA2686089A1 (enExample)
IL (1) IL201794A0 (enExample)
MX (1) MX2009012358A (enExample)
NZ (1) NZ581161A (enExample)
WO (1) WO2008139206A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103813713A (zh) * 2011-07-20 2014-05-21 乔治亚州大学研究基金会 细胞识别缀合物及使用maldi-ms成像对癌症组织进行组织学分析的方法
CN104540819A (zh) * 2012-08-28 2015-04-22 皮尔斯生物科技有限公司 苯并吡喃鎓化合物
CN104804463A (zh) * 2015-03-10 2015-07-29 西安美佳家医疗科技有限责任公司 用于靶向肿瘤组织的近红外荧光染色剂及制备方法和应用
CN107406872A (zh) * 2015-01-22 2017-11-28 里兰斯坦福初级大学理事会 用于体内成像的蛋白酶活化造影剂
CN107739528A (zh) * 2017-09-30 2018-02-27 武汉工程大学 一种五肽改性菁染料化合物及其制备方法和应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100291706A1 (en) * 2009-05-15 2010-11-18 Millipore Corporation Dye conjugates and methods of use
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
WO2012001063A1 (en) 2010-06-29 2012-01-05 Ge Healthcare As Dye compositions and dye syntheses
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
JP6793122B2 (ja) * 2014-12-19 2020-12-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 術中イメージング
WO2016127150A1 (en) * 2015-02-08 2016-08-11 Nanohybrids Methods of detecting biological activity, cellular behavior and drug delivery using encapsulated polymethine aggregates
US20240131199A1 (en) * 2020-12-17 2024-04-25 Bracco Imaging S.P.A. Ph responsive cyanine dyes and conjugates thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627027A (en) * 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US6593148B1 (en) * 1994-03-01 2003-07-15 Li-Cor, Inc. Cyanine dye compounds and labeling methods
IT1276833B1 (it) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US7175953B2 (en) * 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE10018199A1 (de) * 2000-04-12 2001-10-31 Few Chemicals Gmbh Fluoreszenzmarker
EP2258776A1 (en) * 2002-05-10 2010-12-08 Carnegie Mellon University Fluorescent cyanine dyes containing functional groups
EP1594551A2 (en) * 2003-02-19 2005-11-16 Sicel Technologies, Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
US7750163B2 (en) * 2003-10-31 2010-07-06 GE Healthcare U.K. Limited Cyanine dye labelling reagents
WO2006073314A1 (en) * 2005-01-06 2006-07-13 Ge Healthcare As Optical imaging
US8053415B2 (en) * 2005-01-21 2011-11-08 Washington University In St. Louis Compounds having RD targeting motifs
GB2425315B (en) * 2005-04-22 2009-10-07 Ge Healthcare Uk Ltd Water-soluble fluoro-substituted cyanine dyes as reactive fluorescence labelling reagents
ES2612738T3 (es) * 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
DE102006029454A1 (de) * 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
ATE480596T1 (de) * 2005-12-05 2010-09-15 Dyomics Gmbh Hydrophile marker auf der basis von diastereomeren cyaninen
US8273325B2 (en) * 2006-12-20 2012-09-25 Ge Healthcare As Contrast agents
EP2146749B1 (en) * 2007-05-16 2012-03-28 GE Healthcare AS Labelled hgf binding peptides for imaging

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103813713A (zh) * 2011-07-20 2014-05-21 乔治亚州大学研究基金会 细胞识别缀合物及使用maldi-ms成像对癌症组织进行组织学分析的方法
CN104540819A (zh) * 2012-08-28 2015-04-22 皮尔斯生物科技有限公司 苯并吡喃鎓化合物
CN104540819B (zh) * 2012-08-28 2019-04-19 皮尔斯生物科技有限公司 苯并吡喃鎓化合物
CN107406872A (zh) * 2015-01-22 2017-11-28 里兰斯坦福初级大学理事会 用于体内成像的蛋白酶活化造影剂
CN107406872B (zh) * 2015-01-22 2023-03-28 里兰斯坦福初级大学理事会 用于标记动物组织的化合物、组合物及其应用
CN104804463A (zh) * 2015-03-10 2015-07-29 西安美佳家医疗科技有限责任公司 用于靶向肿瘤组织的近红外荧光染色剂及制备方法和应用
CN104804463B (zh) * 2015-03-10 2016-08-24 西安交通大学第一附属医院 用于靶向肿瘤组织的近红外荧光染色剂及制备方法和应用
CN107739528A (zh) * 2017-09-30 2018-02-27 武汉工程大学 一种五肽改性菁染料化合物及其制备方法和应用

Also Published As

Publication number Publication date
WO2008139206A3 (en) 2009-04-16
IL201794A0 (en) 2010-06-16
BRPI0811588A2 (pt) 2014-10-21
NZ581161A (en) 2012-06-29
US20100303727A1 (en) 2010-12-02
EP2148702A2 (en) 2010-02-03
AU2008249820A1 (en) 2008-11-20
JP2010527922A (ja) 2010-08-19
WO2008139206A2 (en) 2008-11-20
MX2009012358A (es) 2010-02-17
KR20100017102A (ko) 2010-02-16
CA2686089A1 (en) 2008-11-20

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