KR20100010509A - 면역자극 효과를 갖는 ａ 클래스 올리고뉴클레오타이드 - Google Patents
면역자극 효과를 갖는 ａ 클래스 올리고뉴클레오타이드 Download PDFInfo
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- KR20100010509A KR20100010509A KR1020097026396A KR20097026396A KR20100010509A KR 20100010509 A KR20100010509 A KR 20100010509A KR 1020097026396 A KR1020097026396 A KR 1020097026396A KR 20097026396 A KR20097026396 A KR 20097026396A KR 20100010509 A KR20100010509 A KR 20100010509A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US93058007P | 2007-05-17 | 2007-05-17 | |
| US60/930,580 | 2007-05-17 |
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| KR20100010509A true KR20100010509A (ko) | 2010-02-01 |
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| US (1) | US20100285041A1 (OSRAM) |
| EP (1) | EP2160199A2 (OSRAM) |
| JP (1) | JP2009035530A (OSRAM) |
| KR (1) | KR20100010509A (OSRAM) |
| CN (1) | CN101678098A (OSRAM) |
| AR (1) | AR066626A1 (OSRAM) |
| AU (1) | AU2008252577A1 (OSRAM) |
| BR (1) | BRPI0811621A2 (OSRAM) |
| CA (1) | CA2687441A1 (OSRAM) |
| IL (1) | IL202096A0 (OSRAM) |
| MX (1) | MX2009012482A (OSRAM) |
| RU (1) | RU2009142211A (OSRAM) |
| TW (1) | TW200916115A (OSRAM) |
| WO (1) | WO2008142509A2 (OSRAM) |
| ZA (1) | ZA200908062B (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019240503A1 (ko) * | 2018-06-12 | 2019-12-19 | 주식회사 에이엠사이언스 | B형 간염 예방 또는 치료용 조성물 |
| WO2019240504A1 (en) * | 2018-06-12 | 2019-12-19 | Am Sciences Co., Ltd. | Modified oligonucleotides for inhibition of target gene expression |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| CA2480775C (en) | 2002-04-04 | 2016-05-31 | Coley Pharmaceutical Gmbh | Immunostimulatory g,u-containing oligoribonucleotides |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| CA2503693A1 (en) | 2002-10-29 | 2004-05-13 | Coley Pharmaceutical Group, Ltd. | Use of cpg oligonucleotides in the treatment of hepatitis c virus infection |
| CN101454451A (zh) | 2003-10-30 | 2009-06-10 | 科勒制药有限公司 | 具有增强免疫刺激能力的c类寡核苷酸类似物 |
| CN101517082B (zh) | 2006-09-27 | 2014-01-22 | 科勒制药有限责任公司 | 具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物 |
| EP2575878B1 (en) * | 2010-05-28 | 2018-06-13 | Zoetis Belgium S.A. | Vaccines comprising cholesterol and cpg as sole adjuvant-carrier molecules |
| EP2471926A3 (en) * | 2010-12-30 | 2012-07-11 | Intervet International BV | Immunostimulatory oligodeoxynucleotides |
| CN112007045B (zh) * | 2012-07-13 | 2026-01-06 | 波涛生命科学有限公司 | 手性控制 |
| EP3238727B1 (en) * | 2014-12-25 | 2023-01-18 | National Institutes of Biomedical Innovation, Health and Nutrition | Non-aggregating immunostimulatory oligonucleotides |
| WO2016152767A1 (ja) * | 2015-03-20 | 2016-09-29 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途 |
| EP3752194A4 (en) | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY |
| SG11202009647VA (en) | 2018-04-09 | 2020-10-29 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| US20250376689A1 (en) * | 2021-08-31 | 2025-12-11 | City Of Hope | Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof |
| CN113517062B (zh) * | 2021-09-14 | 2021-12-10 | 青岛未来移动医疗科技有限公司 | 一种智能疫苗雾化系统及使用方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5023243A (en) * | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4452775A (en) * | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| DE4321946A1 (de) * | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| US5658738A (en) * | 1994-05-31 | 1997-08-19 | Becton Dickinson And Company | Bi-directional oligonucleotides that bind thrombin |
| WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| WO1998037919A1 (en) * | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| US6218371B1 (en) | 1998-04-03 | 2001-04-17 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| CN1227030C (zh) * | 1999-04-19 | 2005-11-16 | 史密丝克莱恩比彻姆生物有限公司 | 包含皂甙和免疫刺激寡核苷酸的佐剂组合物 |
| NZ517928A (en) * | 1999-09-27 | 2004-09-24 | Coley Pharm Gmbh | Methods related to immunostimulatory nucleic acid-induced interferon |
| US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| ES2314099T3 (es) | 2001-08-17 | 2009-03-16 | Coley Pharmaceutical Gmbh | Oligonucleotidos inmunoestimulantes con motivos combinados con actividad mejorada. |
| AU2006216493A1 (en) * | 2005-02-24 | 2006-08-31 | Coley Pharmaceutical Gmbh | Immunostimulatory oligonucleotides |
| EP1874325A2 (en) * | 2005-04-08 | 2008-01-09 | Coley Pharmaceutical Group, Inc. | Methods for treating infectious disease exacerbated asthma |
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2008
- 2008-05-15 AU AU2008252577A patent/AU2008252577A1/en not_active Abandoned
- 2008-05-15 US US12/600,364 patent/US20100285041A1/en not_active Abandoned
- 2008-05-15 EP EP08750940A patent/EP2160199A2/en not_active Withdrawn
- 2008-05-15 MX MX2009012482A patent/MX2009012482A/es unknown
- 2008-05-15 CA CA002687441A patent/CA2687441A1/en not_active Abandoned
- 2008-05-15 BR BRPI0811621-0A2A patent/BRPI0811621A2/pt not_active IP Right Cessation
- 2008-05-15 WO PCT/IB2008/001199 patent/WO2008142509A2/en not_active Ceased
- 2008-05-15 CN CN200880016477A patent/CN101678098A/zh active Pending
- 2008-05-15 RU RU2009142211/15A patent/RU2009142211A/ru not_active Application Discontinuation
- 2008-05-15 KR KR1020097026396A patent/KR20100010509A/ko not_active Ceased
- 2008-05-16 TW TW097118306A patent/TW200916115A/zh unknown
- 2008-05-16 AR ARP080102108A patent/AR066626A1/es unknown
- 2008-05-16 JP JP2008129762A patent/JP2009035530A/ja active Pending
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2009
- 2009-11-12 IL IL202096A patent/IL202096A0/en unknown
- 2009-11-16 ZA ZA200908062A patent/ZA200908062B/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019240503A1 (ko) * | 2018-06-12 | 2019-12-19 | 주식회사 에이엠사이언스 | B형 간염 예방 또는 치료용 조성물 |
| WO2019240504A1 (en) * | 2018-06-12 | 2019-12-19 | Am Sciences Co., Ltd. | Modified oligonucleotides for inhibition of target gene expression |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100285041A1 (en) | 2010-11-11 |
| BRPI0811621A2 (pt) | 2014-10-21 |
| EP2160199A2 (en) | 2010-03-10 |
| WO2008142509A3 (en) | 2009-03-05 |
| AU2008252577A1 (en) | 2008-11-27 |
| MX2009012482A (es) | 2009-12-02 |
| AR066626A1 (es) | 2009-09-02 |
| TW200916115A (en) | 2009-04-16 |
| CA2687441A1 (en) | 2008-11-27 |
| WO2008142509A2 (en) | 2008-11-27 |
| CN101678098A (zh) | 2010-03-24 |
| JP2009035530A (ja) | 2009-02-19 |
| IL202096A0 (en) | 2010-06-16 |
| ZA200908062B (en) | 2010-06-30 |
| RU2009142211A (ru) | 2011-05-27 |
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